Published in Proc Natl Acad Sci U S A on September 01, 1970
Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infect Immun (1974) 12.51
A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate. Biochem J (1971) 8.85
Cyclic adenosine 5'-monophosphate in Escherichia coli. Bacteriol Rev (1976) 7.55
Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc Natl Acad Sci U S A (1978) 6.01
The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet (1973) 3.84
Cyclic adenosine 3',5'-monophosphate in Escherichia coli. J Bacteriol (1973) 3.65
Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function. J Clin Invest (1974) 3.65
Guanosine 3':5'-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes. Proc Natl Acad Sci U S A (1972) 3.65
Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. J Exp Med (1972) 3.31
Morphine receptors as regulators of adenylate cyclase activity. Proc Natl Acad Sci U S A (1975) 3.10
Soluble adenylate cyclase from the culture medium of Bordetella pertussis: purification and characterization. J Bacteriol (1976) 2.95
Maturation of neuroblastoma cells in the presence of dimethylsulfoxide. Proc Natl Acad Sci U S A (1976) 2.93
Effect of dibutyryladenosine 3':5'-cyclic monophosphate on growth and differentiation in Caulobacter crescentus. Proc Natl Acad Sci U S A (1972) 2.73
Evidence for alteration of the vitamin D-endocrine system in blacks. J Clin Invest (1985) 2.72
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. Proc Natl Acad Sci U S A (1975) 2.71
Cyclic nucleotides in procaryotes. Microbiol Rev (1981) 2.67
Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest (1985) 2.61
Cyclic adenosine 3',5'-monophosphate levels and activities of adenylate cyclase and cyclic adenosine 3',5'-monophosphate phosphodiesterase in Pseudomonas and Bacteroides. J Bacteriol (1977) 2.49
Pleiotypic control by adenosine 3':5'-cyclic monophosphate: a model for growth control in animal cells. Proc Natl Acad Sci U S A (1973) 2.49
Glucose and the metabolism of adenosine 3':5'-cyclic monophosphate in Escherichia coli. Proc Natl Acad Sci U S A (1971) 2.46
Regulation of luminescence by cyclic AMP in cya-like and crp-like mutants of Vibrio fischeri. J Bacteriol (1989) 2.34
Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa. J Clin Invest (1974) 2.28
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci U S A (1993) 2.24
Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces. Proc Natl Acad Sci U S A (1975) 2.20
Glucose inhibition of adenylate cyclase in intact cells of Escherichia coli B. Proc Natl Acad Sci U S A (1974) 2.17
Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase. J Clin Invest (1973) 2.16
Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness. Proc Natl Acad Sci U S A (1976) 2.14
Saccharomyces mutants with invertase formation resistant to repression by hexoses. J Bacteriol (1973) 2.11
Parenchymal cells from adult rat liver in nonproliferating monolayer culture. I. Functional studies. J Cell Biol (1973) 2.09
Release of prostaglandin by mitogen- and antigen-stimulated leukocytes in culture. J Clin Invest (1974) 2.01
Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Invest (1995) 2.01
Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones. J Clin Invest (1974) 1.98
Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium. Proc Natl Acad Sci U S A (1986) 1.98
Comparative studies of five heat-labile toxic products of Escherichia coli. Infect Immun (1978) 1.96
Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. Further evidence for the role of cyclic adenosine 3',5'-monophosphate. J Clin Invest (1973) 1.94
The modulating influence of cyclic nucleotides upon lymphocyte-mediated cytotoxicity. J Exp Med (1973) 1.92
Effects of prostaglandins and cholera enterotoxin on intestinal mucosal cyclic AMP accumulation. Evidence against an essential role for prostaglandins in the action of toxin. J Clin Invest (1974) 1.89
Glia-induced morphological differentiation in neuroblastoma cells. Proc Natl Acad Sci U S A (1973) 1.82
Escherichia coli enterotoxin-induced steroidogenesis in cultured adrenal tumor cells. Infect Immun (1974) 1.74
Differences in Cyclic AMP Changes after Stimulation by Prostaglandins and Isoproterenol in Lymphocyte Subpopulations. J Clin Invest (1975) 1.73
A secreted factor and cyclic AMP jointly regulate cell-type-specific gene expression in Dictyostelium discoideum. Mol Cell Biol (1985) 1.72
Cyclic 3':5'-adenosine monophosphate in Escherichia coli during transient and catabolite repression. Proc Natl Acad Sci U S A (1974) 1.71
Fine control of adenylate cyclase by the phosphoenolpyruvate:sugar phosphotransferase systems in Escherichia coli and Salmonella typhimurium. J Bacteriol (1980) 1.71
Prostaglandin E 1 effects on adenosine 3':5'-cyclic monophosphate concentration and phosphodiesterase activity in fibroblasts (mouse L cells-tissue culture-enzyme kinetics-prostaglandin homologues). Proc Natl Acad Sci U S A (1972) 1.68
Human rotavirus enteritis induced in conventional piglets. Intestinal structure and transport. J Clin Invest (1977) 1.68
Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc Natl Acad Sci U S A (2002) 1.67
Cyclic adenosine monophosphate in the nervous system of Aplysia californica. II. Effect of serotonin and dopamine. J Gen Physiol (1972) 1.66
Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons. Proc Natl Acad Sci U S A (1971) 1.65
Adenosine 3',5'-phosphate in fungi. Microbiol Rev (1981) 1.62
Induction of cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic monophosphate and the isolation of resistant variants. Proc Natl Acad Sci U S A (1973) 1.61
Effect of purified Escherichia coli heat-stable enterotoxin on intestinal cyclic nucleotide metabolism and fluid secretion. Infect Immun (1979) 1.60
Protein kinase activity in membrane preparations from ox brain. Stimulation of intrinsic activity by adenosine 3':5'-cyclic monophosphate. Biochem J (1973) 1.59
Control of Neurospora crassa morphology by cyclic adenosine 3', 5'-monophosphate and dibutyryl cyclic adenosine 3', 5'-monophosphate. J Bacteriol (1976) 1.59
Hormonal control of lysosomal enzyme release from human neutrophils. Effects of autonomic agents on enzyme release, phagocytosis, and cylic nucleotide levels. J Exp Med (1974) 1.58
Mode of action of cholera toxin: stabilization of catecholamine-sensitive adenylate cyclase in turkey erythrocytes. Proc Natl Acad Sci U S A (1974) 1.57
Intracellular cyclic AMP concentration responds specifically to growth regulation by serum. Proc Natl Acad Sci U S A (1974) 1.57
A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate. Proc Natl Acad Sci U S A (1971) 1.57
Control of pancreatic amylase release in vitro: effects of ions, cyclic AMP, and colchicine. Br J Pharmacol (1972) 1.56
Interaction between isoprenaline and aminophylline in asthma. Thorax (1977) 1.52
Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion. Proc Natl Acad Sci U S A (1972) 1.51
Role of cyclic 3':5'-adenosine monophosphate in the early transport changes induced by serum and insulin in quiescent fibroblasts. Proc Natl Acad Sci U S A (1973) 1.50
A role for cyclic AMP in expression of developmentally regulated genes in Dictyostelium discoideum. Proc Natl Acad Sci U S A (1980) 1.49
The effect of polystyrene beads on cyclic 3',5'-adenosine monophosphate concentration in leukocytes. J Clin Invest (1971) 1.49
Hormonal control of lysosomal enzyme release from human neutrophils: elevation of cyclic nucleotide levels by autonomic neurohormones. Proc Natl Acad Sci U S A (1974) 1.48
Twice daily slow-release theophylline vs placebo for 'morning-dipping' in asthma. Br J Clin Pharmacol (1984) 1.48
Nephrogenous cyclic adenosine monophosphate as a parathyroid function test. J Clin Invest (1977) 1.47
Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes. Br J Pharmacol (1992) 1.45
Effect of insulin on the growth pattern and adenylate cyclase activity of BHK fibroblasts. Proc Natl Acad Sci U S A (1973) 1.45
Genetic and biochemical investigation of the Escherichia coli mutant hfl-1 which is lysogenized at high frequency by bacteriophage lambda. J Bacteriol (1973) 1.45
The roles of the lambda c3 gene and the Escherichia coli catabolite gene activation system in the establishment of lysogeny by bacteriophage lambda. Proc Natl Acad Sci U S A (1974) 1.44
The hypercalciurias. Causes, parathyroid functions, and diagnostic criteria. J Clin Invest (1974) 1.43
Measurements of rates of adenosine 3':5'-cyclic monophosphate synthesis in intact Escherichia coli B. Proc Natl Acad Sci U S A (1973) 1.43
Comparison of thermosensitive alleles of the CDC25 gene involved in the cAMP metabolism of Saccharomyces cerevisiae. Genetics (1990) 1.42
The effect of prostaglandins on ox pituitary content of adenosine 3':5'-cyclic monophosphate and the release of growth hormone. Biochem J (1972) 1.42
Interaction of the subunits of adenosine 3':5'-cyclic monophosphate-dependent protein kinase of muscle. Proc Natl Acad Sci U S A (1971) 1.42
Stimulation by dopamine of adenylate cyclase in retinal homogenates and of adenosine-3':5'-cyclic monophosphate formation in intact retina. Proc Natl Acad Sci U S A (1972) 1.41
Colchicine-binding protein and the secretion of thyroid hormone. J Cell Biol (1972) 1.40
Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma cells. Proc Natl Acad Sci U S A (1975) 1.40
Synthesis of plasmalemmal glycoproteins in intestinal epithelial cells. Separation of Golgi membranes from villus and crypt cell surface membranes; glycosyltransferase activity of surface membrane. J Cell Biol (1978) 1.39
Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen. J Clin Invest (1985) 1.39
Specific leukocyte receptors for small endogenous hormones. Detection by cell binding to insolubilized hormone preparations. J Clin Invest (1973) 1.39
The role of 1 alpha, 25-dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria. J Clin Invest (1977) 1.37
Some physiological and biochemical effects of a Coxiella burneti lipopolysaccharide preparation on guinea pigs. Infect Immun (1974) 1.37
A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proc Natl Acad Sci U S A (1975) 1.36
Modulation of Bordetella pertussis by nicotinic acid. Infect Immun (1983) 1.36
The beta-adrenoceptor of the human lymphocyte and human lung parenchyma. Br J Pharmacol (1977) 1.36
Mechanism of translational control by hemin in reticulocyte lysates. Proc Natl Acad Sci U S A (1977) 1.36
Kinetics of early changes in phosphate and uridine transport and cyclic AMP levels stimulated by serum in density-inhibited 3T3 cells. Proc Natl Acad Sci U S A (1974) 1.35
Alteration of vein cyclic 3':5' nucleotide concentrations during changes in contractility. Proc Natl Acad Sci U S A (1974) 1.35
Cyclic adenosine monophosphate in the nervous system of Aplysia californica. I. Increased synthesis in response to synaptic stimulation. J Gen Physiol (1972) 1.34
Transcriptional repression of the mouse insulin-responsive glucose transporter (GLUT4) gene by cAMP. Proc Natl Acad Sci U S A (1991) 1.33
Estrogen-related increases in uterine guanosine 3':5'-cyclic momophosphate levels. Proc Natl Acad Sci U S A (1974) 1.32
The effects of the immunologic release of histamine upon human lung cyclic nucleotide levels and prostaglandin generation. J Clin Invest (1978) 1.30
Comparison of the action of Escherichia coli enterotoxin on the thymocyte adenylate cyclase-cyclic adenosine monophosphate system to that of cholera toxin and prostaglandin E1. Infect Immun (1974) 1.29
Increased cyclic adenosine 3',5'-monophosphate content in guinea pig ileum after exposure to Staphylococcus aureus delta-toxin. Infect Immun (1976) 1.28
Human transforming growth factor-alpha stimulates bone resorption in vitro. J Clin Invest (1985) 1.28
Mechanism of fever induction in rabbits. Infect Immun (1976) 1.28
Adenosine 3',5'-cyclic monophosphate and morphology in Neurospora crassa: drug-induced alterations. J Bacteriol (1975) 1.26
Changes in cyclic nucleotide levels and dimorphic transition in Candida albicans. J Bacteriol (1980) 1.26
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. J Biol Chem (1962) 12.79
An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle. J Biol Chem (1968) 8.62
Radioimmunoassay for the measurement of adenosine 3',5'-cyclic phosphate. Proc Natl Acad Sci U S A (1969) 7.81
Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. Proc Natl Acad Sci U S A (1969) 6.02
Adenosine 3',5'-monophosphate in biological materials. II. The measurement of adenosine 3',5'-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine. J Biol Chem (1965) 5.86
Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain. J Biol Chem (1969) 5.37
The assay of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate in biological materials by enzymatic radioisotopic displacement. Biochemistry (1968) 4.60
Histone phosphorylation: stimulation by adenosine 3',5'-monophosphate. Science (1968) 3.82
The influence of chemical agents on the accumulation of adenosine 3',5'-Phosphate in slices of rabbit cerebellum. Mol Pharmacol (1968) 3.76
Determination of guanosine 3',5'-monophosphate in tissues and of guanyl cyclase in rat intestine. J Biol Chem (1969) 3.54
Enzymic analysis of cyclic 3', 5'-AMP in mammalian tissues and urine. Anal Biochem (1969) 2.99
A cyclic-3',5'-adenosine monophosphate dependent protein kinase from the adrenal cortex: comparison with a cyclic AMP binding protein. Biochem Biophys Res Commun (1970) 2.98
Cyclic guanosine 3',5'-monophosphate in mammalian tissues and urine. J Biol Chem (1969) 2.97
Cyclic nucleotide-dependent protein kinases. VI. Isolation and partial purification of a protein kinase activated by guanosine 3',5'-monophosphate. J Biol Chem (1970) 2.89
Binding of adenosine 3':5'-cyclic phosphate to G factor of Escherichia coli, and its effects on GTPase, RNase V, and protein synthesis. Proc Natl Acad Sci U S A (1970) 2.49
Determination of 3',5'-adenosine monophosphate with a method based on a radioactive phosphate exchange reaction. J Biol Chem (1968) 2.47
THE ASSAY OF ADENOSINE-3' ,5'-PHOSPHATE IN SKELETAL MUSCLE. Biochemistry (1964) 2.40
THE MEASUREMENT OF CYCLIC ADENYLATE IN TISSUES. Proc Natl Acad Sci U S A (1964) 2.28
Factors affecting the activity of muscle glycogen synthetase. 3. The reaction with adenosine triphosphate Mg++, and cyclic 3'5'-adenosine monophosphate. Arch Biochem Biophys (1966) 2.22
G proteins: transducers of receptor-generated signals. Annu Rev Biochem (1987) 27.41
Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infect Immun (1974) 12.51
G proteins and dual control of adenylate cyclase. Cell (1984) 11.05
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell (1995) 7.66
Regulation of axon formation by clonal lines of a neural tumor. Proc Natl Acad Sci U S A (1970) 5.12
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell (1996) 4.76
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell (1997) 4.74
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science (1998) 4.62
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science (1997) 4.52
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (1994) 4.43
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science (1998) 4.32
Homologies between signal transducing G proteins and ras gene products. Science (1984) 3.85
Biochemical properties of hormone-sensitive adenylate cyclase. Annu Rev Biochem (1980) 3.79
G proteins. Trends Biochem Sci (1992) 3.79
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci U S A (1982) 3.73
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. J Biol Chem (1986) 3.54
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature (1994) 3.54
Purification and characterization of smooth muscle cell caveolae. J Cell Biol (1994) 3.18
Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem (1983) 3.11
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. J Biol Chem (1982) 3.09
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur J Biochem (1985) 3.04
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science (1991) 3.00
Relationship between the beta-adrenergic receptor and adenylate cyclase. J Biol Chem (1977) 2.99
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
Mammalian membrane-bound adenylyl cyclases. J Biol Chem (1995) 2.93
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1987) 2.93
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1986) 2.87
Purification of the regulatory component of adenylate cyclase. Proc Natl Acad Sci U S A (1980) 2.81
Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol (1996) 2.70
The regulatory component of adenylate cyclase. Purification and properties. J Biol Chem (1981) 2.69
Crystal structure of the adenylyl cyclase activator Gsalpha. Science (1997) 2.68
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. J Biol Chem (1978) 2.64
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science (1995) 2.64
Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. J Biol Chem (1995) 2.61
Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science (1989) 2.59
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. J Biol Chem (1996) 2.48
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. J Biol Chem (1984) 2.43
Expression of G-protein alpha subunits in Escherichia coli. Methods Enzymol (1994) 2.39
G protein involvement in receptor-effector coupling. J Biol Chem (1988) 2.38
A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). J Biol Chem (1998) 2.36
Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem (1986) 2.35
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science (1985) 2.35
Mammalian RGS proteins: barbarians at the gate. J Biol Chem (1998) 2.34
Lipid modifications of G proteins: alpha subunits are palmitoylated. Proc Natl Acad Sci U S A (1993) 2.32
G protein gamma subunits contain a 20-carbon isoprenoid. Proc Natl Acad Sci U S A (1990) 2.32
Two-metal-Ion catalysis in adenylyl cyclase. Science (1999) 2.31
G proteins control diverse pathways of transmembrane signaling. FASEB J (1989) 2.21
Resolution of some components of adenylate cyclase necessary for catalytic activity. J Biol Chem (1977) 2.20
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proc Natl Acad Sci U S A (1997) 2.14
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells. Proc Natl Acad Sci U S A (1990) 2.13
Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha. J Biol Chem (1989) 2.12
The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins. J Biol Chem (1983) 2.12
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. J Biol Chem (1983) 2.06
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. J Biol Chem (1984) 2.05
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins. J Biol Chem (1987) 2.02
Adenylyl cyclases. Cell (1992) 1.96
Expression and characterization of calmodulin-activated (type I) adenylylcyclase. J Biol Chem (1991) 1.94
A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Proc Natl Acad Sci U S A (1998) 1.94
Receptor regulation of G-protein palmitoylation. Proc Natl Acad Sci U S A (1994) 1.93
Inhibition of adenylyl cyclase by Gi alpha. Science (1993) 1.87
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A (1986) 1.86
The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go. J Biol Chem (1987) 1.85
The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. J Biol Chem (1986) 1.83
ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation. J Biol Chem (1984) 1.83
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem (1999) 1.82
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma. J Biol Chem (1992) 1.75
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. J Biol Chem (1989) 1.75
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. J Biol Chem (1993) 1.74
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein. J Biol Chem (1989) 1.73
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells. J Biol Chem (1977) 1.71
Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma. J Biol Chem (1991) 1.70
Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones. J Biol Chem (1976) 1.69
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. J Biol Chem (1984) 1.69
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. J Biol Chem (1990) 1.69
Gz, a guanine nucleotide-binding protein with unique biochemical properties. J Biol Chem (1990) 1.67
Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors. J Biol Chem (1979) 1.67
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. J Biol Chem (1998) 1.66
Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons. Proc Natl Acad Sci U S A (1971) 1.65
Autoacylation of G protein alpha subunits. J Biol Chem (1996) 1.64
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. J Biol Chem (1984) 1.62
Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci (1998) 1.62
The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins. J Biol Chem (1987) 1.61
Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase. J Clin Invest (1984) 1.60
Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin. Science (1995) 1.60
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. J Biol Chem (1983) 1.60
An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor. Mol Pharmacol (1976) 1.59
Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell. J Biol Chem (1979) 1.52
Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes. Mol Biol Cell (1992) 1.52
Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci U S A (1991) 1.50
Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci U S A (1991) 1.50
Truncation and alanine-scanning mutants of type I adenylyl cyclase. Biochemistry (1995) 1.48
Synthetic peptide antisera with determined specificity for G protein alpha or beta subunits. Methods Enzymol (1991) 1.46
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. Biochemistry (1989) 1.46
ADP-ribosylation of Gs promotes the dissociation of its alpha and beta subunits. J Biol Chem (1984) 1.45
GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. J Biol Chem (1998) 1.45
Binding of (3H)prostaglandin E1 to putative receptors linked to adenylate cyclase of cultured cell clones. J Biol Chem (1976) 1.44
Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain. J Biol Chem (1988) 1.42
Interaction of the two cytosolic domains of mammalian adenylyl cyclase. Proc Natl Acad Sci U S A (1996) 1.41
Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes. Proc Natl Acad Sci U S A (1977) 1.41