PubRank

John W Kappler

Author PubWeight™ 95.26‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 How the T cell repertoire becomes peptide and MHC specific. Cell 2005 3.39
2 The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity 2003 3.19
3 Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol 2010 2.80
4 T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol 2001 2.80
5 Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol 2008 2.79
6 Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat Immunol 2006 2.57
7 Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol 2009 2.47
8 Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature 2009 2.43
9 Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity 2008 2.31
10 T cell allorecognition via molecular mimicry. Immunity 2009 2.25
11 Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity. Blood 2011 2.20
12 Epitope dominance, competition and T cell affinity maturation. Curr Opin Immunol 2003 2.09
13 Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A 2010 1.87
14 A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity 2011 1.84
15 Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A 2011 1.68
16 IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol 2011 1.54
17 Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc Natl Acad Sci U S A 2010 1.47
18 CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc Natl Acad Sci U S A 2006 1.46
19 Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol 2011 1.43
20 Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. PLoS Biol 2004 1.40
21 Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A 2010 1.37
22 Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands. Immunol Rev 2006 1.33
23 CD4 memory T cells: what are they and what can they do? Semin Immunol 2009 1.29
24 Genetic and hormonal factors in female-biased autoimmunity. Autoimmun Rev 2010 1.24
25 Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A 2013 1.23
26 Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc Natl Acad Sci U S A 2004 1.23
27 Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol 2010 1.22
28 Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci U S A 2011 1.18
29 Non-malignant clonal expansions of CD8+ memory T cells in aged individuals. Immunol Rev 2005 1.17
30 Memory CD4 T cells: generation, reactivation and re-assignment. Immunology 2010 1.16
31 Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties. Proc Natl Acad Sci U S A 2008 1.16
32 T cells and their eons-old obsession with MHC. Immunol Rev 2012 1.13
33 Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood 2010 1.12
34 Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol 2007 1.12
35 Not all CD4+ memory T cells are long lived. Immunol Rev 2006 1.11
36 T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A 2013 1.08
37 The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim. Proc Natl Acad Sci U S A 2009 1.08
38 Using a baculovirus display library to identify MHC class I mimotopes. Proc Natl Acad Sci U S A 2005 1.07
39 Evolutionarily conserved features contribute to αβ T cell receptor specificity. Immunity 2011 1.06
40 Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions. Proc Natl Acad Sci U S A 2009 1.04
41 Yeast surface display of a noncovalent MHC class II heterodimer complexed with antigenic peptide. Biotechnol Bioeng 2005 1.01
42 Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity. J Immunol 2008 0.99
43 CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome. Exp Gerontol 2007 0.98
44 Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens. Proc Natl Acad Sci U S A 2010 0.96
45 Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. J Exp Med 2013 0.95
46 Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival. Ann N Y Acad Sci 2002 0.95
47 Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. Int Immunol 2008 0.94
48 A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol 2009 0.94
49 Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice. Diabetes Metab Res Rev 2011 0.93
50 Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases? Cold Spring Harb Perspect Med 2012 0.92
51 Mutagenesis of beryllium-specific TCRs suggests an unusual binding topology for antigen recognition. J Immunol 2011 0.92
52 TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice. Immunol Res 2013 0.92
53 T cell receptor specificity for major histocompatibility complex proteins. Curr Opin Immunol 2008 0.92
54 Homeostasis of the memory T cell pool. Int Arch Allergy Immunol 2006 0.91
55 The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles. Proc Natl Acad Sci U S A 2008 0.91
56 A closer look at TCR germline recognition. Immunity 2012 0.91
57 TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines. Cancer Immunol Immunother 2012 0.89
58 Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A 2013 0.88
59 T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Proc Natl Acad Sci U S A 2012 0.87
60 Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A 2014 0.86
61 Bcl-xl does not have to bind Bax to protect T cells from death. J Exp Med 2006 0.85
62 Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence. PLoS One 2013 0.84
63 Identification of multiple public TCR repertoires in chronic beryllium disease. J Immunol 2014 0.84
64 B cells expressing the transcription factor T-bet drive lupus-like autoimmunity. J Clin Invest 2017 0.83
65 Linking genetic susceptibility and T cell activation in beryllium-induced disease. Proc Am Thorac Soc 2010 0.81
66 Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor. J Biol Chem 2013 0.81
67 Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains. Mol Immunol 2008 0.80
68 Transgenic Bcl-3 slows T cell proliferation. Int Immunol 2009 0.79
69 Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990. J Immunol 2010 0.79
70 Molecules in medicine mini review: the αβ T cell receptor. J Mol Med (Berl) 2014 0.78
71 Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line. Eur J Immunol 2012 0.78
72 Vaccination of mice with baculovirus-infected insect cells expressing antigenic proteins. Curr Protoc Immunol 2009 0.77
73 The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells. PLoS One 2013 0.76
74 Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine αβ T Cell Receptors. J. Immunol. 1989. 142: 2736-2742. J Immunol 2016 0.75