Published in Science on September 06, 2007
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell (2008) 9.92
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81
The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol (2008) 4.43
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat Rev Cancer (2010) 3.48
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment. Science (2010) 3.33
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Plzf regulates germline progenitor self-renewal by opposing mTORC1. Cell (2010) 2.29
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The germline stem cell niche unit in mammalian testes. Physiol Rev (2012) 1.86
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Stem cells, their niches and the systemic environment: an aging network. Genetics (2008) 1.46
Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output. Development (2011) 1.36
Drosophila follicle cells: morphogenesis in an eggshell. Semin Cell Dev Biol (2008) 1.36
Blood vessels restrain pancreas branching, differentiation and growth. Development (2011) 1.35
Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol (2008) 1.32
Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques. Hum Reprod (2009) 1.21
Targeting neural precursors in the adult brain rescues injured dopamine neurons. Proc Natl Acad Sci U S A (2009) 1.21
Genetics of germ cell development. Nat Rev Genet (2012) 1.20
Mouse spermatogenic stem cells continually interconvert between equipotent singly isolated and syncytial states. Cell Stem Cell (2014) 1.20
Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. Proc Natl Acad Sci U S A (2010) 1.19
A stem cell niche for intermediate progenitor cells of the embryonic cortex. Cereb Cortex (2009) 1.17
Stem cell competition: finding balance in the niche. Trends Cell Biol (2013) 1.14
Functional and molecular features of the Id4+ germline stem cell population in mouse testes. Genes Dev (2014) 1.11
Sertoli cells dictate spermatogonial stem cell niches in the mouse testis. Biol Reprod (2010) 1.11
Diverse roles of the vasculature within the neural stem cell niche. Regen Med (2009) 1.09
Spermatogonial stem cells, infertility and testicular cancer. J Cell Mol Med (2011) 1.09
Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells (2010) 1.06
Germline stem cells: origin and destiny. Cell Stem Cell (2012) 1.04
CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells. Stem Cells (2008) 1.04
Jak-STAT regulation of male germline stem cell establishment during Drosophila embryogenesis. Dev Biol (2009) 1.03
Vascular instruction of pancreas development. Development (2012) 1.01
Asymmetric distribution of UCH-L1 in spermatogonia is associated with maintenance and differentiation of spermatogonial stem cells. J Cell Physiol (2009) 1.01
ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells (2010) 0.98
Angiogenesis potential of human limbal stromal niche cells. Invest Ophthalmol Vis Sci (2012) 0.97
Evolution and spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 0.96
Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties. FASEB J (2011) 0.93
Concise review: Defining characteristics of mammalian spermatogenic stem cells. Stem Cells (2013) 0.93
Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells. J Cell Biol (2009) 0.93
Extracellular matrix and the neural stem cell niche. Dev Neurobiol (2011) 0.92
Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal. Stem Cell Reports (2015) 0.92
Intravital imaging of hair follicle regeneration in the mouse. Nat Protoc (2015) 0.92
Spermatogonial stem cell niche and spermatogonial stem cell transplantation in zebrafish. PLoS One (2010) 0.91
Myh11-Cre is not limited to peritubular myoid cells and interaction between Sertoli and peritubular myoid cells needs investigation. Proc Natl Acad Sci U S A (2016) 0.88
Niche players: spermatogonial progenitors marked by GPR125. Cell Cycle (2007) 0.88
Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. Biol Reprod (2013) 0.87
The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells (2012) 0.87
Spermatogonial stem cell markers and niche in equids. PLoS One (2012) 0.87
Signaling pathways in spermatogonial stem cells and their disruption by toxicants. Birth Defects Res C Embryo Today (2009) 0.86
Stem cells: novel players in the treatment of erectile dysfunction. Asian J Androl (2011) 0.86
Age affects gene expression in mouse spermatogonial stem/progenitor cells. Reproduction (2010) 0.86
Regulation of the spermatogonial stem cell niche. Reprod Domest Anim (2008) 0.85
CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS One (2012) 0.85
Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells. PLoS One (2012) 0.84
Endocrine regulation of spermatogonial stem cells in the seminiferous epithelium of adult mice. Biores Open Access (2012) 0.84
De novo morphogenesis of testis tissue: an improved bioassay to investigate the role of VEGF165 during testis formation. Reproduction (2014) 0.84
Germline stem cells: stems of the next generation. Curr Opin Cell Biol (2010) 0.84
VEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivo. Endocrinology (2011) 0.84
Gene expression profiling of rat spermatogonia and Sertoli cells reveals signaling pathways from stem cells to niche and testicular cancer cells to surrounding stroma. BMC Genomics (2011) 0.83
Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia. Endocrinology (2013) 0.83
Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling. EMBO Rep (2015) 0.82
Hierarchical differentiation competence in response to retinoic acid ensures stem cell maintenance during mouse spermatogenesis. Development (2015) 0.82
Short term interactions with long term consequences: modulation of chimeric vessels by neural progenitors. PLoS One (2012) 0.82
The niche-derived glial cell line-derived neurotrophic factor (GDNF) induces migration of mouse spermatogonial stem/progenitor cells. PLoS One (2013) 0.82
Generation of a germ cell-specific mouse transgenic CHERRY reporter, Sohlh1-mCherryFlag. Genesis (2012) 0.81
A-single spermatogonia heterogeneity and cell cycles synchronize with rat seminiferous epithelium stages VIII-IX. Biol Reprod (2014) 0.81
The spermatogonial stem cell niche in the collared peccary (Tayassu tajacu). Biol Reprod (2012) 0.81
Cell-cycle-dependent colonization of mouse spermatogonial stem cells after transplantation into seminiferous tubules. J Reprod Dev (2013) 0.81
Challenges in long-term imaging and quantification of single-cell dynamics. Nat Biotechnol (2016) 0.80
Engineering the CNS stem cell microenvironment. Regen Med (2009) 0.80
A single cell bioengineering approach to elucidate mechanisms of adult stem cell self-renewal. Integr Biol (Camb) (2012) 0.80
The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development (2016) 0.80
IGF-1R signaling is essential for the proliferation of cultured mouse spermatogonial stem cells by promoting the G2/M progression of the cell cycle. Stem Cells Dev (2014) 0.80
Perivascular hair follicle stem cells associate with a venule annulus. J Invest Dermatol (2013) 0.80
Three-dimensional synthetic niche components to control germ cell proliferation. Tissue Eng Part A (2009) 0.79
Neurovascular signals suggest a propagation mechanism for endogenous stem cell activation along blood vessels. CNS Neurol Disord Drug Targets (2012) 0.79
The effects of poly L-lactic acid nanofiber scaffold on mouse spermatogonial stem cell culture. Int J Nanomedicine (2013) 0.79
Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Res (2016) 0.78
Propagation of adult SSCs: from mouse to human. Biomed Res Int (2013) 0.78
Beyond the mouse monopoly: studying the male germ line in domestic animal models. ILAR J (2015) 0.78
Adult stem cell and mesenchymal progenitor theories of aging. Front Cell Dev Biol (2014) 0.78
GPCRs Direct Germline Development and Somatic Gonad Function in Planarians. PLoS Biol (2016) 0.78
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Responses to glial cell line-derived neurotrophic factor change in mice as spermatogonial stem cells form progenitor spermatogonia which replicate and give rise to more differentiated progeny. Biol Reprod (2014) 0.78
Profiling of Cxcl12 receptors, Cxcr4 and Cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for Cxcr7 in controlling Cxcl12 activity. PLoS One (2014) 0.77
Development of quantitative microscopy-based assays for evaluating dynamics of living cultures of mouse spermatogonial stem/progenitor cells. Biol Reprod (2012) 0.77
Local signalling environments and human male infertility: what we can learn from mouse models. Expert Rev Mol Med (2010) 0.77
EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis. Biol Reprod (2010) 0.77
Downregulation of Col1a1 induces differentiation in mouse spermatogonia. Asian J Androl (2012) 0.77
Pluripotency of male germline stem cells. Mol Cells (2011) 0.77
Signaling molecules and pathways regulating the fate of spermatogonial stem cells. Microsc Res Tech (2009) 0.77
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett (2004) 4.02
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol (2003) 3.15
Functional identification of the actual and potential stem cell compartments in mouse spermatogenesis. Dev Cell (2007) 2.95
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron (2005) 2.66
Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. J Clin Invest (2005) 2.62
Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science (2007) 2.55
Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci U S A (2010) 2.27
Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun (2010) 2.20
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol (2004) 2.13
The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development (2006) 2.07
Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking. Neuron (2010) 1.95
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology (2002) 1.90
A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proc Natl Acad Sci U S A (2008) 1.56
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res (2008) 1.38
Analysis of cell lineage in two- and four-cell mouse embryos. Development (2003) 1.26
Stem cell heterogeneity: actual and potential stem cell compartments in mouse spermatogenesis. Ann N Y Acad Sci (2007) 1.18
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing. J Biol Chem (2004) 1.17
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development (2009) 1.05
Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved. J Neurosci Res (2010) 0.98
Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice. Mol Cell Neurosci (2007) 0.92
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology (2013) 0.89
Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons. J Neurosci (2014) 0.88
Double mutations in klotho and osteoprotegerin gene loci rescued osteopetrotic phenotype. Endocrinology (2002) 0.84
Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord. Dev Dyn (2005) 0.83
Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus. J Psychopharmacol (2013) 0.81
Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling. Biochimie (2010) 0.80
Nampt/PBEF/Visfatin: a new player in beta cell physiology and in metabolic diseases? Cell Metab (2007) 0.80
Impaired regulation of gonadotropins leads to the atrophy of the female reproductive system in klotho-deficient mice. Endocrinology (2005) 0.79
Persistent alpha-Klotho (a-Kl) expression in the parathyroid glands of patients with secondary hyperparathyroidism. Nephrol Dial Transplant (2010) 0.79
Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus. Neuropharmacology (2013) 0.79
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