Published in J Biol Chem on November 08, 2007
A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. PLoS Pathog (2008) 1.55
Importance of the collagen adhesin ace in pathogenesis and protection against Enterococcus faecalis experimental endocarditis. PLoS Pathog (2010) 1.43
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen. J Biol Chem (2009) 1.24
Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin. PLoS Pathog (2012) 1.16
Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans. Proc Natl Acad Sci U S A (2011) 1.11
Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactions. J Biol Chem (2011) 1.10
Structural insights into serine-rich fimbriae from Gram-positive bacteria. J Biol Chem (2010) 1.09
Binding of glycoprotein Srr1 of Streptococcus agalactiae to fibrinogen promotes attachment to brain endothelium and the development of meningitis. PLoS Pathog (2012) 1.09
A collagen-binding adhesin, Acb, and ten other putative MSCRAMM and pilus family proteins of Streptococcus gallolyticus subsp. gallolyticus (Streptococcus bovis Group, biotype I). J Bacteriol (2009) 1.09
Structural biology of Gram-positive bacterial adhesins. Protein Sci (2011) 1.07
Fibrinogen is a ligand for the Staphylococcus aureus microbial surface components recognizing adhesive matrix molecules (MSCRAMM) bone sialoprotein-binding protein (Bbp). J Biol Chem (2011) 1.05
beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC. PLoS Pathog (2010) 1.04
The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans. PLoS One (2011) 1.00
A family of fibrinogen-binding MSCRAMMs from Enterococcus faecalis. Microbiology (2009) 0.93
Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae. J Biol Chem (2013) 0.92
Structural basis of Staphylococcus epidermidis biofilm formation: mechanisms and molecular interactions. Front Cell Infect Microbiol (2015) 0.90
The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response. Microbiol Spectr (2016) 0.79
Crystal structure of the functional region of Uro-adherence factor A from Staphylococcus saprophyticus reveals participation of the B domain in ligand binding. Protein Sci (2011) 0.78
Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody. EBioMedicine (2016) 0.75
Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria. Microbiol Spectr (2015) 0.75
A Novel MSCRAMM Subfamily in Coagulase Negative Staphylococcal Species. Front Microbiol (2016) 0.75
Crystal Structure of an Invasivity-Associated Domain of SdrE in S. aureus. PLoS One (2017) 0.75
Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science (2007) 7.06
Functional reconstitution of ESCRT-III assembly and disassembly. Cell (2009) 3.52
Endocarditis and biofilm-associated pili of Enterococcus faecalis. J Clin Invest (2006) 3.33
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins. Cell (2004) 3.03
Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol (2010) 2.35
Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein. Nat Struct Mol Biol (2005) 2.33
Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. Nature (2003) 2.27
Retracted The structure of complement C3b provides insights into complement activation and regulation. Nature (2006) 2.20
The molecular basis of fibronectin-mediated bacterial adherence to host cells. Mol Microbiol (2004) 2.20
SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites. Cell (2008) 2.09
A "dock, lock, and latch" structural model for a staphylococcal adhesin binding to fibrinogen. Cell (2003) 2.06
A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A. EMBO J (2002) 2.06
Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin. Nat Struct Biol (2002) 1.96
Streptococcal Scl1 and Scl2 proteins form collagen-like triple helices. J Biol Chem (2002) 1.95
Fluorescence mapping of mitochondrial TIM23 complex reveals a water-facing, substrate-interacting helix surface. Cell (2008) 1.94
Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi. Mol Microbiol (2006) 1.93
Importin-alpha-16 is a translocon-associated protein involved in sorting membrane proteins to the nuclear envelope. Nat Struct Mol Biol (2006) 1.90
Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex. Cell (2011) 1.86
Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins. Proc Natl Acad Sci U S A (2003) 1.79
N-linked glycans direct the cotranslational folding pathway of influenza hemagglutinin. Mol Cell (2003) 1.79
A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen. EMBO J (2005) 1.78
The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall. Structure (2004) 1.76
Translation arrest requires two-way communication between a nascent polypeptide and the ribosome. Mol Cell (2006) 1.74
Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment. Nat Struct Mol Biol (2004) 1.71
Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens. J Biol Chem (2003) 1.71
Cotranslational membrane protein biogenesis at the endoplasmic reticulum. J Biol Chem (2004) 1.70
Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface. Proc Natl Acad Sci U S A (2010) 1.66
An IgG-like domain in the minor pilin GBS52 of Streptococcus agalactiae mediates lung epithelial cell adhesion. Structure (2007) 1.64
The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses. J Clin Invest (2002) 1.63
A family of putative MSCRAMMs from Enterococcus faecalis. Microbiology (2004) 1.63
Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains. Proc Natl Acad Sci U S A (2008) 1.62
Inhibition of complement activation by a secreted Staphylococcus aureus protein. J Infect Dis (2004) 1.62
Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin. J Biol Chem (2002) 1.62
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol (2004) 1.61
Crystal structures of Staphylococcus aureus sortase A and its substrate complex. J Biol Chem (2004) 1.60
Assembly and topography of the prepore complex in cholesterol-dependent cytolysins. J Biol Chem (2003) 1.58
Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions. Proc Natl Acad Sci U S A (2007) 1.57
Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb). J Biol Chem (2004) 1.55
A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. PLoS Pathog (2008) 1.55
Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex. J Cell Biol (2003) 1.54
The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum. J Cell Biol (2005) 1.52
The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation. Proc Natl Acad Sci U S A (2005) 1.52
Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development (2009) 1.50
A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel. Proc Natl Acad Sci U S A (2009) 1.49
Identification and phenotypic characterization of a second collagen adhesin, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium. Microbiology (2008) 1.47
Fibronectin-binding proteins of gram-positive cocci. Microbes Infect (2006) 1.47
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A (2013) 1.45
Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system. Cell (2007) 1.44
Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins. Mol Cell (2003) 1.44
Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin. J Biol Chem (2007) 1.44
Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding. Biochemistry (2009) 1.39
Identification and preliminary characterization of cell-wall-anchored proteins of Staphylococcus epidermidis. Microbiology (2005) 1.37
Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol (2009) 1.36
Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol Cell (2004) 1.36
Virulence potential of the staphylococcal adhesin CNA in experimental arthritis is determined by its affinity for collagen. J Infect Dis (2004) 1.36
Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection. Infect Immun (2008) 1.36
A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen (2006) 1.33
The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission? Nat Rev Microbiol (2006) 1.33
The tandem beta-zipper model defines high affinity fibronectin-binding repeats within Staphylococcus aureus FnBPA. J Biol Chem (2007) 1.32
Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma. Neuro Oncol (2012) 1.30
A new role for BiP: closing the aqueous translocon pore during protein integration into the ER membrane. J Cell Biol (2002) 1.30
Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices. J Biol Chem (2007) 1.28
Fluorescence resonance energy transfer analysis of protein translocase. SecYE from Thermus thermophilus HB8 forms a constitutive oligomer in membranes. J Biol Chem (2003) 1.28
Bax forms an oligomer via separate, yet interdependent, surfaces. J Biol Chem (2010) 1.27
A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling. J Biol Chem (2005) 1.27
Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes. J Biol Chem (2005) 1.27
Assessment of prokaryotic collagen-like sequences derived from streptococcal Scl1 and Scl2 proteins as a source of recombinant GXY polymers. Appl Microbiol Biotechnol (2006) 1.26
A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo. Neuro Oncol (2010) 1.24
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen. J Biol Chem (2009) 1.24
Fibrinogen-binding proteins of Gram-positive bacteria. Thromb Haemost (2007) 1.23
MSCRAMM--targeted vaccines and immunotherapy for staphylococcal infection. Curr Opin Drug Discov Devel (2004) 1.21
Scl1-dependent internalization of group A Streptococcus via direct interactions with the alpha2beta(1) integrin enhances pathogen survival and re-emergence. Mol Microbiol (2007) 1.21
Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax. J Biol Chem (2004) 1.20
How interaction of perfringolysin O with membranes is controlled by sterol structure, lipid structure, and physiological low pH: insights into the origin of perfringolysin O-lipid raft interaction. J Biol Chem (2007) 1.20
BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand binding. J Biol Chem (2004) 1.17
Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis. J Biol Chem (2004) 1.16
A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1. J Biol Chem (2005) 1.15
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A (2008) 1.15
High affinity streptococcal binding to human fibronectin requires specific recognition of sequential F1 modules. J Biol Chem (2004) 1.14
Cotranslational integration and initial sorting at the endoplasmic reticulum translocon of proteins destined for the inner nuclear membrane. Proc Natl Acad Sci U S A (2004) 1.14
Identification and biochemical characterization of two novel collagen binding MSCRAMMs of Bacillus anthracis. J Biol Chem (2004) 1.13
The Enterococcus faecalis MSCRAMM ACE binds its ligand by the Collagen Hug model. J Biol Chem (2007) 1.13
Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon. Mol Biol Cell (2008) 1.11
Identification of nascent chain interaction sites on trigger factor. J Biol Chem (2007) 1.11
Crystal structure of the first plant urease from jack bean: 83 years of journey from its first crystal to molecular structure. J Mol Biol (2010) 1.11
Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactions. J Biol Chem (2011) 1.10