Published in Mol Cell on August 05, 2010
Regulation of cytoplasmic mRNA decay. Nat Rev Genet (2012) 3.30
Long noncoding RNAs are rarely translated in two human cell lines. Genome Res (2012) 2.64
Organizing principles of mammalian nonsense-mediated mRNA decay. Annu Rev Genet (2013) 2.55
Upf1 senses 3'UTR length to potentiate mRNA decay. Cell (2010) 2.09
The pioneer round of translation: features and functions. Cell (2010) 1.66
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev (2011) 1.52
Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay. Genome Res (2013) 1.39
Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev (2013) 1.18
Rules that govern UPF1 binding to mRNA 3' UTRs. Proc Natl Acad Sci U S A (2013) 1.13
Nonsense-mediated decay in genetic disease: friend or foe? Mutat Res Rev Mutat Res (2014) 1.10
A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes Dev (2014) 1.09
Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U S A (2012) 1.06
The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev (2011) 1.05
Cap-binding complex (CBC). Biochem J (2014) 1.05
RNA surveillance is required for endoplasmic reticulum homeostasis. Proc Natl Acad Sci U S A (2012) 1.03
Selenium regulation of the selenoprotein and nonselenoprotein transcriptomes in rodents. Adv Nutr (2011) 1.01
Nonsense-mediated mRNA decay in humans at a glance. J Cell Sci (2016) 1.01
CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter. Cold Spring Harb Symp Quant Biol (2011) 1.00
eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol (2013) 0.99
The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis. Hum Mol Genet (2013) 0.99
The dharma of nonsense-mediated mRNA decay in mammalian cells. Mol Cells (2014) 0.95
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. Mol Cell (2015) 0.89
Nonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiency. RNA (2014) 0.87
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Res (2013) 0.86
The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. Cell Rep (2014) 0.85
When a ribosome encounters a premature termination codon. BMB Rep (2013) 0.83
Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype. Haematologica (2011) 0.83
Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity. Nucleic Acids Res (2015) 0.82
Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms. PLoS One (2014) 0.82
MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1. PLoS One (2013) 0.81
Functional characterization of Upf1 targets in Schizosaccharomyces pombe. RNA Biol (2013) 0.81
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. Nucleic Acids Res (2013) 0.79
The eIF4AIII RNA helicase is a critical determinant of human cytomegalovirus replication. Virology (2016) 0.77
Making sense of nonsense. Nat Struct Mol Biol (2013) 0.77
Control of mRNA Stability in Fungi by NMD, EJC and CBC Factors Through 3'UTR Introns. Genetics (2015) 0.77
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. Mol Cell Biol (2014) 0.76
CBP80 choreographs the NMD two-step. Mol Cell (2010) 0.75
Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. RNA (2016) 0.75
Premature Termination Codons Are Recognized in the Nucleus in A Reading-Frame Dependent Manner. Cell Discov (2015) 0.75
Molecular signal networks and regulating mechanisms of the unfolded protein response. J Zhejiang Univ Sci B (2017) 0.75
Interaction between quality control systems for ER protein folding and RNA biogenesis. Worm (2013) 0.75
Pre-mRNA processing reaches back to transcription and ahead to translation. Cell (2009) 7.45
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol (2002) 5.80
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell (2000) 5.54
RNA-binding proteins and post-transcriptional gene regulation. FEBS Lett (2008) 5.00
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell (2001) 4.92
The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae. EMBO J (1995) 4.68
A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell (1994) 4.56
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell (2003) 4.17
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover. Nat Struct Mol Biol (2005) 4.01
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
Messenger RNA regulation: to translate or to degrade. EMBO J (2008) 3.38
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell (2008) 3.26
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol (1999) 3.18
Y14 and hUpf3b form an NMD-activating complex. Mol Cell (2003) 3.17
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell (2004) 3.05
The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet (2008) 3.00
The ever-increasing complexities of the exon junction complex. Curr Opin Cell Biol (2004) 2.85
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol Cell (2005) 2.79
The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J (2002) 2.76
hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol Cell Biol (2006) 2.69
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol (2004) 2.65
Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense? Trends Biochem Sci (2008) 2.64
A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol (2008) 2.61
Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr Opin Cell Biol (2009) 2.59
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J (2008) 2.52
Translation factors promote the formation of two states of the closed-loop mRNP. Nature (2008) 2.31
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat Struct Mol Biol (2007) 2.30
Translation is required to remove Y14 from mRNAs in the cytoplasm. Curr Biol (2002) 2.28
Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol (2008) 2.25
A protein interaction framework for human mRNA degradation. Genome Res (2004) 2.25
Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol Cell Biol (1998) 2.24
Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol (1994) 2.13
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell (2004) 2.09
An alternative branch of the nonsense-mediated decay pathway. EMBO J (2007) 2.01
CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol (2005) 2.00
SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev (2008) 1.97
The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev (2004) 1.93
SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J (2003) 1.83
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Genes Dev (2007) 1.74
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Biochem J (2003) 1.74
Disassembly of exon junction complexes by PYM. Cell (2009) 1.69
Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases. Genes Dev (2007) 1.68
The mammalian nonsense-mediated mRNA decay pathway: to decay or not to decay! Which players make the decision? FEBS Lett (2009) 1.66
SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans. Mol Cell Biol (2004) 1.62
Structural and functional insights into the human Upf1 helicase core. EMBO J (2006) 1.61
Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. Nat Struct Biol (2002) 1.61
eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol (2004) 1.54
Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails. Mol Cell Biol (2006) 1.50
The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta (2005) 1.49
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA (2006) 1.46
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. EMBO J (2009) 1.44
Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Mol Cell (2007) 1.41
Association of yeast Upf1p with direct substrates of the NMD pathway. Proc Natl Acad Sci U S A (2007) 1.40
SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. Mol Cell Biol (2007) 1.33
Crystal structure of the human nuclear cap binding complex. Mol Cell (2001) 1.32
Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol (2007) 1.26
The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA. Mol Cell (2009) 1.23
How and where are nonsense mRNAs degraded in mammalian cells? RNA Biol (2010) 1.23
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev (2009) 1.22
Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. Nucleic Acids Res (2007) 1.18
Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons. Mol Cell Biol (2007) 1.18
A UPF3-mediated regulatory switch that maintains RNA surveillance. Nat Struct Mol Biol (2009) 1.16
Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA (2008) 1.06
Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A (2005) 1.05
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep (2008) 0.95
lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature (2011) 5.42
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev (2007) 4.97
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell (2003) 4.17
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Cell (2005) 4.02
Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells. Curr Opin Cell Biol (2005) 3.99
Regulation of cytoplasmic mRNA decay. Nat Rev Genet (2012) 3.30
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell (2008) 3.26
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18
The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nat Rev Genet (2008) 3.00
The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J (2002) 2.76
Organizing principles of mammalian nonsense-mediated mRNA decay. Annu Rev Genet (2013) 2.55
Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges. Trends Mol Med (2006) 2.39
Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol (2008) 2.25
Staufen1 regulates diverse classes of mammalian transcripts. EMBO J (2007) 2.18
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell (2004) 2.09
CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol (2005) 2.00
SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev (2008) 1.97
A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol (2011) 1.95
The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev (2004) 1.93
eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol (2004) 1.54
Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question. Curr Opin Genet Dev (2011) 1.52
Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails. Mol Cell Biol (2006) 1.50
Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon. Proc Natl Acad Sci U S A (2002) 1.33
STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes Dev (2013) 1.32
Re-capping the message. Trends Biochem Sci (2009) 1.28
Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol (2007) 1.26
Staufen-mediated mRNA decay. Wiley Interdiscip Rev RNA (2013) 1.26
Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay. Mol Cell (2008) 1.22
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev (2009) 1.22
Control of myogenesis by rodent SINE-containing lncRNAs. Genes Dev (2013) 1.21
Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev (2013) 1.18
Rules that govern UPF1 binding to mRNA 3' UTRs. Proc Natl Acad Sci U S A (2013) 1.13
Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U S A (2012) 1.06
Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A (2005) 1.05
mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay. Nat Struct Mol Biol (2013) 1.01
Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nat Struct Mol Biol (2013) 1.00
The dharma of nonsense-mediated mRNA decay in mammalian cells. Mol Cells (2014) 0.95
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep (2008) 0.95
"Alu"strious long ncRNAs and their role in shortening mRNA half-lives. Cell Cycle (2011) 0.92
Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes. Methods (2012) 0.91
CREB in the pond snail Lymnaea stagnalis: cloning, gene expression, and function in identifiable neurons of the central nervous system. J Neurobiol (2004) 0.88
Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells. Methods Enzymol (2008) 0.87
Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells. Methods Mol Biol (2004) 0.85
The 5' leader of the mRNA encoding the marek's disease virus serotype 1 pp14 protein contains an intronic internal ribosome entry site with allosteric properties. J Virol (2009) 0.81
An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA. Trends Cell Biol (2004) 0.80
A Novel Microbubble Capable of Ultrasound-Triggered Release of Drug-Loaded Nanoparticles. J Biomed Nanotechnol (2016) 0.78
Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells. Methods Mol Biol (2015) 0.78
New gene expression pipelines gush lncRNAs. Genome Biol (2013) 0.77
UPF1 learns to relax and unwind. Mol Cell (2011) 0.77
RNA turnover in eukaryotes: nucleases, pathways and analysis of mRNA decay. Preface. Methods Enzymol (2008) 0.77
RNA-protein interactions: insight into gene function. Methods (2002) 0.76
Nonsense-mediated decay: assaying for effects on selenoprotein mRNAs. Methods Enzymol (2002) 0.76
Telomeric RNAs as a novel player in telomeric integrity. F1000 Biol Rep (2009) 0.75
[Construction of Pichia pastoris strain expressing salivary plasminogen activator from vampire bat (Desmodus rotundus)]. Sheng Wu Gong Cheng Xue Bao (2009) 0.75
RNA turnover in prokaryotes, archaea and organelles. Preface. Methods Enzymol (2008) 0.75
RNA turnover in eukaryotes: analysis of specialized and quality control RNA decay pathways. Preface. Methods Enzymol (2008) 0.75
[Effect of diet composition on expression of uncoupling protein-1 gene of rat]. Wei Sheng Yan Jiu (2002) 0.75