Published in J Biol Chem on February 13, 2008
Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog (2014) 1.51
Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD. PLoS One (2012) 1.01
Infectious complications associated with monoclonal antibodies and related small molecules. Clin Microbiol Rev (2009) 0.96
Role of alveolar macrophages in chronic obstructive pulmonary disease. Front Immunol (2014) 0.96
Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kappaB-independent and EGFR-dependent pathway. PLoS One (2010) 0.96
Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium. J Exp Med (2013) 0.95
Brief bout of exercise alters gene expression in peripheral blood mononuclear cells of early- and late-pubertal males. Pediatr Res (2009) 0.94
Epiregulin: roles in normal physiology and cancer. Semin Cell Dev Biol (2014) 0.91
Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF/c-Met and TGF-α/EGFR signaling. Am J Physiol Lung Cell Mol Physiol (2015) 0.89
COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link. Br J Pharmacol (2015) 0.87
Polarized secretion of interleukin (IL)-6 and IL-8 by human airway epithelia 16HBE14o- cells in response to cationic polypeptide challenge. PLoS One (2010) 0.85
Regulatory mechanisms of betacellulin in CXCL8 production from lung cancer cells. J Transl Med (2014) 0.84
Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX-2/PGE2, inducing COX-2, CXCL8, and VEGF expression in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2015) 0.84
Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One (2013) 0.82
Targeting pro-resolution pathways to combat chronic inflammation in COPD. J Thorac Dis (2014) 0.81
EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol (2014) 0.81
Perilla frutescens leaf extract inhibits mite major allergen Der p 2-induced gene expression of pro-allergic and pro-inflammatory cytokines in human bronchial epithelial cell BEAS-2B. PLoS One (2013) 0.80
Lower nasopharyngeal epithelial cell repair and diminished innate inflammation responses contribute to the onset of acute otitis media in otitis-prone children. Med Microbiol Immunol (2013) 0.80
HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo. PLoS One (2015) 0.78
Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. PLoS Pathog (2016) 0.76
Involvement of Toll-like receptor 2 and epidermal growth factor receptor signaling in epithelial expression of airway remodeling factors. Am J Respir Cell Mol Biol (2015) 0.76
Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans. J Immunol (2016) 0.75
Comparison of temporal transcriptomic profiles from immature lungs of two rat strains reveals a viral response signature associated with chronic lung dysfunction. PLoS One (2014) 0.75
How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol (2009) 2.46
Neutrophils ameliorate lung injury and the development of severe disease during influenza infection. J Immunol (2009) 2.28
Lyn tyrosine kinase: accentuating the positive and the negative. Immunity (2005) 2.01
Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91
GM-CSF Biology. Growth Factors (2004) 1.90
Severe asthma in adults: what are the important questions? J Allergy Clin Immunol (2007) 1.85
Plasma cell development and survival. Immunol Rev (2010) 1.74
Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation. PLoS Pathog (2011) 1.62
B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor. Immunol Rev (2010) 1.54
Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Mol Cell Biol (2005) 1.47
Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice. Respir Res (2008) 1.46
Increased net gelatinase but not serine protease activity in bronchiolitis obliterans syndrome. J Heart Lung Transplant (2010) 1.41
Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 1.35
Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A (2012) 1.35
Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo. J Biol Chem (2002) 1.34
Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4. Am J Physiol Lung Cell Mol Physiol (2003) 1.31
Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells. J Immunol (2004) 1.30
Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease. J Immunol (2012) 1.28
Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood (2004) 1.28
SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem (2004) 1.25
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2. FASEB J (2007) 1.24
Evaluation of NHMRC funded research completed in 1992, 1997 and 2003: gains in knowledge, health and wealth. Med J Aust (2006) 1.21
A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD. Respir Med (2007) 1.21
Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammation. Am J Respir Crit Care Med (2010) 1.17
Acquired somatic mutations in the molecular pathogenesis of COPD. Trends Pharmacol Sci (2003) 1.17
Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intake. Brain Res (2008) 1.13
Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J Immunol (2005) 1.11
Recent advances in pre-clinical mouse models of COPD. Clin Sci (Lond) (2014) 1.10
Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss. Am J Respir Crit Care Med (2006) 1.09
Effect of short-term cigarette smoke exposure on body weight, appetite and brain neuropeptide Y in mice. Neuropsychopharmacology (2005) 1.09
Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am J Respir Cell Mol Biol (2006) 1.09
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. EMBO Mol Med (2012) 1.07
The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression? Pharmacol Ther (2003) 1.05
Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J Immunol (2009) 1.03
Detrimental metabolic effects of combining long-term cigarette smoke exposure and high-fat diet in mice. Am J Physiol Endocrinol Metab (2007) 1.02
Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD. PLoS One (2012) 1.01
Sexual dimorphism in lung function responses to acute influenza A infection. Influenza Other Respir Viruses (2011) 0.99
Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response. J Exp Med (2002) 0.99
Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit. Blood (2010) 0.97
Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation. Immunol Cell Biol (2011) 0.96
Glucocorticoid-resistant asthma and novel anti-inflammatory drugs. Drug Discov Today (2012) 0.95
Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity. Am J Respir Cell Mol Biol (2010) 0.94
Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice. Respir Res (2005) 0.94
IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo--effects of anti-inflammatory pharmacotherapy. Pulm Pharmacol Ther (2008) 0.94
TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung. Stem Cell Res (2013) 0.94
Serum amyloid A promotes lung neutrophilia by increasing IL-17A levels in the mucosa and γδ T cells. Am J Respir Crit Care Med (2013) 0.93
Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression. Mol Cell Biol (2004) 0.91
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice. J Immunol (2011) 0.90
Asthma: time to confront some inconvenient truths. Respirology (2010) 0.89
Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation. Am J Respir Cell Mol Biol (2012) 0.89
DNA vector augments inflammation in epithelial cells via EGFR-dependent regulation of TLR4 and TLR2. Am J Respir Cell Mol Biol (2008) 0.88
A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. J Immunol (2009) 0.88
Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proc Natl Acad Sci U S A (2013) 0.88
Oseltamivir treatment of mice before or after mild influenza infection reduced cellular and cytokine inflammation in the lung. Influenza Other Respir Viruses (2011) 0.87
Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice. Am J Physiol Lung Cell Mol Physiol (2010) 0.87
S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. J Proteome Res (2005) 0.87
Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells. J Biol Chem (2006) 0.87
Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. Am J Respir Cell Mol Biol (2011) 0.87
A system for quantifying the patterning of the lymphatic vasculature. Growth Factors (2007) 0.86
Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion. J Neurochem (2008) 0.86
Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways. Pharmacol Ther (2013) 0.85
CTLA4Ig alters the course of autoimmune disease development in Lyn-/- mice. J Immunol (2009) 0.85
Update on lung transplantation: programmes, patients and prospects. Eur Respir Rev (2012) 0.84
Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice. J Immunol (2009) 0.84
Akt in the pathogenesis of COPD. Int J Chron Obstruct Pulmon Dis (2006) 0.84
Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.84
Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivo. PLoS One (2012) 0.84
What is the contribution of respiratory viruses and lung proteases to airway remodelling in asthma and chronic obstructive pulmonary disease? Pulm Pharmacol Ther (2005) 0.83
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease. J Autoimmun (2012) 0.83
Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Arthritis Rheum (2013) 0.83
Unaltered TNF-alpha production by macrophages and monocytes in diet-induced obesity in the rat. J Inflamm (Lond) (2005) 0.83
Therapeutic prospects to treat skeletal muscle wasting in COPD (chronic obstructive lung disease). Pharmacol Ther (2005) 0.83
Identifying viral infections in vaccinated Chronic Obstructive Pulmonary Disease (COPD) patients using clinical features and inflammatory markers. Influenza Other Respir Viruses (2010) 0.83
Lyn-dependent signaling regulates the innate immune response by controlling dendritic cell activation of NK cells. J Immunol (2012) 0.82
Regulation of hypothalamic NPY by diet and smoking. Peptides (2007) 0.82