PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib.

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Published in Cancer Res on December 15, 2007

Authors

Jeffrey A Engelman1, Kreshnik Zejnullahu, Christopher-Michael Gale, Eugene Lifshits, Andrea J Gonzales, Takeshi Shimamura, Feng Zhao, Patrick W Vincent, George N Naumov, James E Bradner, Irene W Althaus, Leena Gandhi, Geoffrey I Shapiro, James M Nelson, John V Heymach, Matthew Meyerson, Kwok-Kin Wong, Pasi A Jänne

Author Affiliations

1: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

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