Published in Proc Natl Acad Sci U S A on May 01, 1976
Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol Rev (1992) 5.15
Antiviral activity of interferons. Bacteriol Rev (1977) 2.25
Ultrastructural localization of cell membrane GM1 ganglioside by cholera toxin. Proc Natl Acad Sci U S A (1977) 1.61
Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells. Microbiol Rev (1978) 1.39
Effects of thyrotropin on the thyroid cell membrane: hyperpolarization induced by hormone-receptor interaction. Proc Natl Acad Sci U S A (1977) 1.24
Use of thyrotropin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity. Proc Natl Acad Sci U S A (1976) 1.14
Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen. Proc Natl Acad Sci U S A (1977) 1.11
Immunoglobulin G inhibitor of thyroid-stimulating antibody is a cause of delay in the onset of neonatal Graves' disease. J Clin Invest (1983) 0.94
Interaction of human chorionic gonadotropin with membrane components of rat testes. Proc Natl Acad Sci U S A (1978) 0.93
Relationship of gangliosides to the structure and function of thyrotropin receptors: their absence on plasma membranes of a thyroid tumor defective in thyrotropin receptor activity. Proc Natl Acad Sci U S A (1976) 0.82
Reevaluation of the role of gangliosides in the binding and action of thyrotropin. Proc Natl Acad Sci U S A (1981) 0.80
Effect of cholera toxin on the antiviral and anticellular activities of human leukocyte interferon. Infect Immun (1979) 0.80
Lateral diffusion of ganglioside GM1 in phospholipid bilayer membranes. Biophys J (1986) 0.78
Effect of thyroid phospholipids on the interaction of thyrotropin with thyroid membranes. Proc Natl Acad Sci U S A (1978) 0.77
Mechanism of action of glycopeptide hormones and cholera toxin: what is the role of ADP-ribosylation? Proc Natl Acad Sci U S A (1983) 0.76
Imperial Cancer Research Fund British Association for Cancer Research. Joint symposium held at the Royal College of Surgeons, Lincolns Inn Fields, London 30 November--1 December 1978. Abstracts of papers. Br J Cancer (1979) 0.75
Direct evidence that ganglioside is an integral component of the thyrotropin receptor. Proc Natl Acad Sci U S A (1991) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1970) 23.79
Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. Biochim Biophys Acta (1957) 11.28
Interaction of Vibrio cholerae enterotoxin with cell membranes. Biochemistry (1973) 4.84
The mechanism of action of cholera toxin in pigeon erythrocyte lysates. J Biol Chem (1975) 4.22
External labeling of cell surface galactose and galactosamine in glycolipid and glycoprotein of human erythrocytes. J Biol Chem (1973) 4.11
Tissue receptor for cholera exotoxin: postulated structure from studies with GM1 ganglioside and related glycolipids. Infect Immun (1973) 4.08
Deactivation of cholera toxin by a sialidase-resistant monosialosylganglioside. J Infect Dis (1973) 3.38
Involvement of nicotinamide adenine dinucleotide in the action of cholera toxin in vitro. Proc Natl Acad Sci U S A (1975) 3.04
The ultraviolet fluorescence of proteins in neutral solution. Biochem J (1960) 2.50
Gangliosides of human, bovine, and rabbit plasma. J Lipid Res (1972) 1.99
Physical and chemical studies on ceruloplasmin. IV. Preparation of radioactive, sialic acid-free ceruloplasmin labeled with tritium on terminal D-galactose residues. J Biol Chem (1966) 1.84
Elongation factor 2. Amino acid sequence at the site of adenosine diphosphate ribosylation. J Biol Chem (1974) 1.70
Mechanism of activation of adenylate cyclase by cholera toxin. Proc Natl Acad Sci U S A (1975) 1.65
Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors. Proc Natl Acad Sci U S A (1976) 1.48
The binding of thyrotropin to isolated bovine thyroid plasma membranes. J Biol Chem (1973) 1.43
Absence of a specific ganglioside galactosyltransferase in mouse cells transformed by murine sarcoma virus. Proc Natl Acad Sci U S A (1974) 1.29
Relationships of thyrotropin to exophthalmic-producing substance. Purification of homogeneous glycoproteins containing both activities from [3H]-labeled pituitary extracts. J Biol Chem (1970) 1.29
The purification of bovine thyroid plasma membranes and the properties of membrane-bound adenyl cyclase. J Biol Chem (1971) 1.26
Thyrotropin receptors in thyroid plasma membranes. Characteristics of thyrotropin binding and solubilization of thyrotropin receptor activity by tryptic digestion. J Biol Chem (1975) 1.24
Ganglioside biosynthesis in mouse cells: glycosyltransferase activities in normal and virally-transformed lines. Biochem Biophys Res Commun (1972) 1.19
The contribution of subunits of thyroid stimulating hormone to the binding and biological activity of thyrotropin. Proc Natl Acad Sci U S A (1974) 0.96
Location and the primary structure around the disulfide bonds in cholera toxin. Biochem Biophys Res Commun (1975) 0.95
Stimulation of adenylate cyclase activity in retro-orbital tissue membranes by thyrotropin and an exophthalmogenic factor derived from thyrotropin. J Biol Chem (1975) 0.90
Nucleotide sequences that signal the initiation of transcription and translation in Bacillus subtilis. Mol Gen Genet (1982) 12.95
Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science (1997) 6.66
Replacement therapy for inherited enzyme deficiency--macrophage-targeted glucocerebrosidase for Gaucher's disease. N Engl J Med (1991) 6.09
Enzymatic defect in Fabry's disease. Ceramidetrihexosidase deficiency. N Engl J Med (1967) 5.63
Enzyme replacement therapy in Fabry disease: a randomized controlled trial. JAMA (2001) 5.54
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev (1997) 5.13
Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains. J Cell Biol (1998) 4.94
B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol (1989) 4.61
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A (1996) 4.16
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A (2000) 3.71
Solitary necrotic nodules of the liver simulating hepatic metastases. J Clin Pathol (1983) 3.67
Gains in bone mineral density with resolution of vitamin D intoxication. Ann Intern Med (1997) 3.36
Epitopes that span the tau molecule are shared with paired helical filaments. Neuron (1988) 3.28
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci U S A (2000) 3.11
Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles. Proc Natl Acad Sci U S A (1996) 3.07
Necrotising granulomata in prostatic resection specimens--a sequel to previous operation. J Clin Pathol (1983) 2.97
Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A (1988) 2.95
Antigens displayed on murine B lymphocyte precursors. J Immunol (1981) 2.91
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res (1995) 2.79
Defect in conversion of procollagen to collagen in a form of Ehlers-Danlos syndrome. Science (1973) 2.74
Laryngoscopy: time to change our view. Anaesthesia (2009) 2.70
Localization of D-lactate dehydrogenase in native and reconstituted Escherichia coli membrane vesicles. J Biol Chem (1975) 2.64
Overexpression and overactivation of Akt in thyroid carcinoma. Cancer Res (2001) 2.51
Biosynthesis and function of gangliosides. Science (1976) 2.51
Niemann-Pick disease group C: clinical variability and diagnosis based on defective cholesterol esterification. A collaborative study on 70 patients. Clin Genet (1988) 2.50
High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells. J Virol (1998) 2.47
The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. J Biol Chem (1999) 2.45
alpha-Galactosidase A deficient mice: a model of Fabry disease. Proc Natl Acad Sci U S A (1997) 2.43
Enzyme therapy in type 1 Gaucher disease: comparative efficacy of mannose-terminated glucocerebrosidase from natural and recombinant sources. Ann Intern Med (1995) 2.39
A defect in cholesterol esterification in Niemann-Pick disease (type C) patients. Proc Natl Acad Sci U S A (1985) 2.38
The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick diseae. Proc Natl Acad Sci U S A (1966) 2.32
Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J Cell Biol (1995) 2.29
Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc Natl Acad Sci U S A (1999) 2.27
Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen. Proc Natl Acad Sci U S A (1979) 2.24
Occult fractures of the carpals and metacarpals: demonstration by CT. AJR Am J Roentgenol (1989) 2.18
Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness. Proc Natl Acad Sci U S A (1976) 2.14
The sphingolipidoses. N Engl J Med (1966) 2.13
Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. J Biol Chem (1999) 2.05
Genomic DNA released by dying cells induces the maturation of APCs. J Immunol (2001) 2.03
Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher's disease. J Clin Invest (1966) 2.01
Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. Endocrinology (2000) 2.01
Infusion of alpha-galactosidase A reduces tissue globotriaosylceramide storage in patients with Fabry disease. Proc Natl Acad Sci U S A (2000) 2.00
Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol. J Biol Chem (1988) 1.98
Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther (2001) 1.97
Role of membrane gangliosides in the binding and action of bacterial toxins. J Membr Biol (1982) 1.97
Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action. J Biol Chem (1993) 1.95
Replacement therapy for inherited enzyme deficiency. Use of purified ceramidetrihexosidase in Fabry's disease. N Engl J Med (1973) 1.94
Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. Neuron (1996) 1.93
D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J Neurosci (1997) 1.93
Localization of transforming growth factor-beta isotypes in lesions of the human breast. Hum Pathol (1992) 1.91
Therapeutic response to intravenous infusions of glucocerebrosidase in a patient with Gaucher disease. Proc Natl Acad Sci U S A (1990) 1.88
Nucleotide sequence of a promoter recognized by Bacillus subtilis RNA polymerase. Mol Gen Genet (1980) 1.87
Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science (1987) 1.81
Cells and molecules that regulate B lymphopoiesis in bone marrow. Annu Rev Immunol (1989) 1.78
Diagnosis of gaucher's disease and niemann-pick disease with small samples of venous blood. Science (1967) 1.78
Overexpression of tau in a nonneuronal cell induces long cellular processes. J Cell Biol (1991) 1.77
Gangliosides in DNA virus-transformed and spontaneously transformed tumorigenic mouse cell lines. Proc Natl Acad Sci U S A (1969) 1.76
Monoclonal rat antibodies to murine IgM determinants. J Immunol Methods (1981) 1.75
Adult Gaucher's disease: kindred studies and demonstration of a deficiency of acid beta-glucosidase in cultured fibroblasts. Am J Hum Genet (1972) 1.74
Premature ejaculation and erectile dysfunction prevalence and attitudes in the Asia-Pacific region. J Sex Med (2011) 1.73
Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc Natl Acad Sci U S A (2001) 1.73
Procollagen peptidase: an enzyme excising the coordination peptides of procollagen. Proc Natl Acad Sci U S A (1971) 1.73
Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med (1989) 1.72
Lactosylceramide galactosidase: comparison with other sphingolipid hydrolases in developing rat brain. Brain Res (1969) 1.72
The fate of fetal and adult B-cell progenitors grafted into immunodeficient CBA/N mice. J Exp Med (1979) 1.68
Replacement therapy for inherited enzyme deficiency. Use of purified glucocerebrosidase in Gaucher's disease. N Engl J Med (1974) 1.67
Metachromatic leukodystrophy: diagnosis with samples of venous blood. Science (1968) 1.67
The inflammatory response within Dukes' B colorectal cancers: implications for progression of micrometastases and patient survival. Am J Gastroenterol (2000) 1.65
Mutations of glucocerebrosidase: discrimination of neurologic and non-neurologic phenotypes of Gaucher disease. Proc Natl Acad Sci U S A (1982) 1.64
Delayed hypersensitivity in Graves' disease and exophthalmos: identification of thyroglobulin in normal human orbital muscle. Endocrinology (1977) 1.64
A lysosomal storage disorder in mice characterized by a dual deficiency of sphingomyelinase and glucocerebrosidase. Biochim Biophys Acta (1980) 1.63
Isolation and characterization of glucocerebrosidase from human placental tissue. J Biol Chem (1973) 1.62
Comparative efficacy of dose regimens in enzyme replacement therapy of type I Gaucher disease. Blood Cells Mol Dis (2000) 1.61
Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction. Am J Med (1976) 1.61
Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. J Neurosci (1996) 1.61
Primary synovial sarcoma of the kidney. Am J Surg Pathol (2000) 1.61
Isolation and relationship of human hexosaminidases. J Biol Chem (1974) 1.61
Factors affecting the development of pneumothorax associated with thoracentesis. AJR Am J Roentgenol (1991) 1.60
Mechanisms of active transport in isolated bacterial membrane vesicles. XV. Purification and properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli. J Biol Chem (1973) 1.60
Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease. Neurology (2006) 1.57
AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans. Anesthesiology (1998) 1.57
Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc Natl Acad Sci U S A (1996) 1.56
Enzyme replacement therapy in Gaucher's disease: large-scale purification of glucocerebrosidase suitable for human administration. Proc Natl Acad Sci U S A (1977) 1.56
Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes. Proc Natl Acad Sci U S A (1988) 1.56
Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies. J Biol Chem (1999) 1.54
A genetic storage disorder in BALB/C mice with a metabolic block in esterification of exogenous cholesterol. J Biol Chem (1984) 1.54
A prospective comparison of laparoscopy and imaging in the staging of esophagogastric cancer before surgery. Am J Gastroenterol (1995) 1.53
Tetanus toxin interactions with thyroid plasma membranes. Implications for structure and function of tetanus toxin receptors and potential pathophysiological significance. J Biol Chem (1977) 1.53
Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities. J Clin Invest (1999) 1.53
The effect on IVF outcome of small intramural fibroids not compressing the uterine cavity as determined by a prospective matched control study. Hum Reprod (2002) 1.52
Interaction of choleragen with the oligosaccharide of ganglioside GM1: evidence for multiple oligosaccharide binding sites. Biochemistry (1978) 1.50
Posttransplantation plasmacytic proliferations related to Kaposi's sarcoma-associated herpesvirus. Am J Surg Pathol (1999) 1.49
IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside. Proc Natl Acad Sci U S A (1984) 1.49
Cocaine detoxification by human plasma butyrylcholinesterase. Toxicol Appl Pharmacol (1997) 1.49
Multicomponent structure of the thyrotropin receptor: relationship to Graves' disease. Life Sci (1983) 1.48
Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors. Proc Natl Acad Sci U S A (1976) 1.48