Published in FEBS Lett on May 07, 2004
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem (2006) 6.50
The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov (2009) 6.23
Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol (2010) 4.59
The parathyroid is a target organ for FGF23 in rats. J Clin Invest (2007) 4.47
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A (2007) 3.13
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Clin Invest (2007) 2.79
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A (2008) 2.62
Aging and disease as modifiers of efficacy of cell therapy. Circ Res (2008) 2.51
Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int (2010) 2.50
Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem (2011) 2.46
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc Natl Acad Sci U S A (2009) 2.23
Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun (2010) 2.20
Life extension factor klotho enhances cognition. Cell Rep (2014) 1.81
Circulating αKlotho influences phosphate handling by controlling FGF23 production. J Clin Invest (2012) 1.80
Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol (2013) 1.78
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol (2009) 1.75
Initial FGF23-mediated signaling occurs in the distal convoluted tubule. J Am Soc Nephrol (2009) 1.74
Current understanding of klotho. Ageing Res Rev (2008) 1.64
Klotho: a novel regulator of calcium and phosphorus homeostasis. Pflugers Arch (2011) 1.63
Klotho and aging. Biochim Biophys Acta (2009) 1.58
Klotho is a substrate for alpha-, beta- and gamma-secretase. FEBS Lett (2009) 1.45
Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease. J Am Soc Nephrol (2011) 1.42
Klotho. Pflugers Arch (2010) 1.34
Regulation of phosphate transport in proximal tubules. Pflugers Arch (2008) 1.33
FGFR3 and FGFR4 do not mediate renal effects of FGF23. J Am Soc Nephrol (2008) 1.28
Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol (2012) 1.28
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun (2012) 1.25
Plasma klotho and mortality risk in older community-dwelling adults. J Gerontol A Biol Sci Med Sci (2011) 1.25
Plasma klotho and cardiovascular disease in adults. J Am Geriatr Soc (2011) 1.20
Overview of the FGF23-Klotho axis. Pediatr Nephrol (2009) 1.15
A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PLoS One (2013) 1.15
Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. Aging (Albany NY) (2010) 1.15
Role of Klotho in aging, phosphate metabolism, and CKD. Am J Kidney Dis (2011) 1.15
Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Gastroenterology (2009) 1.15
Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism. PLoS One (2014) 1.13
Secreted klotho and chronic kidney disease. Adv Exp Med Biol (2012) 1.13
Klotho and chronic kidney disease. Contrib Nephrol (2013) 1.11
The emerging role of Klotho in clinical nephrology. Nephrol Dial Transplant (2012) 1.08
Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease. BMC Nephrol (2012) 1.08
The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci (2013) 1.08
Klotho as a potential biomarker and therapy for acute kidney injury. Nat Rev Nephrol (2012) 1.06
Phosphate and Klotho. Kidney Int Suppl (2011) 1.05
Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway. Aging Cell (2012) 1.05
Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549. J Exp Clin Cancer Res (2010) 1.04
Recent advances in renal phosphate handling. Nat Rev Nephrol (2010) 1.04
Renal and extrarenal actions of Klotho. Semin Nephrol (2013) 1.04
Regulation of phosphate homeostasis by the phosphatonins and other novel mediators. Pediatr Nephrol (2008) 1.03
Klotho and the aging process. Korean J Intern Med (2011) 1.01
Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility. Pigment Cell Melanoma Res (2010) 1.00
Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Mol Cell Endocrinol (2008) 1.00
α-Klotho protects against oxidative damage in pulmonary epithelia. Am J Physiol Lung Cell Mol Physiol (2014) 1.00
Molecular basis of Klotho: from gene to function in aging. Endocr Rev (2015) 0.99
Down-Regulation of Soluble α-Klotho is Associated with Reduction in Serum Irisin Levels in Chronic Obstructive Pulmonary Disease. Lung (2016) 0.98
Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study. Eur J Appl Physiol (2011) 0.97
Nuclear localization of Klotho in brain: an anti-aging protein. Neurobiol Aging (2012) 0.96
Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate. J Am Soc Nephrol (2014) 0.96
Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice. Biogerontology (2013) 0.95
FGF23 and the parathyroid glands. Pediatr Nephrol (2010) 0.95
Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease. Neurosci Lett (2013) 0.95
Klotho and kidney disease. J Nephrol (2010) 0.95
Hyperaldosteronism in Klotho-deficient mice. Am J Physiol Renal Physiol (2010) 0.94
RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway. Physiol Genomics (2010) 0.92
The relationship between the soluble Klotho protein and the residual renal function among peritoneal dialysis patients. Clin Exp Nephrol (2012) 0.91
The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody. Nephrol Dial Transplant (2014) 0.91
Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho. Kidney Int (2016) 0.89
Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem (2012) 0.89
Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients. BMC Nephrol (2014) 0.89
Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood. Brain Res (2013) 0.87
Evidence against a direct role of klotho in insulin resistance. Pflugers Arch (2009) 0.87
Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. J Biol Chem (2013) 0.86
Promoter methylation confers kidney-specific expression of the Klotho gene. FASEB J (2012) 0.86
Renal Production, Uptake, and Handling of Circulating αKlotho. J Am Soc Nephrol (2015) 0.86
Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry (2014) 0.86
Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis. Proc Jpn Acad Ser B Phys Biol Sci (2009) 0.84
Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 β-cells. Endocrinology (2012) 0.84
Upregulation of KCNQ1/KCNE1 K+ channels by Klotho. Channels (Austin) (2014) 0.84
Klotho: its various functions and association with sickle cell disease subphenotypes. Rev Bras Hematol Hemoter (2014) 0.84
Is fibroblast growth factor 23 a harbinger of mortality in CKD? Pediatr Nephrol (2011) 0.84
Accelerated suicidal erythrocyte death in Klotho-deficient mice. Pflugers Arch (2009) 0.83
FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo. J Biol Chem (2012) 0.83
Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients. PLoS One (2014) 0.82
Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma. Lab Invest (2015) 0.82
Association between decreased klotho blood levels and organic growth hormone deficiency in children with growth impairment. PLoS One (2014) 0.82
Tumor-induced osteomalacia. Expert Rev Endocrinol Metab (2009) 0.82
αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy. J Am Soc Nephrol (2015) 0.82
The FGF23 and Klotho system beyond mineral metabolism. Clin Exp Nephrol (2016) 0.81
Post-Translational Modifications of TRP Channels. Cells (2014) 0.81
Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms. J Biol Chem (2014) 0.81
Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters. Eur J Endocrinol (2012) 0.80
Klotho protein lowered in elderly hypertension. Int J Clin Exp Med (2014) 0.80
Infection and smoking are associated with decreased plasma concentration of the anti-aging protein, α-klotho. J Perinat Med (2013) 0.80
Comparative endocrinology of aging and longevity regulation. Front Endocrinol (Lausanne) (2011) 0.79
Developmental immunolocalization of the Klotho protein in mouse kidney epithelial cells. Eur J Histochem (2014) 0.79
Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells. Toxicol In Vitro (2015) 0.78
Vascular calcification: When should we interfere in chronic kidney disease patients and how? World J Nephrol (2016) 0.78
Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4. PLoS One (2013) 0.78
Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes. J Am Soc Nephrol (2016) 0.78
α-Klotho is an acute phase protein and altered by restraint stress in mice. Int J Clin Exp Pathol (2014) 0.78
Development and characterization of monoclonal antibodies to detect klotho. Monoclon Antib Immunodiagn Immunother (2014) 0.78
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74
The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med (2012) 5.57
A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis. Science (2007) 3.60
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol (2003) 3.15
Functional identification of the actual and potential stem cell compartments in mouse spermatogenesis. Dev Cell (2007) 2.95
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol Cell (2005) 2.88
alpha-Klotho as a regulator of calcium homeostasis. Science (2007) 2.71
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron (2005) 2.66
Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. J Clin Invest (2005) 2.62
Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. Science (2007) 2.55
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev (2002) 2.41
Long-term outcome in patients harboring intracranial ependymoma. J Neurosurg (2005) 2.28
Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci U S A (2010) 2.27
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest (2005) 2.25
Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun (2010) 2.20
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci (2010) 2.18
Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol (2004) 2.13
Effects of extracranial-intracranial bypass for patients with hemorrhagic moyamoya disease: results of the Japan Adult Moyamoya Trial. Stroke (2014) 2.12
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res (2005) 2.05
Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One (2011) 2.01
Radiological findings, clinical course, and outcome in asymptomatic moyamoya disease: results of multicenter survey in Japan. Stroke (2007) 2.00
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation (2004) 2.00
Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking. Neuron (2010) 1.95
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology (2002) 1.90
Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci U S A (2008) 1.87
Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci U S A (2007) 1.83
Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J Neurosci Res (2008) 1.70
Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats. Stroke (2008) 1.67
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke (2008) 1.64
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell (2008) 1.63
Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. J Cell Biol (2003) 1.58
Transdifferentiation of bone marrow-derived endothelial progenitor cells into the smooth muscle cell lineage mediated by tansforming growth factor-beta1. Atherosclerosis (2010) 1.57
Survival and differentiation of neural progenitor cells derived from embryonic stem cells and transplanted into ischemic brain. J Neurosurg (2005) 1.57
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem (2003) 1.57
Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Stroke (2006) 1.56
A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proc Natl Acad Sci U S A (2008) 1.56
Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging. Genesis (2011) 1.54
Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation. Stroke (2009) 1.45
Clinical significance of axillary microresiduals after neoadjuvant chemotherapy in breast cancer patients with cytologically proven metastases. Ann Surg Oncol (2009) 1.43
Expression and activation of STAT family proteins in cerebral arteriovenous malformations. World Neurosurg (2011) 1.43
Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells (2005) 1.42
Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia. J Cereb Blood Flow Metab (2008) 1.41
Mouse model of cerebral aneurysm: experimental induction by renal hypertension and local hemodynamic changes. Stroke (2002) 1.41
NF-kappaB is a key mediator of cerebral aneurysm formation. Circulation (2007) 1.39
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res (2008) 1.38
Gene expression-based molecular diagnostic system for malignant gliomas is superior to histological diagnosis. Clin Cancer Res (2007) 1.26
Analysis of cell lineage in two- and four-cell mouse embryos. Development (2003) 1.26
Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Mol Endocrinol (2007) 1.25
Risk factors for subsequent hemorrhage in patients with cerebral arteriovenous malformations. J Neurosurg (2007) 1.21
Stem cell heterogeneity: actual and potential stem cell compartments in mouse spermatogenesis. Ann N Y Acad Sci (2007) 1.18
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing. J Biol Chem (2004) 1.17
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain. J Cereb Blood Flow Metab (2006) 1.16
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury. J Neurochem (2006) 1.16
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J Biol Chem (2003) 1.15
Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models. Cancer Sci (2014) 1.13
Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter. Development (2012) 1.13
Histological features of middle cerebral arteries from patients treated for Moyamoya disease. Neurol Med Chir (Tokyo) (2007) 1.12
Liliequist membrane: three-dimensional constructive interference in steady state MR imaging. Radiology (2003) 1.12
Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Stroke (2007) 1.10
Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Biochim Biophys Acta (2002) 1.10
Evaluation of primary brain tumors with FLT-PET: usefulness and limitations. Clin Nucl Med (2006) 1.10
Matrigel supports survival and neuronal differentiation of grafted embryonic stem cell-derived neural precursor cells. J Neurosci Res (2010) 1.10
Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice. Antioxid Redox Signal (2004) 1.08
A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians. Environ Health Prev Med (2009) 1.08
Asymptomatic microbleeds in moyamoya disease: T2*-weighted gradient-echo magnetic resonance imaging study. J Neurosurg (2005) 1.07
Klotho protein deficiency leads to overactivation of mu-calpain. J Biol Chem (2002) 1.07
High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas. J Neurooncol (2004) 1.07
Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development (2009) 1.05
Automatic extraction of nuclei centroids of mouse embryonic cells from fluorescence microscopy images. PLoS One (2012) 1.04
Administration of ex vivo-expanded bone marrow-derived endothelial progenitor cells attenuates focal cerebral ischemia-reperfusion injury in rats. Neurosurgery (2006) 1.03