Multiple mutations and cancer.

Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 10.52

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A (2003) 4.79

Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A (2006) 3.11

Protein tolerance to random amino acid change. Proc Natl Acad Sci U S A (2004) 3.07

Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach. BMC Genomics (2006) 2.98

Non-genetic heterogeneity--a mutation-independent driving force for the somatic evolution of tumours. Nat Rev Genet (2009) 2.69

The chromosomal instability pathway in colon cancer. Gastroenterology (2010) 2.59

Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol (2004) 2.09

Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2004) 2.03

Mutational heterogeneity in human cancers: origin and consequences. Annu Rev Pathol (2010) 2.02

Evidence for mutation showers. Proc Natl Acad Sci U S A (2007) 2.00

Spatial heterogeneity in sarcoma 18F-FDG uptake as a predictor of patient outcome. J Nucl Med (2008) 1.86

Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol (2007) 1.74

Accurate human microsatellite genotypes from high-throughput resequencing data using informed error profiles. Nucleic Acids Res (2012) 1.65

Cancer-related changes in prostate DNA as men age and early identification of metastasis in primary prostate tumors. Proc Natl Acad Sci U S A (2003) 1.60

DNA methyltransferases, DNA damage repair, and cancer. Adv Exp Med Biol (2013) 1.57

An evolutionary hybrid cellular automaton model of solid tumour growth. J Theor Biol (2007) 1.55

Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator. Proc Natl Acad Sci U S A (2006) 1.55

Cancer genome sequencing--an interim analysis. Cancer Res (2009) 1.52

The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity. Proc Natl Acad Sci U S A (2008) 1.50

DNA mismatch-specific targeting and hypersensitivity of mismatch-repair-deficient cells to bulky rhodium(III) intercalators. Proc Natl Acad Sci U S A (2006) 1.48

Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. PLoS Genet (2008) 1.45

Oxygen independent DNA interstrand cross-link formation by a nucleotide radical. J Am Chem Soc (2006) 1.38

Too many mutants with multiple mutations. Crit Rev Biochem Mol Biol (2007) 1.38

Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res (2010) 1.35

Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer. Eur J Hum Genet (2010) 1.30

Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.25

An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response. Proc Natl Acad Sci U S A (2007) 1.22

Insertion of a bulky rhodium complex into a DNA cytosine-cytosine mismatch: an NMR solution study. J Am Chem Soc (2007) 1.21

Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochim Biophys Acta (2007) 1.21

Genetic evidence for a link between glycolysis and DNA replication. PLoS One (2007) 1.20

Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86. Mol Cell Biol (2004) 1.20

Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2. Mol Biol Cell (2005) 1.19

DNA base mismatch detection with bulky rhodium intercalators: synthesis and applications. Nat Protoc (2007) 1.19

Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer. Gigascience (2012) 1.18

A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae. Genetics (2008) 1.18

Cancer in light of experimental evolution. Curr Biol (2012) 1.17

Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2004) 1.16

APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair. Blood (2012) 1.15

Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints. Eukaryot Cell (2004) 1.14

Negative clonal selection in tumor evolution. Genetics (2005) 1.13

Zebrafish genomic instability mutants and cancer susceptibility. Genetics (2006) 1.12

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding. Biochemistry (2008) 1.10

Somatic mutaome profile in human cancer tissues. Genomics Inform (2013) 1.05

A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. J Am Chem Soc (2011) 1.05

Lethal mutagenesis: targeting the mutator phenotype in cancer. Semin Cancer Biol (2010) 1.05

Advances in radiobiological studies using a microbeam. J Radiat Res (2009) 1.04

Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny. Neoplasia (2008) 1.04

Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance. Neuro Oncol (2010) 1.03

Smad phosphoisoform signaling specificity: the right place at the right time. Carcinogenesis (2011) 1.02

Cell selection as driving force in lung and colon carcinogenesis. Cancer Res (2010) 1.01

Exposure to anticancer drugs can result in transgenerational genomic instability in mice. Proc Natl Acad Sci U S A (2012) 0.98

Mutator phenotype in cancer: origin and consequences. Semin Cancer Biol (2010) 0.98

COLD-PCR: improving the sensitivity of molecular diagnostics assays. Expert Rev Mol Diagn (2011) 0.97

Infection with the carcinogenic human liver fluke, Opisthorchis viverrini. Mol Biosyst (2011) 0.97

Do mutator mutations fuel tumorigenesis? Cancer Metastasis Rev (2013) 0.96

Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications. DNA Repair (Amst) (2008) 0.96

Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability. Proc Natl Acad Sci U S A (2006) 0.95

The mutator phenotype in cancer: molecular mechanisms and targeting strategies. Curr Drug Targets (2010) 0.95

c-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1balpha. Proc Natl Acad Sci U S A (2007) 0.94

Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention. BMC Syst Biol (2012) 0.94

Extracting consistent knowledge from highly inconsistent cancer gene data sources. BMC Bioinformatics (2010) 0.94

Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events. PLoS One (2008) 0.94

The Rad1-Rad10 complex promotes the production of gross chromosomal rearrangements from spontaneous DNA damage in Saccharomyces cerevisiae. Genetics (2005) 0.93

Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion. World J Gastroenterol (2005) 0.93

Tumor hypoxia and genetic alterations in sporadic cancers. J Obstet Gynaecol Res (2011) 0.93

APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion. Cancer Res (2013) 0.92

Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer. J Mol Diagn (2006) 0.92

Nuclear oxidative damage correlates with poor survival in colorectal cancer. Br J Cancer (2008) 0.92

Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway. PLoS Genet (2008) 0.92

Suppression of gross chromosomal rearrangements by a new alternative replication factor C complex. Biochem Biophys Res Commun (2007) 0.92

Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae. Genetics (2008) 0.91

Clinicopathological significance of loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in China. World J Gastroenterol (2005) 0.91

DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer. Clin Cancer Res (2010) 0.90

Recognition of abasic sites and single base bulges in DNA by a metalloinsertor. Biochemistry (2009) 0.90

Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction. PLoS One (2012) 0.89

Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer (2013) 0.88

Mutations in clusters and showers. Proc Natl Acad Sci U S A (2007) 0.88

Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae. DNA Repair (Amst) (2008) 0.88

Oral squamous cell carcinoma in relation to field precancerisation: pathobiology. Cancer Cell Int (2013) 0.87

Resistance to microtubule-stabilizing drugs involves two events: beta-tubulin mutation in one allele followed by loss of the second allele. Cell Cycle (2005) 0.87

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms. Proc Natl Acad Sci U S A (2012) 0.86

Development and inter-laboratory validation of unlabeled probe melting curve analysis for detection of JAK2 V617F mutation in polycythemia vera. PLoS One (2011) 0.86

Tumbling down a different pathway to genetic instability. J Clin Invest (2003) 0.86

Epigenetics in radiation biology: a new research frontier. Front Genet (2013) 0.85

Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53. Cell Cycle (2012) 0.85

Establishment and characterization of cell lines from chromosomal instable colorectal cancer. World J Gastroenterol (2015) 0.85

Caveolin 1 protein expression in renal cell carcinoma predicts survival. BMC Urol (2011) 0.85

Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2010) 0.84

Genome aberrations in canine mammary carcinomas and their detection in cell-free plasma DNA. PLoS One (2013) 0.84

How virus persistence can initiate the tumorigenesis process. World J Virol (2013) 0.84

Modeling variation in tumors in vivo. Proc Natl Acad Sci U S A (2005) 0.84

Genomic instability and carcinogenesis: an update. Curr Genomics (2008) 0.84

Microsatellite instability in gastrointestinal tract cancers: a brief update. Surg Today (2005) 0.83

Early events during neoplastic progression in Barrett's esophagus. Cancer Biomark (2010) 0.83

Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif. Hum Mutat (2009) 0.83

PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ. DNA Repair (Amst) (2013) 0.83

Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract. J Biol Chem (2012) 0.81

Dynamics of MutS-mismatched DNA complexes are predictive of their repair phenotypes. Biochemistry (2014) 0.81

Impaired expression of NER gene network in sporadic solid tumors. Nucleic Acids Res (2007) 0.80

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Molecular portraits of human breast tumours. Nature (2000) 94.14

A genetic model for colorectal tumorigenesis. Cell (1990) 44.37

Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05

The clonal evolution of tumor cell populations. Science (1976) 24.39

Genetic instabilities in human cancers. Nature (1998) 22.76

Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. Bacteriol Rev (1976) 18.20

Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (1992) 16.38

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (1993) 12.74

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature (1999) 10.87

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66

The RB and p53 pathways in cancer. Cancer Cell (2002) 8.02

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When checkpoints fail. Cell (1997) 4.21

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Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci U S A (2002) 3.57

Proliferation of mutators in A cell population. J Bacteriol (1997) 3.55

Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J (1999) 3.31

Evolution of neoplastic cell lineages in Barrett oesophagus. Nat Genet (1999) 3.30

Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci U S A (2002) 3.25

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The role of DNA methylation in cancer genetic and epigenetics. Annu Rev Genet (1996) 2.63

Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci U S A (1998) 2.58

Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog. Nat Med (1999) 2.14

Defective DNA polymerase-delta proofreading causes cancer susceptibility in mice. Nat Med (2001) 2.08

Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis. Proc Natl Acad Sci U S A (1989) 2.01

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene (1995) 1.91

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Gastric MALT lymphoma: from aetiology to treatment. Lancet Oncol (2002) 1.79

Carcinogen-specific induction of genetic instability. Proc Natl Acad Sci U S A (2001) 1.76

Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res (1996) 1.74

Novel DNA polymerases offer clues to the molecular basis of mutagenesis. Cell (1999) 1.61

Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase. J Bacteriol (2000) 1.51

DNA polymerase active site is highly mutable: evolutionary consequences. Proc Natl Acad Sci U S A (2000) 1.41

Karyotypic evolution in human malignant melanoma. Cancer Genet Cytogenet (1986) 1.34

Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas. Cancer Res (1997) 1.33

Microsatellite alterations in adenoma and differentiated adenocarcinoma of the stomach. Cancer Res (1995) 1.17

Microsatellite instability induced by hydrogen peroxide in Escherichia coli. Mutat Res (2000) 1.07

Parallel analysis of sporadic primary ovarian carcinomas by spectral karyotyping, comparative genomic hybridization, and expression microarrays. Cancer Res (2002) 1.04

Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase. Carcinogenesis (2000) 0.88

Molecular diagnostics in follicular non-Hodgkin's lymphoma: a review. Semin Oncol (2000) 0.87

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol Cell (2003) 3.91

Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A (2006) 3.11

Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. Blood (2010) 2.45

Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev (2008) 1.25

Ultrasound enhances gene delivery of human factor IX plasmid. Hum Gene Ther (2005) 1.18

Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. J Clin Invest (2015) 1.13

Allogeneic hematopoietic cell transplantation for chronic myelomonocytic leukemia: relapse-free survival is determined by karyotype and comorbidities. Biol Blood Marrow Transplant (2010) 1.10

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. Blood (2012) 0.99

Proteomic classification of acute leukemias by alignment-based quantitation of LC-MS/MS data sets. J Proteome Res (2012) 0.95

Ultrasound-targeted microbubble destruction-mediated gene delivery into canine livers. Mol Ther (2013) 0.90

Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity. DNA Repair (Amst) (2005) 0.87

An artificial processivity clamp made with streptavidin facilitates oriented attachment of polymerase-DNA complexes to surfaces. Nucleic Acids Res (2008) 0.84

Synthesis and stability of novel terminal phosphate-labeled nucleotides. Nucleosides Nucleotides Nucleic Acids (2008) 0.84

Donor cell-derived leukemia and myelodysplastic neoplasm: unique forms of leukemia. Am J Clin Pathol (2011) 0.82

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Fibrosing cholestatic hepatitis C after hematopoietic cell transplantation: report of 3 fatal cases. Am J Surg Pathol (2015) 0.81

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