Published in J Leukoc Biol on January 22, 2008
Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest (2009) 2.71
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol (2011) 1.91
Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med (2010) 1.84
Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med (2010) 1.50
A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation. J Immunol (2010) 1.33
Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of TLR4 during sepsis. J Immunol (2013) 1.23
Regulation of lymphocyte trafficking by CXC chemokine receptor 3 during septic shock. Am J Respir Crit Care Med (2011) 1.10
Toll-like receptors and myocardial inflammation. Int J Inflam (2011) 1.03
MyD88 and Trif signaling play distinct roles in cardiac dysfunction and mortality during endotoxin shock and polymicrobial sepsis. Anesthesiology (2011) 1.03
Regulation of MyD88 aggregation and the MyD88-dependent signaling pathway by sequestosome 1 and histone deacetylase 6. J Biol Chem (2010) 1.02
Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages. Shock (2009) 1.00
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology (2010) 0.98
Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity. Am J Respir Crit Care Med (2009) 0.97
Lymphocytes, apoptosis and sepsis: making the jump from mice to humans. Crit Care (2009) 0.95
Nonhematopoietic toll-like receptor 2 contributes to neutrophil and cardiac function impairment during polymicrobial sepsis. Shock (2011) 0.92
IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model. J Leukoc Biol (2012) 0.91
Sepsis: links between pathogen sensing and organ damage. Curr Pharm Des (2008) 0.90
Toll-like receptors 2 and 4 contribute to sepsis-induced depletion of spleen dendritic cells. Infect Immun (2009) 0.90
Innate immunity and inflammation in sepsis: mechanisms of suppressed host resistance in mice treated with ethanol in a binge-drinking model. Toxicol Sci (2010) 0.88
A historical perspective on sepsis. Am J Pathol (2012) 0.88
STAT1-deficient mice are resistant to cecal ligation and puncture-induced septic shock. Shock (2012) 0.85
Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis. PLoS One (2015) 0.85
Induction and termination of inflammatory signaling in group B streptococcal sepsis. Immunol Rev (2008) 0.84
Neuropilin-1(high)CD4(+)CD25(+) Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators Inflamm (2016) 0.84
G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice. J Innate Immun (2013) 0.83
Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Sci Rep (2015) 0.82
Toll-like receptor 4 is essential to preserving cardiac function and survival in low-grade polymicrobial sepsis. Anesthesiology (2014) 0.81
Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis. J Leukoc Biol (2013) 0.81
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. J Immunol (2014) 0.78
Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration. Nat Commun (2014) 0.78
Toll-like receptor 4 stimulation before or after Streptococcus pneumoniae induced sepsis improves survival and is dependent on T-cells. PLoS One (2014) 0.77
MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS One (2014) 0.77
Editorial: Control issues in sepsis: what modulates apoptosis? J Leukoc Biol (2011) 0.75
The role of myeloid differentiation factor 88 on mitochondrial dysfunction of peritoneal leukocytes during polymicrobial sepsis. Cent Eur J Immunol (2016) 0.75
Tuftsin prevents the negative immunoregulation of neuropilin-1highCD4+CD25+regulatory T cells and improves survival rate in septic mice. Oncotarget (2016) 0.75
Blood-Brain Barrier Deterioration and Hippocampal Gene Expression in Polymicrobial Sepsis: An Evaluation of Endothelial MyD88 and the Vagus Nerve. PLoS One (2016) 0.75
Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA (2011) 7.10
Cell death. N Engl J Med (2009) 4.75
The sepsis seesaw: tilting toward immunosuppression. Nat Med (2009) 3.95
Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med (2013) 3.25
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 2.98
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol (2010) 2.81
The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Crit Care Med (2015) 2.81
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol (2005) 2.70
Abandon the mouse research ship? Not just yet! Shock (2014) 2.60
Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science (2002) 2.51
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol (2009) 2.27
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA (2002) 2.20
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med (2002) 2.20
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol (2009) 1.91
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86
Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med (2003) 1.83
Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol (2003) 1.76
Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun (2010) 1.76
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J (2007) 1.73
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock (2003) 1.73
Effects of aging on the immunopathologic response to sepsis. Crit Care Med (2009) 1.72
Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc Natl Acad Sci U S A (2003) 1.71
Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock (2004) 1.68
Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med (2010) 1.68
High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit Care Med (2004) 1.54
Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2004) 1.54
A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Mol Cancer Ther (2010) 1.53
Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit Care Med (2005) 1.49
Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer (2007) 1.46
Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res (2007) 1.44
Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem (2014) 1.43
TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol (2006) 1.41
Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest (2009) 1.41
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care (2012) 1.41
Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2006) 1.40
Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Crit Care (2013) 1.37
Myeloperoxidase produces nitrating oxidants in vivo. J Clin Invest (2002) 1.35
Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock (2014) 1.30
Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. J Surg Res (2008) 1.30
Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer. Cancer Res (2012) 1.30
Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock (2011) 1.26
Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock (2006) 1.26
Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infect Immun (2010) 1.25
Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels. Am J Physiol Regul Integr Comp Physiol (2005) 1.24
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J Exp Med (2005) 1.22
The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. J Immunol (2006) 1.22
Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology (2011) 1.21
Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis. Shock (2008) 1.19
Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis. Shock (2008) 1.16
Parallels between cancer and infectious disease. N Engl J Med (2014) 1.16
CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis. FASEB J (2009) 1.14
Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med (2010) 1.14
Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol (2010) 1.13
Targeted delivery of siRNA to cell death proteins in sepsis. Shock (2009) 1.12
Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy. Am J Physiol Gastrointest Liver Physiol (2010) 1.11
Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. J Infect Dis (2012) 1.10