Published in Cell on July 25, 2003
Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol (2009) 7.77
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol (2008) 5.06
Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells. J Cell Biol (2007) 4.03
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev (2009) 3.65
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
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Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev (2007) 3.30
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PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 3.06
The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci (2008) 3.04
Concentric zones of active RhoA and Cdc42 around single cell wounds. J Cell Biol (2005) 3.01
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
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Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell (2010) 2.56
Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol (2004) 2.56
Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. J Cell Biol (2007) 2.31
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Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility. J Cell Biol (2007) 2.16
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To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol (2006) 2.10
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Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol (2008) 1.88
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Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol (2004) 1.85
Directional sensing during chemotaxis. FEBS Lett (2008) 1.84
Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol (2010) 1.82
Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes. Immunology (2004) 1.82
Neutrophil microtubules suppress polarity and enhance directional migration. Proc Natl Acad Sci U S A (2005) 1.81
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Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. J Cell Biol (2007) 1.80
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci (2010) 1.78
Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell (2004) 1.76
Bringing up the rear: defining the roles of the uropod. Nat Rev Mol Cell Biol (2009) 1.74
Oscillatory ROP GTPase activation leads the oscillatory polarized growth of pollen tubes. Mol Biol Cell (2005) 1.69
Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum. J Cell Biol (2008) 1.69
Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell (2006) 1.67
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.67
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood (2007) 1.65
Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. J Cell Biol (2012) 1.65
Chemotaxis, chemokine receptors and human disease. Cytokine (2008) 1.63
Chemotaxis: signalling modules join hands at front and tail. EMBO Rep (2004) 1.61
Polar stimulation and constrained cell migration in microfluidic channels. Lab Chip (2007) 1.60
Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J (2006) 1.58
The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. Am J Physiol Cell Physiol (2012) 1.57
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol (2010) 1.55
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A (2006) 1.54
Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proc Natl Acad Sci U S A (2007) 1.54
The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol (2009) 1.53
Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell (2012) 1.52
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins. Nat Immunol (2008) 1.51
A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol (2007) 1.51
Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells. PLoS One (2010) 1.49
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49
Polarity reveals intrinsic cell chirality. Proc Natl Acad Sci U S A (2007) 1.48
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J (2007) 1.48
Protons make tumor cells move like clockwork. Pflugers Arch (2009) 1.48
Neutrophil traction stresses are concentrated in the uropod during migration. Biophys J (2007) 1.45
Exploring the control circuit of cell migration by mathematical modeling. Biophys J (2008) 1.44
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol (2012) 1.43
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J Cell Biol (2010) 1.40
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Rho GTPases in hematopoiesis and hemopathies. Blood (2009) 1.37
Coordination of Rho and Rac GTPase function via p190B RhoGAP. Curr Biol (2008) 1.36
Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. J Cell Biol (2011) 1.36
A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput Biol (2007) 1.32
Mechanical forces induced by the transendothelial migration of human neutrophils. Biophys J (2008) 1.28
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis. Mol Biol Cell (2007) 1.27
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Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL). Proc Natl Acad Sci U S A (2005) 1.25
G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. Mol Biol Cell (2007) 1.24
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts. J Cell Sci (2009) 1.22
Distinguishing modes of eukaryotic gradient sensing. Biophys J (2005) 1.22
Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants. Biophys J (2004) 1.21
GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. Cell Res (2011) 1.21
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration. Small GTPases (2014) 1.21
Coordinating cytoskeletal tracks to polarize cellular movements. J Cell Biol (2004) 1.20
Traction forces of neutrophils migrating on compliant substrates. Biophys J (2011) 1.20
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. J Cell Biol (2007) 1.20
Directional decisions during neutrophil chemotaxis inside bifurcating channels. Integr Biol (Camb) (2010) 1.20
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2. Mol Cell Biol (2004) 1.17
Calling heads from tails: the role of mathematical modeling in understanding cell polarization. Curr Opin Cell Biol (2009) 1.17
Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet. Curr Opin Cell Biol (2014) 1.17
Forming the cell rear first: breaking cell symmetry to trigger directed cell migration. Nat Cell Biol (2010) 1.16
The PIX-GIT complex: a G protein signaling cassette in control of cell shape. Semin Cell Dev Biol (2008) 1.16
Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood (2005) 1.16
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
The gated gait of the processive molecular motor, myosin V. Nat Cell Biol (2002) 5.34
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol (2002) 4.64
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood (2002) 4.56
TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol (2012) 4.19
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
Identification of an organelle receptor for myosin-Va. Nat Cell Biol (2002) 4.06
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J (2004) 3.72
Load-dependent kinetics of myosin-V can explain its high processivity. Nat Cell Biol (2005) 3.69
Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells. Nat Mater (2009) 3.30
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol (2003) 3.01
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil (2004) 2.96
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol (2004) 2.93
Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res (2003) 2.85
Determining the position of the cell division plane. Nature (2003) 2.80
Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. Gastroenterology (2009) 2.75
Dynamics of neutrophil migration in lymph nodes during infection. Immunity (2008) 2.70
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron (2003) 2.51
Disparities in diabetes care: impact of mental illness. Arch Intern Med (2005) 2.45
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Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science (2013) 2.34
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Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J (2008) 2.29
Neck length and processivity of myosin V. J Biol Chem (2003) 2.23
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
The prepower stroke conformation of myosin V. J Cell Biol (2002) 2.12
The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head. J Biol Chem (2005) 2.11
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol (2006) 2.10
The effects of statins and renin-angiotensin system blockers on atrial fibrillation recurrence following antral pulmonary vein isolation. J Cardiovasc Electrophysiol (2007) 2.09
Determinants of ABH expression on human blood platelets. Blood (2004) 2.05
Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. J Biol Chem (2003) 2.03
Medial patella retinaculum plasty for treatment of habitual patellar dislocation in adolescents. Int Orthop (2012) 2.02
Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol (2007) 2.01
Residual risk of transfusion-transmitted viral infections in Shenzhen, China, 2001 through 2004. Transfusion (2007) 1.99
Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids. Proc Natl Acad Sci U S A (2012) 1.97
Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol (2003) 1.94
Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell (2002) 1.89
Multipotent and unipotent progenitors contribute to prostate postnatal development. Nat Cell Biol (2012) 1.89
The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. J Cell Biol (2002) 1.86
Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. Cancer Res (2003) 1.83
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Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol Biol Cell (2003) 1.82
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Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. Neuropsychopharmacology (2011) 1.50
A critical role of autophagy in plant resistance to necrotrophic fungal pathogens. Plant J (2011) 1.49
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Changes and their prognostic implications in the abbreviated VitalPAC™ Early Warning Score (ViEWS) after admission to hospital of 18,827 surgical patients. Resuscitation (2012) 1.49
Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33. Biochem J (2011) 1.49
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Polarity reveals intrinsic cell chirality. Proc Natl Acad Sci U S A (2007) 1.48
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Elevated levels of oxidized low-density lipoprotein correlate positively with C-reactive protein in patients with acute coronary syndrome. Cell Biochem Biophys (2012) 1.47
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Combining knowledge and data driven insights for identifying risk factors using electronic health records. AMIA Annu Symp Proc (2012) 1.46
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Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed. J Immune Based Ther Vaccines (2004) 1.46
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