Published in Proc Natl Acad Sci U S A on September 25, 2007
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Linking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans. BMC Syst Biol (2010) 0.91
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Regulation of insect behavior via the insulin-signaling pathway. Front Physiol (2013) 0.87
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Circadian redox and metabolic oscillations in mammalian systems. Antioxid Redox Signal (2013) 0.77
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The impact of FOXO on dopamine and octopamine metabolism in Drosophila under normal and heat stress conditions. Biol Open (2016) 0.75
The potential role of epigenetic modulations in BPPV maneuver exercises. Oncotarget (2016) 0.75
Circadian molecular clock in lung pathophysiology. Am J Physiol Lung Cell Mol Physiol (2015) 0.75
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A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42
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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature (2002) 10.52
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Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell (2004) 8.53
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature (2004) 6.38
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol (2001) 6.15
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science (1998) 5.72
A nutrient sensor mechanism controls Drosophila growth. Cell (2003) 5.61
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A (2005) 5.34
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev (2003) 5.10
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science (2001) 5.03
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science (2004) 4.70
NPAS2: an analog of clock operative in the mammalian forebrain. Science (2001) 3.88
FoxO proteins in insulin action and metabolism. Trends Endocrinol Metab (2005) 3.47
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The circadian timekeeping system of Drosophila. Curr Biol (2005) 3.26
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Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport. Curr Opin Plant Biol (2004) 2.79
Cycling vrille expression is required for a functional Drosophila clock. Cell (1999) 2.51
A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci U S A (2006) 2.27
Reduced insulin/IGF-1 signalling and human longevity. Aging Cell (2005) 2.13
Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science (2002) 2.05
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Photic signaling by cryptochrome in the Drosophila circadian system. Mol Cell Biol (2001) 1.54
Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Aging Cell (2002) 1.49
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Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand (2004) 1.42
Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster. Curr Biol (2003) 1.40
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Control of triglyceride storage by a WD40/TPR-domain protein. EMBO Rep (2003) 1.20
The Malpighian tubule: rapid insights from post-genomic biology. J Insect Physiol (2005) 1.19
A fly's eye view of circadian entrainment. J Biol Rhythms (2003) 1.18
Redox potential: differential roles in dCRY and mCRY1 functions. Curr Biol (2002) 1.15
Calorie restriction delays lipid oxidative damage in Drosophila melanogaster. Aging Cell (2005) 1.13
Down-regulation of a forkhead transcription factor, FOXO3a, accelerates cellular senescence in human dermal fibroblasts. J Gerontol A Biol Sci Med Sci (2005) 1.13
A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer. J Hypertens (2005) 1.11
The neuroendocrine regulation of Drosophila aging. Exp Gerontol (2004) 1.06
Extended longevity and insulin signaling in adipose tissue. Exp Gerontol (2005) 1.06
Renal tubule development in Drosophila: a closer look at the cellular level. J Am Soc Nephrol (2005) 0.98
Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin-treated diabetic mouse. FEBS Lett (2004) 0.91
Light pulse-induced heme and iron-associated transcripts in mouse brain: a microarray analysis. Chronobiol Int (2005) 0.90
Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation. Exp Cell Res (1991) 0.80
Identification of SLEEPLESS, a sleep-promoting factor. Science (2008) 4.56
Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome. Neuron (2005) 4.11
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37
Sleep in Drosophila is regulated by adult mushroom bodies. Nature (2006) 3.36
Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab (2008) 2.85
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell (2004) 2.62
A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci U S A (2006) 2.27
A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr Biol (2006) 2.26
JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science (2006) 2.13
Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron (2002) 2.03
AKT and TOR signaling set the pace of the circadian pacemaker. Curr Biol (2010) 1.97
The circadian clock interacts with metabolic physiology to influence reproductive fitness. Cell Metab (2011) 1.96
Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J Biol Rhythms (2003) 1.85
Interaction of MLL amino terminal sequences with menin is required for transformation. Cancer Res (2007) 1.82
Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior. Neuron (2010) 1.75
An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. J Neurosci (2003) 1.73
A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. PLoS One (2010) 1.72
Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms. J Neurosci (2008) 1.66
Drosophila melanogaster: an insect model for fundamental studies of sleep. Methods Enzymol (2005) 1.59
Serotonin modulates circadian entrainment in Drosophila. Neuron (2005) 1.51
Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish. Sleep (2007) 1.45
A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep (2008) 1.45
Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster. Curr Biol (2003) 1.40
Probing the relative importance of molecular oscillations in the circadian clock. Genetics (2008) 1.38
Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1). Genes Dev (2007) 1.33
The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice. J Biol Rhythms (2008) 1.30
Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit. Cell (2012) 1.27
SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nat Neurosci (2009) 1.27
Genetic analysis of sleep. Genes Dev (2010) 1.26
The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms. Am J Surg Pathol (2015) 1.25
A Drosophila model for Angelman syndrome. Proc Natl Acad Sci U S A (2008) 1.21
Why a fly? Using Drosophila to understand the genetics of circadian rhythms and sleep. Sleep (2004) 1.21
The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. J Neurosci (2009) 1.21
A fly's eye view of circadian entrainment. J Biol Rhythms (2003) 1.18
Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases. Am J Surg Pathol (2014) 1.17
Non-cyclic and developmental stage-specific expression of circadian clock proteins during murine spermatogenesis. Biol Reprod (2003) 1.13
Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. Aging Cell (2012) 1.13
Novel insights into the regulation of the timeless protein. J Neurosci (2003) 1.11
Quantitative genetic analysis of sleep in Drosophila melanogaster. Genetics (2008) 1.09
Speed control: cogs and gears that drive the circadian clock. Trends Neurosci (2012) 1.08
A critical period of sleep for development of courtship circuitry and behavior in Drosophila. Science (2014) 1.03
Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila. BMC Neurosci (2004) 1.03
Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAF-mutant metastatic colon cancer. Cancer Biol Ther (2013) 1.03
Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Genes Dev (2008) 1.03
An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator. J Neurosci (2009) 1.01
Dopamine acts through Cryptochrome to promote acute arousal in Drosophila. Genes Dev (2012) 0.99
A critical role of teashirt for patterning the ventral epidermis is masked by ectopic expression of tiptop, a paralog of teashirt in Drosophila. Dev Biol (2005) 0.97
Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genet (2013) 0.96
Interaction between sleep and metabolism in Drosophila with altered octopamine signaling. J Biol Chem (2012) 0.95
The thymus is similar to the testis in its pattern of circadian clock gene expression. J Biol Rhythms (2005) 0.95
Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount. Elife (2014) 0.93
Signaling components that drive circadian rhythms. Curr Opin Neurobiol (2002) 0.90
Mitotic count by phosphohistone H3 immunohistochemical staining predicts survival and improves interobserver reproducibility in well-differentiated neuroendocrine tumors of the pancreas. Am J Surg Pathol (2015) 0.89
Predicting therapy response in live tumor cells isolated with the flexible micro spring array device. Cell Cycle (2013) 0.88
Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels. J Neurosci (2011) 0.88
Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila. PLoS Genet (2013) 0.87
Energy stores are not altered by long-term partial sleep deprivation in Drosophila melanogaster. PLoS One (2009) 0.87
The central clock neurons regulate lipid storage in Drosophila. PLoS One (2011) 0.86
Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs. Proc Biol Sci (2013) 0.86
Circulating tumor cell isolation during resection of colorectal cancer lung and liver metastases: a prospective trial with different detection techniques. Cancer Biol Ther (2015) 0.85
Small-molecule screen in adult Drosophila identifies VMAT as a regulator of sleep. J Neurosci (2013) 0.82
Clinico-pathological correlation of serial measurement of circulating tumor cells in 24 metastatic colorectal cancer patients receiving chemotherapy reveals interpatient heterogeneity correlated with CEA levels but independent of KRAS and BRAF mutation. Cancer Biol Ther (2015) 0.82
Circulating tumor cell levels are elevated in colorectal cancer patients with high tumor burden in the liver. Cancer Biol Ther (2015) 0.81
Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2. Genes Cells (2002) 0.81
Casein kinase 1 promotes synchrony of the circadian clock network. Mol Cell Biol (2014) 0.79
Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant. J Neurosci (2011) 0.79
Circadian rhythms: finer clock control. Nature (2002) 0.79
Contradictory KRAS mutation test results in a patient with metastatic colon cancer: a clinical dilemma in the era of personalized medicine. Cancer Biol Ther (2013) 0.78
Effect of taurine and caffeine on sleep-wake activity in Drosophila melanogaster. Nat Sci Sleep (2010) 0.78
Opportunities posed by novel patient selection biomarker approaches in oncology drug development: going beyond the cytotoxics. Biomark Med (2008) 0.77
Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis. Proc Natl Acad Sci U S A (2014) 0.76
FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer. Cancer Biol Ther (2013) 0.76
New routes for memory retrieval and reinforcement. Cell (2009) 0.75
A case of heterogeneous sensitivity to panitumumab in cetuximab-refractory colorectal adenocarcinoma metastases. Cancer Biol Ther (2015) 0.75
New perspectives on circadian rhythms and sleep. Curr Opin Neurobiol (2013) 0.75
Methods in Enzymology. Circadian rhythms and biological clocks, part B. Preface. Methods Enzymol (2015) 0.75
Paired Box 5 (PAX5) Expression in Poorly Differentiated Neuroendocrine Carcinoma of the Gastrointestinal and Pancreatobiliary Tract: Diagnostic and Potentially Therapeutic Implications. Appl Immunohistochem Mol Morphol (2016) 0.75
Flies come through again, period. J Clin Invest (2017) 0.75
Methods in Enzymology. Circadian rhythms and biological clocks, part A. Preface. Methods Enzymol (2015) 0.75
REV-ving up the clock. Dev Cell (2002) 0.75
Endobronchial Sarcoidosis. J Bronchology Interv Pulmonol (2017) 0.75