Published in Nat Rev Genet on September 01, 2008
Genome-wide mapping of alternative splicing in Arabidopsis thaliana. Genome Res (2009) 5.24
NMD: a multifaceted response to premature translational termination. Nat Rev Mol Cell Biol (2012) 3.64
Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet (2011) 3.27
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet (2012) 2.55
Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J Biol Chem (2012) 2.25
UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell (2010) 2.04
SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev (2008) 1.97
A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol (2011) 1.95
Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay. Nature (2010) 1.73
The pioneer round of translation: features and functions. Cell (2010) 1.66
CpG-island promoters drive transcription of human telomeres. RNA (2009) 1.66
Preventing dangerous nonsense: selection for robustness to transcriptional error in human genes. PLoS Genet (2011) 1.63
Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention. Genes Dev (2012) 1.59
Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol (2010) 1.55
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev (2011) 1.52
RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD. Mol Cell (2011) 1.50
Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol (2009) 1.44
Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis. Mol Cancer Res (2010) 1.44
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis. Mol Cell Biol (2011) 1.42
CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex. Nat Struct Mol Biol (2012) 1.40
Mutations in AtPS1 (Arabidopsis thaliana parallel spindle 1) lead to the production of diploid pollen grains. PLoS Genet (2008) 1.39
High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans. Genome Biol (2009) 1.36
Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. Mol Cell (2013) 1.35
Whole-exome sequencing, without prior linkage, identifies a mutation in LAMB3 as a cause of dominant hypoplastic amelogenesis imperfecta. Eur J Hum Genet (2013) 1.28
Re-capping the message. Trends Biochem Sci (2009) 1.28
Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Mol Cell Biol (2011) 1.24
Nonsense-mediated decay of alternative precursor mRNA splicing variants is a major determinant of the Arabidopsis steady state transcriptome. Plant Cell (2013) 1.19
Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex. Proc Natl Acad Sci U S A (2010) 1.14
Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability. RNA Biol (2012) 1.13
Suppression of premature termination codons as a therapeutic approach. Crit Rev Biochem Mol Biol (2012) 1.13
Comparative proteomics reveals a significant bias toward alternative protein isoforms with conserved structure and function. Mol Biol Evol (2012) 1.12
The exon junction complex differentially marks spliced junctions. Nat Struct Mol Biol (2010) 1.12
Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. PLoS One (2013) 1.11
Aberrant growth and lethality of Arabidopsis deficient in nonsense-mediated RNA decay factors is caused by autoimmune-like response. Nucleic Acids Res (2012) 1.08
Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay. BMC Genomics (2010) 1.07
Lariat sequencing in a unicellular yeast identifies regulated alternative splicing of exons that are evolutionarily conserved with humans. Proc Natl Acad Sci U S A (2013) 1.07
Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U S A (2012) 1.06
Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era? Mol Cell Biol (2009) 1.05
The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev (2011) 1.05
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end. Nat Struct Mol Biol (2012) 1.04
Replication of telomeres and the regulation of telomerase. Cold Spring Harb Perspect Biol (2013) 1.03
Mechanisms of endonuclease-mediated mRNA decay. Wiley Interdiscip Rev RNA (2011) 1.03
The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nat Med (2014) 1.03
Cytoplasmic and nuclear quality control and turnover of single-stranded RNA modulate post-transcriptional gene silencing in plants. Nucleic Acids Res (2013) 1.00
Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors. RNA (2010) 1.00
Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic Acids Res (2011) 1.00
Proofreading and spellchecking: a two-tier strategy for pre-mRNA splicing quality control. RNA (2011) 1.00
CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Cold Spring Harb Symp Quant Biol (2011) 1.00
HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition. Nucleic Acids Res (2013) 1.00
Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation. Eur J Hum Genet (2009) 0.99
Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex. Genes Dev (2011) 0.96
Gene expression networks: competing mRNA decay pathways in mammalian cells. Biochem Soc Trans (2009) 0.96
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. Proc Natl Acad Sci U S A (2012) 0.96
Perispeckles are major assembly sites for the exon junction core complex. Mol Biol Cell (2012) 0.95
The RNA binding protein ELF9 directly reduces SUPPRESSOR OF OVEREXPRESSION OF CO1 transcript levels in arabidopsis, possibly via nonsense-mediated mRNA decay. Plant Cell (2009) 0.95
Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex. Nucleic Acids Res (2010) 0.93
Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease. J Pediatr Gastroenterol Nutr (2011) 0.93
Gemin5 promotes IRES interaction and translation control through its C-terminal region. Nucleic Acids Res (2012) 0.93
Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity. Nucleic Acids Res (2012) 0.92
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion. EMBO Mol Med (2014) 0.91
Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling. J Clin Invest (2013) 0.91
A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells. J Neurosci (2009) 0.91
Mutually exclusive splicing regulates the Nav 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands. Nucleic Acids Res (2012) 0.90
Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations. RNA (2009) 0.89
Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit. RNA (2013) 0.88
A multiprotein occupancy map of the mRNP on the 3' end of histone mRNAs. RNA (2015) 0.87
mRNA 3' tagging is induced by nonsense-mediated decay and promotes ribosome dissociation. Mol Cell Biol (2012) 0.87
Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development. Mol Cell Biol (2011) 0.86
In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila. G3 (Bethesda) (2014) 0.86
A novel role for hSMG-1 in stress granule formation. Mol Cell Biol (2011) 0.86
Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet (2013) 0.86
Alternative Splicing Substantially Diversifies the Transcriptome during Early Photomorphogenesis and Correlates with the Energy Availability in Arabidopsis. Plant Cell (2016) 0.85
The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. Cell Rep (2014) 0.85
Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. Nucleic Acids Res (2014) 0.85
Regulation of alternative splicing in Drosophila by 56 RNA binding proteins. Genome Res (2015) 0.85
MicroProtein-Mediated Recruitment of CONSTANS into a TOPLESS Trimeric Complex Represses Flowering in Arabidopsis. PLoS Genet (2016) 0.85
Endogenous mechanisms for the origins of spliceosomal introns. J Hered (2009) 0.84
Signaling pathways that control mRNA turnover. Cell Signal (2013) 0.84
TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres. Front Oncol (2013) 0.84
The life history of retrocopies illuminates the evolution of new mammalian genes. Genome Res (2016) 0.84
Deletion of amelotin exons 3-6 is associated with amelogenesis imperfecta. Hum Mol Genet (2016) 0.84
To die or not to die? Lessons from lesion mimic mutants. Front Plant Sci (2015) 0.83
Frame-disrupting mutations elicit pre-mRNA accumulation independently of frame disruption. Nucleic Acids Res (2009) 0.83
Posttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition. Cell Mol Life Sci (2013) 0.83
Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2. Nucleic Acids Res (2013) 0.83
Activation of Src and transformation by an RPTPα splice mutant found in human tumours. EMBO J (2011) 0.83
When a ribosome encounters a premature termination codon. BMB Rep (2013) 0.83
A critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors. Neural Dev (2015) 0.82
The role of mRNA splicing in prostate cancer. Asian J Androl (2014) 0.82
Nonsense-mediated mRNA decay controls the changes in yeast ribosomal protein pre-mRNAs levels upon osmotic stress. PLoS One (2013) 0.81
Alternative splicing: An important mechanism in stem cell biology. World J Stem Cells (2015) 0.81
Functional characterization of Upf1 targets in Schizosaccharomyces pombe. RNA Biol (2013) 0.81
Targeted Knock-Down of miR21 Primary Transcripts Using snoMEN Vectors Induces Apoptosis in Human Cancer Cell Lines. PLoS One (2015) 0.81
In silico to in vivo splicing analysis using splicing code models. Methods (2013) 0.81
RNA around the clock - regulation at the RNA level in biological timing. Front Plant Sci (2015) 0.80
Interplay between nonsense-mediated mRNA decay and DNA damage response pathways reveals that Stn1 and Ten1 are the key CST telomere-cap components. Cell Rep (2014) 0.79
The plausible reason why the length of 5' untranslated region is unrelated to organismal complexity. BMC Res Notes (2011) 0.79
Increased expression of X-linked genes in mammals is associated with a higher stability of transcripts and an increased ribosome density. Genome Biol Evol (2015) 0.79
Analysis of human protein replacement stable cell lines established using snoMEN-PR vector. PLoS One (2013) 0.79
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci U S A (2002) 10.28
RNA regulons: coordination of post-transcriptional events. Nat Rev Genet (2007) 10.12
The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem (2007) 8.94
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell (2007) 7.99
Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements. Nature (2007) 7.12
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science (2007) 6.33
Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat Genet (2004) 6.14
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell (2000) 5.54
Nonsense-mediated decay approaches the clinic. Nat Genet (2004) 5.12
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev (2007) 4.97
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell (2001) 4.92
Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. Genes Dev (2007) 4.75
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay. Mol Cell (2004) 4.13
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Cell (2005) 4.02
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep (2007) 3.89
Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. Science (2002) 3.84
Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J (2003) 3.68
Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast. Mol Cell (2003) 3.66
A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay. Nature (2004) 3.60
SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs. EMBO J (2001) 3.55
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell (2008) 3.26
Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1. Mol Cell (2007) 3.22
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol (1999) 3.18
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18
Y14 and hUpf3b form an NMD-activating complex. Mol Cell (2003) 3.17
Early nonsense: mRNA decay solves a translational problem. Nat Rev Mol Cell Biol (2006) 3.11
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell (2004) 3.05
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature (2004) 2.95
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell (2005) 2.79
The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J (2002) 2.76
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell (2005) 2.71
hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol Cell Biol (2006) 2.69
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol (2004) 2.65
Regulation of an intergenic transcript controls adjacent gene transcription in Saccharomyces cerevisiae. Genes Dev (2005) 2.64
Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol Cell Biol (2001) 2.61
Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA (2005) 2.59
REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol (2002) 2.55
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J (2008) 2.52
The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation. EMBO J (1997) 2.43
The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. Nat Struct Mol Biol (2005) 2.40
eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol (2004) 2.38
Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome. Mol Cell Biol (1999) 2.37
The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. EMBO J (2001) 2.37
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. Nat Genet (2007) 2.35
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat Struct Mol Biol (2005) 2.34
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat Struct Mol Biol (2007) 2.30
Translation is required to remove Y14 from mRNAs in the cytoplasm. Curr Biol (2002) 2.28
NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev (2008) 2.26
Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol (2008) 2.25
Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol Cell Biol (1998) 2.24
mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett (2007) 2.22
Staufen1 regulates diverse classes of mammalian transcripts. EMBO J (2007) 2.18
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J (2006) 2.16
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr Biol (2006) 2.16
A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr Biol (2003) 2.14
Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. EMBO J (2001) 2.13
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell (2004) 2.09
Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci (2006) 2.07
Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. Mol Cell Biol (2000) 2.07
smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1997) 2.05
An alternative branch of the nonsense-mediated decay pathway. EMBO J (2007) 2.01
CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol (2005) 2.00
Functional conservation of the telomerase protein Est1p in humans. Curr Biol (2003) 2.00
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A (2004) 1.97
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. RNA (2005) 1.96
eIF4A3 is a novel component of the exon junction complex. RNA (2004) 1.93
The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev (2004) 1.93
The protein Mago provides a link between splicing and mRNA localization. EMBO Rep (2001) 1.92
Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay. Mol Cell (2005) 1.79
Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Genes Dev (2007) 1.74
Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem (2001) 1.74
The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation. Mol Cell (2000) 1.71
Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response. Mol Cell Biol (2008) 1.68
Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.63
SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans. Mol Cell Biol (2004) 1.62
The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA (2003) 1.58
Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast. PLoS Genet (2006) 1.55
eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol (2004) 1.54
Telomere dysfunction, genome instability and cancer. Front Biosci (2008) 1.53
The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidation. J Virol (2000) 1.50
Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails. Mol Cell Biol (2006) 1.50
Evolutionary conservation and regulation of particular alternative splicing events in plant SR proteins. Nucleic Acids Res (2006) 1.47
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA (2006) 1.46
mRNA surveillance of expressed pseudogenes in C. elegans. Curr Biol (2005) 1.45
Association of yeast Upf1p with direct substrates of the NMD pathway. Proc Natl Acad Sci U S A (2007) 1.40
mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae. Eukaryot Cell (2003) 1.40
Ectopic expression of atRSZ33 reveals its function in splicing and causes pleiotropic changes in development. Mol Biol Cell (2003) 1.37
Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. PLoS Genet (2006) 1.36
Telomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway. Mol Cell Biol (1998) 1.35
Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. J Biol Chem (2004) 1.34
Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles. Mol Cell Biol (2004) 1.31
Translation termination is involved in histone mRNA degradation when DNA replication is inhibited. Mol Cell Biol (2005) 1.30
Alternative splicing of intron 3 of the serine/arginine-rich protein 9G8 gene. Identification of flanking exonic splicing enhancers and involvement of 9G8 as a trans-acting factor. J Biol Chem (2000) 1.30
lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature (2011) 5.42
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev (2007) 4.97
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell (2003) 4.17
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Cell (2005) 4.02
Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol (2005) 3.99
Regulation of cytoplasmic mRNA decay. Nat Rev Genet (2012) 3.30
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell (2008) 3.26
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18
The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J (2002) 2.76
Organizing principles of mammalian nonsense-mediated mRNA decay. Annu Rev Genet (2013) 2.55
Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges. Trends Mol Med (2006) 2.39
Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol (2008) 2.25
Staufen1 regulates diverse classes of mammalian transcripts. EMBO J (2007) 2.18
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell (2004) 2.09
UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell (2010) 2.04
CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol (2005) 2.00
SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev (2008) 1.97
A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol (2011) 1.95
The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev (2004) 1.93
eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol (2004) 1.54
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev (2011) 1.52
Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails. Mol Cell Biol (2006) 1.50
Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon. Proc Natl Acad Sci U S A (2002) 1.33
STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes Dev (2013) 1.32
Re-capping the message. Trends Biochem Sci (2009) 1.28
Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol (2007) 1.26
Staufen-mediated mRNA decay. Wiley Interdiscip Rev RNA (2013) 1.26
Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay. Mol Cell (2008) 1.22
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev (2009) 1.22
Control of myogenesis by rodent SINE-containing lncRNAs. Genes Dev (2013) 1.21
Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev (2013) 1.18
Rules that govern UPF1 binding to mRNA 3' UTRs. Proc Natl Acad Sci U S A (2013) 1.13
Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U S A (2012) 1.06
Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A (2005) 1.05
mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay. Nat Struct Mol Biol (2013) 1.01
Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nat Struct Mol Biol (2013) 1.00
The dharma of nonsense-mediated mRNA decay in mammalian cells. Mol Cells (2014) 0.95
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep (2008) 0.95
"Alu"strious long ncRNAs and their role in shortening mRNA half-lives. Cell Cycle (2011) 0.92
Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes. Methods (2012) 0.91
Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells. Methods Enzymol (2008) 0.87
Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells. Methods Mol Biol (2004) 0.85
An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA. Trends Cell Biol (2004) 0.80
Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells. Methods Mol Biol (2015) 0.78
New gene expression pipelines gush lncRNAs. Genome Biol (2013) 0.77
RNA turnover in eukaryotes: nucleases, pathways and analysis of mRNA decay. Preface. Methods Enzymol (2008) 0.77
UPF1 learns to relax and unwind. Mol Cell (2011) 0.77
Nonsense-mediated decay: assaying for effects on selenoprotein mRNAs. Methods Enzymol (2002) 0.76
RNA-protein interactions: insight into gene function. Methods (2002) 0.76
Telomeric RNAs as a novel player in telomeric integrity. F1000 Biol Rep (2009) 0.75
RNA turnover in eukaryotes: analysis of specialized and quality control RNA decay pathways. Preface. Methods Enzymol (2008) 0.75
RNA turnover in prokaryotes, archaea and organelles. Preface. Methods Enzymol (2008) 0.75