Published in Mol Cell on October 09, 2009
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat Cell Biol (2011) 4.23
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev (2012) 1.81
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun (2015) 1.65
A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. Cell Cycle (2012) 1.46
Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer (2012) 1.45
Epigenetic modifications in double-strand break DNA damage signaling and repair. Clin Cancer Res (2010) 1.18
Histone exchange and histone modifications during transcription and aging. Biochim Biophys Acta (2014) 1.09
Histone modifications and DNA double-strand break repair after exposure to ionizing radiations. Radiat Res (2013) 1.04
Chromatin modifications and the DNA damage response to ionizing radiation. Front Oncol (2013) 0.95
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Mol Cancer (2015) 0.94
Epigenetic regulation of genomic integrity. Chromosoma (2012) 0.93
BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Mol Cell Biol (2012) 0.92
Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair. Trends Cell Biol (2014) 0.91
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Mol Biol Cell (2014) 0.90
Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation. Cell Rep (2013) 0.87
Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers. Cell Cycle (2015) 0.86
HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma. Oncotarget (2015) 0.86
Generation of nonhydrolyzable ubiquitin-histone mimics. Methods (2014) 0.84
Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation. Nat Commun (2015) 0.83
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat. Mol Biol Cell (2011) 0.83
Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway. Oncotarget (2015) 0.83
Radiation-induced alterations of histone post-translational modification levels in lymphoblastoid cell lines. Radiat Oncol (2014) 0.83
Overview for the histone codes for DNA repair. Prog Mol Biol Transl Sci (2012) 0.81
Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. PLoS One (2015) 0.81
DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Mol Cancer (2014) 0.81
SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation. Nat Commun (2015) 0.80
Sites of acetylation on newly synthesized histone H4 are required for chromatin assembly and DNA damage response signaling. Mol Cell Biol (2013) 0.78
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. Nat Immunol (2015) 0.78
Genetic interactions between POB3 and the acetylation of newly synthesized histones. Curr Genet (2011) 0.78
Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair. Front Genet (2016) 0.78
Protein and DNA modifications: evolutionary imprints of bacterial biochemical diversification and geochemistry on the provenance of eukaryotic epigenetics. Cold Spring Harb Perspect Biol (2014) 0.77
A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs. Neurotox Res (2014) 0.77
Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response. PLoS One (2017) 0.75
Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest (2017) 0.75
Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. Oncotarget (2016) 0.75
A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining. Open Biol (2016) 0.75
ADP-ribosyltransferases and poly ADP-ribosylation. Curr Protein Pept Sci (2015) 0.75
Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. Mol Cell (2017) 0.75
Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control. Nat Genet (2017) 0.75
Translating the histone code. Science (2001) 56.77
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol (2005) 12.70
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood (2004) 11.07
Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem (2006) 8.66
Interferons, immunity and cancer immunoediting. Nat Rev Immunol (2006) 8.23
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature (2002) 7.54
Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol (2001) 6.96
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science (2007) 6.70
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell (2009) 5.96
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59
Ubiquitin-binding domains. Biochem J (2006) 5.32
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell (2004) 4.99
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem (2002) 4.75
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A (2007) 4.75
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature (2008) 3.55
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J Biol Chem (2002) 3.14
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol (2007) 3.03
The histone code at DNA breaks: a guide to repair? Nat Rev Mol Cell Biol (2005) 2.97
Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol (2004) 2.76
Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev (2005) 2.56
Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol (2009) 2.47
The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. Cancer Res (2007) 2.43
Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae. Mol Cell Biol (2005) 2.33
The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. Mol Cell (2003) 2.29
The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem (2005) 2.27
Transcriptional regulation by histone ubiquitination and deubiquitination. Genes Dev (2003) 2.27
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Genes Dev (2006) 2.22
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell (2004) 2.16
Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes? Curr Opin Immunol (2007) 2.05
Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. J Biol Chem (2008) 1.99
Complicated tails: histone modifications and the DNA damage response. Cell (2005) 1.74
Chromatin remodeling finds its place in the DNA double-strand break response. Nucleic Acids Res (2009) 1.66
DNA double-strand breaks: their cellular and clinical impact? Oncogene (2007) 1.51
Tying the loose ends together in DNA double strand break repair with 53BP1. Cell Div (2006) 1.47
Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assembly. Mol Cell (2005) 1.45
B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. J Biol Chem (2005) 1.38
Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation. Nucleic Acids Res (2009) 1.34
BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Mol Cell Biol (2006) 1.29
The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. J Biol Chem (2003) 1.28
BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Blood (2000) 1.19
H2B ubiquitylation in transcriptional control: a FACT-finding mission. Genes Dev (2007) 1.12
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood (2004) 11.07
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med (2014) 10.10
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A (2012) 7.14
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood (2009) 5.84
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood (2007) 3.52
PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies. Clin Cancer Res (2013) 3.48
Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med (2006) 3.14
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy. Clin Cancer Res (2012) 2.39
Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med (2003) 2.36
The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci U S A (2007) 2.31
Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J Immunol (2006) 2.15
Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach. Blood (2005) 2.13
Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Proc Natl Acad Sci U S A (2007) 2.06
Rituximab and CHOP induction therapy for newly diagnosed mantle-cell lymphoma: molecular complete responses are not predictive of progression-free survival. J Clin Oncol (2002) 1.98
Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell (2012) 1.98
Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels. Proc Natl Acad Sci U S A (2013) 1.91
p63 and p73 are not required for the development and p53-dependent apoptosis of T cells. Cancer Cell (2004) 1.86
Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature (2003) 1.84
Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis. Blood (2011) 1.84
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease. Cancer Res (2012) 1.74
BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood (2007) 1.72
Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation. Blood (2006) 1.70
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. J Clin Oncol (2007) 1.63
Role of osteopontin in synovial Th17 differentiation in rheumatoid arthritis. Arthritis Rheum (2010) 1.62
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. Blood (2005) 1.59
Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation. Proc Natl Acad Sci U S A (2004) 1.54
Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. Cancer Cell (2012) 1.54
Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders. Blood (2011) 1.53
Vaccination with selected synovial T cells in rheumatoid arthritis. Arthritis Rheum (2007) 1.53
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A (2004) 1.53
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med (2014) 1.49
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med (2008) 1.47
Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. Proteomics (2013) 1.46
Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci U S A (2002) 1.44
The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma. Blood (2004) 1.43
Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J Clin Invest (2005) 1.42
High dose CHOP: a phase II study of initial treatment in aggressive non-Hodgkin lymphoma. Cancer and Leukemia Group B 9351. Leuk Lymphoma (2007) 1.39
Retracted Clinical application of contrast enhanced ultrasound to diagnose benign prostatic hyperplasia. Diagn Pathol (2014) 1.39
B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. J Biol Chem (2005) 1.38
Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas. PLoS One (2012) 1.35
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. J Exp Med (2012) 1.31
SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas. Cancer Cell (2013) 1.30
BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Mol Cell Biol (2006) 1.29
Sharper and faster "nano darts" kill more bacteria: a study of antibacterial activity of individually dispersed pristine single-walled carbon nanotube. ACS Nano (2009) 1.29
The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. J Biol Chem (2003) 1.28
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A (2006) 1.27
Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain. Nat Struct Mol Biol (2008) 1.26
Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. DNA Repair (Amst) (2006) 1.24
Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. J Exp Med (2011) 1.24
Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery. Clin Cancer Res (2013) 1.21
Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma. Leuk Lymphoma (2002) 1.17
Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse (2006) 1.17
AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. Mol Cell (2010) 1.16
BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt. Blood (2009) 1.15
Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. Blood (2003) 1.14
Contrast-enhanced ultrasound is helpful in the differentiation of malignant and benign breast lesions. Eur J Radiol (2009) 1.14
AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features. Clin Cancer Res (2008) 1.11
Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis. Arthritis Rheum (2009) 1.11
Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H). Clin Cancer Res (2006) 1.11
The Lexicon Builder Web service: Building Custom Lexicons from two hundred Biomedical Ontologies. AMIA Annu Symp Proc (2010) 1.10
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity (2007) 1.10
A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. Methods Mol Biol (2015) 1.09
A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia. Mol Endocrinol (2002) 1.09
The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels. Proc Natl Acad Sci U S A (2008) 1.09
Template-free formation of uniform urchin-like α-FeOOH hollow spheres with superior capability for water treatment. Adv Mater (2012) 1.08
A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. J Gen Physiol (2013) 1.04
Solitary fibrous tumor of the central nervous system: a clinicopathologic study of 24 cases. Acta Neurochir (Wien) (2011) 1.04
The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas. Br J Haematol (2008) 1.03
Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proc Natl Acad Sci U S A (2005) 1.02
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc Natl Acad Sci U S A (2011) 1.02
Hereditary 1,25-dihydroxyvitamin D resistant rickets due to a mutation causing multiple defects in vitamin D receptor function. Endocrinology (2004) 1.01
Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. Proc Natl Acad Sci U S A (2013) 1.00
SimQ: real-time retrieval of similar consumer health questions. J Med Internet Res (2015) 0.99
Clinical characteristics and outcomes of "silent" and "non-silent" peritonitis in patients on peritoneal dialysis. Perit Dial Int (2012) 0.98
Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain. Am J Surg Pathol (2014) 0.97
Association of human leukocyte antigen ancestral haplotype 8.1 with adverse outcome of non-Hodgkin's lymphoma. Genes Chromosomes Cancer (2007) 0.97
Multi-topic assignment for exploratory navigation of consumer health information in NetWellness using formal concept analysis. BMC Med Inform Decis Mak (2014) 0.97
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1. Biochim Biophys Acta (2008) 0.96
Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A (2010) 0.96
The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. J Exp Med (2002) 0.96
Extracellular vesicle isolation and characterization: toward clinical application. J Clin Invest (2016) 0.95
B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. J Allergy Clin Immunol (2007) 0.95