Published in Apoptosis on January 01, 2008
Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci U S A (2010) 3.00
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis (2010) 2.61
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum (2010) 2.43
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Am J Pathol (2010) 2.24
Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J Cell Biol (2008) 2.02
Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ (2008) 1.84
Autophagy and apoptosis: what is the connection? Trends Cell Biol (2011) 1.81
Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol (2009) 1.74
Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis. Proc Natl Acad Sci U S A (2008) 1.49
Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection. Arthritis Rheum (2011) 1.38
Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes (2012) 1.37
A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J Pharmacol Exp Ther (2010) 1.37
Chikungunya virus-induced autophagy delays caspase-dependent cell death. J Exp Med (2012) 1.34
Autophagy and cancer therapy. Cancer Biol Ther (2011) 1.32
A novel image-based cytometry method for autophagy detection in living cells. Autophagy (2012) 1.31
Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy (2013) 1.19
Critical role for transcription factor C/EBP-beta in regulating the expression of death-associated protein kinase 1. Mol Cell Biol (2008) 1.19
Mitochondrial content and distribution changes specific to mouse diaphragm after chronic normobaric hypoxia. Am J Physiol Regul Integr Comp Physiol (2009) 1.16
The role of cell signalling in the crosstalk between autophagy and apoptosis. Cell Signal (2013) 1.13
Role of inositol trisphosphate receptors in autophagy in DT40 cells. J Biol Chem (2010) 1.11
Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage. Biol Open (2015) 1.07
A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer (2009) 1.06
N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway. PLoS One (2014) 1.03
Autophagy and senescence: a partnership in search of definition. Autophagy (2013) 1.03
Induction of reactive oxygen species-mediated autophagy by a novel microtubule-modulating agent. J Biol Chem (2010) 1.03
The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? J Pharmacol Exp Ther (2012) 1.03
Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells. PLoS One (2012) 0.99
Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells. Mol Cancer (2010) 0.99
Cytotoxic autophagy in cancer therapy. Int J Mol Sci (2014) 0.99
The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease. Toxicol Sci (2013) 0.98
Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries. Autophagy (2013) 0.97
The fate of chemoresistance in triple negative breast cancer (TNBC). BBA Clin (2015) 0.94
Macroautophagy in T lymphocyte development and function. Front Immunol (2012) 0.93
SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells. Sci Rep (2014) 0.93
Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy. Int J Mol Sci (2014) 0.92
Biological behaviour of human umbilical artery smooth muscle cell grown on nickel-free and nickel-containing stainless steel for stent implantation. Sci Rep (2016) 0.91
Modulation of apoptosis pathways by oxidative stress and autophagy in β cells. Exp Diabetes Res (2012) 0.90
Autophagy postpones apoptotic cell death in PRRSV infection through Bad-Beclin1 interaction. Virulence (2015) 0.90
Effect of temozolomide on the U-118 glioma cell line. Oncol Lett (2011) 0.90
Studying autophagy's relationship to cell death. Autophagy (2008) 0.90
Dendropanoxide induces autophagy through ERK1/2 activation in MG-63 human osteosarcoma cells and autophagy inhibition enhances dendropanoxide-induced apoptosis. PLoS One (2013) 0.89
A differential autophagic response to hyperglycemia in the developing murine embryo. Reproduction (2011) 0.89
The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells. Neuro Oncol (2010) 0.89
Trehalose Accumulation Triggers Autophagy during Plant Desiccation. PLoS Genet (2015) 0.89
Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells. PLoS One (2014) 0.86
Valsartan regulates myocardial autophagy and mitochondrial turnover in experimental hypertension. Hypertension (2014) 0.86
Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistence. J Virol (2011) 0.86
ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. PLoS One (2014) 0.85
An executioner caspase regulates autophagy. Autophagy (2009) 0.84
Prenatal exposure to hypoxia induced Beclin 1 signaling-mediated renal autophagy and altered renal development in rat fetuses. Reprod Sci (2014) 0.83
Lactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts. PLoS One (2014) 0.82
Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells. Oncol Rep (2015) 0.82
Turning up the heat: heat stress induces markers of programmed cell death in Plasmodium falciparum in vitro. Cell Death Dis (2013) 0.81
Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy. Sci Rep (2016) 0.80
Concomitant treatment with pertussis toxin plus temozolomide increases the survival of rats bearing intracerebral RG2 glioma. J Cancer Res Clin Oncol (2013) 0.80
Histologic changes of the fetal membranes after fetoscopic laser surgery for twin-twin transfusion syndrome. Pediatr Res (2015) 0.80
The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy. Cancer Res (2016) 0.80
Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)-related lectins. Glycoconj J (2012) 0.79
Multiple Modes of Cell Death Discovered in a Prokaryotic (Cyanobacterial) Endosymbiont. PLoS One (2013) 0.79
Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population. Histochem Cell Biol (2014) 0.79
Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells. PLoS One (2012) 0.79
The Effect of Lactobacillus crispatus and Lactobacillus rhamnosusCulture Supernatants on Expression of Autophagy Genes and HPV E6 and E7 Oncogenes in The HeLa Cell Line. Cell J (2016) 0.79
Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PLoS One (2014) 0.79
Autophagy appears during the development of the mouse lower first molar. Histochem Cell Biol (2012) 0.79
Molecular Mechanism of Silver Nanoparticles-Induced Human Osteoblast Cell Death: Protective Effect of Inducible Nitric Oxide Synthase Inhibitor. PLoS One (2016) 0.79
Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells. Autophagy (2016) 0.78
Gambogenic acid kills lung cancer cells through aberrant autophagy. PLoS One (2014) 0.78
Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro. Acta Pharmacol Sin (2014) 0.78
Role of oxidative stress in cytotoxicity of grape seed extract in human bladder cancer cells. Food Chem Toxicol (2013) 0.78
Reduction of in-stent restenosis risk on nickel-free stainless steel by regulating cell apoptosis and cell cycle. PLoS One (2013) 0.78
Bcl-2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose-dependent toxicity and resistance. J Transl Med (2015) 0.78
High dose of extracellular ATP switched autophagy to apoptosis in anchorage-dependent and anchorage-independent hepatoma cells. Purinergic Signal (2013) 0.77
Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. Mol Biol Int (2011) 0.77
Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice. Oncol Rep (2015) 0.77
Blue-Print Autophagy: Potential for Cancer Treatment. Mar Drugs (2016) 0.77
Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways. Oncotarget (2016) 0.76
Galectin-3 and Beclin1/Atg6 genes in human cancers: using cDNA tissue panel, qRT-PCR, and logistic regression model to identify cancer cell biomarkers. PLoS One (2011) 0.76
Sann-Joong-Kuey-Jian-Tang induces autophagy in HepG2 cells via regulation of the phosphoinositide-3 kinase/Akt/mammalian target of rapamycin and p38 mitogen-activated protein kinase pathways. Mol Med Rep (2015) 0.76
Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells. Mol Vis (2014) 0.76
MiR-299-5p regulates apoptosis through autophagy in neurons and ameliorates cognitive capacity in APPswe/PS1dE9 mice. Sci Rep (2016) 0.75
Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis. Gastroenterol Res Pract (2012) 0.75
Evaluation of the efficacy & biochemical mechanism of cell death induction by Piper longum extract selectively in in-vitro and in-vivo models of human cancer cells. PLoS One (2014) 0.75
Bone fracture in a rat femoral fracture model is associated with the activation of autophagy. Exp Ther Med (2015) 0.75
Toxoplasma gondii induces autophagy and apoptosis in human umbilical cord mesenchymal stem cells via down-regulation of Mcl-1. Cell Cycle (2017) 0.75
Localization of Beclin1 in mouse developing tooth germs: possible implication of the interrelation between autophagy and apoptosis. J Mol Histol (2013) 0.75
Autophagy and its implication in human oral diseases. Autophagy (2016) 0.75
S-Nitrosylation of Bcl-2 Negatively Affects Autophagy in Lung Epithelial Cells. J Cell Biochem (2016) 0.75
Di-n-butyl phthalate Induced Hypospadias Relates to Autophagy in Genital Tubercle via the PI3K/Akt/mTOR Pathway. J Occup Health (2016) 0.75
Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells. PLoS One (2017) 0.75
Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta. Open Biol (2016) 0.75
Promising Role of Melatonin as Neuroprotectant in Neurodegenerative Pathology. Mol Neurobiol (2014) 0.75
Euptox A Induces G1 Arrest and Autophagy via p38 MAPK- and PI3K/Akt/mTOR-Mediated Pathways in Mouse Splenocytes. J Histochem Cytochem (2017) 0.75
Expression of autophagy-associated proteins in papillary thyroid carcinoma. Oncol Lett (2017) 0.75
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Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
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Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol (2007) 10.79
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science (2004) 10.77
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54
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Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol (2006) 9.36
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17
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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol (2005) 7.11
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Ambra1 regulates autophagy and development of the nervous system. Nature (2007) 6.94
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Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
A unified model for apical caspase activation. Mol Cell (2003) 6.12
Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell (2005) 5.57
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Calpain is required for macroautophagy in mammalian cells. J Cell Biol (2006) 1.75
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