Published in Proc Natl Acad Sci U S A on March 03, 2008
The therapeutic potential of carbon monoxide. Nat Rev Drug Discov (2010) 3.03
Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. Nat Struct Mol Biol (2008) 2.28
Molecular mechanisms of BK channel activation. Cell Mol Life Sci (2009) 1.81
BK channel activation: structural and functional insights. Trends Neurosci (2010) 1.65
Trafficking of heme and porphyrins in metazoa. Chem Rev (2009) 1.48
Modulation of BKCa channel gating by endogenous signaling molecules. Physiology (Bethesda) (2009) 1.38
Carbon monoxide as an endogenous vascular modulator. Am J Physiol Heart Circ Physiol (2011) 1.23
Properties of Slo1 K+ channels with and without the gating ring. Proc Natl Acad Sci U S A (2013) 1.02
Novel lead structures and activation mechanisms for CO-releasing molecules (CORMs). Br J Pharmacol (2014) 1.02
Identification of a thiol/disulfide redox switch in the human BK channel that controls its affinity for heme and CO. J Biol Chem (2010) 1.00
Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol. Pharmacol Ther (2012) 0.96
Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. Br J Pharmacol (2014) 0.95
Function and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cells. Drug Discov Today (2012) 0.95
Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease. Int J Hypertens (2012) 0.95
Carbon monoxide: an emerging regulator of ion channels. J Physiol (2011) 0.91
BK channels: multiple sensors, one activation gate. Front Physiol (2015) 0.88
Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J Biol Chem (2011) 0.88
Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain. J Biol Chem (2009) 0.87
The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen Physiol (2010) 0.87
CO-releasing Metal Carbonyl Compounds as Antimicrobial Agents in the Post-antibiotic Era. J Biol Chem (2015) 0.87
Thiol/Disulfide redox switches in the regulation of heme binding to proteins. Antioxid Redox Signal (2010) 0.86
Carbon Monoxide and the brain: time to rethink the dogma. Curr Pharm Des (2013) 0.85
Ru(CO)3Cl(Glycinate) (CORM-3): a carbon monoxide-releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coli. Antioxid Redox Signal (2013) 0.85
Carbon monoxide--physiology, detection and controlled release. Chem Commun (Camb) (2014) 0.85
Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin) (2009) 0.84
Cysteine residue 911 in C-terminal tail of human BK(Ca)α channel subunit is crucial for its activation by carbon monoxide. Pflugers Arch (2011) 0.83
Uncoupling charge movement from channel opening in voltage-gated potassium channels by ruthenium complexes. J Biol Chem (2011) 0.82
Heme Oxygenase-1 and Carbon Monoxide in the Heart: The Balancing Act Between Danger Signaling and Pro-Survival. Circ Res (2016) 0.82
Cytochrome bd-I in Escherichia coli is less sensitive than cytochromes bd-II or bo'' to inhibition by the carbon monoxide-releasing molecule, CORM-3: N-acetylcysteine reduces CO-RM uptake and inhibition of respiration. Biochim Biophys Acta (2013) 0.81
Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function. Clin Pharmacol (2015) 0.75
Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels. PLoS One (2016) 0.75
A heme-binding domain controls regulation of ATP-dependent potassium channels. Proc Natl Acad Sci U S A (2016) 0.75
CO-independent modification of K(+) channels by tricarbonyldichlororuthenium(II) dimer (CORM-2). Eur J Pharmacol (2017) 0.75
Crystal structure and mechanism of a calcium-gated potassium channel. Nature (2002) 10.03
Carbon monoxide: a putative neural messenger. Science (1993) 5.47
Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol (2002) 5.18
A novel calcium-sensing domain in the BK channel. Biophys J (1997) 3.86
Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature (2002) 3.82
Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. Nature (2001) 3.67
Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron (2001) 3.62
Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science (2004) 3.28
Cellular mechanism of oxygen sensing. Annu Rev Physiol (2001) 2.84
Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res (2002) 2.73
Mechanism of magnesium activation of calcium-activated potassium channels. Nature (2002) 2.50
Gating mechanism of BK (Slo1) channels: so near, yet so far. J Gen Physiol (2003) 2.31
NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism. EMBO J (2007) 2.08
CO as a cellular signaling molecule. Annu Rev Pharmacol Toxicol (2006) 2.03
Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels. Cell (2006) 1.98
Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone. Acta Physiol Scand (1998) 1.91
Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature (2003) 1.84
Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels. Circ Res (2005) 1.80
Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation. Proc Natl Acad Sci U S A (2001) 1.77
Heme-based sensors in biological systems. Curr Opin Chem Biol (1999) 1.65
The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells. Pflugers Arch (1997) 1.57
Oxidative regulation of large conductance calcium-activated potassium channels. J Gen Physiol (2001) 1.54
The chemical modification of KCa channels by carbon monoxide in vascular smooth muscle cells. J Biol Chem (1997) 1.42
Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. Proc Natl Acad Sci U S A (1996) 1.38
Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol (2005) 1.32
Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of alpha-subunits. Am J Physiol Heart Circ Physiol (2003) 1.32
Oxygenases without requirement for cofactors or metal ions. Appl Microbiol Biotechnol (2002) 1.29
CO-metal interaction: Vital signaling from a lethal gas. Trends Biochem Sci (2006) 1.22
A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits. Proc Natl Acad Sci U S A (2005) 1.15
Biophysical properties and metabolic regulation of a TASK-like potassium channel in rat carotid body type 1 cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.11
Carbon monoxide stimulates the Ca2(+)-activated big conductance k channels in cultured human endothelial cells. Hypertension (2007) 1.11
Large-conductance, ca(2+)-activated k(+) channels: function, pharmacology and drugs. Curr Med Chem (2002) 1.07
Hypoxia inhibits human recombinant large conductance, Ca(2+)-activated K(+) (maxi-K) channels by a mechanism which is membrane delimited and Ca(2+) sensitive. J Physiol (2002) 1.03
Activation of whole cell currents in isolated human jejunal circular smooth muscle cells by carbon monoxide. Am J Physiol (1993) 1.02
Acute oxygen sensing in heme oxygenase-2 null mice. J Gen Physiol (2006) 1.00
Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BKCa channels. Cardiovasc Res (2005) 0.99
Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats. J Pharmacol Exp Ther (2007) 0.97
Carbon monoxide and Ca2+-activated K+ channels in cerebral arteriolar responses to glutamate and hypoxia in newborn pigs. Am J Physiol Heart Circ Physiol (2007) 0.90
Kinetics and mechanism of heme-induced refolding of human alpha-globin. Proc Natl Acad Sci U S A (1981) 0.90
Trans effects on cysteine ligation in the proximal His93Cys variant of horse heart myoglobin. Biochemistry (1995) 0.89
A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BK Ca channels. Pflugers Arch (2008) 0.87
CO sniffing through heme-based sensor proteins. IUBMB Life (2004) 0.83
Homogeneous segmental profile of carbon monoxide-mediated pulmonary vasodilation in rats. Am J Physiol Lung Cell Mol Physiol (2001) 0.80
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature (2008) 5.38
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron (2002) 4.11
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature (2002) 3.96
High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proc Natl Acad Sci U S A (2002) 2.85
Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. Arch Biochem Biophys (2002) 2.76
Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J Immunol (2006) 2.15
Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron (2002) 1.95
Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels. Proc Natl Acad Sci U S A (2013) 1.91
Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature (2003) 1.84
Role of osteopontin in synovial Th17 differentiation in rheumatoid arthritis. Arthritis Rheum (2010) 1.62
A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nat Genet (2013) 1.61
Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing. Nat Struct Mol Biol (2004) 1.57
Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation. Proc Natl Acad Sci U S A (2004) 1.54
Vaccination with selected synovial T cells in rheumatoid arthritis. Arthritis Rheum (2007) 1.53
The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation. J Invest Dermatol (2006) 1.52
Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. Proteomics (2013) 1.46
Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J Clin Invest (2005) 1.42
Retracted Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia. Diagn Pathol (2014) 1.39
Modulation of BKCa channel gating by endogenous signaling molecules. Physiology (Bethesda) (2009) 1.38
Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins. FASEB J (2002) 1.35
Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol (2005) 1.32
Sharper and faster "nano darts" kill more bacteria: a study of antibacterial activity of individually dispersed pristine single-walled carbon nanotube. ACS Nano (2009) 1.29
SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nat Neurosci (2009) 1.27
Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain. Nat Struct Mol Biol (2008) 1.26
BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. Mol Cell (2009) 1.23
Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels. J Physiol (2006) 1.22
Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery. Clin Cancer Res (2013) 1.21
Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain. J Neurosci (2010) 1.20
Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channels. FEBS Lett (2007) 1.20
Stimulatory action of internal protons on Slo1 BK channels. Biophys J (2003) 1.19
Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms. J Neurosci (2007) 1.18
Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse (2006) 1.17
Metabolic regulation of potassium channels. Annu Rev Physiol (2004) 1.14
Contrast-enhanced ultrasound is helpful in the differentiation of malignant and benign breast lesions. Eur J Radiol (2009) 1.14
Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis. Arthritis Rheum (2009) 1.11
The Lexicon Builder Web service: Building Custom Lexicons from two hundred Biomedical Ontologies. AMIA Annu Symp Proc (2010) 1.10
Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. Biochim Biophys Acta (2005) 1.10
A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. Methods Mol Biol (2015) 1.09
A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia. Mol Endocrinol (2002) 1.09
Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3. Mol Pharmacol (2006) 1.08
Molecular interaction of delta-conotoxins with voltage-gated sodium channels. FEBS Lett (2005) 1.08
Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels. J Physiol (2010) 1.08
Template-free formation of uniform urchin-like α-FeOOH hollow spheres with superior capability for water treatment. Adv Mater (2012) 1.08
Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1. FEBS Lett (2002) 1.06
Inhibition of human ether à go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. FEBS J (2006) 1.06
Mechanisms of the inhibition of Shaker potassium channels by protons. Pflugers Arch (2003) 1.06
A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. J Gen Physiol (2013) 1.04
Molecular mechanism of pharmacological activation of BK channels. Proc Natl Acad Sci U S A (2012) 1.04
Solitary fibrous tumor of the central nervous system: a clinicopathologic study of 24 cases. Acta Neurochir (Wien) (2011) 1.04
Functional distinction of human EAG1 and EAG2 potassium channels. FEBS Lett (2002) 1.03
Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2. EMBO J (2008) 1.02
Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE. Biochem Biophys Res Commun (2005) 1.01
Expression of ether à go-go potassium channels in human gliomas. Neurosci Lett (2004) 1.01
Hereditary 1,25-dihydroxyvitamin D resistant rickets due to a mutation causing multiple defects in vitamin D receptor function. Endocrinology (2004) 1.01
muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2. Channels (Austin) (2007) 1.00
Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. Proc Natl Acad Sci U S A (2013) 1.00
Oxidation of multiple methionine residues impairs rapid sodium channel inactivation. Pflugers Arch (2008) 1.00
SimQ: real-time retrieval of similar consumer health questions. J Med Internet Res (2015) 0.99
Clinical characteristics and outcomes of "silent" and "non-silent" peritonitis in patients on peritoneal dialysis. Perit Dial Int (2012) 0.98
Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3. Mol Pharmacol (2004) 0.98
Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol (2003) 0.97
Multi-topic assignment for exploratory navigation of consumer health information in NetWellness using formal concept analysis. BMC Med Inform Decis Mak (2014) 0.97
Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome. Cardiovasc Res (2007) 0.96
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1. Biochim Biophys Acta (2008) 0.96
Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion. J Neurophysiol (2005) 0.96
C-027 inhibits IgE-mediated passive sensitization bronchoconstriction and acts as a histamine and serotonin antagonist in human airways. Allergy Asthma Proc (2011) 0.95
Extracellular vesicle isolation and characterization: toward clinical application. J Clin Invest (2016) 0.95
Imaging characteristics of Rosai-Dorfman disease in the central nervous system. Eur J Radiol (2011) 0.95
Distant neighbor base sequence context effects in human nucleotide excision repair of a benzo[a]pyrene-derived DNA lesion. J Mol Biol (2010) 0.95
Nickel-thiolate complex catalyst assembled in one step in water for solar H2 production. J Am Chem Soc (2011) 0.95
Epidemiology and vector efficiency during a dengue fever outbreak in Cixi, Zhejiang Province, China. J Vector Ecol (2009) 0.95
The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner. J Biol Chem (2002) 0.94
The unique pharmacology of the scorpion alpha-like toxin Lqh3 is associated with its flexible C-tail. FEBS J (2007) 0.94
Fast precipitation of uniform CaCO3 nanospheres and their transformation to hollow hydroxyapatite nanospheres. J Colloid Interface Sci (2010) 0.94
Functional consequences of methionine oxidation of hERG potassium channels. Biochem Pharmacol (2007) 0.94