Published in Methods Mol Biol on January 01, 2008
Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis. J Exp Med (2012) 1.39
ENU-induced phenovariance in mice: inferences from 587 mutations. BMC Res Notes (2012) 1.28
iRhom2 is required for the secretion of mouse TNFα. Blood (2012) 1.08
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol (2015) 1.06
A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. Proc Natl Acad Sci U S A (2010) 1.01
Mouse models in male fertility research. Asian J Androl (2010) 1.01
Increased susceptibility to DNA virus infection in mice with a GCN2 mutation. J Virol (2011) 0.95
Real-time resolution of point mutations that cause phenovariance in mice. Proc Natl Acad Sci U S A (2015) 0.93
ZBTB1 is a determinant of lymphoid development. J Exp Med (2011) 0.91
Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proc Natl Acad Sci U S A (2012) 0.84
Going forward with genetics: recent technological advances and forward genetics in mice. Am J Pathol (2013) 0.83
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice. Proc Natl Acad Sci U S A (2017) 0.82
Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Proc Natl Acad Sci U S A (2015) 0.78
Modelling age-related metabolic disorders in the mouse. Mamm Genome (2014) 0.78
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A (2016) 0.77
New genetic resources for mammalian developmental biologists. F1000 Biol Rep (2010) 0.77
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Innate immunity and the new forward genetics. Best Pract Res Clin Haematol (2016) 0.75
Creatine maintains intestinal homeostasis and protects against colitis. Proc Natl Acad Sci U S A (2017) 0.75
Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. J Exp Med (2017) 0.75
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol (2005) 7.74
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (2005) 7.72
Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science (2006) 6.47
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol (2006) 5.51
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol (2006) 5.35
CD36 is a sensor of diacylglycerides. Nature (2005) 5.20
CD14 is required for MyD88-independent LPS signaling. Nat Immunol (2005) 5.20
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A (2004) 4.88
Intracellular toll-like receptors. Immunity (2010) 4.66
Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science (2009) 4.45
Herpes simplex virus encephalitis in human UNC-93B deficiency. Science (2006) 4.26
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol (2003) 4.15
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72
The serine protease TMPRSS6 is required to sense iron deficiency. Science (2008) 3.70
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med (2007) 3.45
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity (2006) 3.38
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity (2007) 3.38
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med (2003) 3.30
The interface between innate and adaptive immunity. Nat Immunol (2004) 3.28
Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem (2007) 2.82
MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nat Med (2012) 2.61
Plant and animal sensors of conserved microbial signatures. Science (2010) 2.16
Cutting edge: Priming of NK cells by IL-18. J Immunol (2008) 2.08
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol (2009) 2.07
Toll-like receptors. Curr Biol (2011) 2.06
Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science (2012) 1.98
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol (2011) 1.96
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology (2007) 1.94
A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. J Immunol (2010) 1.91
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res (2010) 1.88
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A (2006) 1.88
ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet (2007) 1.83
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A (2003) 1.78
Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway. Immunity (2006) 1.78
An essential role for Rxr alpha in the development of Th2 responses. Eur J Immunol (2005) 1.74
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med (2007) 1.73
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc Natl Acad Sci U S A (2010) 1.73
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci U S A (2009) 1.70
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A (2009) 1.69
Pacing or ablation: which is better for paroxysmal atrial fibrillation-related tachycardia-bradycardia syndrome? Pacing Clin Electrophysiol (2014) 1.65
The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung. J Immunol (2005) 1.65
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci U S A (2011) 1.59
Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis. Genetics (2010) 1.56
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 1.55
A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun (2005) 1.55
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med (2009) 1.53
Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity (2007) 1.50
A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation. Mol Cell Biol (2009) 1.43
LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. J Endotoxin Res (2004) 1.42
Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling. J Immunol (2005) 1.42
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc Natl Acad Sci U S A (2004) 1.41
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol (2010) 1.39
Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur J Immunol (2004) 1.39
Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem (2009) 1.39
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease. Proc Natl Acad Sci U S A (2005) 1.39
Murine cerebral malaria development is independent of toll-like receptor signaling. Am J Pathol (2007) 1.38
Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res (2003) 1.38
Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6. Br J Haematol (2009) 1.36
A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet (2008) 1.36
Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Eur J Immunol (2006) 1.32
Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol (2009) 1.31
Homoharringtonine-based induction regimens for patients with de-novo acute myeloid leukaemia: a multicentre, open-label, randomised, controlled phase 3 trial. Lancet Oncol (2013) 1.31
The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A (2011) 1.29
NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses. Blood (2009) 1.29
ENU-induced phenovariance in mice: inferences from 587 mutations. BMC Res Notes (2012) 1.28