Published in Bioessays on September 01, 2007
Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms. Ann N Y Acad Sci (2010) 1.54
Intermolecular interactions of Sprouty proteins and their implications in development and disease. Mol Pharmacol (2009) 1.52
From synapse to nucleus: novel targets for treating depression. Neuropharmacology (2009) 1.06
Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure. Genes Dev (2010) 1.04
Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract. Mol Med (2012) 0.95
Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. Development (2011) 0.94
Activation of Ras requires the ERM-dependent link of actin to the plasma membrane. PLoS One (2011) 0.91
Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation. PLoS One (2012) 0.91
Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease. Br J Cancer (2009) 0.88
Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid. Arterioscler Thromb Vasc Biol (2008) 0.87
Sprouty2 downregulates angiogenesis during mouse skin wound healing. Am J Physiol Heart Circ Physiol (2010) 0.87
Biology using engineering tools: the negative feedback amplifier. Cell Cycle (2011) 0.87
Sprouty genes regulate proliferation and survival of human embryonic stem cells. Sci Rep (2013) 0.86
SPRED proteins provide a NF-ty link to Ras suppression. Genes Dev (2012) 0.84
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2. Blood (2012) 0.83
Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer. Br J Cancer (2012) 0.82
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J Biol Chem (2010) 0.81
MicroRNA-132/212 family enhances arteriogenesis after hindlimb ischaemia through modulation of the Ras-MAPK pathway. J Cell Mol Med (2015) 0.79
The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation. Proc Natl Acad Sci U S A (2016) 0.79
Expression of Sproutys and SPREDs is decreased during lung branching morphogenesis in nitrofen-induced pulmonary hypoplasia. Pediatr Surg Int (2013) 0.78
Signaling in cell differentiation and morphogenesis. Cold Spring Harb Perspect Biol (2012) 0.78
Lymphatic vessel abnormalities arising from disorders of Ras signal transduction. Trends Cardiovasc Med (2013) 0.78
Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids. PLoS One (2011) 0.77
Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases. J Biol Chem (2015) 0.76
Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas. Lung Cancer (2014) 0.75
SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling. Mol Cell Biol (2016) 0.75
Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med (2005) 3.59
Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res (2002) 2.56
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med (2006) 2.54
The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood (2012) 2.47
Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv (2003) 1.95
Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice. Circ Res (2003) 1.82
Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance. J Am Coll Cardiol (2003) 1.73
Platelet protein interactions: map, signaling components, and phosphorylation groundstate. Arterioscler Thromb Vasc Biol (2008) 1.71
Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I. Eur Heart J (2011) 1.67
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A (2004) 1.57
Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins. Neuron (2005) 1.54
Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice. Cardiovasc Res (2003) 1.51
Calcineurin in human heart hypertrophy. Circulation (2002) 1.47
Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. J Biol Chem (2010) 1.47
Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett (2002) 1.46
Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase [corrected]. Circulation (2003) 1.45
ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay. Thromb Haemost (2008) 1.40
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. Mol Cell Proteomics (2005) 1.38
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. Free Radic Biol Med (2005) 1.36
Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes. J Cell Biol (2008) 1.35
Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2004) 1.31
EVH1 domains: structure, function and interactions. FEBS Lett (2002) 1.31
Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. J Biol Chem (2004) 1.30
Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b. Circulation (2007) 1.27
Phosphoproteome of resting human platelets. J Proteome Res (2007) 1.24
AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem (2006) 1.23
Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat Cell Biol (2002) 1.21
Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation (2002) 1.21
Targeted proteolysis sustains calcineurin activation. Circulation (2005) 1.21
Differential VASP phosphorylation controls remodeling of the actin cytoskeleton. J Cell Sci (2009) 1.19
Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. Blood (2005) 1.15
Local bradykinin formation is controlled by glycosaminoglycans. J Immunol (2005) 1.14
Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice. Blood (2003) 1.13
PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood (2006) 1.12
Platelet membrane proteomics: a novel repository for functional research. Blood (2009) 1.10
Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility. Circ Res (2007) 1.10
Analysis of SAGE data in human platelets: features of the transcriptome in an anucleate cell. Thromb Haemost (2006) 1.10
Use of functional highly purified human platelets for the identification of new proteins of the IPP signaling pathway. Thromb Res (2007) 1.07
Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. Am J Physiol Heart Circ Physiol (2003) 1.04
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits. J Am Coll Cardiol (2002) 1.04
Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells. Arterioscler Thromb Vasc Biol (2003) 1.04
Monitoring of clopidogrel action: comparison of methods. Clin Chem (2005) 1.04
Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF study. Atherosclerosis (2008) 1.04
Increased spreading, Rac/p21-activated kinase (PAK) activity, and compromised cell motility in cells deficient in vasodilator-stimulated phosphoprotein (VASP). J Biol Chem (2002) 1.04
The human platelet membrane proteome reveals several new potential membrane proteins. Mol Cell Proteomics (2005) 1.03
Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion. Blood (2003) 1.01
Variable extent of clopidogrel responsiveness in patients after coronary stenting. Thromb Haemost (2004) 0.99
Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation. J Biol Chem (2003) 0.99
Conditional overexpression of neuronal nitric oxide synthase is cardioprotective in ischemia/reperfusion. Circulation (2010) 0.98
Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. FASEB J (2009) 0.96
Inhibition of nuclear import of calcineurin prevents myocardial hypertrophy. Circ Res (2006) 0.96
Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke (2003) 0.96
Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase. Blood (2003) 0.96
Relaxation, equilibrium oligomerization, and molecular symmetry of the VASP (336-380) EVH2 tetramer. Biochemistry (2002) 0.95
What can proteomics tell us about platelets? Circ Res (2014) 0.95
Enhanced N-glycosylation site analysis of sialoglycopeptides by strong cation exchange prefractionation applied to platelet plasma membranes. Mol Cell Proteomics (2007) 0.94
Expression and subcellular localization of Spred proteins in mouse and human tissues. Histochem Cell Biol (2004) 0.94
Tracking functions of cGMP-dependent protein kinases (cGK). Front Biosci (2005) 0.93
A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Atherosclerosis (2007) 0.93
Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase. Blood (2006) 0.93
Cyclic nucleotide-regulated proliferation and differentiation vary in human hematopoietic progenitor cells derived from healthy persons, tumor patients, and chronic myelocytic leukemia patients. Stem Cells Dev (2008) 0.91
Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS. Blood Cells Mol Dis (2006) 0.91
Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury. Circulation (2011) 0.91
Gene disruption of Spred-2 causes dwarfism. J Biol Chem (2005) 0.90
The VASP-Spred-Sprouty domain puzzle. J Biol Chem (2006) 0.90
Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3. Neurogenetics (2010) 0.90
Endothelium-dependent and -independent relaxation and VASP serines 157/239 phosphorylation by cyclic nucleotide-elevating vasodilators in rat aorta. Biochem Pharmacol (2003) 0.90
AT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway. FASEB J (2002) 0.90
Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma. Biol Chem (2006) 0.89
Vasodilator-stimulated phosphoprotein-deficient mice demonstrate increased platelet activation but improved renal endothelial preservation and regeneration in passive nephrotoxic nephritis. J Am Soc Nephrol (2005) 0.89
Fibroblast migration after myocardial infarction is regulated by transient SPARC expression. J Mol Med (Berl) (2006) 0.89
Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2010) 0.89
The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells. Br J Pharmacol (2012) 0.88
Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways. Blood (2013) 0.87
High factor VIII levels in venous thromboembolism show linkage to imprinted loci on chromosomes 5 and 11. Blood (2004) 0.87
Detection of serum free light chains: the problem with antigen excess. Clin Chem Lab Med (2010) 0.86
Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO/cGMP signaling. Genomics (2004) 0.86
Response: platelet transcriptome and proteome--relation rather than correlation. Blood (2013) 0.86
Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo. Thromb Haemost (2008) 0.86
Increased effects of C-type natriuretic peptide on contractility and calcium regulation in murine hearts overexpressing cyclic GMP-dependent protein kinase I. Br J Pharmacol (2003) 0.86
High factor VIII (FVIII) levels in venous thromboembolism: role of unbound FVIII. Thromb Haemost (2004) 0.85
Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors. Clin Chem Lab Med (2012) 0.85
Vasodilator-stimulated phosphoprotein regulates inside-out signaling of beta2 integrins in neutrophils. J Immunol (2010) 0.84
Increased noise sensitivity and altered inner ear MENA distribution in VASP-/- mice. Cell Tissue Res (2004) 0.83
Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP. Am J Physiol Endocrinol Metab (2005) 0.83
Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis. J Biol Chem (2011) 0.82
Design of N-substituted peptomer ligands for EVH1 domains. J Biol Chem (2003) 0.82
VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen. J Cell Physiol (2010) 0.82
Calcium transport in cardiovascular health and disease--the sarcolemmal calcium pump enters the stage. J Mol Cell Cardiol (2005) 0.82
Roles of cGMP/cGMP-dependent protein kinase in platelet activation. Blood (2004) 0.82
Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy. Cell Commun Signal (2013) 0.81
Phosphatidylserine surface expression and integrin alpha IIb beta 3 activity on thrombin/convulxin stimulated platelets/particles of different sizes. Br J Haematol (2008) 0.81