Published in J Pharmacol Exp Ther on July 25, 2007
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev (2009) 3.18
Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov (2011) 2.25
The functions of TRPA1 and TRPV1: moving away from sensory nerves. Br J Pharmacol (2012) 1.69
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Ann Rheum Dis (2013) 1.64
The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol (2008) 1.48
Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia. J Neurosci (2010) 1.35
Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection. J Neurosci (2014) 1.06
Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis. BMC Vet Res (2012) 1.06
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. Nat Commun (2011) 1.03
Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data. Mol Pain (2013) 1.01
Moving towards supraspinal TRPV1 receptors for chronic pain relief. Mol Pain (2010) 0.99
Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol Pain (2012) 0.94
TRPV1: A Potential Drug Target for Treating Various Diseases. Cells (2014) 0.91
An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol (2011) 0.89
Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice. Channels (Austin) (2012) 0.87
Trafficking of ThermoTRP Channels. Membranes (Basel) (2014) 0.83
TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation. Curr Top Med Chem (2011) 0.81
TRPA1 mediates the hypothermic action of acetaminophen. Sci Rep (2015) 0.80
Targeting TRP channels for chronic cough: from bench to bedside. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.80
Probing the Effects and Mechanisms of Electroacupuncture at Ipsilateral or Contralateral ST36-ST37 Acupoints on CFA-induced Inflammatory Pain. Sci Rep (2016) 0.80
Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain. Curr Neuropharmacol (2013) 0.78
Released lipids regulate transient receptor potential channel (TRP)-dependent oral cancer pain. Mol Pain (2015) 0.78
Regulation of MMP-9 by a WIN-binding site in the monocyte-macrophage system independent from cannabinoid receptors. PLoS One (2012) 0.78
Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors. Neuroscience (2012) 0.78
TRP ion channels in thermosensation, thermoregulation and metabolism. Temperature (Austin) (2015) 0.77
AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.77
TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now? J Bioenerg Biomembr (2016) 0.77
Altered pharmacology of native rodent spinal cord TRPV1 after phosphorylation. Br J Pharmacol (2013) 0.77
Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: pharmacokinetic/ pharmacodynamic analysis of three phase 1 trials. Br J Clin Pharmacol (2013) 0.76
Neonatal capsaicin treatment in rats induces chronic hyperthermia resulting in infectious disease. Exp Ther Med (2015) 0.75
Ion channel therapeutics for pain. Channels (Austin) (2015) 0.75
Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats. Mol Pain (2016) 0.75
TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy. EMBO Rep (2016) 0.75
The pattern of polymorphism in Arabidopsis thaliana. PLoS Biol (2005) 10.13
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev (2009) 3.18
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain (2008) 2.91
Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci (2007) 2.57
FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. J Clin Invest (2012) 2.41
NCCN clinical practice guidelines in oncology: kidney cancer. J Natl Compr Canc Netw (2009) 2.40
A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Res (2005) 2.27
Subintimal angioplasty for below-the-ankle arterial occlusions in diabetic patients with chronic critical limb ischemia. J Endovasc Ther (2009) 2.22
Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem (2004) 2.17
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther (2004) 2.08
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci (2007) 2.07
Effect of thimerosal on the neurodevelopment of premature rats. World J Pediatr (2013) 2.04
ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons. Mol Pain (2005) 1.95
NCCN clinical practice guidelines in oncology: testicular cancer. J Natl Compr Canc Netw (2009) 1.86
High-throughput discovery of rare insertions and deletions in large cohorts. Genome Res (2010) 1.83
Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. Pain (2006) 1.83
Circulating serum xenoestrogens and mammographic breast density. Breast Cancer Res (2013) 1.65
Calcimimetic inhibits late-stage cyst growth in ADPKD. J Am Soc Nephrol (2009) 1.58
Functional NMDA receptors in rat erythrocytes. Am J Physiol Cell Physiol (2010) 1.54
Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Endocrinology (2003) 1.49
Retrograde transdorsal-to-plantar or transplantar-to-dorsal intraluminal re-entry following unsuccessful subintimal angioplasty for below-the-ankle arterial occlusion. J Endovasc Ther (2010) 1.47
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain (2005) 1.46
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci (2012) 1.46
Sodium channels and nociception: recent concepts and therapeutic opportunities. Curr Opin Pharmacol (2007) 1.41
Differences in the prevalence of asthma and current wheeze between Jews and Arabs: results from a national survey of schoolchildren in Israel. Ann Allergy Asthma Immunol (2002) 1.40
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc Natl Acad Sci U S A (2005) 1.33
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology (2009) 1.31
Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival. Radiat Res (2009) 1.31
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat Struct Mol Biol (2012) 1.30
Human urine proteome analysis by three separation approaches. Proteomics (2005) 1.29
Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide. Neuroendocrinology (2005) 1.26
Follow the money. Nature (2010) 1.24
Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem (2014) 1.22
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther (2008) 1.21
Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats. Stroke (2005) 1.18
New lignans from Kadsura coccinea and their nitric oxide inhibitory activities. Chem Pharm Bull (Tokyo) (2006) 1.16
Tapetum degeneration retardation is critical for aliphatic metabolism and gene regulation during rice pollen development. Mol Plant (2008) 1.15
Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin. FASEB J (2005) 1.15
Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol (2012) 1.14
Concanavalin A-captured glycoproteins in healthy human urine. Mol Cell Proteomics (2005) 1.13
Conserved regulatory elements in AMPK. Nature (2013) 1.11
Antibodies to nerve growth factor reverse established tactile allodynia in rodent models of neuropathic pain without tolerance. J Pharmacol Exp Ther (2007) 1.11
Testicular cancer. J Natl Compr Canc Netw (2012) 1.11
Hemispheric asymmetry in cognitive division of anterior cingulate cortex: a resting-state functional connectivity study. Neuroimage (2009) 1.10
The influence of community and individual health literacy on self-reported health status. J Gen Intern Med (2013) 1.09
Biomimetic approach to perophoramidine and communesin via an intramolecular cyclopropanation reaction. Org Lett (2006) 1.09
Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiat Res (2008) 1.09
Antihypertensive adherence and drug class among Asian Pacific Americans. Ethn Health (2007) 1.08
Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res (2010) 1.08
Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Circulation (2011) 1.07
Western Trauma Association critical decisions in trauma: nonoperative management of adult blunt hepatic trauma. J Trauma (2009) 1.07
Eyes-open/eyes-closed dataset sharing for reproducibility evaluation of resting state fMRI data analysis methods. Neuroinformatics (2013) 1.07
Disrupted causal connectivity in mesial temporal lobe epilepsy. PLoS One (2013) 1.07
Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials (2009) 1.06