Published in Int Immunol on March 14, 2008
Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol (2009) 3.51
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 2.47
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A (2013) 1.23
Mechanism of immunopotentiation and safety of aluminum adjuvants. Front Immunol (2013) 1.13
IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness. PLoS Negl Trop Dis (2010) 0.94
The inflammasome and alum-mediated adjuvanticity. F1000 Biol Rep (2009) 0.86
The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm. Springerplus (2015) 0.80
Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol (2003) 15.65
Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54
Decoding the patterns of self and nonself by the innate immune system. Science (2002) 7.19
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science (2006) 6.47
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48
Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity (2001) 5.46
Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol (2006) 4.55
Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity (1998) 4.15
Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity (2000) 3.93
Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol (1991) 3.65
The interface between innate and adaptive immunity. Nat Immunol (2004) 3.28
Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J Immunol (2007) 3.17
Pathogen recognition with Toll-like receptors. Curr Opin Immunol (2005) 3.05
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med (2006) 2.70
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A (1997) 2.67
Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling. J Immunol (1999) 2.53
Promotion of B cell immune responses via an alum-induced myeloid cell population. Science (2004) 2.47
CD8- dendritic cell activation status plays an integral role in influencing Th2 response development. J Immunol (2001) 2.42
Helminth antigens modulate TLR-initiated dendritic cell activation. J Immunol (2004) 2.21
Toll-like receptors as adjuvant receptors. Biochim Biophys Acta (2002) 2.20
Different T helper cell subsets elicited in mice utilizing two different adjuvant vehicles: the role of endogenous interleukin 1 in proliferative responses. Cell Immunol (1989) 2.15
Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J Exp Med (1997) 2.15
A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J Immunol (2000) 2.01
A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1(+) macrophages that suppress naive CD4(+) T cell proliferation via an IFN-gamma and nitric oxide-dependent mechanism. J Immunol (2001) 1.78
Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants. Vaccine (2007) 1.76
Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro. Vaccine (2003) 1.73
TLR4 as the mammalian endotoxin sensor. Curr Top Microbiol Immunol (2002) 1.65
In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production. Eur J Immunol (1996) 1.59
Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine (2005) 1.51
Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response. J Immunol (2001) 1.45
The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells. J Immunol (2002) 1.32
TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. Science (2001) 1.31
Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo. Immunol Rev (2004) 1.24
Interleukin-18 plays a role in both the alum-induced T helper 2 response and the T helper 1 response induced by alum-adsorbed interleukin-12. Immunology (2003) 1.22
Ia-mediated signal transduction leads to proliferation of primed B lymphocytes. J Exp Med (1989) 1.21
Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants. Immunobiology (1993) 1.15
Lack of antigen-specific Th1 response alters granuloma formation and composition in Schistosoma mansoni-infected MyD88-/- mice. Eur J Immunol (2005) 1.10
The concept of type 1 and type 2 antigen-presenting cells. Immunol Lett (1999) 1.06
Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells. Eur J Immunol (2004) 1.02
Functional dichotomy in the CD4+ T cell response to Schistosoma mansoni. Exp Parasitol (1991) 0.86
Using bicistronic IL-4 reporter mice to identify IL-4 expressing cells following immunisation with aluminium adjuvant. Vaccine (2006) 0.84
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity (2002) 4.61
How the T cell repertoire becomes peptide and MHC specific. Cell (2005) 3.39
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity (2003) 3.19
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood (2004) 3.19
Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol (2007) 3.19
Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol (2010) 2.80
T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat Immunol (2001) 2.80
Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol (2008) 2.79
Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide. Nat Immunol (2006) 2.57
Promotion of B cell immune responses via an alum-induced myeloid cell population. Science (2004) 2.47
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 2.47
CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc Natl Acad Sci U S A (2002) 2.44
Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection. Nature (2009) 2.43
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity (2008) 2.31
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem (2004) 2.30
T cell allorecognition via molecular mimicry. Immunity (2009) 2.25
Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity. Blood (2011) 2.20
Epitope dominance, competition and T cell affinity maturation. Curr Opin Immunol (2003) 2.09
How do adjuvants work? Important considerations for new generation adjuvants. Immunity (2007) 2.01
Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory. Eur J Immunol (2006) 1.95
A molecular basis for NKT cell recognition of CD1d-self-antigen. Immunity (2011) 1.94
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A (2010) 1.87
Molecular mechanisms of activated T cell death in vivo. Curr Opin Immunol (2002) 1.85
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire. Immunity (2009) 1.85
A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity (2011) 1.84
Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol (2005) 1.77
Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A (2007) 1.74
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci U S A (2004) 1.72
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity (2006) 1.71
Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Nat Immunol (2003) 1.69
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A (2011) 1.68
IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol (2011) 1.54
Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol (2007) 1.49
Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc Natl Acad Sci U S A (2010) 1.47
CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc Natl Acad Sci U S A (2006) 1.46
Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol (2011) 1.43
Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library. PLoS Biol (2004) 1.40
Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A (2010) 1.37
T cell apoptosis and reactive oxygen species. J Clin Invest (2003) 1.35
Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands. Immunol Rev (2006) 1.33
Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J Clin Invest (2007) 1.32
CD4 memory T cells: what are they and what can they do? Semin Immunol (2009) 1.29
RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR-dependent process. Immunity (2002) 1.26
Control of Bcl-2 expression by reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.26
CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A (2008) 1.25
Genetic and hormonal factors in female-biased autoimmunity. Autoimmun Rev (2010) 1.24
Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc Natl Acad Sci U S A (2004) 1.23
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A (2013) 1.23
Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol (2012) 1.22
Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol (2010) 1.22
Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci U S A (2011) 1.18
Non-malignant clonal expansions of CD8+ memory T cells in aged individuals. Immunol Rev (2005) 1.17
Alternate interactions define the binding of peptides to the MHC molecule IA(b). Proc Natl Acad Sci U S A (2002) 1.16
Negative selection imparts peptide specificity to the mature T cell repertoire. Proc Natl Acad Sci U S A (2003) 1.16