Published in J Immunol on December 21, 2009
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Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells (2010) 2.72
Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg (2012) 2.24
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Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Infect Immun (2012) 1.12
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Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade. PLoS One (2012) 0.98
Adenosine negative feedback on A2A adenosine receptors mediates hyporesponsiveness in chronically septic mice. Shock (2011) 0.96
Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection. J Immunol (2013) 0.95
Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. J Immunol (2014) 0.95
Impact of sepsis on CD4 T cell immunity. J Leukoc Biol (2014) 0.94
T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression. Crit Rev Immunol (2013) 0.91
Revisiting caspases in sepsis. Cell Death Dis (2014) 0.91
Potential role of porcine reproductive and respiratory syndrome virus structural protein GP2 in apoptosis inhibition. Biomed Res Int (2014) 0.90
Persistent inflammation and T cell exhaustion in severe sepsis in the elderly. Crit Care (2014) 0.90
Critical role of cRel subunit of NF-κB in sepsis survival. Infect Immun (2011) 0.89
Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response. Eur J Clin Microbiol Infect Dis (2013) 0.89
Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia. J Immunol (2014) 0.89
Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis. J Immunol (2014) 0.88
Sepsis induced immunosuppression: Implications for secondary infections and complications. Indian J Crit Care Med (2013) 0.87
Prevention of lymphocyte apoptosis in septic mice with cancer increases mortality. J Immunol (2011) 0.86
Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome. Crit Care Med (2016) 0.86
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function. PLoS One (2014) 0.85
Role of NK cells in host defense against pulmonary type A Francisella tularensis infection. Microbes Infect (2012) 0.85
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
Galectin-9 prolongs the survival of septic mice by expanding Tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages. Crit Care (2013) 0.85
Acute-Phase Deaths from Murine Polymicrobial Sepsis Are Characterized by Innate Immune Suppression Rather Than Exhaustion. J Immunol (2015) 0.84
G-protein-coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in a polymicrobial sepsis model in mice. J Innate Immun (2013) 0.83
Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model. Crit Care Med (2017) 0.83
Differential alterations of tissue T-cell subsets after sepsis. Immunol Lett (2015) 0.82
Alterations of dendritic cells in sepsis: featured role in immunoparalysis. Biomed Res Int (2015) 0.82
Blood dendritic cells: "canary in the coal mine" to predict chronic inflammatory disease? Front Microbiol (2014) 0.82
N-terminal pro-C-natriuretic peptide and cytokine kinetics in dogs with endotoxemia. J Vet Intern Med (2014) 0.81
Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour? Pathog Dis (2013) 0.81
CD1d- and MR1-Restricted T Cells in Sepsis. Front Immunol (2015) 0.81
Emerging therapeutic targets of sepsis-associated acute kidney injury. Semin Nephrol (2015) 0.81
Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol (2015) 0.80
Removal of regulatory T cells prevents secondary chronic infection but increases the mortality of subsequent sub-acute infection in sepsis mice. Oncotarget (2016) 0.80
Role of circulating lymphocytes in patients with sepsis. Biomed Res Int (2014) 0.80
Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression. Pharmacol Res (2016) 0.79
IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production. J Immunol (2015) 0.79
The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol (2017) 0.79
Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies-A review. Oncoimmunology (2015) 0.78
The immune system's role in sepsis progression, resolution, and long-term outcome. Immunol Rev (2016) 0.78
IL-15 Superagonist Expands mCD8+ T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection. PLoS One (2016) 0.78
IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function. J Immunol (2016) 0.76
Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression? PLoS One (2013) 0.76
Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis. Crit Care Med (2017) 0.76
Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity. Crit Rev Immunol (2016) 0.76
Dying to protect: cell death and the control of T-cell homeostasis. Immunol Rev (2017) 0.75
Human AdV-specific T cells: persisting in vitro functionality despite lethal irradiation. Bone Marrow Transplant (2014) 0.75
Natural Killer Cell Assessment in Peripheral Circulation and Bronchoalveolar Lavage Fluid of Patients with Severe Sepsis: A Case Control Study. Int J Mol Sci (2017) 0.75
Escherichia coli-induced immune paralysis is not exacerbated during chronic filarial infection. Immunology (2015) 0.75
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog (2017) 0.75
Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer's disease, and neuronal injury in humans: a cohort study. J Neuroinflammation (2017) 0.75
The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med (2000) 9.78
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol (2006) 6.22
Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity (2007) 5.50
Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med (1997) 5.19
Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol (2006) 4.98
Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol (2006) 4.82
The role of BH3-only proteins in the immune system. Nat Rev Immunol (2005) 4.69
Interleukin 15: biology and relevance to human disease. Blood (2001) 4.47
Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA (2008) 4.19
The sepsis seesaw: tilting toward immunosuppression. Nat Med (2009) 3.95
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med (2003) 3.89
Pathophysiology of sepsis. Am J Pathol (2007) 3.19
The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol (2006) 3.11
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}. Proc Natl Acad Sci U S A (2006) 3.04
IL-15 and IL-2: a matter of life and death for T cells in vivo. Nat Med (2001) 2.29
Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation. Am J Respir Crit Care Med (2007) 2.27
Interleukin-15 protects from lethal apoptosis in vivo. Nat Med (1997) 2.22
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA (2002) 2.20
IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med (2007) 2.00
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97
Effect of sepsis on tissue adenine nucleotide levels. Surgery (1979) 1.91
Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action. J Immunol (2008) 1.85
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J (2007) 1.73
IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis. Proc Natl Acad Sci U S A (2008) 1.72
Injury, sepsis, and the regulation of Toll-like receptor responses. J Leukoc Biol (2003) 1.71
Cytokines in host defense against Salmonella. Microbes Infect (2001) 1.48
Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity. J Biol Chem (2007) 1.47
The apoptotic pathway as a therapeutic target in sepsis. Curr Drug Targets (2007) 1.47
CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15. J Immunol (2002) 1.31
Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Infect Immun (2000) 1.29
Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock (2006) 1.26
Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.23
The pleiotropic functions of interleukin 15: not so interleukin 2-like after all. J Exp Med (2000) 1.22
Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis. Shock (2008) 1.16
Targeted delivery of siRNA to cell death proteins in sepsis. Shock (2009) 1.12
Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis. J Infect Dis (2003) 1.06
Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages. Shock (2009) 1.00
Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury. J Leukoc Biol (2008) 0.99
IL-15-induced CD8+CD122+ T cells increase antibacterial and anti-tumor immune responses: implications for immune function in aged mice. J Leukoc Biol (2008) 0.86
Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA (2011) 7.10
Cell death. N Engl J Med (2009) 4.75
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity (2008) 4.37
The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci (2012) 4.11
The sepsis seesaw: tilting toward immunosuppression. Nat Med (2009) 3.95
Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med (2013) 3.25
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 2.98
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol (2010) 2.81
The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Crit Care Med (2015) 2.81
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol (2005) 2.70
Abandon the mouse research ship? Not just yet! Shock (2014) 2.60
Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science (2002) 2.51
Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock (2007) 2.37
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med (2002) 2.34
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol (2009) 2.27
Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol (2002) 2.25
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA (2002) 2.20
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med (2002) 2.20
Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med (2006) 2.18
Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients. Crit Care Med (2005) 2.09
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86
Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med (2003) 1.83
Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol (2003) 1.76
Mitochondrial resuscitation with exogenous cytochrome c in the septic heart. Crit Care Med (2007) 1.76
Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun (2010) 1.76
Noncanonical autophagy promotes the visual cycle. Cell (2013) 1.74
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J (2007) 1.73
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock (2003) 1.73
Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest (2007) 1.72
Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med (2002) 1.72
Effects of aging on the immunopathologic response to sepsis. Crit Care Med (2009) 1.72
Prevalence and cost of full-time research fellowships during general surgery residency: a national survey. Ann Surg (2009) 1.71
Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc Natl Acad Sci U S A (2003) 1.71
Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med (2010) 1.68
Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock (2004) 1.68
Interaction of ICP34.5 with Beclin 1 modulates herpes simplex virus type 1 pathogenesis through control of CD4+ T-cell responses. J Virol (2009) 1.67
The Accreditation Council for Graduate Medical Education resident duty hour new standards: history, changes, and impact on staffing of intensive care units. Crit Care Med (2011) 1.60
Prevention of lymphocyte apoptosis--a potential treatment of sepsis? Clin Infect Dis (2005) 1.58
Tracheostomy protocol: experience with development and potential utility. Crit Care Med (2008) 1.56
High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit Care Med (2004) 1.54
Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol (2008) 1.54
Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2004) 1.54
A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Mol Cancer Ther (2010) 1.53
Patient safety event reporting in critical care: a study of three intensive care units. Crit Care Med (2007) 1.51
Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit Care Med (2005) 1.49
Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration. Invest Ophthalmol Vis Sci (2013) 1.48
Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis. Crit Care (2014) 1.48
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest (2007) 1.47
Prescribing patterns of hydrocortisone in septic shock: a single-center experience of how surviving sepsis guidelines are interpreted and translated into bedside practice. Crit Care Med (2013) 1.47
Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer (2007) 1.46
Treatment of hypophosphatemia using a protocol based on patient weight and serum phosphorus level in a surgical intensive care unit. J Am Coll Surg (2004) 1.45
Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res (2007) 1.44
Impact of a methicillin-resistant Staphylococcus aureus active surveillance program on contact precaution utilization in a surgical intensive care unit. Crit Care Med (2007) 1.44
Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem (2014) 1.43
Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age. Pediatr Crit Care Med (2008) 1.43
Genetic research and testing in critical care: surrogates' perspective. Crit Care Med (2006) 1.42
Providing care for critically ill surgical patients: challenges and recommendations. JAMA Surg (2013) 1.42
Examination of non-clinical factors affecting tracheostomy practice in an academic surgical intensive care unit. Crit Care Med (2009) 1.42
TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol (2006) 1.41
Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest (2009) 1.41
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care (2012) 1.41
Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2006) 1.40