Published in Nature on October 24, 2007
The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol (2013) 3.84
Structure of the human smoothened receptor bound to an antitumour agent. Nature (2013) 3.08
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev (2009) 2.59
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A (2009) 2.47
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A (2009) 2.41
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J Cell Biol (2009) 2.10
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer (2013) 2.05
The Hedgehog signal transduction network. Sci Signal (2012) 1.80
Mechanism and evolution of cytosolic Hedgehog signal transduction. Development (2010) 1.58
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One (2009) 1.42
Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway. Dev Cell (2016) 1.41
Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nat Cell Biol (2010) 1.41
The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr Biol (2009) 1.39
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol (2011) 1.36
BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes. Hum Mol Genet (2012) 1.33
PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development (2008) 1.23
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev (2010) 1.17
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell (2013) 1.15
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol (2012) 1.13
Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res (2012) 1.11
At the crossroads of differentiation and proliferation: precise control of cell-cycle changes by multiple signaling pathways in Drosophila follicle cells. Bioessays (2011) 1.11
Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol (2012) 1.09
Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J Biol Chem (2010) 1.07
Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res (2013) 1.06
The role of kinases in the Hedgehog signalling pathway. EMBO Rep (2008) 1.03
Acetylation modulates prolactin receptor dimerization. Proc Natl Acad Sci U S A (2010) 1.01
The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation. Development (2012) 1.01
Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Dev Biol (2009) 1.00
Targeting hedgehog signaling in cancer: research and clinical developments. Onco Targets Ther (2013) 0.99
Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal (2011) 0.99
RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J Biol Chem (2012) 0.98
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development (2011) 0.98
Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annu Rev Pharmacol Toxicol (2011) 0.97
Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev Cell (2011) 0.97
G-protein-coupled receptors, Hedgehog signaling and primary cilia. Semin Cell Dev Biol (2014) 0.96
Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Res (2011) 0.92
Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors. Cancers (Basel) (2016) 0.91
Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. EMBO J (2010) 0.91
Converse conformational control of smoothened activity by structurally related small molecules. J Biol Chem (2009) 0.90
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. Nat Commun (2013) 0.89
Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89
Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner. Dev Biol (2012) 0.88
Clinical implications of hedgehog signaling pathway inhibitors. Chin J Cancer (2011) 0.88
Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila. Proc Natl Acad Sci U S A (2014) 0.88
The Hedgehog pathway: role in cell differentiation, polarity and proliferation. Arch Toxicol (2015) 0.88
Hedgehog signaling in skin cancers. Cell Signal (2011) 0.87
Endocytosis and signaling during development. Cold Spring Harb Perspect Biol (2014) 0.87
Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction. J Biol Chem (2013) 0.87
An analysis of oligomerization interfaces in transmembrane proteins. BMC Struct Biol (2013) 0.87
A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol (2013) 0.86
Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning. Dev Biol (2009) 0.86
Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation. Development (2011) 0.85
Hedgehog Signaling in the Maintenance of Cancer Stem Cells. Cancers (Basel) (2015) 0.85
Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun (2015) 0.84
Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. PLoS Biol (2013) 0.84
Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal. PLoS One (2010) 0.84
Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation. Sci Signal (2014) 0.83
Hedgehog signaling pathway in ovarian cancer. Int J Mol Sci (2013) 0.82
Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer. Curr Opin Pharmacol (2012) 0.82
Smoothened goes molecular: new pieces in the hedgehog signaling puzzle. J Biol Chem (2014) 0.82
Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1. Proc Natl Acad Sci U S A (2015) 0.81
A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity. PLoS Genet (2014) 0.81
Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia. Haematologica (2014) 0.81
Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. J Cell Biol (2013) 0.81
Hedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila. Cell Res (2014) 0.81
MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling. World J Gastroenterol (2016) 0.80
Patched-one or smoothened gene mutations are infrequent in chondrosarcoma. Clin Orthop Relat Res (2008) 0.80
The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway. J Biol Chem (2014) 0.79
A quantification of pathway components supports a novel model of Hedgehog signal transduction. J Biol Chem (2009) 0.79
PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. PLoS Biol (2016) 0.79
Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling. Nat Commun (2014) 0.79
Regulation of Hedgehog signaling by ubiquitination. Front Biol (Beijing) (2015) 0.78
Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase. PLoS Biol (2016) 0.78
Smoothened Regulation: A Tale of Two Signals. Trends Pharmacol Sci (2015) 0.78
A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model. PLoS One (2011) 0.78
Differential involvement of Hedgehog signaling in butterfly wing and eyespot development. PLoS One (2012) 0.78
Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. PLoS Genet (2015) 0.77
Smoothened regulation in response to Hedgehog stimulation. Front Biol (Beijing) (2015) 0.76
Coordinated niche-associated signals promote germline homeostasis in the Drosophila ovary. J Cell Biol (2015) 0.76
Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Proc Natl Acad Sci U S A (2014) 0.76
Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila. Cell Discov (2015) 0.76
Regulation of Hedgehog Signalling Inside and Outside the Cell. J Dev Biol (2016) 0.76
Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma. Mol Cancer Ther (2016) 0.75
Anti-Cancer Phytometabolites Targeting Cancer Stem Cells. Curr Genomics (2017) 0.75
Hedgehog in the Drosophila testis niche: what does it do there? Protein Cell (2013) 0.75
SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling. Sci Rep (2017) 0.75
The T-box transcription factor Midline regulates wing development by repressing wingless and hedgehog in Drosophila. Sci Rep (2016) 0.75
Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling. PLoS One (2015) 0.75
The Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy. Oncotarget (2017) 0.75
The emerging roles of phosphatases in Hedgehog pathway. Cell Commun Signal (2017) 0.75
Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A. Sci Rep (2017) 0.75
Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling. Nat Commun (2017) 0.75
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev (2003) 3.53
Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell (2009) 3.43
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature (2002) 2.99
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell (2005) 2.50
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A (2009) 2.41
The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell (2008) 2.40
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature (2004) 2.39
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature (2002) 2.26
Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem (2003) 2.23
Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A (2010) 2.16
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell (2006) 2.13
100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future. Nat Rev Neurosci (2010) 1.76
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell (2005) 1.62
Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart. Circulation (2010) 1.56
Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Dev Biol (2009) 1.54
Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo. Development (2005) 1.51
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2009) 1.47
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev (2003) 1.44
Oxidation of sulfoxides and arsenic(III) in corrosion of nanoscale zero valent iron by oxygen: evidence against ferryl ions (Fe(IV)) as active intermediates in Fenton reaction. Environ Sci Technol (2010) 1.42
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol (2011) 1.36
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev (2007) 1.24
Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization. Sci Signal (2012) 1.23
Hippo signaling pathway and organ size control. Fly (Austin) (2009) 1.21
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev (2010) 1.17
The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell (2012) 1.16
Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. J Biol Chem (2003) 1.16
Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells. J Cell Biol (2011) 1.13
A novel mutation in the major intrinsic protein (MIP) associated with autosomal dominant congenital cataracts in a Chinese family. Mol Vis (2010) 1.13
Cytotoxicity evaluation of endosequence root repair material. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2010) 1.12
Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res (2012) 1.11
Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol (2012) 1.09
Novel FBN1 mutations associated with predominant ectopia lentis and marfanoid habitus in Chinese patients. Mol Vis (2007) 1.09
Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J Biol Chem (2010) 1.07
Actin-related protein 2/3 complex is required for actin ring formation. J Bone Miner Res (2003) 1.07
Acute rosiglitazone treatment is cardioprotective against ischemia-reperfusion injury by modulating AMPK, Akt, and JNK signaling in nondiabetic mice. Am J Physiol Heart Circ Physiol (2011) 1.06
Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res (2013) 1.06
The confounding effects of dissolved humic acid on the oxidation of simple substituted phenols by permanganate: comment on "reinvestigation of the role of humic acid in the oxidation of phenols by permanganate". Environ Sci Technol (2014) 1.06
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. FASEB J (2010) 1.05
Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol (2006) 1.04
Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction. Circulation (2013) 1.02
Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms. Dev Biol (2004) 1.01
Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2004) 0.98
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development (2011) 0.98
Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function. Infect Immun (2010) 0.97
A nonsense mutation in CRYGC associated with autosomal dominant congenital nuclear cataract in a Chinese family. Mol Vis (2008) 0.96
Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut. Elife (2014) 0.96
Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells. J Neurooncol (2015) 0.95
Effect of selected accelerants on setting time and biocompatibility of mineral trioxide aggregate (MTA). Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011) 0.95
Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun (2013) 0.94
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science (2013) 0.94
Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases. Mol Cell Biol (2009) 0.94
Using immunoprecipitation to study protein-protein interactions in the Hedgehog-signaling pathway. Methods Mol Biol (2007) 0.94
Modes of failure of ProTaper nickel-titanium rotary instruments after clinical use. J Endod (2007) 0.93
A newly synthetic chromium complex-chromium (D-phenylalanine)3 activates AMP-activated protein kinase and stimulates glucose transport. Biochem Pharmacol (2008) 0.93
Actin binding activity of subunit B of vacuolar H+-ATPase is involved in its targeting to ruffled membranes of osteoclasts. J Bone Miner Res (2006) 0.93
Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS Biol (2013) 0.92
Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila. Proc Natl Acad Sci U S A (2003) 0.92
Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. Dev Biol (2007) 0.90
Converse conformational control of smoothened activity by structurally related small molecules. J Biol Chem (2009) 0.90
Cytotoxicity evaluation of Gutta Flow and Endo Sequence BC sealers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011) 0.90
Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. Clin Exp Pharmacol Physiol (2010) 0.89
Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. J Biol Chem (2012) 0.89
[Relationship between ephemeral plants distribution and soil moisture on longitudinal dune surface in Gurbantonggut desert]. Ying Yong Sheng Tai Xue Bao (2004) 0.88
Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1. Biochem Biophys Res Commun (2013) 0.87
Apical infection spreading to adjacent teeth: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011) 0.87
Transducing the Hedgehog signal across the plasma membrane. Fly (Austin) (2007) 0.87
Characterization of ribosomal S6 protein kinase p90rsk during meiotic maturation and fertilization in pig oocytes: mitogen-activated protein kinase-associated activation and localization. Biol Reprod (2003) 0.87
Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration. Cell Res (2013) 0.86
Subvastus versus medial parapatellar approach in total knee arthroplasty: meta-analysis. Orthopedics (2012) 0.86
Cytotoxicity evaluation of Activ GP and Resilon cones in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2008) 0.86
A micro-computed tomography study of canal configuration of multiple-canalled mesiobuccal root of maxillary first molar. Clin Oral Investig (2012) 0.86
Inhibition of MAPK-mediated ACE expression by compound C66 prevents STZ-induced diabetic nephropathy. J Cell Mol Med (2013) 0.86
Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis. Cell Res (2013) 0.86
Alternol exerts prostate-selective antitumor effects through modulations of the AMPK signaling pathway. Prostate (2011) 0.84
Effects of basic fibroblast growth factor on osteoclasts and osteoclast-like cells. Biochem Biophys Res Commun (2004) 0.84
Identification of the immunogenic spore and vegetative proteins of Bacillus anthracis vaccine strain A16R. PLoS One (2013) 0.84
Cytotoxicity evaluation of Activ GP and Resilon sealers in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 0.84
Evaluation of cytotoxicity of MTA employing various additives. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 0.84
Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase. J Biol Chem (2011) 0.83
A novel GJA3 mutation associated with congenital nuclear pulverulent and posterior polar cataract in a Chinese family. Hum Mutat (2011) 0.83
Interactions between vacuolar H+-ATPases and microfilaments in osteoclasts. J Bioenerg Biomembr (2005) 0.82
Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells. J Cardiovasc Pharmacol (2010) 0.82
[Neuroanatomical characteristics of acupoint "Chengshan" (BL 57) in the rat: a cholera toxin subunit B conjugated with Alexa Fluor 488 method study]. Zhen Ci Yan Jiu (2010) 0.82
Ocular leech infestation initially misdiagnosed as conjunctival pigmented nevus. Int J Ophthalmol (2013) 0.81
Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells. Acta Pharmacol Sin (2010) 0.81
Dynamic changes of ocular biometric parameters: a modified form-deprivation myopia model of young guinea pigs. Int J Ophthalmol (2011) 0.81