Published in Neuron on August 29, 2002
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev (2008) 6.18
Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial. Lancet Neurol (2011) 2.27
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev (2011) 2.25
Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. Neuron (2010) 1.75
Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72
Drosophila models of neurodegenerative diseases. Annu Rev Pathol (2009) 1.67
Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies. Proc Natl Acad Sci U S A (2005) 1.52
Brain masculinization requires androgen receptor function. Proc Natl Acad Sci U S A (2004) 1.51
A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. Genes Dev (2009) 1.49
Expression of human Gaucher disease gene GBA generates neurodevelopmental defects and ER stress in Drosophila eye. PLoS One (2013) 1.45
Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. Proc Natl Acad Sci U S A (2005) 1.42
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol (2012) 1.37
Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet (2009) 1.32
Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy. Cell Rep (2014) 1.32
Flightless flies: Drosophila models of neuromuscular disease. Ann N Y Acad Sci (2010) 1.28
The unstable repeats--three evolving faces of neurological disease. Neuron (2013) 1.26
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation. J Biol Chem (2008) 1.24
Probing mechanisms that underlie human neurodegenerative diseases in Drosophila. Annu Rev Genet (2012) 1.21
Cell biology of spinocerebellar ataxia. J Cell Biol (2012) 1.19
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci (2009) 1.15
Polyglutamine neurodegeneration: expanded glutamines enhance native functions. Curr Opin Genet Dev (2012) 1.13
Drosophila models of neurodegenerative disease. NeuroRx (2005) 1.12
Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. J Neurosci (2009) 1.10
Mechanisms mediating spinal and bulbar muscular atrophy: investigations into polyglutamine-expanded androgen receptor function and dysfunction. Front Neurol (2013) 1.05
Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system. Mol Cell Biol (2008) 1.04
An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. J Biol Chem (2010) 1.03
Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis. Neurobiol Dis (2010) 1.02
Spinal and bulbar muscular atrophy: a motoneuron or muscle disease? Curr Opin Pharmacol (2008) 1.01
Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy. J Biol Chem (2013) 0.99
Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action. Hum Mol Genet (2011) 0.98
Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy. Mol Med (2012) 0.96
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. Hum Mol Genet (2014) 0.95
cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila. Proc Natl Acad Sci U S A (2005) 0.95
Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy. Hum Mol Genet (2013) 0.94
Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein. Neurobiol Dis (2005) 0.93
PolyQ disease: misfiring of a developmental cell death program? Trends Cell Biol (2012) 0.93
PolyQ disease: too many Qs, too much function? Neuron (2010) 0.93
Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy. Horm Behav (2008) 0.92
Developing treatment for spinal and bulbar muscular atrophy. Prog Neurobiol (2012) 0.92
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Nat Med (2012) 0.91
Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy. Brain (2013) 0.91
Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet (2011) 0.91
Absence of disturbed axonal transport in spinal and bulbar muscular atrophy. Hum Mol Genet (2011) 0.91
Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Neuron (2015) 0.90
Drosophila melanogaster as a model organism of brain diseases. Int J Mol Sci (2009) 0.90
Drosophila models of proteinopathies: the little fly that could. Curr Pharm Des (2012) 0.89
Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration. Nat Commun (2013) 0.88
Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy. Neurodegener Dis (2010) 0.87
B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy. J Neurosci Res (2010) 0.85
Polyglutamine misfolding in yeast: toxic and protective aggregation. Prion (2011) 0.85
Drosophila as an In Vivo Model for Human Neurodegenerative Disease. Genetics (2015) 0.83
Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc Natl Acad Sci U S A (2009) 0.82
Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy. Endocrinology (2014) 0.81
Proteasome-mediated proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis. J Biol Chem (2015) 0.80
Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy. Brain (2014) 0.80
Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophy. CNS Neurol Disord Drug Targets (2013) 0.80
Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy. Brain Res (2015) 0.78
Current status of treatment of spinal and bulbar muscular atrophy. Neural Plast (2012) 0.78
Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression. PLoS One (2014) 0.78
BAP18 coactivates androgen receptor action and promotes prostate cancer progression. Nucleic Acids Res (2016) 0.78
Neuropathology and therapeutic intervention in spinal and bulbar muscular atrophy. Int J Mol Sci (2009) 0.78
Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy. Dis Model Mech (2011) 0.78
Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients. Hum Mol Genet (2017) 0.77
Polyglutamine androgen receptor-mediated neuromuscular disease. Cell Mol Life Sci (2016) 0.77
Animal models of Kennedy disease. NeuroRx (2005) 0.77
Difference in chronological changes of outcome measures between untreated and placebo-treated patients of spinal and bulbar muscular atrophy. J Neurol (2011) 0.77
Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA. Cell Rep (2015) 0.76
Attacking the flank: targeting new pathways in SBMA. Nat Med (2012) 0.76
Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing. Cell Rep (2016) 0.76
Studying polyglutamine diseases in Drosophila. Exp Neurol (2015) 0.76
Genotype-phenotype correlation in Chinese patients with spinal and bulbar muscular atrophy. PLoS One (2015) 0.76
Trinucleotide repeats and protein folding and disease: the perspective from studies with the androgen receptor. Future Sci OA (2015) 0.75
Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes. Sci Rep (2017) 0.75
Understanding and treating neurodegeneration: insights from the flies. Age (Dordr) (2005) 0.75
A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability. Hum Mol Genet (2012) 0.75
Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. Elife (2015) 0.75
Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders. Mol Neurobiol (2016) 0.75
Anti-androgen treatment for spinal and bulbar muscular atrophy. Ann Neurol (2009) 0.75
Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases. Front Cell Neurosci (2017) 0.75
The 11S Proteasomal Activator REGγ Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms. Front Mol Neurosci (2017) 0.75
Modulation of microRNA processing by p53. Nature (2009) 7.88
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell (2007) 4.71
Retracted DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol (2007) 4.45
A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat Med (2003) 4.08
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell (2008) 3.60
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature (2007) 3.59
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (2003) 3.49
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med (2012) 3.46
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J (2002) 3.16
Retracted GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature (2009) 3.10
Retracted DNA demethylation in hormone-induced transcriptional derepression. Nature (2009) 2.90
Neuronal assemblies of the Drosophila mushroom body. J Comp Neurol (2008) 2.80
Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo. J Biol Chem (2004) 2.72
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A (2006) 2.60
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med (2005) 2.59
Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J Bone Miner Res (2012) 2.53
Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol (2009) 2.50
Retracted Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell (2009) 2.48
The mushroom body of adult Drosophila characterized by GAL4 drivers. J Neurogenet (2009) 2.29
A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature (2012) 2.20
Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans. Development (2003) 2.18
Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell (2006) 2.15
GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature (2011) 2.14
Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology (2003) 2.10
Legionella metaeffector exploits host proteasome to temporally regulate cognate effector. PLoS Pathog (2010) 2.09
Retracted Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol (2003) 2.08
Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination. Trends Cell Biol (2007) 2.05
Vitamin E decreases bone mass by stimulating osteoclast fusion. Nat Med (2012) 2.04
Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development (2002) 1.99
Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects. J Cell Biol (2003) 1.95
Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell (2009) 1.95
Specific dopaminergic neurons for the formation of labile aversive memory. Curr Biol (2010) 1.93
Retracted The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. Cell (2003) 1.88
An engram found? Evaluating the evidence from fruit flies. Curr Opin Neurobiol (2004) 1.85
FGF10 maintains stem cell compartment in developing mouse incisors. Development (2002) 1.84
Light activation of an innate olfactory avoidance response in Drosophila. Curr Biol (2007) 1.81
Limited internal radiation exposure associated with resettlements to a radiation-contaminated homeland after the Fukushima Daiichi nuclear disaster. PLoS One (2013) 1.81
A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing. EMBO Rep (2011) 1.79
p38 MAPK-dependent phagocytic encapsulation confers infection tolerance in Drosophila. Cell Host Microbe (2009) 1.77
Requirements for FGF3 and FGF10 during inner ear formation. Development (2003) 1.76
Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. Nat Neurosci (2012) 1.76
Retracted Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol Cell (2002) 1.75
DRONC coordinates cell death and compensatory proliferation. Mol Cell Biol (2006) 1.75
Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72
Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest (2013) 1.70
Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol (2008) 1.69
Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev Cell (2007) 1.68
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A (2013) 1.67
STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem (2008) 1.64
Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A (2009) 1.63
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A (2012) 1.61
Wnt/beta-catenin and estrogen signaling converge in vivo. J Biol Chem (2004) 1.60
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med (2010) 1.59
IKK epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis. Curr Biol (2006) 1.57
Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption. J Cell Biochem (2010) 1.54
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell (2008) 1.53
Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila. Nat Neurosci (2011) 1.53
Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. EMBO J (2004) 1.52
Brain masculinization requires androgen receptor function. Proc Natl Acad Sci U S A (2004) 1.51
Low molecular weight phenotype of Apo(a) is a risk factor of corticosteroid-induced osteonecrosis of the femoral head after renal transplant. J Rheumatol (2007) 1.50
A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. Genes Dev (2009) 1.49
Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci (2007) 1.48
Evaluation of sperm head shape at high magnification revealed correlation of sperm DNA fragmentation with aberrant head ellipticity and angularity. Fertil Steril (2013) 1.46
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. J Neurosci (2011) 1.45
Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. J Biol Chem (2003) 1.45
Premature ovarian failure in androgen receptor-deficient mice. Proc Natl Acad Sci U S A (2005) 1.44
Retracted Ligand-induced transrepression by VDR through association of WSTF with acetylated histones. EMBO J (2005) 1.43
Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor. J Biol Chem (2007) 1.43
The androgen receptor in health and disease. Annu Rev Physiol (2012) 1.41
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. Proc Natl Acad Sci U S A (2009) 1.40
Three dopamine pathways induce aversive odor memories with different stability. PLoS Genet (2012) 1.40
Retracted A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function. EMBO J (2007) 1.39
Multiple memory traces for olfactory reward learning in Drosophila. J Neurosci (2007) 1.38
Rapid identification of Plasmodium-carrying mosquitoes using loop-mediated isothermal amplification. Biochem Biophys Res Commun (2008) 1.38
Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT. Development (2008) 1.37
PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. Nat Cell Biol (2011) 1.36
Retracted Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching. EMBO J (2004) 1.35
Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc Natl Acad Sci U S A (2010) 1.34
Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure. J Cell Biol (2011) 1.34
A map of octopaminergic neurons in the Drosophila brain. J Comp Neurol (2009) 1.34
Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol (2002) 1.34
Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons. J Neurochem (2007) 1.34
Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J Biol Chem (2002) 1.34
Acute intake of radionuclides immediately after the incident as the main contributor of the internal radiation exposure after Fukushima Daiichi nuclear disaster. JAMA Pediatr (2013) 1.32
Involvement of ER stress in retinal cell death. Mol Vis (2007) 1.32
Retracted Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. Mol Cell Biol (2007) 1.32
Central control of bone remodeling by neuromedin U. Nat Med (2007) 1.32