Published in Biochem J on January 01, 2008
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem (2009) 6.23
Ubiquitylation in innate and adaptive immunity. Nature (2009) 4.60
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep (2009) 3.94
The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity (2008) 3.19
A20: central gatekeeper in inflammation and immunity. J Biol Chem (2008) 2.83
A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol (2012) 2.47
Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell (2011) 2.32
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol (2010) 2.31
TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets. J Clin Invest (2012) 2.10
A20: from ubiquitin editing to tumour suppression. Nat Rev Cancer (2010) 2.08
Deubiquitinases in the regulation of NF-κB signaling. Cell Res (2010) 2.00
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J Mol Biol (2007) 1.82
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82
Regulation of NF-κB by deubiquitinases. Immunol Rev (2012) 1.78
Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev (2008) 1.74
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. Nat Struct Mol Biol (2011) 1.55
African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. J Immunol (2010) 1.52
A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J (2012) 1.45
Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat Struct Mol Biol (2012) 1.42
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation. EMBO J (2012) 1.39
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J (2011) 1.38
Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36
Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. Proc Natl Acad Sci U S A (2011) 1.24
Ubiquitin in NF-kappaB signaling. Chem Rev (2009) 1.20
Regulation of A20 and other OTU deubiquitinases by reversible oxidation. Nat Commun (2013) 1.17
The complexities of p97 function in health and disease. Mol Biosyst (2010) 1.17
Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo hemorrhagic fever virus in complex with covalently bonded ubiquitin. J Virol (2011) 1.16
Forging isopeptide bonds using thiol-ene chemistry: site-specific coupling of ubiquitin molecules for studying the activity of isopeptidases. J Am Chem Soc (2012) 1.14
Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity (2013) 1.13
Molecular control of the NEMO family of ubiquitin-binding proteins. Nat Rev Mol Cell Biol (2013) 1.12
Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling. Biochim Biophys Acta (2008) 1.11
Structural studies of NF-κB signaling. Cell Res (2010) 1.07
Ubiquitin in the immune system. EMBO Rep (2013) 1.06
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochim Biophys Acta (2011) 1.04
A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity. EMBO J (2011) 1.04
Deubiquitinases and the new therapeutic opportunities offered to cancer. Endocr Relat Cancer (2015) 1.02
The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities. J Virol (2009) 0.99
The deubiquitinase activity of A20 is dispensable for NF-κB signaling. EMBO Rep (2014) 0.95
Activation of interferon regulatory factor 5 by site specific phosphorylation. PLoS One (2012) 0.94
Involvement of KDM1C histone demethylase-OTLD1 otubain-like histone deubiquitinase complexes in plant gene repression. Proc Natl Acad Sci U S A (2011) 0.92
Genetics of rheumatic disease. Arthritis Res Ther (2009) 0.91
Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis. J Biol Chem (2010) 0.90
Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen. BMC Chem Biol (2012) 0.85
Upregulated Expression of A20 on Monocytes is Associated With Increased Severity of Acute-on-Chronic Hepatitis B Liver Failure: A Case-Control Study. Medicine (Baltimore) (2015) 0.81
Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease. Cells (2015) 0.79
OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level. PLoS One (2012) 0.77
Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family. PLoS One (2015) 0.76
The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death. J Biol Chem (2016) 0.75
A20 overexpression inhibits lipopolysaccharide-induced NF-κB activation, TRAF6 and CD40 expression in rat peritoneal mesothelial cells. Int J Mol Sci (2014) 0.75
Molecular basis for specificity of the Met1-linked polyubiquitin signal. Biochem Soc Trans (2016) 0.75
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature (2016) 0.75
Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains. Nat Commun (2017) 0.75
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature (2005) 6.23
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature (2003) 4.60
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell (2005) 4.24
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep (2009) 3.94
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol (2002) 3.77
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science (2004) 3.54
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell (2002) 3.53
Structure of the mitotic checkpoint complex. Nature (2012) 2.72
PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects. J Biol Chem (2005) 2.68
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell (2006) 2.33
Argonaute: A scaffold for the function of short regulatory RNAs. Trends Biochem Sci (2006) 2.28
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell (2009) 2.27
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. Mol Cell (2008) 2.27
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J (2003) 2.14
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature (2010) 2.11
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature (2011) 2.07
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO J (2004) 1.86
Getting into position: the catalytic mechanisms of protein ubiquitylation. Biochem J (2004) 1.83
Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe. Mol Cell (2004) 1.81
Structural basis for the subunit assembly of the anaphase-promoting complex. Nature (2011) 1.80
The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical rings. Structure (2012) 1.78
Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Mol Cell (2005) 1.65
Functions and mechanisms of redox regulation of cysteine-based phosphatases. Antioxid Redox Signal (2005) 1.62
The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO J (2003) 1.49
Molecular recognition via coupled folding and binding in a TPR domain. J Mol Biol (2005) 1.48
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science (2009) 1.47
An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol Biol Cell (2008) 1.36
Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell (2011) 1.34
AKAP18 contains a phosphoesterase domain that binds AMP. J Mol Biol (2007) 1.31
Lining the pockets of kinases and phosphatases. Curr Opin Struct Biol (2006) 1.30
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27
Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. Biochemistry (2007) 1.26
Differential oxidation of protein-tyrosine phosphatases. J Biol Chem (2004) 1.24
Structure of TOR and its complex with KOG1. Mol Cell (2007) 1.23
Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23
Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. EMBO Rep (2005) 1.21
Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol Cell (2013) 1.21
A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. J Mol Biol (2007) 1.20
Regulation of protein kinases in insulin, growth factor and Wnt signalling. Curr Opin Struct Biol (2002) 1.20
The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27. EMBO J (2010) 1.19
Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90. Structure (2006) 1.18
Regulation of A20 and other OTU deubiquitinases by reversible oxidation. Nat Commun (2013) 1.17
Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. J Biol Chem (2007) 1.13
Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. J Mol Biol (2002) 1.13
Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C). Biochem J (2013) 1.09
Identification of inhibitors of protein kinase B using fragment-based lead discovery. J Med Chem (2007) 1.06
Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. J Mol Biol (2010) 1.04
Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity. Mol Cell (2006) 1.04
Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors. J Biol Chem (2011) 1.03
Purification and assay of the budding yeast anaphase-promoting complex. Methods Enzymol (2005) 1.02
Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases. Trends Biochem Sci (2009) 1.01
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT. Mol Cell (2011) 1.00
The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. Biochemistry (2007) 0.99
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure (2005) 0.96
Pellino1 is required for interferon production by viral double-stranded RNA. J Biol Chem (2012) 0.89
Getting in the ring: proline-directed substrate specificity in the cell cycle proteins Cdc14 and CDK2-cyclinA3. Cell Cycle (2003) 0.88
The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix. J Mol Biol (2013) 0.86
Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. Pharmacol Ther (2002) 0.83
Building a pseudo-atomic model of the anaphase-promoting complex. Acta Crystallogr D Biol Crystallogr (2013) 0.77
Methods for preparing crystals of reversibly oxidized proteins: crystallization of protein tyrosine phosphatase 1B as an example. Methods Mol Biol (2008) 0.76