Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytes.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 2262979)

Published in Mol Biol Cell on January 02, 2008

Authors

Carmen Nevado1, Manuel Benito, Angela M Valverde

Author Affiliations

1: Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.

Articles cited by this

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32

Cell death: critical control points. Cell (2004) 22.56

Two CD95 (APO-1/Fas) signaling pathways. EMBO J (1998) 10.42

Social controls on cell survival and cell death. Nature (1992) 9.81

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell (2000) 7.26

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol (2000) 6.05

Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem (1999) 5.66

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev (1997) 5.58

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med (1999) 5.08

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol (2002) 4.85

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science (1995) 4.23

Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer (2004) 3.76

Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology (2006) 3.52

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol (1999) 3.50

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr Biol (1998) 3.11

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J (2000) 2.74

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem (1999) 2.52

The CD95 type I/type II model. Semin Immunol (2003) 2.34

The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res (2002) 2.24

Alternative splicing of human insulin receptor messenger RNA. Biochem Biophys Res Commun (1989) 1.90

Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol Endocrinol (1989) 1.77

Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Mol Cell Biol (2002) 1.67

Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. J Biol Chem (2000) 1.55

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes (2003) 1.51

Simultaneous analysis of immunophenotype and apoptosis of murine thymocytes by single laser flow cytometry. Cytometry (1992) 1.33

Intracellular survival pathways in the liver. Liver Int (2006) 1.26

Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts. J Biol Chem (1996) 1.22

The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review. Horm Metab Res (2004) 1.12

Retracted Bi-directional regulation of brown fat adipogenesis by the insulin receptor. J Biol Chem (2003) 1.12

Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide. Toxicol Appl Pharmacol (2005) 1.07

The rat insulin receptor: primary structure and conservation of tissue-specific alternative messenger RNA splicing. Mol Endocrinol (1990) 1.05

Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J Biol Chem (1993) 1.04

Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes. J Cell Physiol (2007) 1.00

Dysregulation of apoptosis as a mechanism of liver disease: an overview. Semin Liver Dis (1998) 0.99

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology (2004) 0.98

Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes. Hepatology (2005) 0.95

The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation. J Biol Chem (2006) 0.91

Apoptosis in the liver and its role in hepatocarcinogenesis. Cell Biol Toxicol (1997) 0.90

Losing balance: cytokine signaling and cell death in the context of hepatocyte injury and hepatic failure. Eur Cytokine Netw (2003) 0.85

Insulin receptor gene expression during development: developmental regulation of insulin receptor mRNA abundance in embryonic rat liver and yolk sac, developmental regulation of insulin receptor gene splicing, and comparison to abundance of insulin-like growth factor 1 receptor mRNA. Mol Endocrinol (1992) 0.85

Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells. Endocrinology (2006) 0.85

Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes. Endocrinology (2006) 0.84

Apoptosis and liver diseases: recent concepts of mechanism and significance. J Gastroenterol Hepatol (2001) 0.83

Co-induction of cell death and survival pathways by phosphoinositide 3-kinase. Life Sci (2005) 0.80

Expression levels of insulin-like growth factor binding proteins and insulin receptor isoforms in hepatoblastomas. Cancer Lett (2001) 0.76

Precocious induction of malic enzyme by nutritional and hormonal factors in rat foetal hepatocyte primary cultures. Biochem Biophys Res Commun (1989) 0.76

Articles by these authors

The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes. Mol Cancer Res (2002) 2.01

Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab (2012) 1.81

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol Biol Cell (2003) 1.65

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes (2003) 1.51

Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function. Biochem J (2013) 1.46

Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action. Bioessays (2002) 1.30

Correlations of telomere length, telomerase activity, and telomeric-repeat binding factor 1 expression in colorectal carcinoma. Cancer (2006) 1.20

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. Diabetes (2009) 1.16

S6K1 deficiency protects against apoptosis in hepatocytes. Hepatology (2009) 1.11

Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging. Aging Cell (2012) 1.09

Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance. Diabetes (2007) 1.05

Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C. J Hepatol (2010) 1.03

Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer. Lung Cancer (2008) 1.03

Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway. Oncogene (2002) 1.02

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes. Endocrinology (2006) 1.02

Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain. Int J Cancer (2002) 1.02

Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. J Biol Chem (2002) 1.00

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes. Exp Cell Res (2004) 1.00

Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes. J Cell Physiol (2007) 1.00

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology (2004) 0.98

Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Oncol Rep (2007) 0.98

Immunohistochemistry and microsatellite instability testing for selecting MLH1, MSH2 and MSH6 mutation carriers in hereditary non-polyposis colorectal cancer. Oncol Rep (2004) 0.98

Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform. Diabetes (2009) 0.96

Cooperative role of telomerase activity and p16 expression in the prognosis of non-small-cell lung cancer. J Clin Oncol (2002) 0.94

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli. Cell Signal (2009) 0.94

Differential Wnt pathway gene expression and E-cadherin truncation in sporadic colorectal cancers with and without microsatellite instability. Clin Cancer Res (2008) 0.94

Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. J Biol Chem (2003) 0.94

Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinoma. Oncol Rep (2007) 0.93

Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1. Cell Signal (2006) 0.93

Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes. Diabetes (2002) 0.93

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. J Hepatol (2013) 0.92

Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death. Autophagy (2012) 0.92

The brown adipose cell: a unique model for understanding the molecular mechanism of insulin resistance. Mini Rev Med Chem (2005) 0.91

Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration. J Biol Chem (2009) 0.91

Differential colorectal carcinogenesis: Molecular basis and clinical relevance. World J Gastrointest Oncol (2010) 0.90

Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes. Endocrinology (2007) 0.88

Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes. Diabetes (2013) 0.87

Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes. Mol Biol Cell (2004) 0.87

Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function. Mol Med (2012) 0.87

Methylation profiling in non-small cell lung cancer: clinical implications. Int J Oncol (2011) 0.86

Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation. Endocrinology (2003) 0.85

Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2. J Biol Chem (2013) 0.85

cIAP-1, but not XIAP, is cleaved by caspases during the apoptosis induced by TGF-beta in fetal rat hepatocytes. FEBS Lett (2002) 0.84

C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death. Cell Signal (2010) 0.84

Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction. Endocrinology (2012) 0.84

Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes. Endocrinology (2006) 0.84

Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice. J Biol Chem (2012) 0.84

Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes. FEBS Lett (2002) 0.83

Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors. Cancer Res (2002) 0.83

Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity. J Exp Clin Cancer Res (2014) 0.82

Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma. Hepatogastroenterology (2007) 0.82

Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation. Endocrinology (2010) 0.82

PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes. Am J Physiol Gastrointest Liver Physiol (2008) 0.82

Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors. Oncogene (2002) 0.82

MMP-7 and SGCE as distinctive molecular factors in sporadic colorectal cancers from the mutator phenotype pathway. Int J Oncol (2010) 0.82

Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice. Endocrinology (2011) 0.82

p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum. FEBS Lett (2007) 0.81

IL-6 cooperates with peroxisome proliferator-activated receptor-α-ligands to induce liver fatty acid binding protein (LFABP) up-regulation. Liver Int (2013) 0.81

Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes. Am J Physiol Endocrinol Metab (2002) 0.81

Implication of insulin receptor A isoform and IRA/IGF-IR hybrid receptors in the aortic vascular smooth muscle cell proliferation: role of TNF-α and IGF-II. Endocrinology (2013) 0.80

Differential expression of senescence and cell death factors in non-small cell lung and colorectal tumors showing telomere attrition. Oncology (2012) 0.80

Differential impact of p16 inactivation by promoter methylation in non-small cell lung and colorectal cancer: clinical implications. Int J Oncol (2004) 0.80

Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1. PLoS One (2010) 0.79

Telomere function in colorectal cancer. World J Gastrointest Oncol (2009) 0.79

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage. Cardiovasc Diabetol (2014) 0.79

Expression of Human MDGA1 Increases Cell Motility and Cell-Cell Adhesion and Reduces Adhesion to Extracellular Matrix Proteins in MDCK Cells. Cancer Microenviron (2010) 0.78

Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes. J Biol Chem (2003) 0.78

Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice. Am J Pathol (2011) 0.77

Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus. Phytochemistry (2012) 0.77

A (1)H NMR metabolic profiling to the assessment of protein tyrosine phosphatase 1B role in liver regeneration after partial hepatectomy. Biochimie (2012) 0.77

Concerted expression of the thermogenic and bioenergetic mitochondrial protein machinery in brown adipose tissue. J Cell Biochem (2013) 0.77

Impairment of stromelysin-1 transcriptional activity by promoter mutations in high microsatellite instability colorectal tumors. Cancer Res (2005) 0.77

IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes. Mol Cell Endocrinol (2006) 0.77

Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress. Endocrinology (2003) 0.77

[Role of white adipose tissue in vascular complications due to obesity]. Clin Investig Arterioscler (2013) 0.76

PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin-like growth factor-I. J Cell Physiol (2010) 0.75

[Role of brown and perivascular adipose tissue in vascular complications due to obesity]. Clin Investig Arterioscler (2013) 0.75

Measurement invariance of the Satisfaction With Life Scale (SWLS)by country, gender and age. Psicothema (2017) 0.75

Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. FEBS Lett (2003) 0.75