Published in J Biol Chem on September 25, 2007
ADAM-17: the enzyme that does it all. Crit Rev Biochem Mol Biol (2010) 1.62
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer? Clin Proteomics (2011) 1.50
Molecular mechanisms of soluble cytokine receptor generation. J Biol Chem (2008) 1.39
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. J Biol Chem (2011) 1.29
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J (2009) 1.28
ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function. Neuron (2013) 1.25
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10. Cell Mol Life Sci (2012) 1.05
The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis. Biochem J (2013) 1.04
Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function. FASEB J (2011) 1.03
MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10). J Biol Chem (2013) 0.99
Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia. Am J Hum Genet (2009) 0.98
Soluble E-cadherin: more than a symptom of disease. Front Biosci (Landmark Ed) (2012) 0.95
Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discov (2016) 0.94
Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region. J Biol Chem (2010) 0.94
Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane. Proc Natl Acad Sci U S A (2012) 0.94
Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis. J Am Chem Soc (2012) 0.92
ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. J Biol Chem (2011) 0.92
Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region. J Biol Chem (2011) 0.90
EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells. Cell Signal (2011) 0.89
Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth. J Cell Sci (2010) 0.89
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3). J Biol Chem (2013) 0.88
N-cadherin prodomain cleavage regulates synapse formation in vivo. Dev Neurobiol (2009) 0.85
Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles. J Biol Chem (2015) 0.83
Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease. Biochem Res Int (2010) 0.81
ADAM Proteases and Gastrointestinal Function. Annu Rev Physiol (2015) 0.81
Fell-Muir Lecture: Metalloproteinases: from demolition squad to master regulators. Int J Exp Pathol (2010) 0.80
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain. Sci Rep (2015) 0.79
Variability in melanoma metalloproteinase expression profiling. J Biomol Tech (2010) 0.79
The role of proteases in regulating Eph/ephrin signaling. Cell Adh Migr (2014) 0.78
The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP). PLoS One (2013) 0.78
A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions. Toxins (Basel) (2016) 0.77
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes. J Neuroinflammation (2016) 0.76
ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview. Toxins (Basel) (2016) 0.76
ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development. PLoS One (2016) 0.75
Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells. ACS Chem Neurosci (2015) 0.75
Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo. Sci Rep (2016) 0.75
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J Exp Med (2016) 0.75
Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol (2005) 6.47
A high-throughput method to monitor the expression of microRNA precursors. Nucleic Acids Res (2004) 5.21
Exosomes: from biogenesis and secretion to biological function. Immunol Lett (2006) 3.82
Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev (2007) 3.46
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A (2009) 2.59
Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain. Science (2010) 2.47
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell (2010) 2.32
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell (2006) 2.24
A novel class of potent influenza virus inhibitors: polysubstituted acylthiourea and its fused heterocycle derivatives. Bioorg Med Chem Lett (2005) 2.01
Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. EMBO Rep (2007) 1.91
A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am J Med Genet A (2004) 1.79
ABO3, a WRKY transcription factor, mediates plant responses to abscisic acid and drought tolerance in Arabidopsis. Plant J (2010) 1.74
Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapy. Ann Surg (2006) 1.70
Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM. Gynecol Oncol (2007) 1.68
L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Lancet (2003) 1.67
Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates. J Biol Chem (2003) 1.67
The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage. Cell Res (2012) 1.66
A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor. Blood (2014) 1.66
Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis. Curr Pharm Biotechnol (2008) 1.66
The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome. Blood (2011) 1.65
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. FASEB J (2002) 1.58
Structure of the LpxC deacetylase with a bound substrate-analog inhibitor. Nat Struct Biol (2003) 1.57
Polar Fourier transforms of radially sampled NMR data. J Magn Reson (2006) 1.56
Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. Clin Cancer Res (2005) 1.54
Exogenous silicon (Si) increases antioxidant enzyme activity and reduces lipid peroxidation in roots of salt-stressed barley (Hordeum vulgare L.). J Plant Physiol (2003) 1.53
Plant phenomics and high-throughput phenotyping: accelerating rice functional genomics using multidisciplinary technologies. Curr Opin Plant Biol (2013) 1.52
Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin Cancer Res (2011) 1.51
High resolution 4-D spectroscopy with sparse concentric shell sampling and FFT-CLEAN. J Biomol NMR (2008) 1.49
Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1. Proc Natl Acad Sci U S A (2005) 1.49
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. Blood (2010) 1.48
cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. J Biol Chem (2010) 1.47
Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer. Dig Dis Sci (2013) 1.43
Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design. Biochemistry (2005) 1.40
RTE1 is a Golgi-associated and ETR1-dependent negative regulator of ethylene responses. Plant Physiol (2007) 1.39
Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. J Transl Med (2011) 1.38
PACES: Protein sequential assignment by computer-assisted exhaustive search. J Biomol NMR (2003) 1.37
Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol Cancer (2009) 1.35
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. Carcinogenesis (2009) 1.35
Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology (2012) 1.34
Receptor signal output mediated by the ETR1 N terminus is primarily subfamily I receptor dependent. Plant Physiol (2006) 1.34
Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology (2009) 1.34
Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One (2013) 1.32
Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness. J Neuropathol Exp Neurol (2006) 1.32
Health care in China: improvement, challenges, and reform. Chest (2013) 1.31
Effects of plant species coexistence on soil enzyme activities and soil microbial community structure under Cd and Pb combined pollution. J Environ Sci (China) (2010) 1.30
IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites. J Immunol (2005) 1.29
Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry (2007) 1.28
Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo. Immunol Rev (2004) 1.24
Transposons inactivate biosynthesis of the nonribosomal peptide microcystin in naturally occurring Planktothrix spp. Appl Environ Microbiol (2006) 1.24
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proc Natl Acad Sci U S A (2007) 1.24
Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. Clin Cancer Res (2009) 1.24
CADgene: a comprehensive database for coronary artery disease genes. Nucleic Acids Res (2010) 1.23
(4,2)D Projection--reconstruction experiments for protein backbone assignment: application to human carbonic anhydrase II and calbindin D(28K). J Am Chem Soc (2005) 1.23
The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion. J Biol Chem (2002) 1.23
Therapeutic benefits from targeting of ADAM family members. Biochemistry (2004) 1.23
Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. Biochemistry (2005) 1.21
Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano (2011) 1.21
Radial sampling for fast NMR: Concepts and practices over three decades. Prog Nucl Magn Reson Spectrosc (2010) 1.21
Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling. Cytotechnology (2009) 1.21
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10. J Biol Chem (2007) 1.21
Jagged1 expression regulated by Notch3 and Wnt/β-catenin signaling pathways in ovarian cancer. Oncotarget (2010) 1.21
Sampling of the NMR time domain along concentric rings. J Magn Reson (2006) 1.20
Upconversion luminescent materials: advances and applications. Chem Rev (2014) 1.19
Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cells. Nucleic Acids Res (2012) 1.19
Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol (2004) 1.19
High-throughput measurement of rice tillers using a conveyor equipped with x-ray computed tomography. Rev Sci Instrum (2011) 1.18
Controllable N-doping of graphene. Nano Lett (2010) 1.18
Laser speckle imaging of blood flow in microcirculation. Phys Med Biol (2004) 1.18
Surface plasmon-coupled emission: what can directional fluorescence bring to the analytical sciences? Annu Rev Anal Chem (Palo Alto Calif) (2012) 1.17
Characterization of hepatic tumors: value of contrast-enhanced coded phase-inversion harmonic angio. AJR Am J Roentgenol (2004) 1.17
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis. Blood (2010) 1.17
The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus. J Immunol (2003) 1.17
Epidemiology and clinical presentation of the four human parainfluenza virus types. BMC Infect Dis (2013) 1.16
Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proc Natl Acad Sci U S A (2013) 1.16
Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J Biol Chem (2004) 1.16
Assembly and molecular activities of the MutS tetramer. J Biol Chem (2003) 1.16
Groundwater nitrogen pollution and assessment of its health risks: a case study of a typical village in rural-urban continuum, China. PLoS One (2012) 1.15
sRNATarBase: a comprehensive database of bacterial sRNA targets verified by experiments. RNA (2010) 1.14
Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem Biol (2010) 1.14
AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome. J Cell Mol Med (2011) 1.14
Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells. Mol Cell (2012) 1.13
Filtered backprojection for the reconstruction of a high-resolution (4,2)D CH3-NH NOESY spectrum on a 29 kDa protein. J Am Chem Soc (2005) 1.13
An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus. J Pathol (2005) 1.12
Rapid protein global fold determination using ultrasparse sampling, high-dynamic range artifact suppression, and time-shared NOESY. J Am Chem Soc (2012) 1.11
Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers. Biosens Bioelectron (2004) 1.10
Kar3 interaction with Cik1 alters motor structure and function. EMBO J (2005) 1.10
Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. Dev Dyn (2005) 1.08
Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. Bioorg Med Chem (2010) 1.08
Fast acquisition of high resolution 4-D amide-amide NOESY with diagonal suppression, sparse sampling and FFT-CLEAN. J Magn Reson (2010) 1.07
Solution structure of the carbon storage regulator protein CsrA from Escherichia coli. J Bacteriol (2005) 1.07
Combinatorial Optimization of (Lu₁₋(x)Gd(x))₃Al₅O₁₂:Ce₃(y) yellow phosphors as precursors for ceramic scintillators. ACS Comb Sci (2010) 1.07
Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. J Biol Chem (2012) 1.07
Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker. BMC Cancer (2013) 1.06
Self-supported nanoporous cobalt phosphide nanowire arrays: an efficient 3D hydrogen-evolving cathode over the wide range of pH 0-14. J Am Chem Soc (2014) 1.06
Antioxidant activity of black currant (Ribes nigrum L.) extract and its inhibitory effect on lipid and protein oxidation of pork patties during chilled storage. Meat Sci (2012) 1.05
Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. Mol Cell (2010) 1.05
Evaluation and application of multiple scoring functions for a virtual screening experiment. J Comput Aided Mol Des (2004) 1.05