Published in J Biol Chem on May 27, 2004
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion. Blood (2009) 1.64
Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev (2009) 1.25
Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells. Blood (2006) 1.12
Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal (2012) 1.11
Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets. J Biol Chem (2009) 1.11
Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth. J Clin Invest (2007) 1.04
An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem (2010) 1.00
Akt signaling in platelets and thrombosis. Expert Rev Hematol (2010) 0.99
Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nat Commun (2011) 0.99
Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J (2007) 0.98
Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. Blood (2011) 0.95
The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. J Cell Sci (2011) 0.92
Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. J Biol Chem (2009) 0.92
Distinct and overlapping functional roles of Src family kinases in mouse platelets. J Thromb Haemost (2012) 0.92
Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. J Biol Chem (2009) 0.92
Src family kinases: at the forefront of platelet activation. Blood (2014) 0.91
Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase. J Biol Chem (2011) 0.86
Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway. Am J Pathol (2010) 0.86
Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circ Res (2014) 0.86
Redox homeostasis: The Golden Mean of healthy living. Redox Biol (2016) 0.86
Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion. Mol Biol Cell (2012) 0.84
Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice. Br J Pharmacol (2012) 0.80
Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils. EMBO Rep (2015) 0.79
A novel role of h2-calponin in regulating whole blood thrombosis and platelet adhesion during physiologic flow. Physiol Rep (2014) 0.77
Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice. J Biol Chem (2014) 0.76
PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis. PLoS One (2015) 0.75
Fibrinogen - a possible extracellular target for inositol phosphates. Messenger (Los Angel) (2012) 0.75
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nat Commun (2016) 0.75
PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med (2005) 3.96
A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med (2009) 3.57
PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science (2012) 3.05
Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis. Med J Aust (2004) 2.74
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry. Nat Methods (2011) 2.56
Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism. Mol Cell (2011) 2.50
Brain networks associated with cognitive reserve in healthy young and old adults. Cereb Cortex (2005) 2.37
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis. Arch Neurol (2003) 2.08
Lyn tyrosine kinase: accentuating the positive and the negative. Immunity (2005) 2.01
The clinically important difference on the unified Parkinson's disease rating scale. Arch Neurol (2010) 1.98
PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal (2011) 1.95
Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91
The evolution of disability in Parkinson disease. Mov Disord (2008) 1.85
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth. Blood (2008) 1.82
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J (2007) 1.74
Plasma cell development and survival. Immunol Rev (2010) 1.74
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood (2009) 1.74
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood (2012) 1.67
Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation. Blood (2006) 1.63
Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects. Neuroimage (2003) 1.62
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood (2011) 1.56
B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor. Immunol Rev (2010) 1.54
Covariance PET patterns in early Alzheimer's disease and subjects with cognitive impairment but no dementia: utility in group discrimination and correlations with functional performance. Neuroimage (2004) 1.49
Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Mol Cell Biol (2005) 1.47
Shear-dependent tether formation during platelet translocation on von Willebrand factor. Blood (2002) 1.42
Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol (2003) 1.42
Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase. J Biol Chem (2007) 1.41
Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation (2009) 1.40
Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency. Blood (2006) 1.37
The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program (2011) 1.34
Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease. Mov Disord (2009) 1.30
Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration. Clin Cancer Res (2008) 1.30
Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem (2001) 1.30
Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease. JAMA Neurol (2013) 1.30
Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease. J Immunol (2012) 1.28
Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood (2004) 1.28
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2. FASEB J (2007) 1.24
Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. J Biol Chem (2003) 1.24
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities. J Biol Chem (2002) 1.23
Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow. J Biol Chem (2001) 1.23
The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils. Blood (2011) 1.23
Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood (2006) 1.21
A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood. Lab Chip (2009) 1.16
P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J Immunol (2010) 1.15
Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction. Arterioscler Thromb Vasc Biol (2011) 1.15
Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2. J Biol Chem (2003) 1.13
Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J Immunol (2005) 1.11
Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets. J Biol Chem (2009) 1.11
Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury. J Biol Chem (2009) 1.10
Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3). Blood (2002) 1.09
APOE genotype and cerebral blood flow in healthy young individuals. JAMA (2003) 1.09
Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation. Circ Res (2008) 1.08
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Proc Natl Acad Sci U S A (2013) 1.07
Cognitive reserve-mediated modulation of positron emission tomographic activations during memory tasks in Alzheimer disease. Arch Neurol (2004) 1.05
A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists. Arterioscler Thromb Vasc Biol (2006) 1.04
Subjective report versus objective measurement of activities of daily living in Parkinson's disease. Mov Disord (2006) 1.04
Platelet factor XIII and calpain negatively regulate integrin alphaIIbbeta3 adhesive function and thrombus growth. J Biol Chem (2004) 1.04
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets. J Biol Chem (2007) 1.04
Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection. J Biol Chem (2008) 1.04
Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J Immunol (2009) 1.03
The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood (2013) 1.03
Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem (2006) 1.03
RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem (2002) 1.01
New insights into the haemostatic function of platelets. Br J Haematol (2009) 1.01
The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis. J Mol Med (Berl) (2006) 1.01
Shear induces a unique series of morphological changes in translocating platelets: effects of morphology on translocation dynamics. Arterioscler Thromb Vasc Biol (2005) 1.01
Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response. J Exp Med (2002) 0.99
Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood (2004) 0.99
Class I phosphoinositide 3-kinases. Int J Biochem Cell Biol (2003) 0.99
Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nat Commun (2011) 0.99
Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha. Biochem J (2005) 0.98
Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit. Blood (2010) 0.97
Novel role for insulin as an autocrine growth factor for malignant brain tumour cells. Biochem J (2007) 0.97
A comparative study of physical performance measures in Parkinson's disease. Mov Disord (2008) 0.97
A comparison of self-report and caregiver assessment of depression, apathy, and irritability in Huntington's disease. J Neuropsychiatry Clin Neurosci (2005) 0.96
Effects of optimism/pessimism and locus of control on disability and quality of life in Parkinson's disease. Parkinsonism Relat Disord (2009) 0.96