Published in J Biol Chem on July 26, 2001
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Autophagy in health and disease: a double-edged sword. Science (2004) 13.69
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29
Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol (2007) 6.45
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol (2008) 3.36
An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29
Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus. Immunity (2009) 2.91
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
Autophagy in malignant transformation and cancer progression. EMBO J (2015) 2.67
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J Clin Invest (2008) 2.63
Metabolic catastrophe as a means to cancer cell death. J Cell Sci (2007) 2.58
Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis (2008) 2.56
Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology (2010) 2.13
Role and regulation of autophagy in cancer. Biochim Biophys Acta (2009) 2.00
Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81
Autophagy and tumorigenesis. FEBS Lett (2009) 1.76
Autophagy in cellular growth control. FEBS Lett (2010) 1.74
CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation. J Biol Chem (2008) 1.71
The role of lipids in the control of autophagy. Curr Biol (2013) 1.59
Autophagy and cancer. Exp Mol Med (2012) 1.57
Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J (2010) 1.54
Autophagy and pattern recognition receptors in innate immunity. Immunol Rev (2009) 1.51
Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol (2011) 1.48
Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila. Autophagy (2008) 1.45
Why sick cells produce tumors: the protective role of autophagy. Autophagy (2007) 1.34
Application and interpretation of current autophagy inhibitors and activators. Acta Pharmacol Sin (2013) 1.32
Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. Curr Top Microbiol Immunol (2009) 1.30
Autophagy and tumorigenesis. Semin Immunopathol (2010) 1.26
Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev (2013) 1.25
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal (2010) 1.22
Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene (2010) 1.17
Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer. Curr Mol Med (2010) 1.17
TGF-{beta}1 protects against mesangial cell apoptosis via induction of autophagy. J Biol Chem (2010) 1.17
Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth. Mol Cancer Ther (2008) 1.12
Assessing metabolic stress and autophagy status in epithelial tumors. Methods Enzymol (2009) 1.11
Autophagy regulation in cancer development and therapy. Am J Cancer Res (2010) 1.11
Molecular mechanisms of autophagy in the cardiovascular system. Circ Res (2015) 1.10
Ceramide-induced autophagy: to junk or to protect cells? Autophagy (2009) 1.09
Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr (2011) 1.08
The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress. Cell Death Dis (2010) 1.07
Involvement of mitophagy in oncogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency. Autophagy (2011) 1.06
A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer (2009) 1.06
Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules. J Biol Chem (2012) 1.05
Autophagic pathways as new targets for cancer drug development. Acta Pharmacol Sin (2010) 1.05
Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. Biochem J (2005) 1.04
CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation. J Cell Biol (2014) 1.04
Herpes simplex virus γ34.5 interferes with autophagosome maturation and antigen presentation in dendritic cells. MBio (2012) 1.03
Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages. Vet Immunol Immunopathol (2008) 1.02
Autophagy - An Emerging Anti-Aging Mechanism. J Clin Exp Pathol (2012) 1.01
Senescent keratinocytes die by autophagic programmed cell death. Am J Pathol (2009) 1.01
Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ (2012) 1.01
Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. Cancer Cell Int (2013) 1.00
Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer, and its expression correlates with a propensity for lymph node metastases. Int J Colorectal Dis (2008) 0.99
Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor. Cell Res (2012) 0.99
Regulation of autophagy by amino acids and MTOR-dependent signal transduction. Amino Acids (2014) 0.97
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies. Front Microbiol (2012) 0.97
Insulin-like growth factor-I prevents the accumulation of autophagic vesicles and cell death in Purkinje neurons by increasing the rate of autophagosome-to-lysosome fusion and degradation. J Biol Chem (2009) 0.96
New function of type I IFN: induction of autophagy. J Interferon Cytokine Res (2014) 0.96
Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncol Rep (2012) 0.96
Immune evasion by Kaposi's sarcoma-associated herpesvirus. Future Microbiol (2010) 0.96
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways. Cell Signal (2006) 0.95
Androgens promote prostate cancer cell growth through induction of autophagy. Mol Endocrinol (2012) 0.95
Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells. Mol Vis (2012) 0.94
Programmed cell death in cardiac myocytes: strategies to maximize post-ischemic salvage. Heart Fail Rev (2008) 0.94
Autophagy in brain tumors: a new target for therapeutic intervention. Brain Pathol (2012) 0.93
Ras and autophagy in cancer development and therapy. Oncotarget (2014) 0.93
Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production. Cell Cycle (2012) 0.92
Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Toxicol Sci (2011) 0.91
Links between autophagy, innate immunity, inflammation and Crohn's disease. Dig Dis (2009) 0.91
MnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes. PLoS One (2010) 0.91
Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma - systematic review and meta-analysis. Cancer Med (2013) 0.91
Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and JNK activation. BMC Cancer (2012) 0.91
Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. Microbes Infect (2013) 0.91
Calcium-permeable ion channels in control of autophagy and cancer. Front Physiol (2013) 0.91
Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells. Infect Immun (2007) 0.90
Survival by self-destruction: a role for autophagy in the placenta? Placenta (2012) 0.90
Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy. Antioxid Redox Signal (2014) 0.89
Targeting autophagy in cancer management - strategies and developments. Cancer Manag Res (2015) 0.89
Involvement of autophagy in ovarian cancer: a working hypothesis. J Ovarian Res (2012) 0.89
Autophagy in the myocardium: Dying for survival? Exp Clin Cardiol (2006) 0.89
Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res (2010) 0.88
PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity. PLoS One (2013) 0.88
(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel inhibitor of autophagy. Br J Pharmacol (2014) 0.88
Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome. PLoS One (2013) 0.87
Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging. Cell Mol Life Sci (2012) 0.86
GOLGA2/GM130, cis-Golgi matrix protein, is a novel target of anticancer gene therapy. Mol Ther (2012) 0.86
Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5. Autophagy (2013) 0.85
High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions. PLoS Genet (2014) 0.85
Heavy metals and metalloids as autophagy inducing agents: focus on cadmium and arsenic. Cells (2012) 0.84
Gangliosides induce autophagic cell death in astrocytes. Br J Pharmacol (2010) 0.83
Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models. Hum Gene Ther (2012) 0.83
Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases. J Cell Mol Med (2014) 0.83
MIF: Implications in the Pathoetiology of Systemic Lupus Erythematosus. Front Immunol (2015) 0.82
Autophagic vacuolation induced by excess ROS generation in HABP1/p32/gC1qR overexpressing fibroblasts and its reversal by polymeric hyaluronan. PLoS One (2013) 0.82
IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway. Sci Rep (2015) 0.81
Diet control to achieve euglycemia induces significant loss of heart and liver weight via increased autophagy compared with ad libitum diet in diabetic rats. Exp Mol Med (2014) 0.81
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem (2000) 8.68
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem (1997) 6.09
Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ (2005) 5.40
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem (1995) 4.36
Autophagic proteolysis: control and specificity. Histochem J (1997) 3.05
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ (2008) 2.89
Does autophagy have a license to kill mammalian cells? Cell Death Differ (2008) 2.30
Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells. J Biol Chem (1996) 2.14
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J Biol Chem (2000) 1.95
Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia. Neuroscience (2005) 1.84
Activity of peroxisomal enzymes and intracellular distribution of catalase in Zellweger syndrome. Biochem Biophys Res Commun (1984) 1.77
Swelling of rat hepatocytes stimulates glycogen synthesis. J Biol Chem (1990) 1.68
hnRNP G: sequence and characterization of a glycosylated RNA-binding protein. Nucleic Acids Res (1993) 1.58
3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism. Eur J Biochem (1988) 1.55
The metabolic significance of anion transport in mitochondria. Biochim Biophys Acta (1974) 1.52
Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes. J Biol Chem (1975) 1.52
Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene (2012) 1.49
The relationship between intramitochondrial N-acetylglutamate and activity of carbamoyl-phosphate synthetase (ammonia). The effect of glucagon. Eur J Biochem (1980) 1.34
Energy dependence of different steps in the autophagic-lysosomal pathway. J Biol Chem (1989) 1.22
Endoplasmic reticulum-to-cytosol transport of free polymannose oligosaccharides in permeabilized HepG2 cells. EMBO J (1995) 1.21
Interrelationships between gluconeogenesis and ureogenesis in isolated hepatocytes. J Biol Chem (1978) 1.20
The stimulation of glutamine hydrolysis in isolated rat liver mitochondria by Mg2+ depletion and hypo-osmotic incubation conditions. Biochem J (1981) 1.19
Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells. Cell Death Dis (2010) 1.17
Signal transduction pathways in macroautophagy. Cell Signal (1997) 1.16
A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29. J Biol Chem (1995) 1.14
Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29. Exp Cell Res (2001) 1.12
Evidence for electrogenic aspartate transport in rat liver mitochondria. Arch Biochem Biophys (1974) 1.12
FGF2 promotes skeletogenic differentiation of cranial neural crest cells. Development (2001) 1.11
Amino-acid-dependent signal transduction. Biochem J (2000) 1.09
Analysis of the control of citrulline synthesis in isolated rat-liver mitochondria. Eur J Biochem (1984) 1.08
Dietary fat content alters insulin-mediated glucose metabolism in healthy men. Am J Clin Nutr (2001) 1.07
Transport of glutamate in rat-liver mitochondria. Biochim Biophys Acta (1972) 1.06
Autophagic degradation of peroxisomes in isolated rat hepatocytes. FEBS Lett (1992) 1.06
Properties of carbamoyl-phosphate synthetase (ammonia) in rat-liver mitochondria made permeable with toluene. Eur J Biochem (1983) 1.06
Control of ureogenesis. Eur J Biochem (1985) 1.06
Control of proteolysis in perifused rat hepatocytes. FEBS Lett (1987) 1.06
Control of the rate of citrulline synthesis by short-term changes in N-acetylglutamate levels in isolated rat-liver mitochondria. FEBS Lett (1978) 1.05
Hepatocyte swelling increases inositol 1,4,5-trisphosphate, calcium and cyclic AMP concentration but antagonizes phosphorylase activation by Ca2(+)-dependent hormones. FEBS Lett (1991) 1.04
Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury. Cell Death Differ (2010) 1.03
Prolone metabolism in isolated rat liver cells. Biochem J (1978) 1.02
Transfer of free polymannose-type oligosaccharides from the cytosol to lysosomes in cultured human hepatocellular carcinoma HepG2 cells. J Cell Biol (1997) 1.02
Energy dependence of autophagic protein degradation in isolated rat hepatocytes. Eur J Biochem (1987) 1.01
A combination of intracellular leucine with either glutamate or aspartate inhibits autophagic proteolysis in isolated rat hepatocytes. Eur J Biochem (1989) 1.00
Stimulation by glucose of gluconeogenesis in hepatocytes isolated from starved rats. Biochem J (1987) 1.00
Acute inhibition of hepatic glucose-6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats. A pharmacological study with the chlorogenic acid derivative S4048. J Biol Chem (2001) 1.00
Effect of uncouplers on anion transport in rat liver mitochondria. Biochem J (1970) 0.98
Cell swelling and the control of autophagic proteolysis in hepatocytes: involvement of phosphorylation of ribosomal protein S6? Biochem Soc Trans (1994) 0.98
Cytosol-to-lysosome transport of free polymannose-type oligosaccharides. Kinetic and specificity studies using rat liver lysosomes. J Biol Chem (1999) 0.98
First case report of melioidosis in Guadeloupe, a French West Indies archipelago. Clin Infect Dis (1997) 0.98
Role of plasma membrane transport in hepatic glutamine metabolism. Eur J Biochem (1985) 0.98
Hepatic autophagy and intracellular ATP. A morphometric study. Exp Cell Res (1988) 0.97
Isoforms of the Lutheran/basal cell adhesion molecule glycoprotein are differentially delivered in polarized epithelial cells. Mapping of the basolateral sorting signal to a cytoplasmic di-leucine motif. J Biol Chem (1999) 0.97
Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains. Biochem Biophys Res Commun (1994) 0.96
Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats. Diabetes (2001) 0.96
Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells. J Biol Chem (1997) 0.96
The inhibitory effects of sulphydryl reagents on the transport and hydrolysis of glutamine in rat-liver mitochondria. Eur J Biochem (1981) 0.96
Measuring vibration sensations with graduated tuning fork. Simple and reliable means to detect diabetic patients at risk of neuropathic foot ulceration. Diabetes Care (1990) 0.95
Human glucocerebrosidase: heterologous expression of active site mutants in murine null cells. Glycobiology (2000) 0.94
Rate-limiting factors in the oxidation of ethanol by isolated rat liver cells. Biochem J (1975) 0.94
Bicarbonate and the pathway of glutamate oxidation in isolated rat-liver mitochondria. Eur J Biochem (1983) 0.94
Phthalonic acid, an inhibitor of alpha-oxoglutarate transport in mitochondria. Biochim Biophys Acta (1976) 0.94
Control of rat-liver glutaminase by ammonia and pH. Eur J Biochem (1983) 0.93
Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects. J Clin Endocrinol Metab (2007) 0.92
N-acetylglutamate and urea synthesis. Biochem J (1984) 0.92
Effect of trifluoperazine on the stimulation by Ca2+-dependent hormones of gluconeogenesis from glutamine in isolated hepatocytes. Biochim Biophys Acta (1981) 0.91
The malate/aspartate shuttle and pyruvate kinase as targets involved in the stimulation of gluconeogenesis by phenylephrine. Eur J Biochem (1986) 0.91
Evolving views in prion glycosylation: functional and pathological implications. Biochimie (2003) 0.91
Dietary carbohydrate deprivation increases 24-hour nitrogen excretion without affecting postabsorptive hepatic or whole body protein metabolism in healthy men. J Clin Endocrinol Metab (2003) 0.91
Turnover of peroxisomal vesicles by autophagic proteolysis in cultured fibroblasts from Zellweger patients. Eur J Cell Biol (1992) 0.91
Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells. Biochem Biophys Res Commun (1993) 0.91
The N-glycan processing in HT-29 cells is a function of their state of enterocytic differentiation. Evidence for an atypical traffic associated with change in polypeptide stability in undifferentiated HT-29 cells. J Biol Chem (1991) 0.90
Nitric oxide inhibits glycogen synthesis in isolated rat hepatocytes. Biochem J (1998) 0.90
Coupling mechanisms in anionic substrate transport across the inner membrane of rat-liver mitochondria. J Bioenerg (1971) 0.89
Ala-Pro-cresyl violet, a synthetic fluorogenic substrate for the analysis of kinetic parameters of dipeptidyl peptidase IV (CD26) in individual living rat hepatocytes. Anal Biochem (1997) 0.89
Subcellular localization of the Galphai3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells. Biochem J (1999) 0.89
Stimulation of glycogen synthesis in hepatocytes by added amino acids is related to the total intracellular content of amino acids. Eur J Biochem (1990) 0.89
Inhibition of urea-cycle activity by high concentrations of alanine. Biochem J (1980) 0.88
The effects of carbohydrate variation in isocaloric diets on glycogenolysis and gluconeogenesis in healthy men. J Clin Endocrinol Metab (2000) 0.88
On the nature of the stimulation by glucagon of citrulline synthesis in rat-liver mitochondria. FEBS Lett (1982) 0.87