Published in J Immunol on June 07, 2010
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity (2011) 2.34
T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology. Immunity (2012) 2.21
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med (2011) 1.79
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Asymmetric B cell division in the germinal center reaction. Science (2011) 1.10
GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome. Am J Hum Genet (2012) 1.08
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Immune synapse: conductor of orchestrated organelle movement. Trends Cell Biol (2013) 1.05
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How signaling between cells can orient a mitotic spindle. Semin Cell Dev Biol (2011) 0.93
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From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells. Immunol Rev (2013) 0.83
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The immunological synapse: the gateway to the HIV reservoir. Immunol Rev (2013) 0.82
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Scribble acts as an oncogene in Eμ-myc-driven lymphoma. Oncogene (2015) 0.79
Polarity and lymphocyte fate determination. Curr Opin Cell Biol (2012) 0.79
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"Cell biology meets physiology: functional organization of vertebrate plasma membranes"--the immunological synapse. Curr Top Membr (2013) 0.75
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Aurora-A shines on T cell activation through the regulation of Lck. Bioessays (2016) 0.75
Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo. Immunol Cell Biol (2015) 0.75
T cell receptor antagonist peptides induce positive selection. Cell (1994) 18.66
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Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science (2003) 6.72
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity (2007) 6.48
Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science (2002) 5.61
Mechanisms of asymmetric stem cell division. Cell (2008) 5.59
The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity (1998) 5.20
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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest (2001) 4.37
Mechanisms of asymmetric cell division: flies and worms pave the way. Nat Rev Mol Cell Biol (2008) 3.69
Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell (2005) 3.36
Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity (2008) 2.98
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Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell (2007) 2.83
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G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell (2005) 2.64
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J Biol Chem (1994) 2.53
Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev (1993) 2.21
Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell (2008) 2.18
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors. Nat Immunol (2006) 2.13
Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation. Immunity (2007) 2.10
Maintenance and modulation of T cell polarity. Nat Immunol (2006) 2.05
T-cell activation through immunological synapses and kinapses. Immunol Rev (2008) 1.97
Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science (2009) 1.96
Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol (2003) 1.86
The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell (2001) 1.85
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aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO J (2007) 1.81
mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression. Nat Cell Biol (2005) 1.78
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A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells. Cancer Res (2006) 1.67
GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J Biol Chem (2000) 1.55
The Scribble and Par complexes in polarity and migration: friends or foes? Trends Cell Biol (2006) 1.53
Asymmetric centrosome behavior and the mechanisms of stem cell division. J Cell Biol (2008) 1.48
Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate. Science (2007) 1.47
Discs large (Dlg1) complexes in lymphocyte activation. J Cell Biol (2004) 1.43
A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity. Dev Biol (2004) 1.41
Mechanisms and functions for the duration of intercellular contacts made by lymphocytes. Nat Rev Immunol (2009) 1.36
Hunter to gatherer and back: immunological synapses and kinapses as variations on the theme of amoeboid locomotion. Annu Rev Cell Dev Biol (2008) 1.32
Single-cell dynamics of T-cell priming. Curr Opin Immunol (2007) 1.31
Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol (2004) 1.28
Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci (2007) 1.16
Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. Int Immunol (2008) 1.12
The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. J Immunol (2009) 1.00
A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts. J Cell Sci (2003) 0.92
Have traditional DMARDs had their day? Effectiveness of parenteral gold compared to biologic agents. Clin Rheumatol (2004) 0.90
How polarity shapes the destiny of T cells. J Cell Sci (2008) 0.86
Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion. Eur J Immunol (2006) 0.85
Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system. Curr Opin Immunol (2008) 0.84
Determination of T-cell fate by dendritic cells: a new role for asymmetric cell division? Immunol Cell Biol (2008) 0.80
Immunology. Ex uno plura. Science (2009) 0.78
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science (2011) 15.79
Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov (2006) 14.01
The lineage decisions of helper T cells. Nat Rev Immunol (2002) 10.61
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27
Adaptive immunity maintains occult cancer in an equilibrium state. Nature (2007) 8.14
NKT cells: what's in a name? Nat Rev Immunol (2004) 7.84
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature (2012) 7.76
Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (2003) 7.75
Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (2007) 7.64
Natural innate and adaptive immunity to cancer. Annu Rev Immunol (2011) 7.09
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73
The quality of medical care provided to vulnerable community-dwelling older patients. Ann Intern Med (2003) 5.28
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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A (2007) 4.92
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med (2010) 4.65
CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J Immunol (2006) 4.48
The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer (2008) 4.42
An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35
The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity (2012) 4.32
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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (2008) 4.04
Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol (2002) 3.96
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity (2013) 3.73
Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. J Immunol (2006) 3.73
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. J Exp Med (2007) 3.67
A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity (2009) 3.66
Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Proc Natl Acad Sci U S A (2005) 3.66
Multimorbidity is associated with better quality of care among vulnerable elders. Med Care (2007) 3.63
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science (2012) 3.39
New and emerging HDAC inhibitors for cancer treatment. J Clin Invest (2014) 3.35
The quality of pharmacologic care for vulnerable older patients. Ann Intern Med (2004) 3.34
The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor. Plant Cell (2009) 3.31
Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity (2013) 3.26
The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood (2010) 3.23
Functional interactions between dendritic cells and NK cells during viral infection. Nat Immunol (2002) 3.20
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A (2008) 3.19
A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J Exp Med (2002) 3.13
The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell (2007) 3.13
Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 3.09
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol (2006) 3.09
Characterization of three H5N5 and one H5N8 highly pathogenic avian influenza viruses in China. Vet Microbiol (2013) 3.05
Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol (2006) 3.04
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol (2007) 2.99
A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity (2005) 2.97
KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity (2009) 2.90
Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol (2002) 2.88
Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol (2002) 2.87
Differential antitumor immunity mediated by NKT cell subsets in vivo. J Exp Med (2005) 2.83
Close encounters of different kinds: dendritic cells and NK cells take centre stage. Nat Rev Immunol (2005) 2.77
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol (2011) 2.76
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A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J Exp Med (2002) 2.73
BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med (2007) 2.70
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci U S A (2010) 2.67
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape. Nat Med (2012) 2.66
Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. J Immunol (2010) 2.63
Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin Cancer Res (2013) 2.62
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity (2009) 2.61
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest (2011) 2.60
Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors. Cancer Res (2011) 2.59
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity (2012) 2.58
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc Natl Acad Sci U S A (2008) 2.57
The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity (2006) 2.55
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The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52
Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther (2009) 2.50
Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol (2003) 2.48
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
Novel reassortant highly pathogenic H5N2 avian influenza viruses in poultry in China. PLoS One (2012) 2.43
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Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity (2011) 2.34
A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance. J Exp Med (2005) 2.32
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors. J Clin Invest (2013) 2.30
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30
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Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell (2012) 2.29
NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. J Immunol (2007) 2.26
Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity (2012) 2.23
Presumed guilty: natural killer T cell defects and human disease. Nat Rev Immunol (2011) 2.21
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Rational combinations using HDAC inhibitors. Clin Cancer Res (2009) 2.12
Eradication of established tumors in mice by a combination antibody-based therapy. Nat Med (2006) 2.10
Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol (2007) 2.10
Supernatural T cells: genetic modification of T cells for cancer therapy. Nat Rev Immunol (2005) 2.08
Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy. Blood (2012) 2.07
Innate immunity defines the capacity of antiviral T cells to limit persistent infection. J Exp Med (2010) 2.06
IFNgamma signaling-does it mean JAK-STAT? Cytokine Growth Factor Rev (2008) 2.06
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med (2011) 2.04