Repurposing CRISPR/Cas9 for in situ functional assays.

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Published in Genes Dev on December 01, 2013

Authors

Abba Malina1, John R Mills, Regina Cencic, Yifei Yan, James Fraser, Laura M Schippers, Marilène Paquet, Josée Dostie, Jerry Pelletier

Author Affiliations

1: Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6 Canada,;

Associated clinical trials:

Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV (Zinc-Finger) | NCT00842634

Phase 1 Dose Escalation Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Patients | NCT01044654

Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Subjects | NCT01252641

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