Published in Pediatr Res on June 01, 2008
Animal models of human respiratory syncytial virus disease. Am J Physiol Lung Cell Mol Physiol (2011) 1.57
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol (2012) 1.39
IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice. PLoS One (2012) 1.23
Decreased activation of inflammatory networks during acute asthma exacerbations is associated with chronic airflow obstruction. Mucosal Immunol (2010) 1.08
Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice. J Immunol (2009) 0.86
Apoptosis in pneumovirus infection. Viruses (2013) 0.80
Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis. Front Immunol (2013) 0.78
Respiratory Syncytial Virus (RSV) Pulmonary Infection in Humanized Mice Induces Human Anti-RSV Immune Responses and Pathology. J Virol (2016) 0.77
The caspase inhibitor zVAD increases lung inflammation in pneumovirus infection in mice. Physiol Rep (2015) 0.75
The Human Immune Response to Respiratory Syncytial Virus Infection. Clin Microbiol Rev (2017) 0.75
RSV infection--an immune balancing act: commentary on the article by Bem et al. on page 650. Pediatr Res (2008) 0.75
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol (2010) 7.73
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell (2007) 7.05
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med (2013) 4.22
The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncol (2012) 2.83
Colon cancer stem cells: promise of targeted therapy. Gastroenterology (2010) 2.58
Apoptosis and non-apoptotic deaths in cancer development and treatment response. Cancer Treat Rev (2008) 2.20
Cancer stem cell niche: the place to be. Cancer Res (2011) 2.14
The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res (2010) 2.12
APRIL modulates B and T cell immunity. J Clin Invest (2002) 2.07
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell Stem Cell (2011) 1.80
Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging. Stem Cells (2015) 1.75
Fluid resuscitation in neonatal and pediatric hypovolemic shock: a Dutch Pediatric Society evidence-based clinical practice guideline. Intensive Care Med (2006) 1.71
Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity. Cancer Res (2010) 1.71
Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology (2008) 1.63
CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. Blood (2011) 1.62
Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers. Am J Respir Crit Care Med (2005) 1.60
Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer. Clin Cancer Res (2012) 1.60
Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. Stem Cells Dev (2007) 1.60
Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells. Stem Cells (2012) 1.55
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J Clin Invest (2010) 1.50
Lung epithelial cell apoptosis during acute lung injury in infancy. Pediatr Crit Care Med (2007) 1.50
Randomized controlled trial of aerosolized prostacyclin therapy in children with acute lung injury. Crit Care Med (2004) 1.49
The TNF family member APRIL dampens collagen-induced arthritis. Ann Rheum Dis (2012) 1.49
Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α. Mol Cell (2011) 1.48
Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms. J Immunol (2010) 1.46
Targeting Wnt signaling in colon cancer stem cells. Clin Cancer Res (2010) 1.46
Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection. Pediatr Crit Care Med (2008) 1.44
Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans. Crit Care Med (2016) 1.40
Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation. Ann Rheum Dis (2012) 1.35
APRIL promotes B-1 cell-associated neoplasm. Cancer Cell (2004) 1.34
Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles. BMC Genomics (2005) 1.34
CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity. Proc Natl Acad Sci U S A (2002) 1.34
Molecular identification and targeting of colorectal cancer stem cells. Oncotarget (2010) 1.33
Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis. Arthritis Rheum (2009) 1.32
IL-4-mediated drug resistance in colon cancer stem cells. Cell Cycle (2007) 1.29
New tools for systematic evaluation of teaching qualities of medical faculty: results of an ongoing multi-center survey. PLoS One (2011) 1.26
IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction--a comparative study of human clinical-applicable DC. Clin Immunol (2011) 1.23
Plasma CC16 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: a retrospective observational study. BMC Pulm Med (2009) 1.20
Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury. Am J Physiol Lung Cell Mol Physiol (2007) 1.19
Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737. Cancer Res (2011) 1.19
Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. J Med Chem (2007) 1.18
Granzymes at a glance. J Cell Sci (2006) 1.18
Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J Leukoc Biol (2002) 1.17
The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization. Vaccine (2007) 1.13
Betulinic acid, a natural compound with potent anticancer effects. Anticancer Drugs (2010) 1.11
Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer Lett (2006) 1.11
Cancer heterogeneity--a multifaceted view. EMBO Rep (2013) 1.11
APRIL but not BLyS serum levels are increased in chronic lymphocytic leukemia: prognostic relevance of APRIL for survival. Haematologica (2007) 1.11
NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma. Blood (2012) 1.09
Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. Apoptosis (2009) 1.09
Tumor microvasculature supports proliferation and expansion of glioma-propagating cells. Int J Cancer (2009) 1.08
Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy. Clin Cancer Res (2006) 1.06
Cancer stem cell dynamics in tumor progression and metastasis: is the microenvironment to blame? Cancer Lett (2012) 1.06
The proteoglycan (heparan sulfate proteoglycan) binding domain of APRIL serves as a platform for ligand multimerization and cross-linking. FASEB J (2009) 1.05
Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation. Mol Immunol (2007) 1.05
Development and characterization of APRIL antagonistic monoclonal antibodies for treatment of B-cell lymphomas. Blood (2011) 1.05
Surviving pediatric intensive care: physical outcome after 3 months. Intensive Care Med (2008) 1.04
Absence of class II-associated invariant chain peptide on leukemic blasts of patients promotes activation of autologous leukemia-reactive CD4+ T cells. Cancer Res (2011) 1.03
Inflammation and repeated infections in CGD: two sides of a coin. Cell Mol Life Sci (2011) 1.03
Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. Anesthesiology (2010) 1.02
The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence. Cancer Discov (2012) 1.01
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. Blood (2011) 1.01
Potential role of soluble TRAIL in epithelial injury in children with severe RSV infection. Am J Respir Cell Mol Biol (2009) 1.01
Circulating transforming growth factor-β as a prognostic biomarker in Marfan syndrome. Int J Cardiol (2013) 1.00
B cell receptor-mediated internalization of salmonella: a novel pathway for autonomous B cell activation and antibody production. J Immunol (2009) 1.00
Azithromycin does not improve disease course in hospitalized infants with respiratory syncytial virus (RSV) lower respiratory tract disease: a randomized equivalence trial. Pediatr Pulmonol (2008) 0.99
Nutritional goals, prescription and delivery in a pediatric intensive care unit. Clin Nutr (2008) 0.99
Alveolar fibrinolytic capacity suppressed by injurious mechanical ventilation. Intensive Care Med (2005) 0.98
Severe adult-onset asthma: A distinct phenotype. J Allergy Clin Immunol (2013) 0.98
Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon. Mol Cancer (2013) 0.97
Prognostic value of apoptosis in rectal cancer patients of the dutch total mesorectal excision trial: radiotherapy is redundant in intrinsically high-apoptotic tumors. Clin Cancer Res (2006) 0.96
Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J Invest Dermatol (2013) 0.95
Memory CD8+ T cells protect dendritic cells from CTL killing. J Immunol (2008) 0.95
Specific TLR ligands regulate APRIL secretion by dendritic cells in a PKR-dependent manner. Eur J Immunol (2007) 0.94
Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection. Am J Physiol Lung Cell Mol Physiol (2008) 0.94
Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities. Mol Cancer Ther (2013) 0.94
Are central line bundles and ventilator bundles effective in critically ill neonates and children? Intensive Care Med (2013) 0.93
Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma. Mol Oncol (2013) 0.92
Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival. Am J Pathol (2012) 0.92
Quality of life in children three and nine months after discharge from a paediatric intensive care unit: a prospective cohort study. Health Qual Life Outcomes (2008) 0.92
Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation. PLoS One (2010) 0.91
Outcome of paediatric intensive care survivors. Eur J Pediatr (2007) 0.91
Follow-up after paediatric intensive care treatment: parental posttraumatic stress. Acta Paediatr (2008) 0.91
Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist. J Pathol (2011) 0.91
Class II-associated invariant chain peptide down-modulation enhances the immunogenicity of myeloid leukemic blasts resulting in increased CD4+ T-cell responses. Haematologica (2009) 0.90
SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. Blood (2004) 0.90
Course and predictors of posttraumatic stress disorder in parents after pediatric intensive care treatment of their child. J Pediatr Psychol (2010) 0.90
Isolation and propagation of colon cancer stem cells. Methods Mol Biol (2013) 0.89
Detection of soluble human granzyme K in vitro and in vivo. Eur J Immunol (2005) 0.89
Betulin is a potent anti-tumor agent that is enhanced by cholesterol. PLoS One (2009) 0.88
Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model. Blood (2013) 0.88
Exploring cancer stem cell niche directed tumor growth. Cell Cycle (2010) 0.88
Disease causing mutations in the TNF and TNFR superfamilies: Focus on molecular mechanisms driving disease. Trends Mol Med (2011) 0.88
TWE-PRIL; a fusion protein of TWEAK and APRIL. Biochem Pharmacol (2003) 0.87