Published in Anesthesiology on December 01, 2011
Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin Pediatr Surg (2013) 0.98
Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock. Crit Care (2013) 0.94
PD-L1 blockade attenuated sepsis-induced liver injury in a mouse cecal ligation and puncture model. Mediators Inflamm (2013) 0.87
Immunological monitoring to prevent and treat sepsis. Crit Care (2013) 0.87
Sepsis induced immunosuppression: Implications for secondary infections and complications. Indian J Crit Care Med (2013) 0.87
A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients' plasma. J Transl Med (2014) 0.86
Dysregulation in microRNA expression in peripheral blood mononuclear cells of sepsis patients is associated with immunopathology. Cytokine (2014) 0.85
Neuropilin-1(high)CD4(+)CD25(+) Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators Inflamm (2016) 0.84
Endotoxin-induced lung alveolar cell injury causes brain cell damage. Exp Biol Med (Maywood) (2014) 0.83
Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Sci Rep (2015) 0.82
The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood. Clin Exp Immunol (2015) 0.79
S100A8/A9 mRNA induction in an ex vivo model of endotoxin tolerance: roles of IL-10 and IFNγ. PLoS One (2014) 0.78
Blockade of ICAM-1 improves the outcome of polymicrobial sepsis via modulating neutrophil migration and reversing immunosuppression. Mediators Inflamm (2014) 0.78
Prospective Testing and Redesign of a Temporal Biomarker Based Risk Model for Patients With Septic Shock: Implications for Septic Shock Biology. EBioMedicine (2015) 0.77
The immune response: targets for the treatment of severe sepsis. Int J Inflam (2012) 0.77
Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators Inflamm (2015) 0.77
Combination therapy with thymosin alpha1 and dexamethasone helps mice survive sepsis. Inflammation (2014) 0.76
Selective endothelin-A receptor blockade attenuates endotoxin-induced pulmonary hypertension and pulmonary vascular dysfunction. Pulm Circ (2014) 0.76
Heterogeneity among septic shock patients in a set of immunoregulatory markers. Eur J Clin Microbiol Infect Dis (2013) 0.76
Mice Survival and Plasmatic Cytokine Secretion in a "Two Hit" Model of Sepsis Depend on Intratracheal Pseudomonas Aeruginosa Bacterial Load. PLoS One (2016) 0.75
Decoy Receptor 3 Improves Survival in Experimental Sepsis by Suppressing the Inflammatory Response and Lymphocyte Apoptosis. PLoS One (2015) 0.75
Corticotropin-releasing hormone improves survival in pneumococcal pneumonia by reducing pulmonary inflammation. Physiol Rep (2017) 0.75
Tuftsin prevents the negative immunoregulation of neuropilin-1highCD4+CD25+regulatory T cells and improves survival rate in septic mice. Oncotarget (2016) 0.75
The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression. Mediators Inflamm (2017) 0.75
Detecting the Hidden Properties of Immunological Data and Predicting the Mortality Risks of Infectious Syndromes. Front Immunol (2016) 0.75
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62
The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol (2010) 17.13
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA (2002) 16.37
Hydrocortisone therapy for patients with septic shock. N Engl J Med (2008) 15.85
Sepsis in European intensive care units: results of the SOAP study. Crit Care Med (2006) 11.78
International study of the prevalence and outcomes of infection in intensive care units. JAMA (2009) 11.57
Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med (2008) 11.00
Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N Engl J Med (1991) 9.99
Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis (2008) 8.58
Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med (2010) 8.58
Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med (2005) 8.55
Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest (1999) 7.40
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med (1999) 7.24
Immunosuppressive effects of apoptotic cells. Nature (1997) 7.03
Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA (2008) 6.29
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med (2008) 5.30
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med (1996) 5.25
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet (2007) 5.23
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med (2009) 4.98
Evolving functions of endothelial cells in inflammation. Nat Rev Immunol (2007) 4.94
Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. Lancet (2007) 4.81
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A (2003) 4.56
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol (2001) 4.49
Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med (2010) 4.39
The enigma of sepsis. J Clin Invest (2003) 4.32
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci U S A (2009) 4.23
Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin. Antimicrob Agents Chemother (2008) 4.21
Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA (2008) 4.19
Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med (2003) 4.18
Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med (2006) 4.10
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med (1987) 3.89
Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet (1998) 3.71
Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest (1991) 3.62
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell (2011) 3.61
Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med (2008) 3.48
Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy. Clin Infect Dis (2007) 3.30
Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit Care Med (2009) 3.23
Pathophysiology of sepsis. Am J Pathol (2007) 3.19
Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol (2002) 3.16
Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med (2008) 2.93
Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest (2009) 2.92
Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med (2001) 2.82
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol (2010) 2.81
Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial. Crit Care Med (1994) 2.66
Bundled care for septic shock: an analysis of clinical trials. Crit Care Med (2010) 2.57
The pathogenesis of sepsis. Annu Rev Pathol (2011) 2.55
Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother (2007) 2.49
Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med (2006) 2.47
Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med (2010) 2.31
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29
Point: adherence to early goal-directed therapy: does it really matter? Yes. After a decade, the scientific proof speaks for itself. Chest (2010) 2.27
Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation. Am J Respir Crit Care Med (2007) 2.27
Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol (2002) 2.25
Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood (1995) 2.20
Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol (2005) 2.17
Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay. Crit Care Med (2011) 2.16
Treatment-related risk factors for hospital mortality in Candida bloodstream infections. Crit Care Med (2008) 2.06
Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg (1990) 2.05
The toll of innate immunity on microbial pathogens. N Engl J Med (1999) 1.98
Regulatory T cell populations in sepsis and trauma. J Leukoc Biol (2007) 1.96
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med (2010) 1.95
Macroscopic postmortem findings in 235 surgical intensive care patients with sepsis. Anesth Analg (2009) 1.95
Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Crit Care Med (2008) 1.94
Sepsis. Am J Med (2007) 1.93
Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment. Crit Care Med (2006) 1.86
Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. J Antimicrob Chemother (2009) 1.73
Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms. Antimicrob Agents Chemother (2007) 1.66
Pseudomonas aeruginosa infections in the Intensive Care Unit: can the adequacy of empirical beta-lactam antibiotic therapy be improved? Int J Antimicrob Agents (2007) 1.64
Counterpoint: adherence to early goal-directed therapy: does it really matter? No. Both risks and benefits require further study. Chest (2010) 1.62
Empiric antibiotic therapy for suspected ventilator-associated pneumonia: a systematic review and meta-analysis of randomized trials. Crit Care Med (2008) 1.61
PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest (2010) 1.53
Toll receptors: a central element in innate immune responses. Infect Immun (2002) 1.53
First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis. Int J Antimicrob Agents (2009) 1.52
The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proc Natl Acad Sci U S A (2008) 1.44
Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia. J Infect Dis (2003) 1.44
Efficacy and safety of dopamine versus norepinephrine in the management of septic shock. Shock (2010) 1.43
Impaired production of interferon-gamma and tumor necrosis factor-alpha but not of interleukin 10 in whole blood of patients with sepsis. Shock (2003) 1.35
Evidence for separate genetic defects in C3H/HeJ and C3HeB/FeJ mice, that affect susceptibility to gram-negative infections. J Immunol (1985) 1.32
Using local microbiologic data to develop institution-specific guidelines for the treatment of hospital-acquired pneumonia. Chest (2006) 1.29
Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis. Antimicrob Agents Chemother (2010) 1.27
Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock (2011) 1.26
Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines. J Infect Dis (2005) 1.23
Influence of previous exposure to antibiotic therapy on the susceptibility pattern of Pseudomonas aeruginosa bacteremic isolates. Clin Infect Dis (2001) 1.22
Experimental therapeutic strategies for severe sepsis: mediators and mechanisms. Ann N Y Acad Sci (2008) 1.20
Downregulation of CD40 ligand response in monocytes from sepsis patients. Clin Vaccine Immunol (2008) 1.20
Germs. N Engl J Med (1972) 1.15
Outcomes of bacteremia due to Pseudomonas aeruginosa with reduced susceptibility to piperacillin-tazobactam: implications on the appropriateness of the resistance breakpoint. Clin Infect Dis (2008) 1.15
A case of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia. J Antimicrob Chemother (2010) 1.14
Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA (2011) 7.10
Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med (2013) 3.25
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 2.98
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol (2010) 2.81
The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Crit Care Med (2015) 2.81
Abandon the mouse research ship? Not just yet! Shock (2014) 2.60
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol (2009) 2.27
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA (2002) 2.20
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med (2002) 2.20
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol (2009) 1.91
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86
Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med (2003) 1.83
Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol (2003) 1.76
Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun (2010) 1.76
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J (2007) 1.73
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock (2003) 1.73
Effects of aging on the immunopathologic response to sepsis. Crit Care Med (2009) 1.72
Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock (2004) 1.68
Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med (2010) 1.68
High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit Care Med (2004) 1.54
Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol (2008) 1.54
Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2004) 1.54
A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Mol Cancer Ther (2010) 1.53
Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit Care Med (2005) 1.49
Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer (2007) 1.46
Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res (2007) 1.44
Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem (2014) 1.43
Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest (2009) 1.41
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care (2012) 1.41
Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2006) 1.40
Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Crit Care (2013) 1.37
Myeloperoxidase produces nitrating oxidants in vivo. J Clin Invest (2002) 1.35
Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock (2014) 1.30
Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. J Surg Res (2008) 1.30
Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock (2011) 1.26
Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock (2006) 1.26
Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infect Immun (2010) 1.25
Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels. Am J Physiol Regul Integr Comp Physiol (2005) 1.24
The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. J Immunol (2006) 1.22
Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis. Shock (2008) 1.19
Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis. Shock (2008) 1.16
Parallels between cancer and infectious disease. N Engl J Med (2014) 1.16
CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis. FASEB J (2009) 1.14
Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med (2010) 1.14
Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol (2010) 1.13
Targeted delivery of siRNA to cell death proteins in sepsis. Shock (2009) 1.12
Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. J Infect Dis (2012) 1.10
Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium. Shock (2004) 1.07
Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma. J Transl Med (2009) 1.03
Molecular diagnostics in sepsis: from bedside to bench. J Am Coll Surg (2006) 1.02
Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages. Shock (2009) 1.00
Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia. Shock (2003) 1.00
Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis. J Am Coll Surg (2006) 0.99
Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury. J Leukoc Biol (2008) 0.99
Leukocyte phenotyping to stratify septic shock patients. Crit Care (2009) 0.99
Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. Am J Physiol Heart Circ Physiol (2003) 0.98
TAT-Bim induces extensive apoptosis in cancer cells. Ann Surg Oncol (2007) 0.97
Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis. J Immunol (2010) 0.97
Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock (2015) 0.97
Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum (2010) 0.95
Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. J Med Chem (2007) 0.94
Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections. Emerg Infect Dis (2007) 0.93
Probiotics for preventing ventilator-associated pneumonia. Cochrane Database Syst Rev (2014) 0.93
Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo. Am J Physiol Regul Integr Comp Physiol (2007) 0.92
Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer Res (2011) 0.92
Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. Crit Care Med (2002) 0.92
Body temperature patterns as a predictor of hospital-acquired sepsis in afebrile adult intensive care unit patients: a case-control study. Crit Care (2013) 0.92
Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival. Shock (2003) 0.92
Lymphocyte phenotyping to distinguish septic from nonseptic critical illness. J Am Coll Surg (2007) 0.91
Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes. Mol Imaging (2011) 0.89
Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis. Shock (2006) 0.88
Development of a new humanized mouse model to study acute inflammatory arthritis. J Transl Med (2012) 0.87
BTLA as a biomarker and mediator of sepsis-induced immunosuppression. Crit Care (2013) 0.87
An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochem Biophys Res Commun (2009) 0.87
Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma. Int J Cancer (2009) 0.86
Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Nucl Med Biol (2011) 0.85
Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. FASEB J (2007) 0.85
Endothelial cell apoptosis in sepsis: a case of habeas corpus? Crit Care Med (2004) 0.84
Anti-apoptotic peptides protect against radiation-induced cell death. Biochem Biophys Res Commun (2007) 0.84
Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells. Hepatology (2003) 0.84
TLR3 agonist improves survival to secondary pneumonia in a double injury model. J Surg Res (2012) 0.83
Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis. Shock (2008) 0.83
Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department. Shock (2014) 0.83
Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury. PLoS One (2013) 0.82
The first step in utilizing immune-modulating therapies: immune status determination. Crit Care (2011) 0.82
Iron dysregulation combined with aging prevents sepsis-induced apoptosis. J Surg Res (2005) 0.82
Adoptive transfer of dying cells causes bystander-induced apoptosis. Biochem Biophys Res Commun (2006) 0.82
Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis. Crit Care Med (2017) 0.82
CD4+ lymphocyte adenosine triphosphate determination in sepsis: a cohort study. Crit Care (2010) 0.80
Change in temperature profile may precede fever and be an early indicator of sepsis: a case report. Shock (2011) 0.79
Counterpoint: Should antipyretic therapy be given routinely to febrile patients in septic shock? No. Chest (2013) 0.79
Sequence makes a difference: paradoxical effects of stress in vivo. Shock (2004) 0.77
The authors reply. Crit Care Med (2015) 0.75
Reply: The role of arrhythmias in defining cardiac dysfunction during sepsis. Am J Respir Crit Care Med (2013) 0.75
A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome. Crit Care Med (2017) 0.75
Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis. Crit Care Med (2017) 0.75
Therapeutic Hyperthermia Is Associated With Improved Survival in Afebrile Critically Ill Patients With Sepsis: A Pilot Randomized Trial. Crit Care Med (2022) 0.75
Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go! Crit Care Med (2017) 0.75