Published in Proc Natl Acad Sci U S A on June 11, 2004
Immunogenic and tolerogenic cell death. Nat Rev Immunol (2009) 4.34
Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res (2008) 3.54
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A (2005) 2.60
Ion channels in innate and adaptive immunity. Annu Rev Immunol (2015) 1.99
The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest (2008) 1.82
Activation and regulation of store-operated calcium entry. J Cell Mol Med (2010) 1.70
Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell (2009) 1.64
K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev (2008) 1.52
The neurology of the immune system: neural reflexes regulate immunity. Neuron (2009) 1.46
Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease. PLoS One (2009) 1.45
Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations. Am J Transplant (2009) 1.27
Extracellular NAD and ATP: Partners in immune cell modulation. Purinergic Signal (2007) 1.26
The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism. Front Biosci (2008) 1.24
Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes (2008) 1.18
Slow spontaneous [Ca2+] i oscillations reflect nucleotide release from renal epithelia. Pflugers Arch (2007) 1.14
Cell death in the maintenance and abrogation of tolerance: the five Ws of dying cells. Immunity (2011) 1.13
Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon. Am J Physiol Cell Physiol (2010) 1.11
Extracellular nucleotides elicit cytosolic free calcium oscillations in Arabidopsis. Plant Physiol (2010) 1.10
The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab (2011) 1.08
The role of reactive-oxygen-species in microbial persistence and inflammation. Int J Mol Sci (2011) 1.08
Extracellular ATP signaling in plants. Trends Cell Biol (2010) 1.07
Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel. J Gen Physiol (2006) 1.01
The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression. Drug Dev Res (2011) 0.98
Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome. PLoS One (2013) 0.97
Purinergic signalling and immune cells. Purinergic Signal (2014) 0.94
The role of released ATP in killing Candida albicans and other extracellular microbial pathogens by cationic peptides. Purinergic Signal (2007) 0.90
Agonist-induced phosphorylation and desensitization of the P2Y2 nucleotide receptor. Mol Cell Biochem (2005) 0.89
The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels. Am J Physiol Cell Physiol (2009) 0.86
Strong glucose dependence of electron current in human monocytes. Am J Physiol Cell Physiol (2011) 0.85
Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides. PeerJ (2014) 0.83
Mechanistic details of BK channel inhibition by the intermediate conductance, Ca2+-activated K channel. Channels (Austin) (2009) 0.82
Enhancing crop innate immunity: new promising trends. Front Plant Sci (2014) 0.82
Purinergic and calcium signaling in macrophage function and plasticity. Front Immunol (2014) 0.81
Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor. PLoS One (2013) 0.81
Activation of cell migration with fibroblast growth factor-2 requires calcium-sensitive potassium channels. Pflugers Arch (2008) 0.81
Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. Oncotarget (2015) 0.80
The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype. J Cell Mol Med (2008) 0.80
Schistosome apyrase SmATPDase1, but not SmATPDase2, hydrolyses exogenous ATP and ADP. Purinergic Signal (2014) 0.79
Extracellular ATP and Toll-like receptor 2 agonists trigger in human monocytes an activation program that favors T helper 17. PLoS One (2013) 0.78
A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica. Sci Rep (2015) 0.78
Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors. Curr Pharm Biotechnol (2013) 0.78
[Ca2+]i Oscillations and IL-6 Release Induced by α-Hemolysin from Escherichia coli Require P2 Receptor Activation in Renal Epithelia. J Biol Chem (2015) 0.77
The therapeutic potential of adenosine triphosphate as an immune modulator in the treatment of HIV/AIDS: a combination approach with HAART. Curr HIV Res (2011) 0.77
Inhibition of P2X receptors protects human monocytes against damage by leukotoxin from Aggregatibacter actinomycetemcomitans and α-hemolysin from Escherichia coli. Infect Immun (2016) 0.76
Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One (2016) 0.75
The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes. J Neurochem (2017) 0.75
A possible role for extra-cellular ATP in plant responses to high frequency, low amplitude electromagnetic field. Plant Signal Behav (2008) 0.75
Measurement of ATP-Induced Membrane Potential Changes in IVD cells. Cell Mol Bioeng (2014) 0.75
Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens. Front Immunol (2017) 0.75
Transient electric changes immediately after surgical trauma. J Athl Train (2008) 0.75
KCa3.1-Dependent Hyperpolarization Enhances Intracellular Ca2+ Signaling Induced by fMLF in Differentiated U937 Cells. PLoS One (2015) 0.75
Inadequate cytoplasmatic calcium signals in alveolar macrophages after cardiac surgery. Inflamm Res (2010) 0.75
Expression and functional characterization of P2X receptors in mouse alveolar macrophages. Pflugers Arch (2011) 0.75
Minimal models of electric potential oscillations in non-excitable membranes. Eur Biophys J (2009) 0.75
Innate immune recognition. Annu Rev Immunol (2001) 26.65
Receptors for purines and pyrimidines. Pharmacol Rev (1998) 13.92
The danger model: a renewed sense of self. Science (2002) 13.85
Molecular physiology of P2X receptors. Physiol Rev (2002) 13.61
Calcium oscillations increase the efficiency and specificity of gene expression. Nature (1998) 9.19
Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature (1994) 8.85
Decoding the patterns of self and nonself by the innate immune system. Science (2002) 7.19
Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol (2001) 7.06
Danger signals: SOS to the immune system. Curr Opin Immunol (2001) 3.91
Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood (2001) 3.84
Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol (2003) 3.47
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol (2000) 3.39
A human intermediate conductance calcium-activated potassium channel. Proc Natl Acad Sci U S A (1997) 3.12
Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J Immunol (1997) 2.81
The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol (2002) 2.63
Molecular pharmacology of P2Y-receptors. Naunyn Schmiedebergs Arch Pharmacol (2000) 2.56
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J Neurosci (2001) 2.54
Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol (2001) 1.85
Disordered cellular migration and angiogenesis in cd39-null mice. Circulation (2001) 1.70
Spontaneous and induced membrane hyperpolarizations in macrophages. J Cell Physiol (1975) 1.64
ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion. J Immunol (2001) 1.60
A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci U S A (1999) 1.58
K+ channels and the microglial respiratory burst. Am J Physiol Cell Physiol (2001) 1.51
P2X4, P2Y1 and P2Y2 receptors on rat alveolar macrophages. Br J Pharmacol (2003) 1.25
Advances in signalling by extracellular nucleotides. the role and transduction mechanisms of P2Y receptors. Cell Signal (2000) 1.23
Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J Neurochem (2001) 1.19
Regulation of a TRPM7-like current in rat brain microglia. J Biol Chem (2003) 1.16
Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes. J Immunol (1999) 1.16
Calcium responses elicited by nucleotides in macrophages. Interaction between two receptor subtypes. J Biol Chem (1993) 1.13
Ion channels in microglia (brain macrophages). Am J Physiol (1998) 1.11
Thapsigargin and cyclopiazonic acid initiate rapid and dramatic increases of IL-6 mRNA expression and IL-6 secretion in murine peritoneal macrophages. J Immunol (1995) 1.04
Extracellular ATP and UTP control the generation of reactive oxygen intermediates in human macrophages through the opening of a charybdotoxin-sensitive Ca2+-dependent K+ channel. J Immunol (1997) 1.01
Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells. Br J Haematol (2000) 1.01
Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1 Ca(2+)-dependent K(+) channels. Neuroscience (2002) 0.95
ATP- and UTP-induced currents in macrophages and macrophage polykaryons. Am J Physiol (1993) 0.80
PD-L1 expression on tolerogenic APCs is controlled by STAT-3. Eur J Immunol (2011) 2.80
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit Care Med (2008) 2.18
K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J Physiol (2002) 2.18
The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle. Cardiovasc Res (2005) 2.14
The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res (2007) 2.00
Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain (2011) 1.95
Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem (2004) 1.86
K(ATP) channels and preconditioning: a re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms. J Mol Cell Cardiol (2005) 1.84
HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat Immunol (2010) 1.70
Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. Proc Natl Acad Sci U S A (2002) 1.58
Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity. J Exp Med (2012) 1.57
Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. J Physiol (2002) 1.56
Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation. J Immunol (2009) 1.54
Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. J Immunol (2007) 1.53
The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C. Cardiovasc Res (2012) 1.51
Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondria. J Physiol (2002) 1.41
Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci U S A (2009) 1.39
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology (2007) 1.35
Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol (2006) 1.27
Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. J Physiol (2002) 1.24
Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus. FASEB J (2010) 1.23
Modifications in small interfering RNA that separate immunostimulation from RNA interference. J Immunol (2008) 1.22
Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment. Eur J Immunol (2008) 1.22
Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins. J Physiol (2009) 1.18
Cutting edge: TLR13 is a receptor for bacterial RNA. J Immunol (2012) 1.17
Construction and validation of a homology model of the human voltage-gated proton channel hHV1. J Gen Physiol (2013) 1.17
The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1. Traffic (2006) 1.15
RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels. EMBO J (2010) 1.12
SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. J Mol Med (Berl) (2006) 1.10
"Host tissue damage" signal ATP promotes non-directional migration and negatively regulates toll-like receptor signaling in human monocytes. J Biol Chem (2005) 1.06
Voltage-gated proton channel in a dinoflagellate. Proc Natl Acad Sci U S A (2011) 1.05
Bacterial RNA is recognized by different sets of immunoreceptors. Eur J Immunol (2009) 1.05
Mycobacterium kansasii tenosynovitis in a rheumatoid arthritis patient with long-term therapeutic immunosuppression. Arthritis Rheum (2008) 1.05
Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function. J Biol Chem (2010) 1.04
A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J Biol Chem (2011) 1.04
A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3. Traffic (2007) 1.03
Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction. J Immunol (2009) 1.03
Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels. Mol Pharmacol (2005) 1.03
Beta-oxidation of 5-hydroxydecanoate, a putative blocker of mitochondrial ATP-sensitive potassium channels. J Physiol (2003) 1.03
The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis. J Allergy Clin Immunol (2008) 1.03
Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2. EMBO J (2008) 1.02
Knock-out mice reveal the contributions of P2Y and P2X receptors to nucleotide-induced Ca2+ signaling in macrophages. J Biol Chem (2006) 1.01
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease. Am J Respir Crit Care Med (2014) 1.01
Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport. Physiology (Bethesda) (2011) 1.00
5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids. J Physiol (2004) 0.98
Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity. Immunology (2007) 0.98
Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome. Cardiovasc Res (2007) 0.96
Much more than a leak: structure and function of K₂p-channels. Pflugers Arch (2015) 0.96
Detection of carbapenemases by real-time PCR and melt curve analysis on the BD Max system. J Clin Microbiol (2014) 0.96
Effects of divalent cations and spermine on the K+ channel TASK-3 and on the outward current in thalamic neurons. J Physiol (2006) 0.95
Regulation of local immunity by airway epithelial cells. Arch Immunol Ther Exp (Warsz) (2007) 0.94
Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation. Blood (2006) 0.93
Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cell Physiol Biochem (2011) 0.93
Four novel splice variants of sulfonylurea receptor 1. Am J Physiol Cell Physiol (2002) 0.90
Identification of a nuclear localization signal in suppressor of cytokine signaling 1. FASEB J (2008) 0.90
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses. J Immunol (2012) 0.90
TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes. Cell Physiol Biochem (2011) 0.90
Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells. J Immunol (2011) 0.87
A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch (2013) 0.87
Suppressor of cytokine signaling proteins as regulators of innate immune signaling. Front Biosci (Landmark Ed) (2012) 0.86
Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hHV1. J Gen Physiol (2013) 0.86
Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii. Immunobiology (2011) 0.86
Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J Biol Chem (2008) 0.84
Tandem pore domain K(+)-channel TASK-3 (KCNK9) and idiopathic absence epilepsies. Am J Med Genet (2002) 0.84
5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. Biochim Biophys Acta (2009) 0.84
Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols. J Pharmacol Exp Ther (2007) 0.83
Structural and functional analysis of a nuclear localization signal in SOCS1. Mol Immunol (2009) 0.83
Altered stress stimulation of inward rectifier potassium channels in Andersen-Tawil syndrome. FASEB J (2011) 0.81
The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Pflugers Arch (2015) 0.81
HDAC inhibitors block innate immunity. Blood (2011) 0.81