Published in Nucleic Acids Res on December 09, 2009
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Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling. J Mol Biol (2008) 1.64
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Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines. Int J Cancer (2004) 1.17
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Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS. EMBO J (2007) 1.11
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Construction and characterization of a pseudo-immune human antibody library using yeast surface display. Biochem Biophys Res Commun (2006) 0.88
Generation of sequence-specific, high affinity anti-DNA antibodies. J Biol Chem (2001) 0.87
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A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes. Mol Cancer Ther (2009) 0.85
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Cell-penetrating anti-native DNA antibodies trigger apoptosis through both the neglect and programmed pathways. J Autoimmun (2005) 0.82
Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro. Nucleic Acids Res (1996) 0.81
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Nuclear localizing anti-DNA antibodies enter cells via caveoli and modulate expression of caveolin and p53. J Autoimmun (2005) 0.80
Creating a ribonuclease T-tat that preferentially recognizes and hydrolyzes HIV-1 TAR RNA in vitro and in vivo. Nucleic Acids Res (2007) 0.80
DNA and heparin alter the internalization process of anti-DNA monoclonal antibodies according to patterns typical of both the charged molecule and the antibody. J Autoimmun (2001) 0.79
Structural modeling of sequence specificity by an autoantibody against single-stranded DNA. Biochemistry (2007) 0.79
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
MicroRNA-146a downregulates NFκB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma. Clin Cancer Res (2011) 1.54
Expression profiling and subtype-specific expression of stomach cancer. Cancer Res (2003) 1.43
Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments. J Immunol Methods (2004) 1.39
Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proc Natl Acad Sci U S A (2006) 1.32
Application of a weights-of-evidence method and GIS to regional groundwater productivity potential mapping. J Environ Manage (2011) 1.28
STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells. Autophagy (2010) 1.27
Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor. J Biol Chem (2004) 1.23
Screening and characterization of a novel esterase from a metagenomic library. Protein Expr Purif (2005) 1.22
A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells. Cancer Res (2007) 1.19
Structural genomics of minimal organisms and protein fold space. J Struct Funct Genomics (2005) 1.16
Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity. J Biol Chem (2006) 1.14
VDUP1 mediates nuclear export of HIF1alpha via CRM1-dependent pathway. Biochim Biophys Acta (2007) 1.08
Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death. Biochem Biophys Res Commun (2009) 1.05
A surface plasmon enhanced infrared photodetector based on InAs quantum dots. Nano Lett (2010) 1.01
High-resolution structure of ybfF from Escherichia coli K12: a unique substrate-binding crevice generated by domain arrangement. J Mol Biol (2008) 1.01
Improved mutants from directed evolution are biased to orthologous substitutions. Protein Eng Des Sel (2006) 1.00
Comparative analyses of complex formation and binding sites between human tumor necrosis factor-alpha and its three antagonists elucidate their different neutralizing mechanisms. J Mol Biol (2007) 0.99
Gender-dependent hepatic alterations in H-ras12V transgenic mice. J Hepatol (2005) 0.98
Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure. Protein Sci (2005) 0.98
Novel candidate targets of Wnt/beta-catenin signaling in hepatoma cells. Life Sci (2006) 0.98
High prevalence of RET, RAS, and ERK expression in Hashimoto's thyroiditis and in papillary thyroid carcinoma in the Korean population. Thyroid (2007) 0.98
Identification of human thioredoxin as a novel IFN-gamma-induced factor: mechanism of induction and its role in cytokine production. BMC Immunol (2008) 0.94
Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors. Biochem Biophys Res Commun (2005) 0.94
Expression of the nfa1 gene cloned from pathogenic Naegleria fowleri in nonpathogenic N. gruberi enhances cytotoxicity against CHO target cells in vitro. Infect Immun (2005) 0.93
Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism. EMBO J (2002) 0.93
High-level production of arachidonic acid by fed-batch culture of Mortierella alpina using NH4OH as a nitrogen source and pH control. Biotechnol Lett (2005) 0.93
Crystal structure of Cas1 from Archaeoglobus fulgidus and characterization of its nucleolytic activity. Biochem Biophys Res Commun (2013) 0.91
Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells. Mol Immunol (2007) 0.91
An agonistic antibody to human death receptor 4 induces apoptotic cell death in head and neck cancer cells through mitochondrial ROS generation. Cancer Lett (2012) 0.91
A novel anti-EGFR monoclonal antibody inhibiting tumor cell growth by recognizing different epitopes from cetuximab. J Biotechnol (2010) 0.90
Temperature adaptation in Gillichthys (Teleost: Gobiidae) A(4)-lactate dehydrogenases: identical primary structures produce subtly different conformations. J Exp Biol (2002) 0.90
A heterodimeric Fc-based bispecific antibody simultaneously targeting VEGFR-2 and Met exhibits potent antitumor activity. Mol Cancer Ther (2013) 0.90
The fragment structure of a putative HsdR subunit of a type I restriction enzyme from Vibrio vulnificus YJ016: implications for DNA restriction and translocation activity. Nucleic Acids Res (2009) 0.90
Expression of soluble and functional human neonatal Fc receptor in Pichia pastoris. Protein Expr Purif (2009) 0.90
X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum. J Biol Chem (2005) 0.89
Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration. Int J Cancer (2012) 0.88
Direct observation of quasi-coherent thermal emission by a three-dimensional metallic photonic crystal. Opt Lett (2013) 0.88
Construction and characterization of a pseudo-immune human antibody library using yeast surface display. Biochem Biophys Res Commun (2006) 0.88
Gene silencing by H-NS from distal DNA site. Mol Microbiol (2012) 0.87
Activation of mitogen activated protein kinase-Erk kinase (MEK) increases T cell immunoglobulin mucin domain-3 (TIM-3) transcription in human T lymphocytes and a human mast cell line. Mol Immunol (2011) 0.87
Crystal structure of the transcriptional activator HlyU from Vibrio vulnificus CMCP6. FEBS Lett (2010) 0.86
Enhancement of the tumor penetration of monoclonal antibody by fusion of a neuropilin-targeting peptide improves the antitumor efficacy. Mol Cancer Ther (2014) 0.86
Gene expression profiling: canonical molecular changes and clinicopathological features in sporadic colorectal cancers. World J Gastroenterol (2008) 0.86
Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response. J Biol Chem (2008) 0.85
Crystal structure of Cmr5 from Pyrococcus furiosus and its functional implications. FEBS Lett (2013) 0.85
A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes. Mol Cancer Ther (2009) 0.85
Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription. Immunobiology (2012) 0.84
Crystal structure of a minimal nitroreductase, ydjA, from Escherichia coli K12 with and without FMN cofactor. J Mol Biol (2008) 0.84
Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death. J Biol Chem (2011) 0.84
Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells. Apoptosis (2010) 0.83
Crystal structure of single-domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals. Proteins (2008) 0.83
Purification and characterization of two polymorphic variants of short chain acyl-CoA dehydrogenase reveal reduction of catalytic activity and stability of the Gly185Ser enzyme. Biochemistry (2002) 0.82
Cellular internalization mechanism and intracellular trafficking of filamentous M13 phages displaying a cell-penetrating transbody and TAT peptide. PLoS One (2012) 0.82
Pre-operative predictive factors for gallbladder cholesterol polyps using conventional diagnostic imaging. World J Gastroenterol (2008) 0.82
PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis. Diabetologia (2014) 0.81
Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae. Protein Sci (2006) 0.81
Selection of scFvs specific for HBV DNA polymerase using ribosome display. J Immunol Methods (2004) 0.81
Efficient and directed Nano-LED emission by a complete elimination of transverse-electric guided modes. Nano Lett (2010) 0.81
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of an ASCH domain-containing protein from Zymomonas mobilis ZM4. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.80
The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells. Exp Cell Res (2012) 0.80
Functional consequences of complementarity-determining region deactivation in a multifunctional anti-nucleic acid antibody. J Biol Chem (2013) 0.80
Generation of humanized anti-DNA hydrolyzing catalytic antibodies by complementarity determining region grafting. Biochem Biophys Res Commun (2008) 0.80
Structures of iron-dependent alcohol dehydrogenase 2 from Zymomonas mobilis ZM4 with and without NAD+ cofactor. J Mol Biol (2011) 0.80
Naegleria fowleri: functional expression of the Nfa1 protein in transfected Naegleria gruberi by promoter modification. Exp Parasitol (2006) 0.80
Induction of IFN-gamma gene expression by thioredoxin: positive feed-back regulation of Th1 response by thioredoxin and IFN-gamma. Cell Physiol Biochem (2008) 0.80
Structural characterization of a modification subunit of a putative type I restriction enzyme from Vibrio vulnificus YJ016. Acta Crystallogr D Biol Crystallogr (2012) 0.80
An RNA-hydrolyzing recombinant antibody exhibits an antiviral activity against classical swine fever virus. Biochem Biophys Res Commun (2010) 0.80
Humanization of an agonistic anti-death receptor 4 single chain variable fragment antibody and avidity-mediated enhancement of its cell death-inducing activity. Mol Immunol (2009) 0.80
The inhibition of the T-cell immunoglobulin and mucin domain 3 (Tim3) pathway enhances the efficacy of tumor vaccine. Biochem Biophys Res Commun (2010) 0.79
Construction of a large synthetic human Fab antibody library on yeast cell surface by optimized yeast mating. J Microbiol Biotechnol (2014) 0.79
AY4, an agonistic anti-death receptor 4 MAB, induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation. Endocr Relat Cancer (2013) 0.79
Role of the Nfa1 protein in pathogenic Naegleria fowleri cocultured with CHO target cells. Clin Diagn Lab Immunol (2005) 0.79
Treatment with mANT2 shRNA enhances antitumor therapeutic effects induced by MUC1 DNA vaccination. Mol Ther (2010) 0.79
Visible three-dimensional metallic photonic crystal with non-localized propagating modes beyond waveguide cutoff. Opt Express (2007) 0.79
Molecular determinants required for selective interactions between the thyroid hormone receptor homodimer and the nuclear receptor corepressor N-CoR. J Mol Biol (2009) 0.79
High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies. Protein Sci (2005) 0.79
Improvement of virus safety of an antihemophilc factor IX by virus filtration process. J Microbiol Biotechnol (2008) 0.78
Optimized serological isolation of lung-cancer-associated antigens from a yeast surface-expressed cDNA library. J Microbiol Biotechnol (2007) 0.78
T Cell Immunoglobulin Mucin Domain (TIM)-3 Promoter Activity in a Human Mast Cell Line. Immune Netw (2012) 0.78
Crystal structure of a heat-inducible transcriptional repressor HrcA from Thermotoga maritima: structural insight into DNA binding and dimerization. J Mol Biol (2005) 0.78