An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer.

PubWeight™: 1.42‹?› | Rank: Top 5%

🔗 View Article (PMC 2916138)

Published in J Exp Med on August 02, 2010

Authors

Mark Asquith1, Fiona Powrie

Author Affiliations

1: Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, England, UK. mark.asquith@path.ox.ac.uk

Articles citing this

Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43

The gut microbiota in IBD. Nat Rev Gastroenterol Hepatol (2012) 3.88

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest (2013) 2.96

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med (2012) 2.11

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 1.86

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell (2015) 1.81

B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity (2012) 1.47

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity (2014) 1.28

Crucial involvement of tumor-associated neutrophils in the regulation of chronic colitis-associated carcinogenesis in mice. PLoS One (2012) 1.17

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci U S A (2013) 1.12

Emerging cytokine networks in colorectal cancer. Nat Rev Immunol (2015) 1.09

Gastrointestinal malignancy and the microbiome. Gastroenterology (2014) 1.07

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest (2012) 1.05

Role of Th17 Cells in the Pathogenesis of Human IBD. ISRN Inflamm (2014) 1.04

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles. Mol Nutr Food Res (2014) 1.00

Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy. Proc Natl Acad Sci U S A (2011) 0.99

Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice. Inflamm Bowel Dis (2013) 0.97

DNA repair is indispensable for survival after acute inflammation. J Clin Invest (2012) 0.96

ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis. Autophagy (2013) 0.90

Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice. Int J Cancer (2011) 0.87

Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis. Proc Natl Acad Sci U S A (2015) 0.86

The membrane-bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice. Gastroenterology (2011) 0.86

Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells. Mucosal Immunol (2013) 0.83

Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2. PLoS One (2013) 0.81

Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A (2014) 0.81

Mechanisms of Microbe-Host Interaction in Crohn's Disease: Dysbiosis vs. Pathobiont Selection. Front Immunol (2015) 0.80

Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol (2016) 0.80

Associations of microbiota and toll-like receptor signaling pathway in esophageal adenocarcinoma. BMC Cancer (2016) 0.79

A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Mucosal Immunol (2015) 0.78

Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. Pharmacogn Mag (2016) 0.78

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. ACS Med Chem Lett (2015) 0.78

Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol (2017) 0.77

Gut Mesenchymal Stromal Cells in Immunity. Stem Cells Int (2017) 0.75

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection. PLoS Pathog (2016) 0.75

NOD2 prevents emergence of disease-predisposing microbiota. Gut Microbes (2013) 0.75

RAGs and BUGS: An alliance for autoimmunity. Gut Microbes (2016) 0.75

The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease. Crit Rev Immunol (2016) 0.75

Immune responses triggering colitis and colitis-associated carcinoma. Langenbecks Arch Surg (2012) 0.75

Articles cited by this

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31

Microbial influences in inflammatory bowel diseases. Gastroenterology (2008) 9.20

The immunology of mucosal models of inflammation. Annu Rev Immunol (2001) 9.08

Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature (2007) 7.17

Inflammation and colon cancer. Gastroenterology (2010) 6.32

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A (2004) 5.89

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 5.12

Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet (1991) 5.02

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol (2005) 4.28

Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology (2007) 3.99

Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98

Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity (2010) 3.96

MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med (2007) 3.79

Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology (2007) 2.99

Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One (2009) 2.79

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet (2008) 2.67

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med (2010) 2.57

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J Clin Invest (2007) 2.55

TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol (2007) 2.27

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med (2010) 2.09

Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest (2003) 2.02

Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology (2010) 2.01

MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis. Cell Microbiol (2007) 1.94

Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infect Immun (2006) 1.87

Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. Inflamm Bowel Dis (2006) 1.79

Adherent-invasive Escherichia coli in inflammatory bowel disease. Inflamm Bowel Dis (2007) 1.75

Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis. Cell Microbiol (2007) 1.59

Crohn's disease is associated with a toll-like receptor-9 polymorphism. Gastroenterology (2004) 1.55

Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family. Cancer Res (2007) 1.54

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm Bowel Dis (2009) 1.53

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes Immun (2007) 1.50

Interleukin-1 receptor signaling protects mice from lethal intestinal damage caused by the attaching and effacing pathogen Citrobacter rodentium. Infect Immun (2008) 1.42

Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice. Scand J Gastroenterol (2003) 1.41

Interleukin-1beta converting enzyme (caspase-1) in intestinal inflammation. Biochem Pharmacol (2002) 1.04

Use of antibiotics in the treatment of inflammatory bowel disease. Inflamm Bowel Dis (2006) 0.97

Innate immune signalling at intestinal mucosal surfaces: a fine line between host protection and destruction. Curr Opin Gastroenterol (2008) 0.97

Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis. PLoS One (2009) 0.95

Articles by these authors

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17

Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94

Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 7.76

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44

Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med (2003) 6.00

Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol (2003) 5.94

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med (2006) 5.76

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol (2005) 5.43

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity (2006) 5.40

Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med (2005) 4.47

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev (2006) 4.40

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28

Dendritic cells in intestinal immune regulation. Nat Rev Immunol (2008) 4.20

Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol (2006) 4.04

Regulatory T cells and intestinal homeostasis. Immunol Rev (2005) 3.82

Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol (2009) 3.80

Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med (2008) 3.74

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52

Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 3.51

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol (2006) 3.42

Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity (2008) 3.40

Regulatory T cells reinforce intestinal homeostasis. Immunity (2009) 3.27

E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity (2010) 2.78

IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med (2011) 2.74

Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation. Immunity (2012) 2.72

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med (2013) 2.50

Emerging challenges in regulatory T cell function and biology. Science (2007) 2.11

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med (2012) 2.11

Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J Immunol (2003) 2.08

The interleukin-23 axis in intestinal inflammation. Immunol Rev (2008) 2.06

Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology (2010) 2.01

Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. Eur J Immunol (2002) 1.88

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells. Blood (2011) 1.83

Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun (2002) 1.80

Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells. Inflamm Bowel Dis (2007) 1.73

Microbiota, disease, and back to health: a metastable journey. Sci Transl Med (2012) 1.70

OX40 is required for regulatory T cell-mediated control of colitis. J Exp Med (2010) 1.62

Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood (2012) 1.60

Involvement of innate immunity in the development of inflammatory and autoimmune diseases. Ann N Y Acad Sci (2005) 1.59

The IL23 axis plays a key role in the pathogenesis of IBD. Gut (2007) 1.58

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood (2014) 1.58

TLR2-independent induction and regulation of chronic intestinal inflammation. Eur J Immunol (2010) 1.55

Regulatory T cells. Curr Opin Pharmacol (2004) 1.52

Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells. Eur J Immunol (2010) 1.47

Fueling regulation: IL-2 keeps CD4+ Treg cells fit. Nat Immunol (2005) 1.30

Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells. Immunol Lett (2005) 1.20

CD4(+) T-cell subsets in intestinal inflammation. Immunol Rev (2013) 1.17

Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses. J Clin Invest (2003) 1.14

Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier. Immunology (2008) 1.12

Lymphoid microenvironments and innate lymphoid cells in the gut. Trends Immunol (2012) 1.08

Re-establishing immunological self-tolerance in autoimmune disease. Nat Med (2012) 1.06

Mouse models of intestinal inflammation as tools to understand the pathogenesis of inflammatory bowel disease. Eur J Immunol (2009) 1.04

Interleukin-10 in the regulation of T cell-induced colitis. J Autoimmun (2003) 0.99

CTLA-4 expression on antigen-specific cells but not IL-10 secretion is required for oral tolerance. Eur J Immunol (2002) 0.98

Homeostasis of intestinal immune regulation. Microbes Infect (2002) 0.96

Immunology: Dendritic-cell genealogy. Nature (2009) 0.96

Hybrid Treg cells: steel frames and plastic exteriors. Nat Immunol (2009) 0.92

Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. J Immunol (2007) 0.89

The role of mucosal T lymphocytes in regulating intestinal inflammation. Springer Semin Immunopathol (2005) 0.85

Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2. J Immunol (2013) 0.85

Immunology. The gut's Clostridium cocktail. Science (2011) 0.84

Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis. Immunology (2008) 0.84

Prenatal tolerance--a role for regulatory T cells? Eur J Immunol (2005) 0.82

Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A. Vaccine (2012) 0.81

Immunology. Feed your Tregs more fiber. Science (2013) 0.80

Regulatory mechanisms in graft-versus-host responses. Biol Blood Marrow Transplant (2009) 0.77

Homing of intestinal immune cells. Novartis Found Symp (2004) 0.76

Immunology: Malnutrition promotes rogue bacteria. Nature (2012) 0.76

Fiona Powrie: Gut diplomacy. Interview by Amy Maxmen. J Exp Med (2010) 0.75

Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease. Nat Med (2017) 0.75

Gender equality: is it real? Eur J Immunol (2012) 0.75