Published in Proc Natl Acad Sci U S A on October 02, 2007
Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proc Natl Acad Sci U S A (2008) 2.31
The biology of activin: recent advances in structure, regulation and function. J Endocrinol (2009) 1.64
A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Proc Natl Acad Sci U S A (2008) 1.42
Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease. Muscle Nerve (2009) 1.34
Activin a plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes (2010) 1.31
Circulating angiogenic factors associated with response and survival in patients with acute graft-versus-host disease: results from Blood and Marrow Transplant Clinical Trials Network 0302 and 0802. Biol Blood Marrow Transplant (2015) 1.13
Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma. J Allergy Clin Immunol (2009) 1.07
Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J Exp Med (2009) 1.06
Activin A is essential for neurogenesis following neurodegeneration. Stem Cells (2009) 0.96
Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo. J Biomed Sci (2009) 0.96
Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury. Circulation (2009) 0.95
Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study. Crit Care (2013) 0.92
Peripheral inflammation is associated with remote global gene expression changes in the brain. J Neuroinflammation (2014) 0.91
Role of activins and inducible nitric oxide in the pathogenesis of ectopic pregnancy in patients with or without Chlamydia trachomatis infection. Clin Vaccine Immunol (2009) 0.87
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice. Endocrinology (2016) 0.86
Novel therapeutic approaches for inclusion body myositis. Curr Opin Rheumatol (2010) 0.85
Development of novel activin-targeted therapeutics. Mol Ther (2014) 0.85
Activin, neutrophils, and inflammation: just coincidence? Semin Immunopathol (2013) 0.85
Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1. J Biol Chem (2008) 0.84
Delayed activin A administration attenuates tissue death after transient focal cerebral ischemia and is associated with decreased stress-responsive kinase activation. J Neurochem (2009) 0.83
Candidate genes for colour and vision exhibit signals of selection across the pied flycatcher (Ficedula hypoleuca) breeding range. Heredity (Edinb) (2011) 0.83
Activins and Follistatin in Chronic Hepatitis C and Its Treatment with Pegylated-Interferon-α Based Therapy. Mediators Inflamm (2015) 0.82
Effect of physical training on liver expression of activin A and follistatin in a nonalcoholic fatty liver disease model in rats. Braz J Med Biol Res (2014) 0.82
Prenatal endotoxemia and placental drug transport in the mouse: placental size-specific effects. PLoS One (2013) 0.81
Correlation between blood activin levels and clinical parameters of type 2 diabetes. Exp Diabetes Res (2012) 0.81
Upregulation of activin signaling in experimental colitis. Am J Physiol Gastrointest Liver Physiol (2009) 0.81
The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology. Immunol Cell Biol (2015) 0.81
The Role of Activin A and B and the Benefit of Follistatin Treatment in Renal Ischemia-Reperfusion Injury in Mice. Transplant Direct (2016) 0.80
The immunoregulatory and fibrotic roles of activin A in allergic asthma. Clin Exp Allergy (2015) 0.80
Activin a inhibits antigen-induced allergy in murine epicutaneous sensitization. Front Immunol (2013) 0.80
Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PLoS One (2012) 0.79
Voluntary wheel running attenuates lipopolysaccharide-induced liver inflammation in mice. Am J Physiol Regul Integr Comp Physiol (2016) 0.79
Serum Activins and Follistatin during the Treatment of Chronic Hepatitis C Genotypes 1 and 4 and Their Correlations with Viral Load and Liver Enzymes: A Preliminary Report. Gastroenterol Res Pract (2014) 0.79
Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection. BMC Infect Dis (2014) 0.79
Effects of chronic hepatitis C genotype 1 and 4 on serum activins and follistatin in treatment naïve patients and their correlations with interleukin-6, tumour necrosis factor-α, viral load and liver damage. Clin Exp Med (2014) 0.78
Activin A: a potential therapeutic target for characterizing and stopping joint pain early in rheumatoid arthritis patients. Inflammation (2014) 0.78
Obesity and low-grade inflammation increase plasma follistatin-like 3 in humans. Mediators Inflamm (2014) 0.78
Beneficial effects of follistatin in hepatic ischemia-reperfusion injuries in rats. Dig Dis Sci (2010) 0.78
Modulation of amniotic fluid activin-a and inhibin-a in women with preterm premature rupture of the membranes and infection-induced preterm birth. Am J Reprod Immunol (2011) 0.78
Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer. Gastroenterology (2016) 0.77
Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS. Gastroenterology (2015) 0.77
Inhibin/activin expression in human and rodent liver: subunits α and βB as new players in human hepatocellular carcinoma? Br J Cancer (2011) 0.77
Circulating follistatin in patients with chronic kidney disease: implications for muscle strength, bone mineral density, inflammation, and survival. Clin J Am Soc Nephrol (2011) 0.76
Pathophysiology of Iron Homeostasis during Inflammatory States. J Pediatr (2015) 0.76
Follistatin alleviates synovitis and articular cartilage degeneration induced by carrageenan. Int J Inflam (2014) 0.76
Follistatin attenuates radiation-induced fibrosis in a murine model. PLoS One (2017) 0.75
Gram-negative bacterial lipopolysaccharide stimulates activin a secretion from human amniotic epithelial cells. Int J Endocrinol (2013) 0.75
Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation. PLoS One (2016) 0.75
In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway. Proc Natl Acad Sci U S A (2016) 0.75
Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling. Adipocyte (2016) 0.75
Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study. J Transl Med (2017) 0.75
Regulation of hepcidin expression by inflammation-induced activin B. Sci Rep (2016) 0.75
Follistatin and the Breast Implant Capsule. Plast Reconstr Surg Glob Open (2017) 0.75
Activin A induces skeletal muscle catabolism via p38β mitogen-activated protein kinase. J Cachexia Sarcopenia Muscle (2016) 0.75
Activin A Predicts Left Ventricular Remodeling and Mortality in Patients with ST-Elevation Myocardial Infarction. Acta Cardiol Sin (2016) 0.75
Unexpected and striking effect of heparin-free dialysis on cytokine release. Int Urol Nephrol (2017) 0.75
Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target. Sci Rep (2017) 0.75
Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model. PLoS One (2017) 0.75
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med (1999) 7.62
Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J Immunol (2000) 6.68
Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr Opin Immunol (1999) 2.85
Functional analysis of activins during mammalian development. Nature (1995) 2.71
Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. J Biol Chem (2003) 1.81
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Proc Natl Acad Sci U S A (1994) 1.60
Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4. J Biol Chem (2004) 1.33
Follistatin: a multifunctional regulatory protein. Front Neuroendocrinol (1998) 1.29
The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin. Biochem Biophys Res Commun (1987) 1.12
Serum activin A and follistatin concentrations during human pregnancy: a cross-sectional and longitudinal study. Hum Reprod (1999) 1.08
Therapeutic potential of follistatin for colonic inflammation in mice. Gastroenterology (2005) 1.07
Development and application of a two-site enzyme immunoassay for the determination of 'total' activin-A concentrations in serum and follicular fluid. J Endocrinol (1996) 1.07
Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice. Mol Endocrinol (1996) 1.04
TGF-beta down-regulates IL-6 signaling in intestinal epithelial cells: critical role of SMAD-2. FASEB J (2003) 1.01
Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe. J Endocrinol (2004) 1.01
Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. J Cell Biochem (2003) 1.00
Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia. Eur J Endocrinol (2003) 0.99
Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies. Clin Exp Immunol (1998) 0.97
Activin A/erythroid differentiation factor is induced during human monocyte activation. J Exp Med (1992) 0.94
Activin A: a novel player and inflammatory marker in inflammatory bowel disease? Lab Invest (1997) 0.94
Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia. J Neurochem (2003) 0.92
Activin A regulates the production of mature interleukin-1beta and interleukin-1 receptor antagonist in human monocytic cells. J Interferon Cytokine Res (1998) 0.92
Induction of prostanoid, nitric oxide, and cytokine formation in rat bone marrow derived macrophages by activin A. Br J Pharmacol (1999) 0.91
Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin. Endocrinology (2000) 0.90
Sertoli cells initiate testicular innate immune responses through TLR activation. J Immunol (2006) 0.89
Activin A exerts both pro- and anti-inflammatory effects on human term gestational tissues. Placenta (2000) 0.86
Human endometrial leukemia inhibitory factor and interleukin-6: control of secretion by transforming growth factor-beta-related members. Neuroimmunomodulation (2005) 0.86
Stimulatory effects of lipopolysaccharide on endothelial cell activin and follistatin. Mol Cell Endocrinol (2006) 0.83
Divergent cell-specific effects of activin-A on thymocyte proliferation stimulated by phytohemagglutinin, and interleukin 1beta or interleukin 6 in vitro. Cytokine (2000) 0.82
The nuts and bolts of IRF structure. Nat Struct Biol (2003) 0.82
Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells. Clin Exp Immunol (1993) 0.81
Possible involvement of protein kinases and Smad2 signaling pathways on osteoclast differentiation enhanced by activin A. J Cell Physiol (2001) 0.81
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment Cell Res (2006) 3.42
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A (2005) 2.56
Men in Australia Telephone Survey (MATeS): a national survey of the reproductive health and concerns of middle-aged and older Australian men. Lancet (2005) 2.25
A periconceptional nutritional origin for noninfectious preterm birth. Science (2003) 1.97
A type III effector antagonizes death receptor signalling during bacterial gut infection. Nature (2013) 1.65
The negative regulation of Toll-like receptor and associated pathways. Immunol Cell Biol (2007) 1.59
Men in Australia Telephone Survey (MATeS): predictors of men's help-seeking behaviour for reproductive health disorders. Med J Aust (2006) 1.55
Evidence that androgens regulate early developmental events, prior to sexual differentiation. Endocrinology (2007) 1.49
Toll/IL-1 signaling is critical for house dust mite-specific helper T cell type 2 and type 17 [corrected] responses. Am J Respir Crit Care Med (2009) 1.47
Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia. BMC Microbiol (2008) 1.46
Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease. PLoS Pathog (2013) 1.39
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol (2010) 1.39
The Australian Toll-way gets the Nod--meeting report of TLROZ 2007: pattern recognition receptors in immunity and disease, Melbourne, Australia, 16-18th May 2007. Immunol Cell Biol (2007) 1.39
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci U S A (2011) 1.38
MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem (2009) 1.34
Immunological, paracrine and endocrine aspects of testicular immune privilege. Mol Cell Endocrinol (2010) 1.31
The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair. Mol Cell Endocrinol (2011) 1.23
Activin and related proteins in inflammation: not just interested bystanders. Cytokine Growth Factor Rev (2009) 1.23
Regulation of ovarian function by the TGF-beta superfamily and follistatin. Reproduction (2003) 1.23
TIR-containing adaptors in Toll-like receptor signalling. Cytokine (2009) 1.21
Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Mol Endocrinol (2006) 1.18
The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Mol Cell Biol (2002) 1.18
Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2. J Biol Chem (2011) 1.17
Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase. FEBS Lett (2006) 1.17
Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett (2007) 1.16
Follistatin attenuates early liver fibrosis: effects on hepatic stellate cell activation and hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol (2005) 1.16
Effects of testosterone plus medroxyprogesterone acetate on semen quality, reproductive hormones, and germ cell populations in normal young men. J Clin Endocrinol Metab (2002) 1.15
Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep. Biol Reprod (2010) 1.15
Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci U S A (2014) 1.14
Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev Biol (2008) 1.13
The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway. J Hepatol (2011) 1.13
Activin A and follistatin in systemic inflammation. Mol Cell Endocrinol (2004) 1.12
Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors. Cancer Res (2006) 1.10
The regulation and functions of activin and follistatin in inflammation and immunity. Vitam Horm (2011) 1.08
Inhibin, activin, follistatin and FSH serum levels and testicular production are highly modulated during the first spermatogenic wave in mice. Reproduction (2008) 1.07
Activin-A: a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production. Blood (2007) 1.06
FGFR-1 [corrected] signaling is involved in spermiogenesis and sperm capacitation. J Cell Sci (2005) 1.05
Adaptors in toll-like receptor signaling and their potential as therapeutic targets. Curr Drug Targets (2012) 1.03
Stereological analysis of the human testis after vasectomy indicates impairment of spermatogenic efficiency with increasing obstructive interval. Fertil Steril (2004) 1.00
Rat resident testicular macrophages have an alternatively activated phenotype and constitutively produce interleukin-10 in vitro. J Leukoc Biol (2011) 0.99
An essential role for katanin p80 and microtubule severing in male gamete production. PLoS Genet (2012) 0.99
Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury. Stroke (2006) 0.99
Stimulation of the interleukin-1 receptor and Toll-like receptor 2 inhibits hepatitis B virus replication in hepatoma cell lines in vitro. Antivir Ther (2009) 0.98
Inflammatory networks in the control of spermatogenesis : chronic inflammation in an immunologically privileged tissue? Adv Exp Med Biol (2008) 0.96
Lipopolysaccharide-deficient Acinetobacter baumannii shows altered signaling through host Toll-like receptors and increased susceptibility to the host antimicrobial peptide LL-37. Infect Immun (2012) 0.95
Toll-like receptors as interferon-regulated genes and their role in disease. J Interferon Cytokine Res (2011) 0.94
Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines. Int Immunol (2006) 0.94
Changes in circulating and testicular levels of inhibin A and B and activin A during postnatal development in the rat. Endocrinology (2004) 0.94
Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity. Am J Respir Cell Mol Biol (2010) 0.94
The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology (2004) 0.94
The role of the activin system in keloid pathogenesis. Am J Physiol Cell Physiol (2006) 0.93
Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2. Biol Reprod (2002) 0.93
A new 'total' activin B enzyme-linked immunosorbent assay (ELISA): development and validation for human samples. Clin Endocrinol (Oxf) (2009) 0.93
Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia. J Neurochem (2003) 0.92
Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms. Mol Endocrinol (2007) 0.91
The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection. Retrovirology (2007) 0.90
Toll-like receptors in the gonads and reproductive tract: emerging roles in reproductive physiology and pathology. Immunol Cell Biol (2007) 0.90
Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB. J Biol Chem (2013) 0.88
Determinants of male reproductive health disorders: the Men in Australia Telephone Survey (MATeS). BMC Public Health (2010) 0.88
GnRH agonist stimulation of the pituitary-gonadal axis in children: age and sex differences in circulating inhibin-B and activin-A. Hum Reprod (2004) 0.87
Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett (2005) 0.86
A stereological analysis of the response of spermatogenesis to an acute inflammatory episode in adult rats. J Androl (2006) 0.85
Fetal responses to maternal and intra-amniotic lipopolysaccharide administration in sheep. Biol Reprod (2002) 0.85
Acute regulation of activin A and its binding protein, follistatin, in serum and tissues following lipopolysaccharide treatment of adult male mice. Am J Physiol Regul Integr Comp Physiol (2012) 0.84
Follistatin is induced by ionizing radiation and potentially predictive of radiosensitivity in radiation-induced fibrosis patient derived fibroblasts. PLoS One (2013) 0.84
Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate. Endocrinology (2003) 0.84
Genetic screening of infertile men. Reprod Fertil Dev (2004) 0.84
LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling. Immunol Cell Biol (2011) 0.84
Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. Am J Pathol (2008) 0.84
Differential responses of epithelial Sertoli cells of the rat testis to Toll-like receptor 2 and 4 ligands: implications for studies of testicular inflammation using bacterial lipopolysaccharides. Innate Immun (2009) 0.84
Stimulatory effects of lipopolysaccharide on endothelial cell activin and follistatin. Mol Cell Endocrinol (2006) 0.83
Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation. Am J Respir Cell Mol Biol (2009) 0.83
Tumour necrosis factor-α stimulates human neutrophils to release preformed activin A. Immunol Cell Biol (2011) 0.83
Effect of heparin administration to sheep on the release profiles of circulating activin A and follistatin. J Endocrinol (2004) 0.83
Epididymitis: revelations at the convergence of clinical and basic sciences. Asian J Androl (2015) 0.82
The men in Australia Telephone Survey (MATeS) - lessons for all. Med J Aust (2006) 0.82
Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses. Am J Physiol Regul Integr Comp Physiol (2005) 0.82
MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke. PLoS One (2013) 0.82
TLR ligands of ryegrass pollen microbial contaminants enhance Th1 and Th2 responses and decrease induction of Foxp3(hi) regulatory T cells. Eur J Immunol (2013) 0.82
The response of testicular leukocytes to lipopolysaccharide-induced inflammation: further evidence for heterogeneity of the testicular macrophage population. Cell Tissue Res (2002) 0.82
Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis. J Neurol Sci (2006) 0.81
Phenotypic and functional heterogeneity of the testicular macrophage population: a new regulatory model. J Reprod Immunol (2013) 0.81
Male reproductive health disorders among Aboriginal and Torres Strait Islander men: a hidden problem? Med J Aust (2013) 0.81
Loss of the nuclear receptor corepressor SLIRP compromises male fertility. PLoS One (2013) 0.81
Correlation between blood activin levels and clinical parameters of type 2 diabetes. Exp Diabetes Res (2012) 0.81
Molecular identification of lyso-glycerophosphocholines as endogenous immunosuppressives in bovine and rat gonadal fluids. Biol Reprod (2008) 0.81