Evaluation of glucose homeostasis.

TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab (2009) 6.91

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech (2010) 3.27

The metabolic footprint of aging in mice. Sci Rep (2011) 1.93

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med (2012) 1.66

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell (2011) 1.55

A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss. Am J Physiol Endocrinol Metab (2009) 1.54

Glucose metabolism and pancreatic defects in spinal muscular atrophy. Ann Neurol (2012) 1.17

Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass. PLoS One (2012) 1.06

Ppargamma2 is a key driver of longevity in the mouse. PLoS Genet (2009) 1.04

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet. Am J Physiol Endocrinol Metab (2013) 1.04

Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther (2013) 0.95

The challenges for molecular nutrition research 2: quantification of the nutritional phenotype. Genes Nutr (2008) 0.92

Integrative miRNA-mRNA profiling of adipose tissue unravels transcriptional circuits induced by sleep fragmentation. PLoS One (2012) 0.92

Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis. Endocrinology (2014) 0.89

Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice. Diabetologia (2011) 0.88

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest (2013) 0.88

Intergenerational effects of prenatal ethanol on glucose tolerance and insulin response. Physiol Genomics (2014) 0.87

Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice. Nutr Res (2010) 0.87

Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS One (2013) 0.87

Elastin-derived peptides are new regulators of insulin resistance development in mice. Diabetes (2013) 0.86

Early-onset type 2 diabetes impairs skeletal acquisition in the male TALLYHO/JngJ mouse. Endocrinology (2014) 0.86

Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome. Int J Mol Sci (2017) 0.83

Antidiabetic effects of chamomile flowers extract in obese mice through transcriptional stimulation of nutrient sensors of the peroxisome proliferator-activated receptor (PPAR) family. PLoS One (2013) 0.81

Wild blueberries (Vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet. PLoS One (2014) 0.81

Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1. J Biol Chem (2015) 0.81

Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease. EMBO Mol Med (2014) 0.81

In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes. Mamm Genome (2014) 0.77

Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans. J Clin Endocrinol Metab (2015) 0.77

Osteoid osteoma is an osteocalcinoma affecting glucose metabolism. Osteoporos Int (2011) 0.76

Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice. Physiol Behav (2015) 0.76

Natural killer T cells in adipose tissue are activated in lean mice. Exp Anim (2013) 0.75

A novel mathematical model detecting early individual changes of insulin resistance. Diabetes Technol Ther (2013) 0.75

Ire1α in Pomc Neurons is Required for Thermogenesis and Glycemia. Diabetes (2016) 0.75

Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span. Aging Cell (2017) 0.75

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36

Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature (2006) 9.36

TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab (2009) 6.91

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65

Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov (2008) 4.43

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab (2008) 4.36

SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31

Mitonuclear protein imbalance as a conserved longevity mechanism. Nature (2013) 4.18

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol (2009) 4.09

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A (2003) 4.03

A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab (2006) 3.22

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab (2012) 3.18

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) (2009) 3.15

Endocrine functions of bile acids. EMBO J (2006) 3.03

Nuclear receptors and the control of metabolism. Annu Rev Physiol (2002) 3.00

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr (2011) 2.98

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell (2011) 2.75

E2Fs regulate adipocyte differentiation. Dev Cell (2002) 2.71

Sirtuins: the 'magnificent seven', function, metabolism and longevity. Ann Med (2007) 2.64

The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell (2002) 2.61

Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology (2003) 2.59

Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol (2007) 2.40

Sirtuin functions in health and disease. Mol Endocrinol (2007) 2.38

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell (2004) 2.31

Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell (2011) 2.26

LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol (2004) 2.24

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab (2011) 2.17

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med (2005) 2.06

mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A (2009) 2.05

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04

Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab (2010) 2.04

Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology. Endocr Rev (2004) 2.04

The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. Environ Health Perspect (2010) 1.98

AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci (2010) 1.95

The metabolic footprint of aging in mice. Sci Rep (2011) 1.93

Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab (2009) 1.89

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A (2003) 1.89

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1. Mol Cell Biol (2007) 1.89

PPAR(gamma) and glucose homeostasis. Annu Rev Nutr (2002) 1.86

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem (2008) 1.85

Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85

SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A (2008) 1.80

Metabolic networks of longevity. Cell (2010) 1.79

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol Genomics (2008) 1.76

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol (2010) 1.69

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol (2004) 1.69

Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. Genes Dev (2012) 1.64

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem (2011) 1.62

The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci (2009) 1.62

PPARgamma in human and mouse physiology. Biochim Biophys Acta (2007) 1.58

LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest (2012) 1.58

Systematic gene expression mapping clusters nuclear receptors according to their function in the brain. Cell (2007) 1.58

Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One (2012) 1.58

Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol (2008) 1.57

Mouse functional genomics requires standardization of mouse handling and housing conditions. Mamm Genome (2004) 1.56

Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest (2004) 1.55

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Mol Endocrinol (2002) 1.54

Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J Exp Med (2003) 1.53

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. J Biol Chem (2003) 1.52

Genetic background determines metabolic phenotypes in the mouse. Mamm Genome (2008) 1.51

Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet (2002) 1.50

Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea. Biochem Biophys Res Commun (2007) 1.49

Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci U S A (2006) 1.49

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol (2003) 1.48

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc Natl Acad Sci U S A (2005) 1.48

Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits. Cell (2012) 1.48

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc Natl Acad Sci U S A (2007) 1.46

Liver receptor homolog 1 is essential for ovulation. Genes Dev (2008) 1.45

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome. PLoS One (2007) 1.44

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Rep (2002) 1.42

Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism. Thyroid (2008) 1.40

Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen. EMBO Rep (2004) 1.37

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem (2008) 1.36

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes (2004) 1.35

Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation. Proc Natl Acad Sci U S A (2002) 1.35

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proc Natl Acad Sci U S A (2007) 1.35

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep (2012) 1.35

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection. Gastroenterology (2005) 1.33

Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm. EMBO Rep (2004) 1.33

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1. Eur Heart J (2011) 1.33

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A (2011) 1.29