Parallels between cancer and infectious disease.

Sepsis-induced immune dysfunction: can immune therapies reduce mortality? J Clin Invest (2016) 1.02

Immune checkpoint inhibitors in clinical trials. Chin J Cancer (2014) 0.98

Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock (2015) 0.97

Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv Nutr (2015) 0.89

Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients. PLoS One (2015) 0.87

Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome. Crit Care Med (2016) 0.86

Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85

A Review of GM-CSF Therapy in Sepsis. Medicine (Baltimore) (2015) 0.84

Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock. Ann Surg (2016) 0.84

Tryptophan Catabolism in Chronic Viral Infections: Handling Uninvited Guests. Int J Tryptophan Res (2015) 0.83

Sepsis: Preventing organ failure in sepsis - the search continues. Nat Rev Nephrol (2016) 0.81

Murine Lung Cancer Increases CD4+ T Cell Apoptosis and Decreases Gut Proliferative Capacity in Sepsis. PLoS One (2016) 0.78

The immune system's role in sepsis progression, resolution, and long-term outcome. Immunol Rev (2016) 0.78

Anti-PD-L1 peptide improves survival in sepsis. J Surg Res (2016) 0.76

ABCB1 transporter and Toll-like receptor 4 in trabecular meshwork cells. Mol Vis (2015) 0.76

Novel GM-CSF-based vaccines: One small step in GM-CSF gene optimization, one giant leap for human vaccines. Hum Vaccin Immunother (2016) 0.75

Hepatitis C virus drives the pathogenesis of hepatocellular carcinoma: from immune evasion to carcinogenesis. Clin Transl Immunology (2016) 0.75

Engineering control into medicine. J Crit Care (2015) 0.75

Adjunct Strategies for Tuberculosis Vaccines: Modulating Key Immune Cell Regulatory Mechanisms to Potentiate Vaccination. Front Immunol (2016) 0.75

Persistent Inflammation, Immunosuppression and Catabolism Syndrome. Crit Care Clin (2017) 0.75

Community deworming alleviates geohelminth-induced immune hyporesponsiveness. Proc Natl Acad Sci U S A (2016) 0.75

The Monocyte That Wasn't. Crit Care Med (2015) 0.75

Applying Precision Medicine and Immunotherapy Advances from Oncology to Host-Directed Therapies for Infectious Diseases. Front Immunol (2017) 0.75

Nutrition Support for Persistent Inflammation, Immunosuppression, and Catabolism Syndrome. Nutr Clin Pract (2017) 0.75

Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis. Crit Care Med (2017) 0.75

Is this critically ill patient immunocompromised? Intensive Care Med (2015) 0.75

Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74

A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60

Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA (2011) 7.10

A genomic storm in critically injured humans. J Exp Med (2011) 6.67

MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48

Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49

Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med (2013) 3.25

Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 2.98

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol (2010) 2.81

The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Crit Care Med (2015) 2.81

Abandon the mouse research ship? Not just yet! Shock (2014) 2.60

Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics (2005) 2.50

Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30

IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29

Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol (2009) 2.27

High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics (2006) 2.25

Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg (2012) 2.24

Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA (2002) 2.20

Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med (2002) 2.20

Anti-TNF-alpha therapies: the next generation. Nat Rev Drug Discov (2003) 2.18

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med (2012) 2.17

Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07

A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med (2010) 2.06

Clinical microfluidics for neutrophil genomics and proteomics. Nat Med (2010) 2.02

B cells enhance early innate immune responses during bacterial sepsis. J Exp Med (2011) 1.99

Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry. Proteomics (2005) 1.94

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med (2013) 1.94

Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood (2008) 1.94

IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol (2009) 1.91

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86

Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol (2006) 1.86

Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med (2003) 1.83

Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A (2006) 1.82

Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug. Crit Care Med (2002) 1.78

Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol (2003) 1.76

Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun (2010) 1.76

Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun (2003) 1.75

Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes. Hepatology (2008) 1.73

Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J (2007) 1.73

Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock (2003) 1.73

Effects of aging on the immunopathologic response to sepsis. Crit Care Med (2009) 1.72

CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol (2005) 1.71

Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock (2005) 1.71

Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med (2010) 1.68

Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock (2004) 1.68

Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis. Crit Care Med (2007) 1.63

A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med (2014) 1.62

Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A (2011) 1.62

Continuous flow microfluidic device for rapid erythrocyte lysis. Anal Chem (2004) 1.61

CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med (2004) 1.58

Role of Toll-like receptors in the development of sepsis. Shock (2008) 1.57

High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit Care Med (2004) 1.54

Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol (2008) 1.54

Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2004) 1.54

Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol (2010) 1.54

A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Mol Cancer Ther (2010) 1.53

Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock (2007) 1.50

Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med (2010) 1.50

Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit Care Med (2005) 1.49

A genomic score prognostic of outcome in trauma patients. Mol Med (2009) 1.48

Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer (2007) 1.46

Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res (2007) 1.44

Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem (2014) 1.43

Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse. Clin Immunol (2004) 1.41

Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest (2009) 1.41

A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care (2012) 1.41

Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2006) 1.40

Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Crit Care (2013) 1.37

Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol (2004) 1.36

Myeloperoxidase produces nitrating oxidants in vivo. J Clin Invest (2002) 1.35

Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33

Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock (2014) 1.30

Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. J Surg Res (2008) 1.30

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood (2007) 1.29

Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients. Ann Surg (2010) 1.27

Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock (2011) 1.26

Cost and Mortality Associated With Postoperative Acute Kidney Injury. Ann Surg (2015) 1.26

Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock (2006) 1.26

Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infect Immun (2010) 1.25

Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels. Am J Physiol Regul Integr Comp Physiol (2005) 1.24

Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled "universal" reference sample. J Proteome Res (2009) 1.24

Preclinical models of shock and sepsis: what can they tell us? Shock (2005) 1.23

The origins of cachexia in acute and chronic inflammatory diseases. Nutr Clin Pract (2006) 1.23

The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. J Immunol (2006) 1.22

Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol (2011) 1.21

Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology (2011) 1.21

Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis. Circulation (2002) 1.19

Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis. Shock (2008) 1.19

Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis. Shock (2008) 1.16

Role of innate immunity in neonatal infection. Am J Perinatol (2013) 1.16

Biology of interleukin-10 and its regulatory roles in sepsis syndromes. Crit Care Med (2005) 1.16

CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis. FASEB J (2009) 1.14

Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med (2010) 1.14

Biology of tumor necrosis factor-alpha- implications for psoriasis. Exp Dermatol (2004) 1.14

Cytokine profile after lung transplantation: correlation with allograft injury. Ann Thorac Surg (2006) 1.13

Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol (2010) 1.13

Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol (2005) 1.12

Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes. Diabetes (2011) 1.12