Published in Proc Natl Acad Sci U S A on September 19, 2007
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell (2008) 3.62
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nat Cell Biol (2010) 3.51
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature (2013) 2.62
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36
WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis. Am J Respir Cell Mol Biol (2009) 2.36
Global gene expression analysis of reactive stroma in prostate cancer. Clin Cancer Res (2009) 2.34
Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat Med (2014) 2.05
Wnt-related molecules and signaling pathway equilibrium in hematopoiesis. Cell Stem Cell (2009) 2.00
Developmental basis of sexually dimorphic digit ratios. Proc Natl Acad Sci U S A (2011) 1.99
Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell (2009) 1.92
The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood (2011) 1.89
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells. Blood (2011) 1.76
Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev (2011) 1.63
Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells. BMC Med Genomics (2009) 1.55
Cytokines regulating hematopoietic stem cell function. Curr Opin Hematol (2008) 1.54
Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells. Blood (2015) 1.50
Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells. Mol Cancer (2009) 1.44
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol (2012) 1.39
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia (2011) 1.37
Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res (2009) 1.29
Contrasting responses of lymphoid progenitors to canonical and noncanonical Wnt signals. J Immunol (2008) 1.29
Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. PLoS One (2009) 1.24
Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev (2008) 1.23
Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes. J Biol Chem (2009) 1.22
Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell (2009) 1.20
Wnt/β-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells. Invest Ophthalmol Vis Sci (2011) 1.20
Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt. Pigment Cell Melanoma Res (2009) 1.19
Communications between bone cells and hematopoietic stem cells. Arch Biochem Biophys (2008) 1.18
Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One (2008) 1.14
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Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ (2013) 1.09
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med (2015) 1.08
Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance. J Immunol (2013) 1.08
Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells. Cancer Res (2015) 1.04
Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals. Mol Cell Biol (2010) 1.02
Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration. Mol Cancer Res (2010) 0.98
Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS One (2011) 0.98
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The Wnts of change: How Wnts regulate phenotype switching in melanoma. Biochim Biophys Acta (2015) 0.95
Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol (2016) 0.93
Role of non-canonical Wnt signaling in osteoblast maturation on microstructured titanium surfaces. Acta Biomater (2011) 0.93
Genome-wide analysis of miRNA-mRNA interactions in marrow stromal cells. Stem Cells (2014) 0.92
Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells. Dev Biol (2013) 0.92
Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways. J Biol Chem (2013) 0.92
Nkd1 functions as a passive antagonist of Wnt signaling. PLoS One (2013) 0.89
Hematopoietic niche and bone meet. Curr Opin Support Palliat Care (2008) 0.89
Maintenance of HSC by Wnt5a secreting AGM-derived stromal cell line. Exp Hematol (2010) 0.89
HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens. Mol Vis (2010) 0.88
Molecular profiling of conjunctival epithelial side-population stem cells: atypical cell surface markers and sources of a slow-cycling phenotype. Invest Ophthalmol Vis Sci (2009) 0.88
Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres. PLoS One (2014) 0.88
The role of pleiotrophin and beta-catenin in fetal lung development. Respir Res (2010) 0.87
WNT-5A: signaling and functions in health and disease. Cell Mol Life Sci (2015) 0.86
Challenging role of Wnt5a and its signaling pathway in cancer metastasis (Review). Exp Ther Med (2014) 0.86
Adenovirus-mediated Wnt5a expression inhibits the telogen-to-anagen transition of hair follicles in mice. Int J Med Sci (2013) 0.85
Wnt signaling: the good and the bad. Acta Biochim Biophys Sin (Shanghai) (2008) 0.84
Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood (2012) 0.84
Early B lymphocyte development: Similarities and differences in human and mouse. World J Stem Cells (2014) 0.83
Activation of the canonical Wnt/β-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines. J Comp Pathol (2012) 0.81
Wnt3a protein reduces growth factor-driven expansion of human hematopoietic stem and progenitor cells in serum-free cultures. PLoS One (2015) 0.80
Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells. J Biomed Sci (2014) 0.80
Downregulation of Wnt signaling by sonic hedgehog activation promotes repopulation of human tumor cell lines. Dis Model Mech (2015) 0.78
Targeted overexpression of TGF-α in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling. Invest Ophthalmol Vis Sci (2013) 0.78
The non-canonical Wnt pathway negatively regulates dendritic cell differentiation by inhibiting the expansion of Flt3(+) lymphocyte-primed multipotent precursors. Cell Mol Immunol (2015) 0.77
PDGF-dependent β-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension. FEBS Lett (2016) 0.77
Wnt5a expression in the hindgut of fetal rats with chemically induced anorectal malformations--studies in the ETU rat model. Int J Colorectal Dis (2011) 0.76
Wnt3a expression during the differentiation of adipose-derived stem cells into cholinergic neurons. Neural Regen Res (2012) 0.76
'WNT-er is coming': WNT signalling in chronic lung diseases. Thorax (2017) 0.76
The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis. Cell Death Dis (2016) 0.75
Wnt3a Mediates the Inhibitory Effect of Hyperoxia on the Transdifferentiation of AECIIs to AECIs. J Histochem Cytochem (2015) 0.75
Bone marrow mesenchymal stem cell-derived Wnt5a inhibits leukemia cell progression in vitro via activation of the non-canonical Wnt signaling pathway. Oncol Lett (2014) 0.75
Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med (2016) 0.75
Bone Marrow-Derived Mesenchymal Stromal Cells from Patients with Sickle Cell Disease Display Intact Functionality. Biol Blood Marrow Transplant (2017) 0.75
Wnt5a does not support hematopoiesis in stroma-free, serum-free cultures. PLoS One (2013) 0.75
Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD. J Exp Med (2016) 0.75
Wnt signalling meets epigenetics. Stem Cell Investig (2016) 0.75
Comparison of Zebrafish tmem88a mutant and morpholino knockdown phenotypes. PLoS One (2017) 0.75
Wnt and related signaling pathways in melanomagenesis. Cancers (Basel) (2010) 0.75
R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Cell Rep (2017) 0.75
Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program. Cell Rep (2017) 0.75
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Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
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Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol (2006) 7.36
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol (2005) 6.49
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev (2004) 5.83
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Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol (2003) 4.70
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Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol (2006) 4.13
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Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell (2011) 3.12
Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development (2003) 2.57
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Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev (2004) 2.18
A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia. Blood (2010) 1.88
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83
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Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med (2013) 1.66
Bone marrow stem cells regenerate infarcted myocardium. Pediatr Transplant (2003) 1.66
Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A (2011) 1.62
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An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation. Blood (2007) 1.57
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Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood (2011) 1.50
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Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol (2007) 1.40
The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J Biol Chem (2012) 1.39
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A dinucleotide deletion in the ankyrin promoter alters gene expression, transcription initiation and TFIID complex formation in hereditary spherocytosis. Hum Mol Genet (2005) 0.83
A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter. Blood (2012) 0.80
Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow. Proc Natl Acad Sci U S A (2002) 0.80
Genome-wide detection of a TFIID localization element from an initial human disease mutation. Nucleic Acids Res (2010) 0.79
A somatic cell defect is associated with the onset of neurological symptoms in a lysosomal storage disease. Mol Genet Metab (2013) 0.77
The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling. FASEB J (2011) 0.77
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Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter. Mol Cell Biol (2010) 0.76
Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest (2016) 0.75
Reply to Mazzeu: Human mutations in RYK might cause Robinow syndrome. J Biol Chem (2013) 0.75
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