Published in Hum Mol Genet on August 29, 2007
The ovary: basic biology and clinical implications. J Clin Invest (2010) 1.65
Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary. Biol Reprod (2014) 1.50
FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Mol Endocrinol (2009) 1.27
Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development. BMC Dev Biol (2008) 1.24
Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol (2009) 1.23
Mammalian sex determination—insights from humans and mice. Chromosome Res (2012) 1.14
Building the mammalian testis: origins, differentiation, and assembly of the component cell populations. Genes Dev (2013) 1.13
Disorders of sex development: new genes, new concepts. Nat Rev Endocrinol (2012) 1.12
Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter. PLoS One (2010) 1.11
Sex-specific roles of beta-catenin in mouse gonadal development. Hum Mol Genet (2008) 1.10
Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol (2009) 1.10
Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech Dev (2009) 1.05
R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation. BMC Dev Biol (2008) 0.95
FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. Endocrinology (2010) 0.95
Divergent expression regulation of gonad development genes in medaka shows incomplete conservation of the downstream regulatory network of vertebrate sex determination. Mol Biol Evol (2013) 0.94
Analyzing the coordinated gene network underlying temperature-dependent sex determination in reptiles. Semin Cell Dev Biol (2008) 0.94
Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS One (2013) 0.93
Human SRY inhibits beta-catenin-mediated transcription. Int J Biochem Cell Biol (2008) 0.92
Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene (2011) 0.92
Epigenetic control of gonadal aromatase (cyp19a1) in temperature-dependent sex determination of red-eared slider turtles. PLoS One (2013) 0.92
DSDs: genetics, underlying pathologies and psychosexual differentiation. Nat Rev Endocrinol (2014) 0.91
The molecular and cellular basis of gonadal sex reversal in mice and humans. Wiley Interdiscip Rev Dev Biol (2012) 0.91
Determination and stability of gonadal sex. J Androl (2009) 0.91
Building pathways for ovary organogenesis in the mouse embryo. Curr Top Dev Biol (2010) 0.90
Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells. Development (2012) 0.89
Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J (2011) 0.89
Cell fate commitment during mammalian sex determination. Curr Opin Genet Dev (2015) 0.88
Impaired FSHbeta expression in the pituitaries of Foxl2 mutant animals. Mol Endocrinol (2011) 0.88
Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One (2012) 0.87
The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation. Mol Hum Reprod (2009) 0.86
Germ cell sex determination: a collaboration between soma and germline. Curr Opin Cell Biol (2010) 0.86
SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies. PLoS One (2011) 0.86
Complementary pathways in mammalian female sex determination. J Biol (2009) 0.86
FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol (2015) 0.86
Distinct transcriptional mechanisms direct expression of the rat Dmrt1 promoter in sertoli cells and germ cells of transgenic mice. Biol Reprod (2009) 0.85
Studies on feminization, sex determination, and differentiation of the Southern catfish, Silurus meridionalis--a review. Fish Physiol Biochem (2008) 0.84
Regulation of male sex determination: genital ridge formation and Sry activation in mice. Cell Mol Life Sci (2014) 0.83
Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. Dev Biol (2013) 0.83
The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. PLoS One (2010) 0.82
Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter. J Ovarian Res (2010) 0.82
FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J (2014) 0.82
New insights into ovarian function. Handb Exp Pharmacol (2010) 0.81
β-catenin/Tcf-signaling appears to establish the murine ovarian surface epithelium (OSE) and remains active in selected postnatal OSE cells. BMC Dev Biol (2012) 0.81
The disparate origins of ovarian cancers: pathogenesis and prevention strategies. Nat Rev Cancer (2016) 0.81
Genomic analysis of the Pacific oyster (Crassostrea gigas) reveals possible conservation of vertebrate sex determination in a mollusc. G3 (Bethesda) (2014) 0.80
How to make a gonad: cellular mechanisms governing formation of the testes and ovaries. Sex Dev (2012) 0.79
Transcriptome analysis reveals differentially expressed genes associated with germ cell and gonad development in the Southern bluefin tuna (Thunnus maccoyii). BMC Genomics (2016) 0.79
Defining the neighborhoods that escort the oocyte through its early life events and into a functional follicle. Mol Reprod Dev (2013) 0.78
Rspo1-activated signalling molecules are sufficient to induce ovarian differentiation in XY medaka (Oryzias latipes). Sci Rep (2016) 0.78
Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure. Reprod Biol Endocrinol (2011) 0.78
FOXL2 suppresses proliferation, invasion and promotes apoptosis of cervical cancer cells. Int J Clin Exp Pathol (2014) 0.78
Profiling spermatogenic failure in adult testes bearing Sox9-deficient Sertoli cells identifies genes involved in feminization, inflammation and stress. Reprod Biol Endocrinol (2010) 0.78
Genetics of the ovarian reserve. Front Genet (2015) 0.76
FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice. BMC Dev Biol (2015) 0.76
Cultured bovine granulosa cells rapidly lose important features of their identity and functionality but partially recover under long-term culture conditions. Cell Tissue Res (2017) 0.75
FGFR2 mutation in 46,XY sex reversal with craniosynostosis. Hum Mol Genet (2015) 0.75
Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells. BMC Syst Biol (2016) 0.75
Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming. PLoS Biol (2016) 0.75
Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish. Genetics (2017) 0.75
Defects in the first wave of folliculogenesis in mouse XO ovaries. J Reprod Dev (2017) 0.75
Environmental influences on ovarian dysgenesis - developmental windows sensitive to chemical exposures. Nat Rev Endocrinol (2017) 0.75
Oleic acid induces down-regulation of the granulosa cell identity marker FOXL2, and up-regulation of the Sertoli cell marker SOX9 in bovine granulosa cells. Reprod Biol Endocrinol (2017) 0.75
Integrated analysis of microRNA and mRNA expression profiles during the sex-differentiation sensitive period in oriental river prawn, Macrobrachium nipponense. Sci Rep (2017) 0.75
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A (2008) 4.46
Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res (2008) 3.29
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica (2008) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet (2004) 2.15
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet (2009) 1.87
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet (2009) 1.87
Genetic variants regulating immune cell levels in health and disease. Cell (2013) 1.86
Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Am J Hum Genet (2008) 1.77
IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am J Hum Genet (2007) 1.77
Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol (2003) 1.75
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
KLF1 gene mutations cause borderline HbA(2). Blood (2011) 1.71
Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny. Science (2013) 1.70
Genome-wide association scan of trait depression. Biol Psychiatry (2010) 1.65
Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study. Atherosclerosis (2010) 1.65
Amelioration of Sardinian beta0 thalassemia by genetic modifiers. Blood (2009) 1.62
Facets of personality linked to underweight and overweight. Psychosom Med (2009) 1.58
Analysis of the temporal requirement for eda in hair and sweat gland development. J Invest Dermatol (2008) 1.55
Fetal HLA typing in beta thalassaemia: implications for haemopoietic stem-cell transplantation. Lancet (2003) 1.48
EDA signaling and skin appendage development. Cell Cycle (2006) 1.39
Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet (2005) 1.38
Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells. DNA Res (2008) 1.35
Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1. Am J Hum Genet (2007) 1.27
Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling. Dev Biol (2002) 1.24
Cholesterol, triglycerides, and the Five-Factor Model of personality. Biol Psychol (2010) 1.24
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet (2013) 1.23
Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol (2009) 1.23
Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin. Haematologica (2011) 1.23
Genes and translocations involved in POF. Am J Med Genet (2002) 1.23
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet (2012) 1.23
Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet (2003) 1.20
Sex-specific correlates of walking speed in a wide age-ranged population. J Gerontol B Psychol Sci Soc Sci (2010) 1.19
COL4A1 is associated with arterial stiffness by genome-wide association scan. Circ Cardiovasc Genet (2009) 1.16