Published in J Pharmacol Exp Ther on April 17, 2008
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev (2009) 3.18
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Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest (2010) 1.85
The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol (2008) 1.48
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci (2012) 1.46
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Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. Blood (2011) 1.42
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Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia. PLoS One (2009) 1.11
The discovery and development of analgesics: new mechanisms, new modalities. J Clin Invest (2010) 1.03
Polypeptide modulators of TRPV1 produce analgesia without hyperthermia. Mar Drugs (2013) 1.01
TRP channels and analgesia. Life Sci (2012) 0.99
Moving towards supraspinal TRPV1 receptors for chronic pain relief. Mol Pain (2010) 0.99
Transient receptor potential A1 channels: insights into cough and airway inflammatory disease. Chest (2011) 0.96
The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1. Br J Pharmacol (2009) 0.94
Transient receptor potential channels as targets for phytochemicals. ACS Chem Neurosci (2014) 0.88
Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels. Pulm Pharmacol Ther (2013) 0.86
ThermoTRPs and Pain. Neuroscientist (2015) 0.86
Vanilloids induce oral cancer apoptosis independent of TRPV1. Oral Oncol (2014) 0.84
TRP channel antagonists as potential antitussives. Lung (2011) 0.83
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Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. J Headache Pain (2015) 0.81
LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain. PLoS One (2014) 0.81
The involvement of TRPV1 in emesis and anti-emesis. Temperature (Austin) (2015) 0.78
Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Mol Pain (2012) 0.78
Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain. Curr Neuropharmacol (2013) 0.78
Altered pharmacology of native rodent spinal cord TRPV1 after phosphorylation. Br J Pharmacol (2013) 0.77
TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats. Temperature (Austin) (2015) 0.77
Breaking barriers to novel analgesic drug development. Nat Rev Drug Discov (2017) 0.77
Targeting peripheral afferent nerve terminals for cough and dyspnea. Curr Opin Pharmacol (2011) 0.76
α-Spinasterol, a TRPV1 receptor antagonist, elevates the seizure threshold in three acute seizure tests in mice. J Neural Transm (Vienna) (2015) 0.75
A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol (2016) 0.75
Short Report: TRPV1-polymorphism 1911 A>G alters capsaicin-induced sensory changes in healthy subjects. PLoS One (2017) 0.75
The pattern of polymorphism in Arabidopsis thaliana. PLoS Biol (2005) 10.13
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Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain (2008) 2.91
Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci (2007) 2.57
NCCN clinical practice guidelines in oncology: kidney cancer. J Natl Compr Canc Netw (2009) 2.40
A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Res (2005) 2.27
Subintimal angioplasty for below-the-ankle arterial occlusions in diabetic patients with chronic critical limb ischemia. J Endovasc Ther (2009) 2.22
Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem (2004) 2.17
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther (2004) 2.08
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci (2007) 2.07
Effect of thimerosal on the neurodevelopment of premature rats. World J Pediatr (2013) 2.04
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. Brain Res Rev (2008) 1.92
NCCN clinical practice guidelines in oncology: testicular cancer. J Natl Compr Canc Netw (2009) 1.86
High-throughput discovery of rare insertions and deletions in large cohorts. Genome Res (2010) 1.83
Antitumor effects and normal tissue toxicity of 111In-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive human breast cancer xenografts. J Nucl Med (2003) 1.74
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain. Pain (2004) 1.65
Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory. Cell Cycle (2012) 1.65
Circulating serum xenoestrogens and mammographic breast density. Breast Cancer Res (2013) 1.65
Nuclear localizing sequences promote nuclear translocation and enhance the radiotoxicity of the anti-CD33 monoclonal antibody HuM195 labeled with 111In in human myeloid leukemia cells. J Nucl Med (2006) 1.58
Functional NMDA receptors in rat erythrocytes. Am J Physiol Cell Physiol (2010) 1.54
Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci (2011) 1.51
123I-labeled HIV-1 tat peptide radioimmunoconjugates are imported into the nucleus of human breast cancer cells and functionally interact in vitro and in vivo with the cyclin-dependent kinase inhibitor, p21(WAF-1/Cip-1). Eur J Nucl Med Mol Imaging (2006) 1.48
Retrograde transdorsal-to-plantar or transplantar-to-dorsal intraluminal re-entry following unsuccessful subintimal angioplasty for below-the-ankle arterial occlusion. J Endovasc Ther (2010) 1.47
Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci (2012) 1.46
p38 MAP kinase inhibitors: many are made, but few are chosen. Curr Opin Drug Discov Devel (2005) 1.43
Differences in the prevalence of asthma and current wheeze between Jews and Arabs: results from a national survey of schoolchildren in Israel. Ann Allergy Asthma Immunol (2002) 1.40
Role of ethics in groundwater management. Ground Water (2009) 1.39
Simultaneous occurrence of pleural effusion and interstitial pneumonitis after treatment with pegylated interferon for hepatitis C virus infection. South Med J (2011) 1.38
Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia. J Neurosci (2010) 1.35
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest (2008) 1.34
Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China. Int J Cancer (2009) 1.32
Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology (2009) 1.31
IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Cancer Biol Ther (2007) 1.30
Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. J Neurochem (2002) 1.30
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat Struct Mol Biol (2012) 1.30
Human urine proteome analysis by three separation approaches. Proteomics (2005) 1.29
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Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
The TRPV1 receptor and nociception. Semin Cell Dev Biol (2006) 1.21
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther (2007) 1.20
Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats. Stroke (2005) 1.18
New lignans from Kadsura coccinea and their nitric oxide inhibitory activities. Chem Pharm Bull (Tokyo) (2006) 1.16
Toward an understanding of the role of dynamics on enzymatic catalysis in lactate dehydrogenase. Biochemistry (2002) 1.15
Tapetum degeneration retardation is critical for aliphatic metabolism and gene regulation during rice pollen development. Mol Plant (2008) 1.15
Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration. Cancer Chemother Pharmacol (2012) 1.14
Are health-care relationships important for mammography adherence in Latinas? J Gen Intern Med (2008) 1.13
Concanavalin A-captured glycoproteins in healthy human urine. Mol Cell Proteomics (2005) 1.13
Secondary branching and nitrogen doping of ZnO nanotetrapods: building a highly active network for photoelectrochemical water splitting. Nano Lett (2011) 1.12
IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1. J Zhejiang Univ Sci B (2006) 1.12
Conserved regulatory elements in AMPK. Nature (2013) 1.11
Antibodies to nerve growth factor reverse established tactile allodynia in rodent models of neuropathic pain without tolerance. J Pharmacol Exp Ther (2007) 1.11
Testicular cancer. J Natl Compr Canc Netw (2012) 1.11
Hemispheric asymmetry in cognitive division of anterior cingulate cortex: a resting-state functional connectivity study. Neuroimage (2009) 1.10
Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells. Br J Pharmacol (2011) 1.10
Biomimetic approach to perophoramidine and communesin via an intramolecular cyclopropanation reaction. Org Lett (2006) 1.09
Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Circulation (2011) 1.07
Eyes-open/eyes-closed dataset sharing for reproducibility evaluation of resting state fMRI data analysis methods. Neuroinformatics (2013) 1.07
Disrupted causal connectivity in mesial temporal lobe epilepsy. PLoS One (2013) 1.07
Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision. Anesthesiology (2008) 1.07
Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials (2009) 1.06
Pharmacokinetics, metabolism and excretion of [(14)C]-lenalidomide following oral administration in healthy male subjects. Cancer Chemother Pharmacol (2011) 1.06