Published in J Immunol on March 01, 2008
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 4.25
Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity. J Exp Med (2012) 1.57
Lipidic systems for in vivo siRNA delivery. AAPS J (2009) 1.33
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. Proc Natl Acad Sci U S A (2012) 1.08
RNA major groove modifications improve siRNA stability and biological activity. Nucleic Acids Res (2008) 1.07
Chemical modification of siRNA bases to probe and enhance RNA interference. J Org Chem (2011) 1.06
Discriminating self from non-self in nucleic acid sensing. Nat Rev Immunol (2016) 1.02
Rational design of immunostimulatory siRNAs. Mol Ther (2010) 1.02
Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA. J Am Chem Soc (2011) 1.01
Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering. Front Genet (2012) 0.95
Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens. FASEB J (2012) 0.93
Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responses. Int Immunol (2009) 0.93
RNA mediated Toll-like receptor stimulation in health and disease. RNA Biol (2012) 0.90
siRNA Genome Screening Approaches to Therapeutic Drug Repositioning. Pharmaceuticals (Basel) (2013) 0.89
Huntington's disease: silencing a brutal killer. Exp Neurol (2009) 0.89
A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery. Biotechnol Bioeng (2009) 0.88
Drug delivery-mediated control of RNA immunostimulation. Mol Ther (2009) 0.86
Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Nucleic Acids Res (2014) 0.84
7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem (2012) 0.83
Adenosine modification may be preferred for reducing siRNA immune stimulation. Nucleic Acid Ther (2012) 0.83
A modified dinucleotide motif specifies tRNA recognition by TLR7. RNA (2014) 0.81
Lentiviral vector-mediated RNA silencing in the central nervous system. Hum Gene Ther Methods (2013) 0.79
Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8. J Virol (2013) 0.78
A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand. PLoS One (2015) 0.75
Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7. Front Immunol (2017) 0.75
An efficient method for gene silencing in human primary plasmacytoid dendritic cells: silencing of the TLR7/IRF-7 pathway as a proof of concept. Sci Rep (2016) 0.75
Identification of an optimized 2'-O-methylated tri-nucleotide RNA motif inhibiting Toll-like receptor 7 and 8. RNA (2017) 0.75
PD-L1 expression on tolerogenic APCs is controlled by STAT-3. Eur J Immunol (2011) 2.80
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit Care Med (2008) 2.18
Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain (2011) 1.95
Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem (2004) 1.86
Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages. Proc Natl Acad Sci U S A (2004) 1.65
Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity. J Exp Med (2012) 1.57
Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation. J Immunol (2009) 1.54
Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. J Immunol (2007) 1.53
Immunostimulatory CpG-DNA activates murine microglia. J Immunol (2002) 1.52
Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA. Nat Chem (2011) 1.45
Removal of protein-bound, hydrophobic uremic toxins by a combined fractionated plasma separation and adsorption technique. Artif Organs (2013) 1.42
Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins. Immunobiology (2007) 1.38
The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype. J Allergy Clin Immunol (2004) 1.35
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology (2007) 1.35
Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance. Immunology (2005) 1.34
Chemical primer extension: efficiently determining single nucleotides in DNA. Angew Chem Int Ed Engl (2005) 1.29
Activation of toll-like receptor 9 by DNA from different bacterial species. Infect Immun (2006) 1.29
Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol (2006) 1.27
Quantitative detection of periodontopathogens by real-time PCR. J Microbiol Methods (2004) 1.26
Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus. FASEB J (2010) 1.23
Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment. Eur J Immunol (2008) 1.22
Relationship between magnesium and clinical biomarkers on inhibition of vascular calcification. Am J Nephrol (2011) 1.17
Cutting edge: TLR13 is a receptor for bacterial RNA. J Immunol (2012) 1.17
Accelerating chemical replication steps of RNA involving activated ribonucleotides and downstream-binding elements. Chem Commun (Camb) (2005) 1.09
Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein. AIDS (2003) 1.07
"Host tissue damage" signal ATP promotes non-directional migration and negatively regulates toll-like receptor signaling in human monocytes. J Biol Chem (2005) 1.06
DNA from periodontopathogenic bacteria is immunostimulatory for mouse and human immune cells. Infect Immun (2003) 1.05
Bacterial RNA is recognized by different sets of immunoreceptors. Eur J Immunol (2009) 1.05
Mycobacterium kansasii tenosynovitis in a rheumatoid arthritis patient with long-term therapeutic immunosuppression. Arthritis Rheum (2008) 1.05
Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction. J Immunol (2009) 1.03
The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis. J Allergy Clin Immunol (2008) 1.03
Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo. Immunology (2002) 1.03
Knock-out mice reveal the contributions of P2Y and P2X receptors to nucleotide-induced Ca2+ signaling in macrophages. J Biol Chem (2006) 1.01
Toll-like receptors differentially induce nucleosome remodelling at the IL-12p40 promoter. EMBO Rep (2004) 1.01
Chemical primer extension in seconds. Angew Chem Int Ed Engl (2008) 1.01
Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir. J Pharm Pharmacol (2003) 1.01
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med (2014) 1.01
Molecular characterization of a respiratory syncytial virus outbreak in a hematology unit in Heidelberg, Germany. J Clin Microbiol (2012) 1.00
Real-time polymerase chain reaction for detection and quantification of bacteria in periodontal patients. J Periodontol (2005) 1.00
Templating efficiency of naked DNA. Proc Natl Acad Sci U S A (2010) 1.00
Poly-guanosine strings improve cellular uptake and stimulatory activity of phosphodiester CpG oligonucleotides in human leukocytes. Vaccine (2004) 0.98
Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity. Immunology (2007) 0.98
Triggering of Toll-like receptors modulates IFN-gamma signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling. Eur J Immunol (2003) 0.98
Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences. J Am Chem Soc (2012) 0.97
Detection of carbapenemases by real-time PCR and melt curve analysis on the BD Max system. J Clin Microbiol (2014) 0.96
Staphylococcus aureus-induced plasmacytoid dendritic cell activation is based on an IgG-mediated memory response. J Immunol (2008) 0.95
Regulation of local immunity by airway epithelial cells. Arch Immunol Ther Exp (Warsz) (2007) 0.94
Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation. Blood (2006) 0.93
Chemical primer extension: individual steps of spontaneous replication. Chem Biodivers (2007) 0.93
Adenosine residues in the template do not block spontaneous replication steps of RNA. Chem Commun (Camb) (2007) 0.92
Identification of a nuclear localization signal in suppressor of cytokine signaling 1. FASEB J (2008) 0.90
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses. J Immunol (2012) 0.90
Structural requirements for uptake and recognition of CpG oligonucleotides. Int J Med Microbiol (2007) 0.89
Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells. Immunobiology (2002) 0.89
CpG oligonucleotides as adjuvant in therapeutic vaccines against parasitic infections. Int J Med Microbiol (2007) 0.88
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. J Immunol (2008) 0.88
Pathogen-triggered activation of plasmacytoid dendritic cells induces IL-10-producing B cells in response to Staphylococcus aureus. J Immunol (2013) 0.87
Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs. J Virol (2002) 0.87
Induction of type I IFN is a physiological immune reaction to apoptotic cell-derived membrane microparticles. J Immunol (2012) 0.87
Differences in innate immune responses upon stimulation with gram-positive and gram-negative bacteria. J Periodontal Res (2006) 0.87
Signal integration following Toll-like receptor triggering. Crit Rev Immunol (2002) 0.87
Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells. J Immunol (2011) 0.87
Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii. Immunobiology (2011) 0.86
Suppressor of cytokine signaling proteins as regulators of innate immune signaling. Front Biosci (Landmark Ed) (2012) 0.86
High fidelity base pairing at the 3'-terminus. J Am Chem Soc (2009) 0.86
An unexpected new optimum in the structure space of DNA solubilizing single-walled carbon nanotubes. Chemistry (2007) 0.86
Chemical primer extension at submillimolar concentration of deoxynucleotides. J Org Chem (2010) 0.85
Convenient syntheses of 3'-amino-2',3'-dideoxynucleosides, their 5'-monophosphates, and 3'-aminoterminal oligodeoxynucleotide primers. J Org Chem (2009) 0.85
Pasteurella multocida toxin-stimulated osteoclast differentiation is B cell dependent. Infect Immun (2010) 0.85
Micromonas (Peptostreptococcus) micros: unusual case of prosthetic joint infection associated with dental procedures. Int J Med Microbiol (2005) 0.84
Template-directed synthesis in 3'- and 5'-direction with reversible termination. Angew Chem Int Ed Engl (2012) 0.84
5'-Tethered stilbene derivatives as fidelity- and affinity-enhancing modulators of DNA duplex stability. J Am Chem Soc (2004) 0.84
A direct glimpse of cross-hybridization: background-passified microarrays that allow mass-spectrometric detection of captured oligonucleotides. Angew Chem Int Ed Engl (2005) 0.84
Nucleotide-based copying of nucleic acid sequences without enzymes. J Org Chem (2013) 0.84
Structural and functional analysis of a nuclear localization signal in SOCS1. Mol Immunol (2009) 0.83
Ca(2+) -related signaling events influence TLR9-induced IL-10 secretion in human B cells. Eur J Immunol (2014) 0.83
How much pi-stacking do DNA termini seek? Solution structure of a self-complementary DNA hexamer with trimethoxystilbenes capping the terminal base pairs. Biochemistry (2004) 0.83
Immunopharmacology of CpG DNA. Biol Chem (2002) 0.83
M1.3--a small scaffold for DNA origami . Nanoscale (2012) 0.83
On the effect of covalently appended quinolones on termini of DNA duplexes. J Am Chem Soc (2002) 0.83
Stabilizing or destabilizing oligodeoxynucleotide duplexes containing single 2'-deoxyuridine residues with 5-alkynyl substituents. Chemistry (2004) 0.83
The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression. Mol Cancer (2010) 0.83
Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling. Cell Commun Signal (2012) 0.83
Four-fold click reactions: Generation of tetrahedral methane- and adamantane-based building blocks for higher-order molecular assemblies. Org Biomol Chem (2009) 0.82
Pyrenylmethyldeoxyadenosine: a 3'-cap for universal DNA hybridization probes. Chemistry (2009) 0.82
Bifunctional oligodeoxynucleotide/antagomiR constructs: evaluation of a new tool for microRNA silencing. Nucleic Acid Ther (2013) 0.82