Published in Science on May 28, 2004
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Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. J Clin Invest (2009) 3.05
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Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet (2006) 1.20
Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol Cell Biol (2009) 1.19
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol (2009) 1.19
Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes (2008) 1.16
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C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab (2011) 1.03
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Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies. J Hum Genet (2013) 1.01
The role of leptin in the control of insulin-glucose axis. Front Neurosci (2013) 1.00
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Insulin resistance: a proinflammatory state mediated by lipid-induced signaling dysfunction and involved in atherosclerotic plaque instability. Mediators Inflamm (2008) 0.99
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The AKTion in non-canonical insulin signaling. Nat Med (2012) 0.94
Akt isoforms and glucose homeostasis - the leptin connection. Trends Endocrinol Metab (2010) 0.93
Obesity and lipodystrophy--where do the circles intersect? Endocrinology (2008) 0.91
Further Evidence of Contrasting Phenotypes Caused by Reciprocal Deletions and Duplications: Duplication of NSD1 Causes Growth Retardation and Microcephaly. Mol Syndromol (2013) 0.91
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Characterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARγ mutation (Y151C). Diabetologia (2011) 0.90
Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling. Nat Commun (2015) 0.89
Gene prioritization in Type 2 Diabetes using domain interactions and network analysis. BMC Genomics (2010) 0.88
Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake. PLoS One (2012) 0.87
Macrophage-induced adipose tissue dysfunction and the preadipocyte: should I stay (and differentiate) or should I go? Adv Nutr (2013) 0.87
Cellular location of insulin-triggered signals and implications for glucose uptake. Pflugers Arch (2005) 0.87
AKT/PKB Signaling: Navigating the Network. Cell (2017) 0.87
Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity. Mol Cancer Ther (2009) 0.86
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes (2014) 0.86
Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy. J Mol Endocrinol (2011) 0.86
Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis. Am J Physiol Regul Integr Comp Physiol (2014) 0.86
Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation. Clin Endocrinol (Oxf) (2007) 0.85
Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol (2010) 0.84
Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. EMBO J (2012) 0.84
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Developmental disease and cancer: biological and clinical overlaps. Am J Med Genet A (2013) 0.83
Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle. Cell Cycle (2011) 0.83
Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo. Dis Model Mech (2012) 0.83
PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest (2016) 0.82
Knockdown of Akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways. Antioxid Redox Signal (2011) 0.82
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Hind limb ischemia-reperfusion injury in diet-induced obese mice. J Surg Res (2014) 0.82
Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma. Cancer Res (2013) 0.82
Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt, but not Akt2. Free Radic Biol Med (2013) 0.81
The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline. J Clin Endocrinol Metab (2016) 0.80
Interaction of constitutive photomorphogenesis 1 protein with protein-tyrosine phosphatase 1B suppresses protein-tyrosine phosphatase 1B activity and enhances insulin signaling. J Biol Chem (2013) 0.80
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Genetics in endocrinology: genetic forms of severe insulin resistance: what endocrinologists should know. Eur J Endocrinol (2013) 0.80
(-)-Epicatechin-3-O-β-d-allopyranoside from Davallia formosana, Prevents Diabetes and Hyperlipidemia by Regulation of Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice. Int J Mol Sci (2015) 0.79
Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1. Mol Cell Biol (2012) 0.79
The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo. Diabetologia (2015) 0.79
Hoofbeats, zebras, and insights into insulin resistance. J Clin Invest (2009) 0.79
IRS2 variants and syndromes of severe insulin resistance. Diabetologia (2009) 0.79
mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. Pharmacol Res (2016) 0.78
Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase. PLoS One (2013) 0.78
Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes. Nat Rev Endocrinol (2016) 0.78
Identification of direct and indirect social network effects in the pathophysiology of insulin resistance in obese human subjects. PLoS One (2014) 0.78
Opposing roles of the oncogene Akt isoforms in tumour progression: is there a dark side to Akt pathway inhibition? J Chem Biol (2012) 0.78
Aged PROP1 deficient dwarf mice maintain ACTH production. PLoS One (2011) 0.78
Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice. Metabolism (2015) 0.78
Clinical Utility Gene Card for: Familial partial lipodystrophy. Eur J Hum Genet (2016) 0.77
Whole-exome sequencing identifies ADRA2A mutation in atypical familial partial lipodystrophy. JCI Insight (2016) 0.77
Biological chemistry and functionality of protein sulfenic acids and related thiol modifications. Free Radic Res (2015) 0.77
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest (2003) 4.79
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol (2002) 3.77
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Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
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Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell (2004) 19.51
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
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A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
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