Published in J Neurosci on July 11, 2007
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev (2009) 3.18
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91
Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov (2009) 2.88
Central control of thermogenesis in mammals. Exp Physiol (2008) 2.74
Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. Proc Natl Acad Sci U S A (2009) 1.94
Central neural regulation of brown adipose tissue thermogenesis and energy expenditure. Cell Metab (2014) 1.85
The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol (2012) 1.69
Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory. Cell Cycle (2012) 1.65
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Ann Rheum Dis (2013) 1.64
Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci (2011) 1.51
The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol (2008) 1.48
Central control of brown adipose tissue thermogenesis. Front Endocrinol (Lausanne) (2012) 1.47
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci (2012) 1.46
Skin temperature: its role in thermoregulation. Acta Physiol (Oxf) (2014) 1.43
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia. J Neurosci (2010) 1.35
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis. BMC Vet Res (2012) 1.06
Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data. Mol Pain (2013) 1.01
Polypeptide modulators of TRPV1 produce analgesia without hyperthermia. Mar Drugs (2013) 1.01
Moving towards supraspinal TRPV1 receptors for chronic pain relief. Mol Pain (2010) 0.99
Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes. Front Neuroendocrinol (2013) 0.97
Central neural control of thermoregulation and brown adipose tissue. Auton Neurosci (2016) 0.95
Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol Pain (2012) 0.94
Central nervous system regulation of brown adipose tissue. Compr Physiol (2014) 0.93
Thermoregulation: channels that are cool to the core. Curr Biol (2007) 0.93
Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1. Br J Pharmacol (2012) 0.92
NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss. Antioxid Redox Signal (2010) 0.92
The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors. J Physiol (2011) 0.91
TRPV1: A Potential Drug Target for Treating Various Diseases. Cells (2014) 0.91
Effect of Maillard reacted peptides on human salt taste and the amiloride-insensitive salt taste receptor (TRPV1t). Chem Senses (2008) 0.89
An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol (2011) 0.89
Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.86
Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia. J Neurosci (2013) 0.85
Physical exercise-induced changes in the core body temperature of mice depend more on ambient temperature than on exercise protocol or intensity. Int J Biometeorol (2013) 0.85
Cold suppresses agonist-induced activation of TRPV1. J Dent Res (2011) 0.84
Acute heat-evoked temperature sensation is impaired but not abolished in mice lacking TRPV1 and TRPV3 channels. PLoS One (2014) 0.83
TRP channels in the digestive system. Curr Pharm Biotechnol (2011) 0.83
Lack of potentiating effect of increasing temperature on responses to chemical activators in vagal sensory neurons isolated from TRPV1-null mice. Am J Physiol Lung Cell Mol Physiol (2008) 0.82
TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation. Curr Top Med Chem (2011) 0.81
Central control of body temperature. F1000Res (2016) 0.81
Effect of capsaicin on thermoregulation: an update with new aspects. Temperature (Austin) (2015) 0.81
TRPA1 mediates the hypothermic action of acetaminophen. Sci Rep (2015) 0.80
Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist. Br J Clin Pharmacol (2014) 0.80
Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol (2012) 0.79
Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain. Curr Neuropharmacol (2013) 0.78
TRPV1 Channel: A Potential Drug Target for Treating Epilepsy. Curr Neuropharmacol (2015) 0.78
The involvement of TRPV1 in emesis and anti-emesis. Temperature (Austin) (2015) 0.78
The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature. FASEB J (2015) 0.78
TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation. Sci Rep (2016) 0.78
TRP ion channels in thermosensation, thermoregulation and metabolism. Temperature (Austin) (2015) 0.77
Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance and physical exercise-induced physiological responses. Braz J Med Biol Res (2016) 0.77
Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: pharmacokinetic/ pharmacodynamic analysis of three phase 1 trials. Br J Clin Pharmacol (2013) 0.76
Current understanding on the neurophysiology of behavioral thermoregulation. Temperature (Austin) (2015) 0.76
Supraspinal-selective TRPV1 desensitization induced by intracerebroventricular treatment with resiniferatoxin. Sci Rep (2017) 0.75
Cold-Induced Thermogenesis and Inflammation-Associated Cold-Seeking Behavior Are Represented by Different Dorsomedial Hypothalamic Sites: A Three-Dimensional Functional Topography Study in Conscious Rats. J Neurosci (2017) 0.75
Turning up the heat on surgical cold. Temperature (Austin) (2017) 0.75
Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates. Temperature (Austin) (2017) 0.75
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev (2009) 3.18
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain (2008) 2.91
Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem (2004) 2.17
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther (2004) 2.08
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci (2007) 2.07
Cellular and molecular bases of the initiation of fever. PLoS Biol (2006) 1.98
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. Brain Res Rev (2008) 1.92
Fever and hypothermia in systemic inflammation: recent discoveries and revisions. Front Biosci (2005) 1.75
Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory. Cell Cycle (2012) 1.65
[Prognostic value of GRACE scores versus TIMI score in acute coronary syndromes]. Arq Bras Cardiol (2010) 1.59
Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature. Am J Physiol Regul Integr Comp Physiol (2005) 1.58
Prostaglandin E2 as a mediator of fever: synthesis and catabolism. Front Biosci (2004) 1.57
Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci (2011) 1.51
Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Endocrinology (2003) 1.49
Nicotine administration and withdrawal affect survival in systemic inflammation models. J Appl Physiol (1985) (2008) 1.48
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci (2012) 1.46
QTc interval prolongation by d-propoxyphene: what about other analgesics? Expert Opin Pharmacother (2012) 1.45
Sodium channels and nociception: recent concepts and therapeutic opportunities. Curr Opin Pharmacol (2007) 1.41
Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia. J Neurosci (2010) 1.35
Neural circuitry engaged by prostaglandins during the sickness syndrome. Nat Neurosci (2012) 1.35
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest (2008) 1.34
Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. J Neurochem (2002) 1.30
Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide. Neuroendocrinology (2005) 1.26
Schistosoma mansoni infection is associated with a reduced course of asthma. J Allergy Clin Immunol (2003) 1.24
Putative dual role of ephrin-Eph receptor interactions in inflammation. IUBMB Life (2006) 1.24
Neural substrate of cold-seeking behavior in endotoxin shock. PLoS One (2006) 1.24
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
The TRPV1 receptor and nociception. Semin Cell Dev Biol (2006) 1.21
Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther (2008) 1.21
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther (2007) 1.20
Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation. Eur J Neurosci (2006) 1.19
Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin. FASEB J (2005) 1.15
Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation. Am J Physiol Regul Integr Comp Physiol (2002) 1.11
Antibodies to nerve growth factor reverse established tactile allodynia in rodent models of neuropathic pain without tolerance. J Pharmacol Exp Ther (2007) 1.11
Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation. Am J Physiol Regul Integr Comp Physiol (2012) 1.10
Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats. Physiol Genomics (2005) 1.08
Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision. Anesthesiology (2008) 1.07
Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol Pharmacol (2005) 1.02
Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res (2006) 1.02
Lipopolysaccharide fever is initiated via a capsaicin-sensitive mechanism independent of the subtype-1 vanilloid receptor. Br J Pharmacol (2004) 0.99
Cocaine- and amphetamine-regulated transcript (CART) peptides modulate the locomotor and motivational properties of psychostimulants. J Pharmacol Exp Ther (2005) 0.99
An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways. Pain (2013) 0.98
Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia? Am J Physiol Regul Integr Comp Physiol (2009) 0.98
Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes. Front Neuroendocrinol (2013) 0.97
Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia. Cancer Res (2004) 0.97
Prognostic value of cytokines and chemokines in addition to the GRACE Score in non-ST-elevation acute coronary syndromes. Clin Chim Acta (2010) 0.96
Platelet-activating factor: a previously unrecognized mediator of fever. J Physiol (2003) 0.95
Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood (2006) 0.93
Enhanced amylin-mediated body weight loss in estradiol-deficient diet-induced obese rats. Endocrinology (2010) 0.92
A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation. J Pharmacol Exp Ther (2006) 0.92
Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever. Am J Physiol Regul Integr Comp Physiol (2002) 0.92
Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists. J Med Chem (2008) 0.91
The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors. J Physiol (2011) 0.91
Fever response to intravenous prostaglandin E2 is mediated by the brain but does not require afferent vagal signaling. Am J Physiol Regul Integr Comp Physiol (2008) 0.91
Fever responses of Zucker rats with and without fatty mutation of the leptin receptor. Am J Physiol Regul Integr Comp Physiol (2002) 0.90
A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia. FASEB J (2004) 0.89
Bilateral splanchnicotomy does not affect lipopolysaccharide-induced fever in rats. Brain Res (2003) 0.89
Noradrenergic neurons of the area postrema mediate amylin's hypophagic action. Am J Physiol Regul Integr Comp Physiol (2010) 0.89
A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability. Br J Pharmacol (2015) 0.88