Published in EMBO Rep on July 23, 2013
G-protein-coupled receptors, Hedgehog signaling and primary cilia. Semin Cell Dev Biol (2014) 0.96
Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties. Sci Rep (2014) 0.85
Ins and outs of GPCR signaling in primary cilia. EMBO Rep (2015) 0.84
Regulation of Hedgehog signaling by ubiquitination. Front Biol (Beijing) (2015) 0.78
Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development. Bioscience (2014) 0.77
Integrin-linked kinase in ciliary Hedgehog signaling. Cell Cycle (2014) 0.75
Intraflagellar transport. Nat Rev Mol Cell Biol (2002) 10.86
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation. Mol Cell (2002) 10.81
Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55
Proteomic analysis of a eukaryotic cilium. J Cell Biol (2005) 6.54
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15
Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87
Overview of structure and function of mammalian cilia. Annu Rev Physiol (2007) 4.90
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol (2006) 4.64
Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer (2005) 3.83
Functional genomic screen for modulators of ciliogenesis and cilium length. Nature (2010) 3.63
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. Nat Genet (2011) 3.57
The proteome of the mouse photoreceptor sensory cilium complex. Mol Cell Proteomics (2007) 3.53
Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expr Patterns (2003) 3.42
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development (2008) 3.30
Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (2008) 3.10
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum. Neuron (2005) 2.93
Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol (2004) 2.77
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci (2011) 2.51
Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development (2004) 2.04
Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol (2003) 1.99
The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development (2006) 1.79
Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia. Trends Cell Biol (2009) 1.76
Complex interactions between genes controlling trafficking in primary cilia. Nat Genet (2011) 1.65
The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell (2009) 1.62
Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J Cell Biol (2008) 1.52
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol (2011) 1.36
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. PLoS One (2010) 1.31
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Res (2011) 1.25
Visualization of protein interactions in living Caenorhabditis elegans using bimolecular fluorescence complementation analysis. Nat Protoc (2008) 1.20
Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. J Biol Chem (2000) 1.17
Induction of Ran GTP drives ciliogenesis. Mol Biol Cell (2011) 1.13
The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci (2009) 1.12
Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity. J Cell Sci (1999) 1.11
Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development. J Neurosci (2006) 1.11
Cell lineage analysis in neural crest ontogeny. J Neurobiol (1993) 1.09
Proper cerebellar development requires expression of β1-integrin in Bergmann glia, but not in granule neurons. Glia (2012) 0.82
The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol (2006) 11.16
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer (2005) 3.83
NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron (2004) 3.72
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res (2004) 3.64
Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res (2008) 3.57
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet (2006) 3.54
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat Biotechnol (2006) 3.46
A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res (2009) 3.38
Cancer survival in China, 2003-2005: a population-based study. Int J Cancer (2014) 3.32
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A (2007) 3.23
Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem (2002) 3.18
Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev (2005) 2.87
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med (2010) 2.86
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene (2004) 2.44
Integrin-linked kinase--essential roles in physiology and cancer biology. J Cell Sci (2008) 2.43
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res (2011) 2.39
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev (2009) 2.30
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res (2008) 2.20
Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer. Cancer Res (2008) 2.16
Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A (2008) 2.06
Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol (2003) 1.99
Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer. Cancer Res (2008) 1.99
A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med (2011) 1.97
Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol (2006) 1.90
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. Oncogene (2005) 1.89
Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell (2004) 1.82
Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev (2006) 1.80
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet (2003) 1.77
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem (2003) 1.77
Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget (2012) 1.77
Community identification of natural health product-drug interactions. Ann Pharmacother (2007) 1.76
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res (2011) 1.76
Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO J (2002) 1.73
Direct, nonoxidative conversion of methane to ethylene, aromatics, and hydrogen. Science (2014) 1.71
Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. J Am Soc Nephrol (2006) 1.70
SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. J Biol Chem (2005) 1.70
Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res (2005) 1.69
Monoclonal antibodies and progressive multifocal leukoencephalopathy. Can J Neurol Sci (2011) 1.69
Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity (2012) 1.62
Novel role for integrin-linked kinase in modulation of coxsackievirus B3 replication and virus-induced cardiomyocyte injury. Circ Res (2006) 1.60
Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium. Am J Physiol Cell Physiol (2006) 1.59
The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Rev (2003) 1.59
Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1. J Am Soc Nephrol (2007) 1.56
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. J Cell Biol (2008) 1.53
Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers. J Natl Cancer Inst (2007) 1.52
β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1. J Am Soc Nephrol (2011) 1.52
Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol (2002) 1.51
Cancer stem cells and the ontogeny of lung cancer. J Clin Oncol (2008) 1.51
ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene (2005) 1.46
Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol (2004) 1.46
Cancer stem cells in lung cancer: Evidence and controversies. Respirology (2013) 1.46
Integrin-linked kinase at the heart of cardiac contractility, repair, and disease. Circ Res (2007) 1.44
A miR-19 regulon that controls NF-κB signaling. Nucleic Acids Res (2012) 1.43
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev (2008) 1.42
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol Biol Cell (2003) 1.38
alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. Oncogene (2003) 1.36
Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism. J Cell Sci (2006) 1.35
Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly. J Neurosci (2005) 1.35
Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. Oncogene (2005) 1.34
Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia. Gastroenterology (2010) 1.33
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim Biophys Acta (2004) 1.32
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (2008) 1.31
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. PLoS One (2010) 1.31
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Res (2006) 1.31
Tumor-stroma ratio is an independent predictor for survival in esophageal squamous cell carcinoma. J Thorac Oncol (2012) 1.30
Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis. Dev Dyn (2008) 1.29
Fine-tuning of the innate immune response by microRNAs. Immunol Cell Biol (2007) 1.25
Mapping the integrin-linked kinase interactome using SILAC. J Proteome Res (2008) 1.25
ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton. Cancer Res (2013) 1.25
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Res (2011) 1.25
The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release. J Biol Chem (2012) 1.24
Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity (2009) 1.22
Targeting hypoxic tumour cells to overcome metastasis. BMC Cancer (2011) 1.19
Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Lab Invest (2005) 1.18
Novel systemic therapies for small cell lung cancer. J Natl Compr Canc Netw (2008) 1.18
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol (2011) 1.16
Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro. World J Gastroenterol (2008) 1.16
Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth. J Neurosci (2003) 1.15
Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. Oncogene (2005) 1.14
Lung cancer: future directions. Respirology (2007) 1.14
The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway. J Hepatol (2011) 1.13
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem (2011) 1.13
Iron encapsulated within pod-like carbon nanotubes for oxygen reduction reaction. Angew Chem Int Ed Engl (2012) 1.13
Developmental signalling pathways in lung cancer. Respirology (2006) 1.12
Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development. J Neurosci (2006) 1.11
Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease. Chembiochem (2006) 1.11
Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development (2009) 1.11
Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell (2008) 1.11