Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
2
|
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
Nature
|
2010
|
20.01
|
3
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
4
|
Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.
|
N Engl J Med
|
2008
|
12.41
|
5
|
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
|
Nat Genet
|
2010
|
7.94
|
6
|
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|
Nat Genet
|
2010
|
6.66
|
7
|
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
|
Nat Genet
|
2010
|
6.49
|
8
|
New loci associated with kidney function and chronic kidney disease.
|
Nat Genet
|
2010
|
5.58
|
9
|
Antioxidants prevent health-promoting effects of physical exercise in humans.
|
Proc Natl Acad Sci U S A
|
2009
|
5.19
|
10
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
11
|
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
Nat Genet
|
2012
|
4.37
|
12
|
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
|
Diabetes
|
2010
|
4.07
|
13
|
Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes: A 2-Year Randomized, Controlled Trial.
|
Ann Intern Med
|
2015
|
3.78
|
14
|
Insulin-sensitive obesity.
|
Am J Physiol Endocrinol Metab
|
2010
|
3.46
|
15
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
16
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
17
|
New gene functions in megakaryopoiesis and platelet formation.
|
Nature
|
2011
|
3.14
|
18
|
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
|
Nat Genet
|
2012
|
3.04
|
19
|
Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity.
|
J Clin Endocrinol Metab
|
2007
|
2.81
|
20
|
FTO genotype is associated with phenotypic variability of body mass index.
|
Nature
|
2012
|
2.77
|
21
|
Seventy-five genetic loci influencing the human red blood cell.
|
Nature
|
2012
|
2.77
|
22
|
Lead poisoning due to adulterated marijuana in leipzig.
|
Dtsch Arztebl Int
|
2008
|
2.72
|
23
|
Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism.
|
Diabetes
|
2003
|
2.71
|
24
|
CUBN is a gene locus for albuminuria.
|
J Am Soc Nephrol
|
2011
|
2.70
|
25
|
Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass.
|
Cell Metab
|
2007
|
2.69
|
26
|
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.
|
Nat Genet
|
2007
|
2.48
|
27
|
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.
|
Diabetes
|
2010
|
2.44
|
28
|
Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity.
|
Diabetes
|
2006
|
2.40
|
29
|
Plasma visfatin concentrations and fat depot-specific mRNA expression in humans.
|
Diabetes
|
2005
|
2.34
|
30
|
Variants in CPA1 are strongly associated with early onset chronic pancreatitis.
|
Nat Genet
|
2013
|
2.10
|
31
|
Serum levels of the adipokine progranulin depend on renal function.
|
Diabetes Care
|
2012
|
2.03
|
32
|
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
|
Proc Natl Acad Sci U S A
|
2011
|
2.01
|
33
|
Serum vaspin concentrations in human obesity and type 2 diabetes.
|
Diabetes
|
2007
|
1.96
|
34
|
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
|
Nat Genet
|
2012
|
1.90
|
35
|
Serum levels of adipokine retinol-binding protein-4 in relation to renal function.
|
Diabetes Care
|
2007
|
1.85
|
36
|
Standardized assessment of whole body adipose tissue topography by MRI.
|
J Magn Reson Imaging
|
2005
|
1.85
|
37
|
MicroRNA expression in human omental and subcutaneous adipose tissue.
|
PLoS One
|
2009
|
1.81
|
38
|
CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?
|
Gut
|
2012
|
1.77
|
39
|
Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance.
|
Eur J Endocrinol
|
2006
|
1.76
|
40
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
41
|
ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children.
|
J Clin Endocrinol Metab
|
2006
|
1.71
|
42
|
Genome-wide association and functional follow-up reveals new loci for kidney function.
|
PLoS Genet
|
2012
|
1.68
|
43
|
Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans.
|
Obes Res
|
2003
|
1.65
|
44
|
Multiple loci are associated with white blood cell phenotypes.
|
PLoS Genet
|
2011
|
1.65
|
45
|
Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity.
|
J Clin Endocrinol Metab
|
2003
|
1.58
|
46
|
Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus.
|
Hepatology
|
2013
|
1.53
|
47
|
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study.
|
Proc Natl Acad Sci U S A
|
2006
|
1.51
|
48
|
Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction.
|
Clin Endocrinol (Oxf)
|
2014
|
1.49
|
49
|
Eigenvector centrality mapping for analyzing connectivity patterns in fMRI data of the human brain.
|
PLoS One
|
2010
|
1.48
|
50
|
Brain activity in hunger and satiety: an exploratory visually stimulated FMRI study.
|
Obesity (Silver Spring)
|
2008
|
1.46
|
51
|
Circulating adipocyte fatty acid-binding protein induces insulin resistance in mice in vivo.
|
Obesity (Silver Spring)
|
2015
|
1.45
|
52
|
Serum levels of the adipokine FGF21 depend on renal function.
|
Diabetes Care
|
2008
|
1.42
|
53
|
Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue.
|
Diabetes
|
2008
|
1.42
|
54
|
Assay-dependent variability of serum insulin levels during oral glucose tolerance test: influence on reference intervals for insulin and on cut-off values for insulin sensitivity indices.
|
Clin Chem Lab Med
|
2008
|
1.42
|
55
|
Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity?
|
Diabetes Care
|
2004
|
1.42
|
56
|
Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging.
|
PLoS One
|
2011
|
1.30
|
57
|
Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes.
|
Biochem Biophys Res Commun
|
2005
|
1.30
|
58
|
Dietary intervention to reverse carotid atherosclerosis.
|
Circulation
|
2010
|
1.28
|
59
|
Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.
|
Diabetes Care
|
2006
|
1.27
|
60
|
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany.
|
Eur J Hum Genet
|
2010
|
1.26
|
61
|
Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes.
|
PLoS One
|
2010
|
1.25
|
62
|
Interleukin-1beta induces the novel adipokine chemerin in adipocytes in vitro.
|
Regul Pept
|
2009
|
1.24
|
63
|
Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes.
|
Mol Cell Endocrinol
|
2005
|
1.20
|
64
|
Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs.
|
Diabetes
|
2003
|
1.19
|
65
|
Serum levels of the adipokine vaspin in relation to metabolic and renal parameters.
|
J Clin Endocrinol Metab
|
2007
|
1.19
|
66
|
Serum levels of the atherosclerosis biomarker sTWEAK are decreased in type 2 diabetes and end-stage renal disease.
|
Atherosclerosis
|
2007
|
1.18
|
67
|
Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention.
|
Diabetes Care
|
2011
|
1.18
|
68
|
Obesity-Related Differences between Women and Men in Brain Structure and Goal-Directed Behavior.
|
Front Hum Neurosci
|
2011
|
1.17
|
69
|
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.
|
Hum Mol Genet
|
2009
|
1.16
|
70
|
Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes.
|
Am J Physiol Endocrinol Metab
|
2005
|
1.15
|
71
|
Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity.
|
Eur J Hum Genet
|
2011
|
1.15
|
72
|
Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.
|
Diabetes
|
2004
|
1.14
|
73
|
Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training.
|
Eur J Endocrinol
|
2009
|
1.14
|
74
|
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
|
Hum Mol Genet
|
2012
|
1.14
|
75
|
Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.
|
Diabetes Care
|
2007
|
1.13
|
76
|
Intramyocellular lipids and insulin resistance.
|
Diabetes Obes Metab
|
2004
|
1.12
|
77
|
Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression.
|
Diabetes
|
2007
|
1.12
|
78
|
Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity.
|
Metabolism
|
2011
|
1.11
|
79
|
Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene.
|
Eur J Endocrinol
|
2008
|
1.11
|
80
|
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity.
|
Diabetes
|
2009
|
1.11
|
81
|
Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans.
|
Diabetes
|
2002
|
1.08
|
82
|
The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia.
|
Diabetes
|
2002
|
1.08
|
83
|
Fatty acids and insulin resistance in muscle and liver.
|
Best Pract Res Clin Endocrinol Metab
|
2005
|
1.08
|
84
|
Genomic insights into the origin of farming in the ancient Near East.
|
Nature
|
2016
|
1.07
|
85
|
Serum levels of adipocyte fatty acid-binding protein (AFABP) are increased in chronic haemodialysis (CD).
|
Clin Endocrinol (Oxf)
|
2008
|
1.07
|
86
|
Adiponectin expression in humans is dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight.
|
Biochem Biophys Res Commun
|
2005
|
1.06
|
87
|
Mitogen-activated protein kinases, inhibitory-kappaB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity.
|
Endocrinology
|
2007
|
1.06
|
88
|
Adiponectin, obesity, and cardiovascular disease.
|
Biochimie
|
2004
|
1.05
|
89
|
TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.
|
J Clin Endocrinol Metab
|
2007
|
1.04
|
90
|
Assessing the shape of the glucose curve during an oral glucose tolerance test.
|
Diabetes Care
|
2003
|
1.04
|
91
|
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.
|
Hum Mol Genet
|
2011
|
1.03
|
92
|
Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function.
|
Diabetes
|
2003
|
1.02
|
93
|
Genetic variation in the visfatin gene (PBEF1) and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humans.
|
J Clin Endocrinol Metab
|
2006
|
1.01
|
94
|
Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity.
|
J Clin Endocrinol Metab
|
2009
|
1.00
|
95
|
Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine.
|
Clin Sci (Lond)
|
2008
|
1.00
|
96
|
Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans.
|
J Hepatol
|
2007
|
1.00
|
97
|
Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects.
|
Diabetes Care
|
2004
|
1.00
|
98
|
Lead poisoning due to adulterated marijuana.
|
N Engl J Med
|
2008
|
0.99
|
99
|
Serum levels of the adipokine zinc-α2-glycoprotein are increased in chronic hemodialysis.
|
Metabolism
|
2010
|
0.99
|
100
|
Serum levels of the myokine irisin in relation to metabolic and renal function.
|
Eur J Endocrinol
|
2014
|
0.99
|
101
|
Peptide hormones regulating appetite--focus on neuroimaging studies in humans.
|
Diabetes Metab Res Rev
|
2011
|
0.98
|
102
|
Renal function following three distinct weight loss dietary strategies during 2 years of a randomized controlled trial.
|
Diabetes Care
|
2013
|
0.97
|
103
|
A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.
|
PLoS Genet
|
2011
|
0.97
|
104
|
Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes.
|
J Endocrinol
|
2005
|
0.97
|
105
|
Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia.
|
Metabolism
|
2009
|
0.96
|
106
|
Genetics of adiponectin.
|
Biochimie
|
2012
|
0.96
|
107
|
Substantial increase in incidence of severe hypoglycemia between 1997-2000 and 2007-2010: a German longitudinal population-based study.
|
Diabetes Care
|
2012
|
0.96
|
108
|
A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo.
|
Diabetes
|
2006
|
0.95
|
109
|
Dairy calcium intake, serum vitamin D, and successful weight loss.
|
Am J Clin Nutr
|
2010
|
0.95
|
110
|
A novel locus for arterial hypertension on chromosome 1p36 maps to a metabolic syndrome trait cluster in the Sorbs, a Slavic population isolate in Germany.
|
J Hypertens
|
2009
|
0.94
|
111
|
The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk.
|
Curr Opin Clin Nutr Metab Care
|
2007
|
0.94
|
112
|
Lipocalin-2 is induced by interleukin-1beta in murine adipocytes in vitro.
|
J Cell Biochem
|
2009
|
0.94
|
113
|
TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes.
|
BMC Med Genet
|
2011
|
0.94
|
114
|
Plasma adiponectin and endogenous glucose production in humans.
|
Diabetes Care
|
2003
|
0.93
|
115
|
TAS2R38 and its influence on smoking behavior and glucose homeostasis in the German Sorbs.
|
PLoS One
|
2013
|
0.93
|
116
|
The association between plasma adiponectin and insulin sensitivity in humans depends on obesity.
|
Obes Res
|
2005
|
0.93
|
117
|
Serum levels of the adipokine chemerin in relation to renal function.
|
Diabetes Care
|
2009
|
0.93
|
118
|
Polygenic contribution to obesity: genome-wide strategies reveal new targets.
|
Front Horm Res
|
2008
|
0.93
|
119
|
Renal substrate exchange and gluconeogenesis in normal postabsorptive humans.
|
Am J Physiol Endocrinol Metab
|
2002
|
0.92
|
120
|
Association of high serum ferritin concentration with glucose intolerance and insulin resistance in healthy people.
|
Ann Intern Med
|
2003
|
0.92
|
121
|
Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays.
|
BMC Genet
|
2011
|
0.91
|
122
|
Reduced lipolysis as possible cause for greater weight gain in subjects with the Pro12Ala polymorphism in PPARgamma2?
|
Diabetologia
|
2002
|
0.91
|
123
|
Serum levels of the adipokine visfatin are increased in pre-eclampsia.
|
Clin Endocrinol (Oxf)
|
2008
|
0.91
|
124
|
The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes.
|
J Cell Biochem
|
2008
|
0.91
|
125
|
Serum levels of the adipokine chemerin are increased in preeclampsia during and 6 months after pregnancy.
|
Regul Pept
|
2011
|
0.91
|
126
|
Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
|
PLoS Genet
|
2010
|
0.91
|
127
|
Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans.
|
Eur J Endocrinol
|
2007
|
0.90
|
128
|
Contemporary paternal genetic landscape of Polish and German populations: from early medieval Slavic expansion to post-World War II resettlements.
|
Eur J Hum Genet
|
2012
|
0.90
|
129
|
Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity.
|
PLoS One
|
2011
|
0.90
|
130
|
On what evidence-base do we recommend self-monitoring of blood glucose?
|
Diabetes Res Clin Pract
|
2009
|
0.90
|
131
|
Common genetic variation near MC4R has a sex-specific impact on human brain structure and eating behavior.
|
PLoS One
|
2013
|
0.90
|
132
|
Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT.
|
Am J Physiol Endocrinol Metab
|
2003
|
0.89
|
133
|
Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase.
|
Diabetes
|
2003
|
0.89
|
134
|
Genetic factors and insulin secretion: gene variants in the IGF genes.
|
Diabetes
|
2004
|
0.89
|
135
|
Effects of genetic variation in the visfatin gene (PBEF1) on obesity, glucose metabolism, and blood pressure in children.
|
Metabolism
|
2007
|
0.88
|
136
|
Genome-wide meta-analysis of common variant differences between men and women.
|
Hum Mol Genet
|
2012
|
0.88
|
137
|
Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro.
|
FEBS Lett
|
2009
|
0.88
|
138
|
Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes.
|
J Cell Biochem
|
2009
|
0.88
|
139
|
TCF7L2 gene expression in human visceral and subcutaneous adipose tissue is differentially regulated but not associated with type 2 diabetes mellitus.
|
Metabolism
|
2008
|
0.88
|
140
|
Circulating levels of the adipokine chemerin in gestational diabetes mellitus.
|
Horm Res Paediatr
|
2010
|
0.88
|
141
|
Low plasma adiponectin concentrations do not predict weight gain in humans.
|
Diabetes
|
2002
|
0.88
|
142
|
Secretory products from human adipocytes impair endothelial function via nuclear factor kappaB.
|
Atherosclerosis
|
2007
|
0.87
|
143
|
Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance.
|
Atherosclerosis
|
2008
|
0.87
|
144
|
Impaired enteral levothyroxine absorption in hypothyroidism refractory to oral therapy after thyroid ablation for papillary thyroid cancer: case report and kinetic studies.
|
Thyroid
|
2006
|
0.87
|
145
|
Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes.
|
Diabetes Care
|
2003
|
0.87
|
146
|
Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children.
|
PLoS One
|
2011
|
0.86
|
147
|
Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus.
|
Eur J Endocrinol
|
2008
|
0.86
|
148
|
Adipokines influencing metabolic and cardiovascular disease are differentially regulated in maintenance hemodialysis.
|
Metabolism
|
2008
|
0.86
|
149
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