Published in J Biol Chem on October 15, 2007
Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci (2011) 1.98
Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx. J Virol (2010) 1.73
Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process. J Biol Chem (2009) 1.03
Prolyl isomerase Pin1 in cancer. Cell Res (2014) 1.01
A distinct role for Pin1 in the induction and maintenance of pluripotency. J Biol Chem (2011) 0.95
The peptidyl-prolyl isomerase, Pin1, facilitates NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury. J Hepatol (2009) 0.93
Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription. Mol Cell Biol (2009) 0.91
The role of PIN1 on odontogenic and adipogenic differentiation in human dental pulp stem cells. Stem Cells Dev (2013) 0.87
Daxx is reciprocally regulated by Mdm2 and Hausp. Biochem Biophys Res Commun (2010) 0.86
Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma. Diagn Pathol (2013) 0.82
Berberine represses DAXX gene transcription and induces cancer cell apoptosis. Lab Invest (2013) 0.81
Pin1-Nanog expression in human glioma is correlated with advanced tumor progression. Oncol Rep (2013) 0.80
Mutant p53 disrupts the stress MAPK activation circuit induced by ASK1-dependent stabilization of Daxx. Cancer Res (2009) 0.79
Hyperthermia stress activates heat shock protein expression via propyl isomerase 1 regulation with heat shock factor 1. Mol Cell Biol (2013) 0.79
Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice. J Neurosci (2016) 0.77
Knockdown of Pin1 leads to reduced angiogenic potential and tumorigenicity in glioblastoma cells. Oncol Lett (2015) 0.75
PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model. Front Cell Neurosci (2017) 0.75
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell (2005) 9.01
Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature (2011) 7.03
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell (2003) 4.37
Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet (2003) 3.71
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell (2007) 3.20
Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature (2008) 2.51
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat Cell Biol (2004) 2.50
Retracted GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol Cell (2009) 2.30
A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol (2009) 2.21
Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol (2003) 2.16
PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol Cell Biol (2002) 2.12
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J (2002) 2.07
Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J Biol Chem (2001) 1.94
Structural and transcriptional analysis of the self-incompatibility locus of almond: identification of a pollen-expressed F-box gene with haplotype-specific polymorphism. Plant Cell (2003) 1.93
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science (2012) 1.84
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem (2002) 1.80
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J (2004) 1.79
Retracted BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem (2004) 1.77
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol (2012) 1.75
Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73
Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med (2008) 1.72
Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytes. Biochem Biophys Res Commun (2002) 1.66
HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res (2004) 1.63
Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. EMBO J (2004) 1.62
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol (2008) 1.58
ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol (2010) 1.54
P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J (2002) 1.48
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 1.47
N-Terminal methylation of proteasome subunit Rpt1 in yeast. Proteomics (2013) 1.45
Axin: a master scaffold for multiple signaling pathways. Neurosignals (2004) 1.45
Three craniosynostotic patients with tracheal sleeve. Clin Dysmorphol (2003) 1.44
p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J (2003) 1.44
The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. J Biol Chem (2005) 1.43
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal (2010) 1.38
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol (2006) 1.37
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest (2008) 1.37
Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer. Clin Cancer Res (2005) 1.35
Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer. J Cell Sci (2003) 1.34
Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem (2009) 1.31
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene (2003) 1.29
The p53 pathway as a target in cancer therapeutics: obstacles and promise. Sci Transl Med (2011) 1.28
ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem (2006) 1.27
A chloroplastic UDP-glucose pyrophosphorylase from Arabidopsis is the committed enzyme for the first step of sulfolipid biosynthesis. Plant Cell (2009) 1.27
Zfp143 regulates Nanog through modulation of Oct4 binding. Stem Cells (2008) 1.27
CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. EMBO J (2007) 1.25
P53 promoter selection: choosing between life and death. Cell Cycle (2007) 1.25
Pathology of asthma. Front Microbiol (2013) 1.25
S locus F-box brothers: multiple and pollen-specific F-box genes with S haplotype-specific polymorphisms in apple and Japanese pear. Genetics (2007) 1.24
Membrane-bound heparin-binding epidermal growth factor like growth factor regulates E-cadherin expression in pancreatic carcinoma cells. Cancer Res (2007) 1.24
Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence. J Cell Sci (2010) 1.24
SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. J Biol Chem (2002) 1.20
Cyclic luciferase for real-time sensing of caspase-3 activities in living mammals. Angew Chem Int Ed Engl (2007) 1.20
Extramammary Paget's disease: analysis of growth signal pathway from the human epidermal growth factor receptor 2 protein. Hum Pathol (2005) 1.19
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Dev Cell (2006) 1.19
Concern DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation. J Biol Chem (2011) 1.18
Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. J Neurosci (2002) 1.17
ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS (2010) 1.17
The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling. Dev Cell (2009) 1.17
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell (2007) 1.16
Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J Biol Chem (2004) 1.16
Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model. Neuroreport (2003) 1.14
SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag. Proc Natl Acad Sci U S A (2008) 1.14
The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. Hum Pathol (2008) 1.14
Deep sequencing analysis of phage libraries using Illumina platform. Methods (2012) 1.13
Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat Cell Biol (2009) 1.13
Pulmonary cysts of Birt-Hogg-Dubé syndrome: a clinicopathologic and immunohistochemical study of 9 families. Am J Surg Pathol (2012) 1.13
The prolyl isomerase Pin1 in breast development and cancer. Breast Cancer Res (2003) 1.12
Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis. Hum Pathol (2008) 1.11
Identification of miR-30d as a novel prognostic maker of prostate cancer. Oncotarget (2012) 1.11
Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem (2004) 1.11
Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat Neurosci (2012) 1.10
N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome. Arch Biochem Biophys (2003) 1.09
Contribution of lysine 11-linked ubiquitination to MIR2-mediated major histocompatibility complex class I internalization. J Biol Chem (2010) 1.09
Prognostic value of integrin beta1-ILK-pAkt signaling pathway in non-small cell lung cancer. Hum Pathol (2007) 1.08
IFI16 as a negative regulator in the regulation of p53 and p21(Waf1). J Biol Chem (2003) 1.08
p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus. J Immunol (2011) 1.08
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol (2013) 1.08
A novel approach and protocol for discovering extremely low-abundance proteins in serum. Proteomics (2006) 1.08
Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun (2013) 1.08
Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. Oncogene (2003) 1.07
β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos. Development (2012) 1.05
Lung cysts in Birt-Hogg-Dubé syndrome: histopathological characteristics and aberrant sequence repeats. Pathol Int (2009) 1.05
Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Res (2007) 1.04
Expression of SPARC in tongue carcinoma of stage II is associated with poor prognosis: an immunohistochemical study of 86 cases. Int J Mol Med (2005) 1.03
The negative role of cyclin G in ATM-dependent p53 activation. Oncogene (2004) 1.03
Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Endocrinology (2012) 1.03
Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process. J Biol Chem (2009) 1.03
Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions. J Biol Chem (2005) 1.02