Published in Cell Adh Migr on January 01, 2014
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Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med (2002) 3.74
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The interplay between Src and integrins in normal and tumor biology. Oncogene (2004) 3.37
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The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol (2006) 2.87
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Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway. Nat Cell Biol (2005) 1.95
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TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells. Int J Oncol (2004) 1.58
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ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage. J Biol Chem (2004) 1.51
Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration. Curr Biol (2001) 1.51
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EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style. Cancer Res (2009) 1.39
Extracellular cleavage of cadherin-11 by ADAM metalloproteases is essential for Xenopus cranial neural crest cell migration. Mol Biol Cell (2008) 1.38
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Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling. Nat Cell Biol (2011) 1.38
Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway. J Biol Chem (2002) 1.37
Ectodomain shedding and ADAMs in development. Development (2012) 1.34
Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature (2011) 1.34
Stochastic models for cell motion and taxis. J Math Biol (2003) 1.30
Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold. EMBO J (2006) 1.30
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation. J Biol Chem (2005) 1.30
Intracellular maturation of the mouse metalloprotease disintegrin MDC15. J Biol Chem (1998) 1.27
Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections. Br J Pharmacol (2012) 1.26
Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination. J Biol Chem (2011) 1.25
Protease signalling: the cutting edge. EMBO J (2012) 1.24
Regulation of mature ADAM17 by redox agents for L-selectin shedding. J Immunol (2009) 1.24
The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J Biol Chem (2007) 1.22
gamma-secretases: from cell biology to therapeutic strategies. Lancet Neurol (2010) 1.22
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Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion. J Biol Chem (2008) 1.21
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol (2004) 1.21
Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep (2011) 1.21
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Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation. J Cell Biol (2009) 1.19
Shedding of membrane proteins by ADAM family proteases. Essays Biochem (2002) 1.18
CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase. Oncogene (2005) 1.17
Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness. Biochem Biophys Res Commun (2004) 1.15
Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2. Biochem Biophys Res Commun (2004) 1.14
ADAM13 disintegrin and cysteine-rich domains bind to the second heparin-binding domain of fibronectin. J Biol Chem (2002) 1.12
ADAM proteases: ligand processing and modulation of the Notch pathway. Cell Mol Life Sci (2008) 1.12
Eph-dependent cell-cell adhesion and segregation in development and cancer. Cell Mol Life Sci (2011) 1.09
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci (2004) 4.22
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell (2005) 3.34
Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A (2010) 1.82
Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. Blood (2008) 1.66
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J Cell Biol (2003) 1.60
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. EMBO J (2003) 1.59
Recruitment of Eph receptors into signaling clusters does not require ephrin contact. J Cell Biol (2004) 1.52
Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen. J Biol Chem (2003) 1.48
EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. Cancer Cell (2013) 1.44
Stress-induced decrease in TRAF2 stability is mediated by Siah2. EMBO J (2002) 1.44
Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. J Cell Sci (2002) 1.38
Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents. Cancer Res (2005) 1.28
Expression of nodal signalling components in cycling human endometrium and in endometrial cancer. Reprod Biol Endocrinol (2009) 1.18
Eph-modulated cell morphology, adhesion and motility in carcinogenesis. IUBMB Life (2005) 1.18
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PTP1B regulates Eph receptor function and trafficking. J Cell Biol (2010) 1.14
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Eph-dependent cell-cell adhesion and segregation in development and cancer. Cell Mol Life Sci (2011) 1.09
Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors. J Cell Biol (2011) 1.08
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10. PLoS Biol (2009) 1.03
The role of the Eph-ephrin signalling system in the regulation of developmental patterning. Int J Dev Biol (2002) 1.03
Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. J Biol Chem (2005) 1.01
Eph/Ephrin signaling in injury and inflammation. Am J Pathol (2012) 1.00
"Eph receptor signalling; dimerisation just isn't enough". Growth Factors (2005) 0.98
Eph/ephrin signalling and function in oncogenesis: lessons from embryonic development. Curr Cancer Drug Targets (2008) 0.90
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Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function. J Cell Sci (2012) 0.78
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Targeting of EPH receptor tyrosine kinases for anticancer therapy. Crit Rev Oncog (2012) 0.77