Published in J Biol Chem on September 20, 2007
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2008) 3.57
CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol (2008) 2.62
Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem (2011) 1.75
The molecular mechanism and cellular functions of mitochondrial division. Biochim Biophys Acta (2008) 1.67
The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Neurochem (2009) 1.67
SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. FASEB J (2009) 1.45
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell (2011) 1.39
Mitochondrial division: molecular machinery and physiological functions. Curr Opin Cell Biol (2011) 1.22
Computational classification of mitochondrial shapes reflects stress and redox state. Cell Death Dis (2013) 1.14
Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements. J Biol Chem (2008) 1.13
The role of mitochondria in neurodegenerative diseases. J Neurol (2011) 1.05
Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects. Cell Death Differ (2008) 1.04
Mitochondrial death pathways in yeast and mammalian cells. Biochim Biophys Acta (2008) 1.04
Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming. Nat Commun (2016) 0.96
The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction. Exp Cell Res (2008) 0.93
Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease? Mol Neurobiol (2010) 0.92
The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci U S A (2015) 0.83
Evidence for conformational heterogeneity of fission protein Fis1 from Saccharomyces cerevisiae. Biochemistry (2009) 0.81
The cytosolic domain of Fis1 binds and reversibly clusters lipid vesicles. PLoS One (2011) 0.80
Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1. J Biol Chem (2009) 0.80
Charcot-Marie-Tooth-related gene GDAP1 complements cell cycle delay at G2/M phase in Saccharomyces cerevisiae fis1 gene-defective cells. J Biol Chem (2011) 0.80
The C. elegans B-cell lymphoma 2 (Bcl-2) homolog cell death abnormal 9 (CED-9) associates with and remodels LIPID membranes. Protein Sci (2011) 0.80
The 1.75 Å resolution structure of fission protein Fis1 from Saccharomyces cerevisiae reveals elusive interactions of the autoinhibitory domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Calcium channel blockers and Alzheimer's disease. Neural Regen Res (2012) 0.78
A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission. J Mol Biol (2012) 0.78
Identification of interaction partners of the dynamin-like protein DynA from Bacillus subtilis. Commun Integr Biol (2012) 0.78
The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species. Dev Cell (2017) 0.78
A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission. J Biol Chem (2016) 0.76
Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L. Autophagy (2017) 0.75
Protein production by auto-induction in high density shaking cultures. Protein Expr Purif (2005) 29.74
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell (2001) 10.33
Mitochondria: dynamic organelles in disease, aging, and development. Cell (2006) 8.30
The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays (1999) 7.89
Localization of mitochondria in living cells with rhodamine 123. Proc Natl Acad Sci U S A (1980) 7.31
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell (2000) 7.25
The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat Cell Biol (1999) 6.26
Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol (2000) 5.86
Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J Cell Biol (1999) 5.53
Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria. Microsc Res Tech (1994) 5.34
A lethal defect of mitochondrial and peroxisomal fission. N Engl J Med (2007) 5.27
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol (2002) 5.01
The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast. J Cell Biol (1998) 4.72
Mitochondrial fission in apoptosis. Nat Rev Mol Cell Biol (2005) 4.67
The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol (2003) 4.56
Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J Cell Biol (2000) 4.07
DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature (2005) 3.99
hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem (2003) 3.84
Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol (2005) 3.75
Mitochondrial dynamics and division in budding yeast. Trends Cell Biol (2002) 3.15
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell (2000) 3.08
Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. Mol Cell (2006) 2.94
Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. J Cell Sci (2004) 2.78
The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission. J Cell Biol (2002) 2.74
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol Cell Biol (2006) 2.71
Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J Cell Biol (2000) 2.62
Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5. Nat Struct Biol (2000) 2.49
The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. J Cell Biol (2005) 2.33
Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev (2004) 2.30
Dynamin-like protein 1 is involved in peroxisomal fission. J Biol Chem (2002) 2.18
Division of mitochondria requires a novel DMN1-interacting protein, Net2p. Mol Biol Cell (2001) 2.17
Mdv1 interacts with assembled dnm1 to promote mitochondrial division. J Biol Chem (2005) 2.01
Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. Mol Biol Cell (2003) 1.98
A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2005) 1.89
Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. J Cell Sci (2005) 1.75
Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. J Cell Sci (2006) 1.73
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J Mol Biol (2003) 1.70
The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11. J Biol Chem (2003) 1.65
The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria. Mol Biol Cell (2003) 1.59
Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. Proteins (2004) 1.39
Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1. J Biol Chem (2006) 1.37
Mitochondrial dynamics and disease, OPA1. Biochim Biophys Acta (2006) 1.35
Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1p. J Cell Sci (2003) 1.35
The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly. J Cell Biol (2005) 1.33
Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission. J Biol Chem (2005) 1.27
Staying in aerobic shape: how the structural integrity of mitochondria and mitochondrial DNA is maintained. Curr Opin Cell Biol (2003) 1.21
Morpho-dynamic changes of mitochondria during ageing of human endothelial cells. Mech Ageing Dev (2005) 1.19
Mechanisms of disease: mitochondria as new therapeutic targets in diabetic neuropathy. Nat Clin Pract Neurol (2006) 1.19
Importance of mitochondrial dynamics during meiosis and sporulation. Mol Biol Cell (2004) 1.14
Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface. J Cell Sci (2006) 1.13
Flexibility and constraint in the nucleosome core landscape of Caenorhabditis elegans chromatin. Genome Res (2006) 3.89
Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev (2004) 2.30
A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division. J Biol Chem (2010) 1.56
Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. Proteins (2004) 1.39
Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels. J Biol Chem (2008) 1.24
After Xigris, researchers look to new targets to combat sepsis. Nat Med (2012) 1.15
Circulating tumor cells. Proc Natl Acad Sci U S A (2013) 1.08
Competitive repair by naturally dispersed repetitive DNA during non-allelic homologous recombination. PLoS Genet (2010) 1.07
Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism. J Mol Biol (2006) 1.01
The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner. Biochemistry (2006) 1.00
News feature: Capturing cancer's complexity. Proc Natl Acad Sci U S A (2015) 0.99
No end in sight for telomerase-targeted cancer drugs. Nat Med (2013) 0.99
CED-9 and mitochondrial homeostasis in C. elegans muscle. J Cell Sci (2008) 0.97
Nodding syndrome leaves baffled scientists shaking their heads. Nat Med (2012) 0.96
New mouse models of autism highlight need for standardized tests. Nat Med (2011) 0.89
Role of conserved cysteines in the alphavirus E3 protein. J Virol (2008) 0.87
Acid destabilization of the solution conformation of Bcl-xL does not drive its pH-dependent insertion into membranes. Protein Sci (2005) 0.85
New biologic drugs get under the skin of psoriasis. Nat Med (2012) 0.84
Under the skin of intradermal vaccines. Proc Natl Acad Sci U S A (2013) 0.83
Epigenetics. Proc Natl Acad Sci U S A (2013) 0.83
Small nanobody drugs win big backing from pharma. Nat Med (2013) 0.82
First IL-6-blocking drug nears approval for rare blood disorder. Nat Med (2013) 0.81
Evidence for conformational heterogeneity of fission protein Fis1 from Saccharomyces cerevisiae. Biochemistry (2009) 0.81
Link between obesity and cancer. Proc Natl Acad Sci U S A (2013) 0.80
The cytosolic domain of Fis1 binds and reversibly clusters lipid vesicles. PLoS One (2011) 0.80
The C. elegans B-cell lymphoma 2 (Bcl-2) homolog cell death abnormal 9 (CED-9) associates with and remodels LIPID membranes. Protein Sci (2011) 0.80
Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli. Protein Expr Purif (2008) 0.79
A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission. J Mol Biol (2012) 0.78
The 1.75 Å resolution structure of fission protein Fis1 from Saccharomyces cerevisiae reveals elusive interactions of the autoinhibitory domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Genetics: Searching for answers. Nature (2012) 0.78
The other microbiome. Proc Natl Acad Sci U S A (2013) 0.77
Gnotobiotics. Proc Natl Acad Sci U S A (2014) 0.77
Drugs targeting mGluR5 receptor offer 'fragile' hope for autism. Nat Med (2012) 0.76
Applications of NMR spin relaxation methods for measuring biological motions. Methods Enzymol (2004) 0.76
Flurry of deal-making surrounds new autoimmunity target. Nat Med (2013) 0.76
Alzheimer's imaging agents struggle to find a market outside trials. Nat Med (2013) 0.76
Potential first-in-class osteoporosis drug speeds through trials. Nat Med (2012) 0.75
News Feature: Genetic mutations you want. Proc Natl Acad Sci U S A (2016) 0.75
News feature: Next-generation antibiotics. Proc Natl Acad Sci U S A (2014) 0.75
New yardstick could speed access to cancer drugs for surgery. Nat Med (2013) 0.75
Inner workings: Raising yellow tang. Proc Natl Acad Sci U S A (2014) 0.75
Alzheimer's disease: Mapping the brain's decline. Nature (2013) 0.75
Spherical nucleic acids: a whole new ball game. Proc Natl Acad Sci U S A (2013) 0.75
Inner workings: Spraying to see cancer cells. Proc Natl Acad Sci U S A (2014) 0.75
Inner workings: Controlling flies with lasers. Proc Natl Acad Sci U S A (2014) 0.75
Inhibitors of rogue enzyme near trials for brain and blood tumors. Nat Med (2013) 0.75
Frailty research strengthens with biomarker and treatment leads. Nat Med (2013) 0.75
Drugmaker reaps what it sows with first plant-made biologic. Nat Med (2012) 0.75
Clinical labs worry proposed FDA rules may force tough choices. Nat Med (2014) 0.75
Early-stage therapies target surgery-induced erectile dysfunction. Nat Med (2012) 0.75
Cell and DNA repository. Proc Natl Acad Sci U S A (2013) 0.75
New HCV drugs trigger race for more tolerable therapies. Nat Med (2011) 0.75
Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. J Biol Chem (2016) 0.75
Studying volcanic eruptions with aerial drones. Proc Natl Acad Sci U S A (2013) 0.75
Studying an elusive cuckoo. Proc Natl Acad Sci U S A (2013) 0.75
Hunting habits of lions. Proc Natl Acad Sci U S A (2013) 0.75
News Feature: Skimming the surface of underwater landslides. Proc Natl Acad Sci U S A (2016) 0.75
Imaging permafrost. Proc Natl Acad Sci U S A (2013) 0.75